[2-(丙基硫代)乙基]胺盐酸盐 | 36517-93-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: [2-(丙基硫代)乙基]胺盐酸盐
• 英文名称: 2-propylthioethylamine
• 英文别名: 2-(propylthio)ethanamine；β-n-Propylmercapto-aethylamin；2-n-Propylmercapto-aethylamin；2-propylsulfanylethylamine；1-Amino-2-propylmercapto-aethan；2-Propylmercapto-aethylamin；2-(Propylthio)ethylamine；2-propylsulfanylethanamine
• CAS: 36517-93-8
• 化学式: C₅H₁₃NS
• mdl: MFCD00015544
• 分子量: 119.231
• InChiKey: KHHKBTRFZTUVRD-UHFFFAOYSA-N

物化性质

• 沸点：
  88-89 °C(Press: 26 Torr)
• 密度：
  0.928 g/cm3(Temp: 25 °C)
• 保留指数：
  1029

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  7
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  [2-(丙基硫代)乙基]胺盐酸盐 在 palladium on activated charcoal Oxone 、 氢气 、 碳酸氢钠 作用下， 以 甲醇 、 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-(Propylsulfonyl)ethanamine
  参考文献：
  名称：

  Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series

  摘要：

  Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3-haloanilino provided the best enzyme potency and cellular selectivity. Changes made to the 6-furanyl group had little impact on the enzyme activity, but appeared to dramatically affect the cellular efficacy. The discovery of lapatinib emerged from this work. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.090
• 作为产物：
  描述：

  丙烷-1-硫醇 、 2-氯乙胺盐酸盐 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以42%的产率得到[2-(丙基硫代)乙基]胺盐酸盐
  参考文献：
  名称：

  Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X=O, S)

  摘要：

  Two series of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X) P-substituted aminodiphosphines (X = O, S) have been prepared and characterized by conventional physico-chemical techniques. The first series includes '3 + 1'-type complexes comprising an aromatic PNP-aminodiphosphine and acetonitrile or triphenylphosphine. In the second series, the central amine function of the PNP-ligand was substituted with functionalized pendant arms containing ether, hydroxyl or thioether groups to enhance the chelation ability of the ligand. Fully coordinated neutral and cationic complexes were isolated. A preliminary study investigating both the labeling of Cu-64 with the prototype PN(S)P ligand and the potential cytotoxic activity of the 'cold' [Cu(PN(S)P)][BF4] complex is reported. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.01.012

文献信息

• Synthesis, characterization, and catalytic behaviours of β-carbonylenamine-derived [O−NS]TiCl3 complexes in ethylene homo- and copolymerization
  作者：Xiao-Hong Yang、Zheng Wang、Xiu-Li Sun、Yong Tang

  DOI：10.1039/b910868h

  日期：——

  A series of [O−NS]TiCl3 complexes 5a–l derived from β-carbonylenamine were synthesized and characterized. In the presence of modified methylaluminoxane (MMAO), complexes 1, 5a–i and 5l are highly active for ethylene polymerization and copolymerization of ethylene with 1-hexene, CPE and NBE. Up to 5.12 × 106 g mol−1 h−1 atm−1 of activity for the copolymerization of ethylene with 1-hexene is achieved with a 28.9 mol% incorporation ratio.

  合成并表征了一系列来自β-羰基胺的[O−NS]TiCl3配合物5a–l。在改性甲基铝氧烯(MMAO)的存在下，配合物1、5a–i和5l对乙烯聚合及乙烯与1-己烯、CPE和NBE的共聚合表现出高活性。在乙烯与1-己烯的共聚合中，活性达到5.12 × 10^6 g mol−1 h−1 atm−1，聚合比例达到28.9 mol%。
• Synthesis, Characterization, and Highly Selective Ethylene Dimerization to 1-Butene of [O−NX]Ni(II) Complexes
  作者：Chongjie Xu、Qi Shen、Xiuli Sun、Yong Tang

  DOI：10.1002/cjoc.201100443

  日期：2012.5

  series of nickel(II) complexes have been synthesized and characterized. Molecular structure analysis exhibits that a square planar geometry around nickel is adopted. Upon activation with MAO, these nickel(II) complexes are efficient in catalyzing the ethylene dimerization, providing 1‐butene with an activity of up to 1.4×107 g/(mol·h·atm). The heteroatoms of the sidearm in the complexes were proved to

  已经合成和表征了一系列镍（II）配合物。分子结构分析表明，采用了围绕镍的正方形平面几何形状。通过MAO活化后，这些镍（II）络合物可有效催化乙烯二聚，从而提供1-丁烯，其活性最高可达1.4×10 7 g /（mol·h·atm）。络合物中侧臂的杂原子被证明对1-丁烯的活性和选择性有很大的影响。
• Thermoresponsive Sulfone and Sulfoxide‐Containing Polyacrylamides
  作者：Jieun Choi、Hyung‐il Lee

  DOI：10.1002/bkcs.12341

  日期：2021.8

  polyacrylamides containing sulfide, sulfone, or sulfoxide was successfully prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The thermal properties of polyacrylamides with sulfone or sulfoxide, which have not been studied before, were investigated for the first time. While poly[N-(2-(propylsulfonyl)ethyl)acrylamide] (P2SO2) with sulfone groups was water insoluble, pol

  通过可逆加成-断裂链转移（RAFT）聚合反应成功制备了一系列含有硫化物、砜或亚砜的热响应聚丙烯酰胺。首次研究了以前没有研究过的含有砜或亚砜的聚丙烯酰胺的热性能。虽然聚[ ñ - （2-（丙基磺酰基）乙基）丙烯酰胺]（P2SO2）与砜基团是不溶于水，聚[ Ñ - （2-（丙基亚磺酰基）乙基）丙烯酰胺]（P2SO）与亚砜基团是水溶性的，指示亚砜部分比砜更具亲水性。通过控制聚合物链的末端，我们合成了聚[ N- (2-(乙基磺酰基)乙基)丙烯酰胺](P1SO2)和聚[ N-(2-(丁基亚磺酰基)乙基)丙烯酰胺] (P3SO)，其在水中的临界溶解温度 (LCST) 较低，约为 24–26°C。为了调整大范围的 LCST，我们通过控制疏水 M2SO2 和亲水 M2SO 的初始进料比合成了无规共聚物。两亲嵌段共聚物也被合成并在水中组装以产生胶束。在该胶束溶液中加入 H 2 O 2 后，疏水性嵌段被氧化并转化为亲水性嵌段，导致胶束转化为单体。
• 非茂类β-酮亚胺型三齿双金属钛配合物、制备 方法与应用
  申请人：中南民族大学

  公开号：CN104292254B

  公开（公告）日：2017-06-20

  本发明公开了一种非茂类β‑酮亚胺型三齿双金属钛配合物、制备方法以及该双金属钛配合物在催化乙烯均聚以及在催化乙烯与α‑烯烃、环烯烃或二烯烃共聚的用途。本发明方法制备的非茂类β‑酮亚胺型三齿双金属钛配合物具有设计新颖、制备方法简单、反应条件温和、催化剂成本低，乙烯聚合活性高的优点，催化乙烯聚合活性高于106g PE/molTi·h；与相应的单核催化剂相比，具有稳定性好、寿命长、助催化剂用量少、所得聚合产物分子量分布宽等优点。
• THE REACTION OF CYANOGEN WITH ORGANIC COMPOUNDS VIII. 2-MERCAPTOETHYLAMINE AND ITS ALKYL DERIVATIVES¹
  作者：HENRY M. WOODBURN、BERNARD G. PAUTLER

  DOI：10.1021/jo01370a028

  日期：1954.5