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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(S)-phenyl(thiophen-2-yl)methyl]acetamide —— C16H15N3OS4
    2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(S)-phenyl(thiophen-2-yl)methyl]acetamide
    —— 2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethanone —— C16H17N3OS3
    2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethanone
    —— [2-[2-(4-Bromophenyl)sulfanylethylamino]-2-oxoethyl] 2,3-dihydro-1,4-dioxine-5-carboxylate —— C15H16BrNO5S
    [2-[2-(4-Bromophenyl)sulfanylethylamino]-2-oxoethyl] 2,3-dihydro-1,4-dioxine-5-carboxylate
    —— [2-Oxo-2-(3-phenylsulfanylpropylamino)ethyl] 2,3-dihydro-1,4-dioxine-5-carboxylate —— C16H19NO5S
    [2-Oxo-2-(3-phenylsulfanylpropylamino)ethyl] 2,3-dihydro-1,4-dioxine-5-carboxylate
    —— N-(2-methylbutan-2-yl)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H23N3O2S
    N-(2-methylbutan-2-yl)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]-N-(2,4,4-trimethylpentan-2-yl)acetamide —— C17H29N3O2S
    2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]-N-(2,4,4-trimethylpentan-2-yl)acetamide
    —— N-[(2-methylphenyl)methyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C17H21N3O2S
    N-[(2-methylphenyl)methyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(S)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C20H20FN3O2S2
    N-[(S)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-benzyl-N-(furan-2-ylmethyl)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C21H23N3O3S
    N-benzyl-N-(furan-2-ylmethyl)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-(2-methoxyethyl)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C16H25N3O5S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-(2-methoxyethyl)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C20H20FN3O2S2
    N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 6-Amino-3-methyl-1-propyl-5-[2-(2,4,6-trimethylphenyl)sulfanylacetyl]pyrimidine-2,4-dione —— C19H25N3O3S
    6-Amino-3-methyl-1-propyl-5-[2-(2,4,6-trimethylphenyl)sulfanylacetyl]pyrimidine-2,4-dione
    —— 2-[2-oxo-2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C20H23N3O2S
    2-[2-oxo-2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one
    —— N-methyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]-N-(thiophen-3-ylmethyl)acetamide —— C15H19N3O2S2
    N-methyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]-N-(thiophen-3-ylmethyl)acetamide
    —— N-[(4-ethylphenyl)methyl]-N-methyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C19H25N3O2S
    N-[(4-ethylphenyl)methyl]-N-methyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— (2S)-N-(1-cyanocyclohexyl)-2-(2,4,6-trimethylphenyl)sulfanylpropanamide —— C19H26N2OS
    (2S)-N-(1-cyanocyclohexyl)-2-(2,4,6-trimethylphenyl)sulfanylpropanamide
    —— 5-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-2,3-dihydro-1H-indene —— C16H15NO4S2
    5-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-2,3-dihydro-1H-indene
    —— 4-(2,3-dihydro-1H-inden-5-ylsulfanyl)-3-nitrobenzenesulfonamide —— C15H14N2O4S2
    4-(2,3-dihydro-1H-inden-5-ylsulfanyl)-3-nitrobenzenesulfonamide
    —— 6-(3-chloro-4-fluorophenyl)sulfanyl-N,N-diethylpyridine-3-sulfonamide —— C15H16ClFN2O2S2
    6-(3-chloro-4-fluorophenyl)sulfanyl-N,N-diethylpyridine-3-sulfonamide
    —— 2-(3-Chloro-4-fluorophenyl)sulfanyl-5-pyrrolidin-1-ylsulfonylpyridine —— C15H14ClFN2O2S2
    2-(3-Chloro-4-fluorophenyl)sulfanyl-5-pyrrolidin-1-ylsulfonylpyridine
    —— 2-(3-Chloro-4-fluorophenyl)sulfanyl-5-nitrobenzonitrile —— C13H6ClFN2O2S
    2-(3-Chloro-4-fluorophenyl)sulfanyl-5-nitrobenzonitrile
    —— 2-(3-Chloro-4-fluorophenyl)sulfanyl-3-nitropyridine —— C11H6ClFN2O2S
    2-(3-Chloro-4-fluorophenyl)sulfanyl-3-nitropyridine
    —— 4,5,6-Trimethyl-2-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)pyridine-3-carbonitrile —— C18H16N4S2
    4,5,6-Trimethyl-2-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)pyridine-3-carbonitrile
    —— 5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-prop-2-enyl-1,3,4-thiadiazol-2-amine —— C17H13N5S3
    5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
    —— 12-[(5-Butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C15H16N4S4
    12-[(5-Butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— N,N-diethyl-2-[(5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C14H15N5OS4
    N,N-diethyl-2-[(5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2-[[5-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C12H11N5OS4
    2-[[5-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-(2-Cyano-4-nitrophenyl)sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile —— C16H12N4O2S
    2-(2-Cyano-4-nitrophenyl)sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile
    —— 2-(3-Chloro-4-fluorophenyl)sulfanyl-5-piperidin-1-ylsulfonylpyridine —— C16H16ClFN2O2S2
    2-(3-Chloro-4-fluorophenyl)sulfanyl-5-piperidin-1-ylsulfonylpyridine
    —— 12-[(5-Butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C16H18N4S4
    12-[(5-Butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— 4-(3-chloro-4-fluorophenyl)sulfanyl-N-methyl-3-nitrobenzenesulfonamide —— C13H10ClFN2O4S2
    4-(3-chloro-4-fluorophenyl)sulfanyl-N-methyl-3-nitrobenzenesulfonamide
    —— 2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C18H14N4O3S2
    2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 5-[2-(diethylaminomethyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-yl]sulfanyl-N-prop-2-enyl-1,3,4-thiadiazol-2-amine —— C18H24N6S3
    5-[2-(diethylaminomethyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-yl]sulfanyl-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
    —— 5-(2-chloro-4-nitrophenyl)sulfanyl-N-prop-2-enyl-1,3,4-thiadiazol-2-amine —— C11H9ClN4O2S2
    5-(2-chloro-4-nitrophenyl)sulfanyl-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(3,5-Dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C17H12N4O5S
    2-[[5-(3,5-Dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 2-(3,5-Dimethoxyphenyl)-5-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-oxadiazole —— C19H16N4O3S2
    2-(3,5-Dimethoxyphenyl)-5-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-oxadiazole
    —— 5-Nitro-2-[(5-propylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]benzonitrile —— C12H10N4O2S3
    5-Nitro-2-[(5-propylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]benzonitrile
    —— 2-(4-Chloro-2-nitrophenyl)sulfanyl-5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazole —— C16H12ClN3O5S
    2-(4-Chloro-2-nitrophenyl)sulfanyl-5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazole
    —— N-prop-2-enyl-5-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-thiadiazol-2-amine —— C14H13N5S3
    N-prop-2-enyl-5-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-thiadiazol-2-amine
    —— 2-Cyclohexyl-5-(2,4-dinitrophenyl)sulfanyl-1,3,4-oxadiazole —— C14H14N4O5S
    2-Cyclohexyl-5-(2,4-dinitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C17H15N3O3S2
    2-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2,5,6-Trimethyl-4-[[5-(2-methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]thieno[2,3-d]pyrimidine —— C15H18N4S4
    2,5,6-Trimethyl-4-[[5-(2-methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]thieno[2,3-d]pyrimidine
    —— 12-[(5-Propylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C14H14N4S4
    12-[(5-Propylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— 2-[[5-(4-chloro-2-nitrophenyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide —— C13H13ClN4O3S3
    2-[[5-(4-chloro-2-nitrophenyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— 5-Nitro-2-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]benzonitrile —— C12H9N5O2S2
    5-Nitro-2-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]benzonitrile
    —— 2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(2-methylpropylsulfanyl)-1,3,4-thiadiazole —— C12H12ClN3O2S3
    2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(2-methylpropylsulfanyl)-1,3,4-thiadiazole
    —— 1-[[5-(2-Nitrophenyl)sulfanyl-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one —— C13H12N4O4S
    1-[[5-(2-Nitrophenyl)sulfanyl-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one
    —— 2-[[5-benzyl-4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide —— C22H26N4O2S
    2-[[5-benzyl-4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide
    —— 1-[[5-(5,6,7,8-Tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one —— C17H17N5O2S2
    1-[[5-(5,6,7,8-Tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one
    —— N-(2-methoxyethyl)-5-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-1,3,4-thiadiazol-2-amine —— C18H17N5OS3
    N-(2-methoxyethyl)-5-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-1,3,4-thiadiazol-2-amine