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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-ethylmercapto-5-fluoro-6-methyl-3<i>H</i>-pyrimidin-4-one 705-50-0 C7H9FN2OS
    2-ethylmercapto-5-fluoro-6-methyl-3<i>H</i>-pyrimidin-4-one
    —— cyclohexanespiro-2'-4'-phenyl-1',3'-oxathiolan-5'-one 71318-64-4 C14H16O2S
    cyclohexanespiro-2'-4'-phenyl-1',3'-oxathiolan-5'-one
    —— 5-(4-Fluorophenyl)sulfanyl-3-methoxy-6-nitro-1-benzofuran 286377-37-5 C15H10FNO4S
    5-(4-Fluorophenyl)sulfanyl-3-methoxy-6-nitro-1-benzofuran
    —— tris[2-(phenylthio)ethyl]phosphine oxide 37753-39-2 C24H27OPS3
    tris[2-(phenylthio)ethyl]phosphine oxide
    —— 4-[2-hydroxy-1-tert-butyldimethylsilyloxy-2-(2-nonyl-1,3-dithian-2-yl)-(1R)-ethyl]-3-methyl-5-phenyl-(4S,5R)-1,3-oxazolan-2-one 651359-05-6 C31H53NO4S2Si
    4-[2-hydroxy-1-tert-butyldimethylsilyloxy-2-(2-nonyl-1,3-dithian-2-yl)-(1R)-ethyl]-3-methyl-5-phenyl-(4S,5R)-1,3-oxazolan-2-one
    —— S-propyl dipropylthiocarbamate S,S-dioxide 51892-64-9 C10H21NO3S
    S-propyl dipropylthiocarbamate S,S-dioxide
    —— [1-((Z)-2-Methoxy-vinyl)-heptylsulfanyl]-benzene 63109-52-4 C16H24OS
    [1-((Z)-2-Methoxy-vinyl)-heptylsulfanyl]-benzene
    —— [((E)-1-Buta-1,3-dienyl)-heptylsulfanyl]-benzene 125153-25-5 C17H24S
    [((E)-1-Buta-1,3-dienyl)-heptylsulfanyl]-benzene
    —— 4-methyl-5-phenylsulfanyl-(Z,4S)-2-penten-1-ol 556834-59-4 C12H16OS
    4-methyl-5-phenylsulfanyl-(Z,4S)-2-penten-1-ol
    —— methyl 4-methyl-5-phenylsulfanyl-(Z,4S)-2-pentenoate 556834-58-3 C13H16O2S
    methyl 4-methyl-5-phenylsulfanyl-(Z,4S)-2-pentenoate
    —— [4-(phenylthio)phenyl]phenylsulfoxide 99901-62-9 C18H14OS2
    [4-(phenylthio)phenyl]phenylsulfoxide
    —— 1,3-Bis(methylthio)-1-propanol 54884-93-4 C5H12OS2
    1,3-Bis(methylthio)-1-propanol
    —— 3-Cyclohexyl-8-Phenyl-1,2,4-triazolo<3,4-b>-1,3,4-thiadiazepine 76457-83-5 C17H18N4S
    3-Cyclohexyl-8-Phenyl-1,2,4-triazolo<3,4-b>-1,3,4-thiadiazepine
    —— 3-Chloro-4-[(2,5-dichlorophenyl)sulfanyl]aniline 87294-30-2 C12H8Cl3NS
    3-Chloro-4-[(2,5-dichlorophenyl)sulfanyl]aniline
    —— 4-(phenylthio)dihydrofuran-2(3H)-one 156540-92-0 C10H10O2S
    4-(phenylthio)dihydrofuran-2(3H)-one
    —— (2S)-1-[2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-3-(2-heptyl-1,3-dithian-2-yl)propyl]-1,3-dithian-2-yl]pent-4-en-2-ol 1431375-90-4 C29H56O2S4Si
    (2S)-1-[2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-3-(2-heptyl-1,3-dithian-2-yl)propyl]-1,3-dithian-2-yl]pent-4-en-2-ol
    —— N,N'-ethylenebis(thioacetylacetonylideneimine) 53103-67-6 C12H20N2S2
    N,N'-ethylenebis(thioacetylacetonylideneimine)
    —— 3-dimethylcarbamoyloxy-5-ethylsulfanyl-[1,2,4]thiadiazole 72182-95-7 C7H11N3O2S2
    3-dimethylcarbamoyloxy-5-ethylsulfanyl-[1,2,4]thiadiazole
    —— 2,5-bis(β-chloroethylsulfonyl)pentylamine hydrochloride 122289-60-5 C9H19Cl2NO4S2*ClH
    2,5-bis(β-chloroethylsulfonyl)pentylamine hydrochloride
    —— cyanomethyl ethylsulfinylacetate 85389-96-4 C6H9NO3S
    cyanomethyl ethylsulfinylacetate
    —— 4-(phenylthio)dihydrofuran-2(3H)-one 1588512-08-6 C10H10O2S
    4-(phenylthio)dihydrofuran-2(3H)-one
    —— 5-allylsulfanyl-3-dimethylcarbamoyloxy-[1,2,4]thiadiazole 72182-96-8 C8H11N3O2S2
    5-allylsulfanyl-3-dimethylcarbamoyloxy-[1,2,4]thiadiazole
    —— 2-[4-[2-[(E)-hex-4-enyl]-1,3-dithian-2-yl]butoxy]oxane 246034-96-8 C19H34O2S2
    2-[4-[2-[(E)-hex-4-enyl]-1,3-dithian-2-yl]butoxy]oxane
    —— 4-(2-phenylethyl)-5-(p-tolylsulfanyl)-4,5-dihydro-3H-furan-2-one 596119-48-1 C19H20O2S
    4-(2-phenylethyl)-5-(p-tolylsulfanyl)-4,5-dihydro-3H-furan-2-one
    —— 4-phenyl-5-(p-tolylsulfanyl)dihydrofuran-2-one 823213-97-4 C17H16O2S
    4-phenyl-5-(p-tolylsulfanyl)dihydrofuran-2-one
    —— 1-[(E)-3-(3-Pyridyl)prop-2-en-1-yl]-6-(phenylthio)thymine 157401-05-3 C19H17N3O2S
    1-[(E)-3-(3-Pyridyl)prop-2-en-1-yl]-6-(phenylthio)thymine
    —— 3,3-di[(phenylsulfanyl)methyl]cyclobutanone 938436-13-6 C18H18OS2
    3,3-di[(phenylsulfanyl)methyl]cyclobutanone
    —— (2R,3S)-N,N-diallyl-3-hydroxy-2,4-dimethylpentanethioamide 1283722-04-2 C13H23NOS
    (2R,3S)-N,N-diallyl-3-hydroxy-2,4-dimethylpentanethioamide
    —— 4,5-dihydro-3-(1-hydroxybutyl)-3-phenylthio-3H-furan-2-one —— C14H18O3S
    4,5-dihydro-3-(1-hydroxybutyl)-3-phenylthio-3H-furan-2-one
    —— 5-(2-nitro-1-phenylethyl)-3-phenylthiofuran-2(5H)-one 1280709-98-9 C18H15NO4S
    5-(2-nitro-1-phenylethyl)-3-phenylthiofuran-2(5H)-one
    —— (1E,3E)-1-bromo-4-phenylthio-1,3-butadiene 161944-20-3 C10H9BrS
    (1E,3E)-1-bromo-4-phenylthio-1,3-butadiene
    —— (2R,3S)-N,N-diallyl-3-cyclohexyl-3-hydroxy-2-methylpropanethioamide 1283722-11-1 C16H27NOS
    (2R,3S)-N,N-diallyl-3-cyclohexyl-3-hydroxy-2-methylpropanethioamide
    —— 2-[4-[2-[(Z)-hex-4-enyl]-1,3-dithian-2-yl]butoxy]oxane 246034-85-5 C19H34O2S2
    2-[4-[2-[(Z)-hex-4-enyl]-1,3-dithian-2-yl]butoxy]oxane
    —— (2R,3S)-N,N-diallyl-3-hydroxy-2-methyldecanethioamide 1283722-14-4 C17H31NOS
    (2R,3S)-N,N-diallyl-3-hydroxy-2-methyldecanethioamide
    —— 3-phenylthio-4-(1'-dimethylphenylsilylmethylethenyl)dihydro-2(3H)-furanone 144602-80-2 C21H24O2SSi
    3-phenylthio-4-(1'-dimethylphenylsilylmethylethenyl)dihydro-2(3H)-furanone
    —— α-chloro-α-(phenylthio)-γ-butyrolactone 62675-47-2 C10H9ClO2S
    α-chloro-α-(phenylthio)-γ-butyrolactone
    —— 4,5-Bis(4-methoxyphenyl)-2-(2-thienylthio)-thiazol 88264-15-7 C21H17NO2S3
    4,5-Bis(4-methoxyphenyl)-2-(2-thienylthio)-thiazol
    —— 4,5-dihydro-3-(1-hydroxymethyl)-3-phenylthio-3H-furan-2-one 109765-91-5 C11H12O3S
    4,5-dihydro-3-(1-hydroxymethyl)-3-phenylthio-3H-furan-2-one
    —— methyl 1-(phenylthio)cyclopropanecarboxylate 342624-00-4 C11H12O2S
    methyl 1-(phenylthio)cyclopropanecarboxylate
    —— Trimethyl-((E)-4-phenylsulfanyl-but-3-en-1-ynyl)-silane 161944-19-0 C13H16SSi
    Trimethyl-((E)-4-phenylsulfanyl-but-3-en-1-ynyl)-silane
    —— 2,5-dibromo-3-(methylthio)thiophene 94781-42-7 C5H4Br2S2
    2,5-dibromo-3-(methylthio)thiophene
    —— (2-allyl-3,5-dimethylphenyl)(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)sulfide 1338723-53-7 C21H17F17S
    (2-allyl-3,5-dimethylphenyl)(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)sulfide
    —— 1,2,3-Trithia-cycloheptan 6576-92-7 C4H8S3
    1,2,3-Trithia-cycloheptan
    —— 4-Methylthiobenzolphosphonsaeure 46061-42-1 C7H9O3PS
    4-Methylthiobenzolphosphonsaeure
    —— <bis(phenylthio)methyl>trimethylsilane 37891-39-7 C16H20S2Si
    <bis(phenylthio)methyl>trimethylsilane
    —— 4-Methylthiophenylphosphonic dichloride 77918-52-6 C7H7Cl2OPS
    4-Methylthiophenylphosphonic dichloride
    —— P-[(phenylthio)[13C]methyl]-phosphonic acid diethyl ester 1190788-52-3 C11H17O3PS
    P-[(phenylthio)[13C]methyl]-phosphonic acid diethyl ester
    —— trithiacyclononane 61775-36-8 C6H12S3
    trithiacyclononane
    —— 2-mercapto-4-methyl-3-penten-1-ol 78585-28-1 C6H12OS
    2-mercapto-4-methyl-3-penten-1-ol
    —— <i>N</i>-ethoxycarbonyl-thioglycine amide 146538-11-6 C5H10N2O2S
    <i>N</i>-ethoxycarbonyl-thioglycine amide