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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-N-[(2-chlorophenyl)methyl]-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C16H21ClN4OS2
    (2R)-N-[(2-chlorophenyl)methyl]-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-(1-cyanocyclopentyl)-2-({5-[(2-methylpropyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide —— C14H21N5OS2
    N-(1-cyanocyclopentyl)-2-({5-[(2-methylpropyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
    —— (2R)-N-[(2-chlorophenyl)methyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H15ClN4OS2
    (2R)-N-[(2-chlorophenyl)methyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2S)-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C14H18N4O3S3
    (2S)-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— methyl N-[(2R)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoyl]carbamate —— C11H12N4O3S2
    methyl N-[(2R)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoyl]carbamate
    —— 1-[(2-chlorophenyl)methyl]-N-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)-3,5-dimethylpyrazole-4-carboxamide —— C17H18ClN5OS2
    1-[(2-chlorophenyl)methyl]-N-(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)-3,5-dimethylpyrazole-4-carboxamide
    —— (2R)-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C13H16N4O3S3
    (2R)-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2R)-N-tert-butyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C13H18N4OS2
    (2R)-N-tert-butyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 1-(2-ethyl-6-methylphenyl)-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea —— C19H23N3OS2
    1-(2-ethyl-6-methylphenyl)-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 1-[3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoylamino]-3-(2-ethyl-6-methylphenyl)thiourea —— C20H27N5OS2
    1-[3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoylamino]-3-(2-ethyl-6-methylphenyl)thiourea
    —— [2-[[4-(Dimethylamino)phenyl]methylamino]-2-oxoethyl] 3-(3,4-difluorophenyl)sulfanylpropanoate —— C20H22F2N2O3S
    [2-[[4-(Dimethylamino)phenyl]methylamino]-2-oxoethyl] 3-(3,4-difluorophenyl)sulfanylpropanoate
    —— (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C13H19N3O3S4
    (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-N-[(4-fluorophenyl)methyl]-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C16H18FN3OS3
    (2S)-N-[(4-fluorophenyl)methyl]-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 7-Methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C15H11N5OS4
    7-Methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— 2-[(2,4-Dimethylphenyl)sulfanylmethyl]-7-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C15H15N3OS2
    2-[(2,4-Dimethylphenyl)sulfanylmethyl]-7-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— 2-[(4-Fluorophenyl)sulfanylmethyl]-7-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C13H10FN3OS2
    2-[(4-Fluorophenyl)sulfanylmethyl]-7-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— [(3R)-1,1-dioxothiolan-3-yl] 2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetate —— C14H17N3O4S3
    [(3R)-1,1-dioxothiolan-3-yl] 2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-(2-chlorophenyl)-2-oxocyclohexyl]-N-methylacetamide —— C17H19ClN4O2S2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-(2-chlorophenyl)-2-oxocyclohexyl]-N-methylacetamide
    —— [(3S)-1,1-dioxothiolan-3-yl] 2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetate —— C11H13NO5S2
    [(3S)-1,1-dioxothiolan-3-yl] 2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetate
    —— N-[(2S)-butan-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C13H21N3OS
    N-[(2S)-butan-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— 2-(4,5,6-Trimethylpyrimidin-2-yl)sulfanylacetamide —— C9H13N3OS
    2-(4,5,6-Trimethylpyrimidin-2-yl)sulfanylacetamide
    —— N-(2-phenylsulfanylphenyl)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C21H21N3OS2
    N-(2-phenylsulfanylphenyl)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— N-[(1R)-1-(2-chlorophenyl)-2-oxocyclohexyl]-N-methyl-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide —— C20H21ClN2O3S
    N-[(1R)-1-(2-chlorophenyl)-2-oxocyclohexyl]-N-methyl-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide
    —— N-cyclopentyl-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C14H21N3OS
    N-cyclopentyl-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— N-methyl-N-[(2-methylphenyl)methyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C18H23N3OS
    N-methyl-N-[(2-methylphenyl)methyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— methyl 2,4-dimethyl-5-[(2R)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanoyl]-1H-pyrrole-3-carboxylate —— C18H23N3O3S
    methyl 2,4-dimethyl-5-[(2R)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanoyl]-1H-pyrrole-3-carboxylate
    —— (2R)-N-(1-adamantyl)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanamide —— C20H29N3OS
    (2R)-N-(1-adamantyl)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanamide
    —— N-[(4-chlorophenyl)methyl]-N-methyl-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C17H20ClN3OS
    N-[(4-chlorophenyl)methyl]-N-methyl-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— (2S)-N-[(2R)-2-phenylpropyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanamide —— C19H25N3OS
    (2S)-N-[(2R)-2-phenylpropyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanamide
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C21H31N3OS
    N-[(1R)-1-(1-adamantyl)ethyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C15H22N4OS
    N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— N-[(2S)-4-phenylbutan-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C19H25N3OS
    N-[(2S)-4-phenylbutan-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C13H19N3O3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— 1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylethanone —— C17H23N3OS
    1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylethanone
    —— (2R)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanamide —— C10H15N3OS
    (2R)-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylpropanamide
    —— N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C19H25N3OS
    N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide —— C14H21N3O3S2
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylacetamide
    —— 1-(5-Bromothiophen-2-yl)-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C12H14BrN3OS3
    1-(5-Bromothiophen-2-yl)-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— (2R)-N-cycloheptyl-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C14H24N4OS2
    (2R)-N-cycloheptyl-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-(2-methylpropyl)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H17N5OS2
    N-(2-methylpropyl)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-cyclopentyl-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C13H22N4OS2
    N-cyclopentyl-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— [(3R)-1,1-dioxothiolan-3-yl] 2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate —— C10H15N3O4S3
    [(3R)-1,1-dioxothiolan-3-yl] 2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
    —— 1-(5-Chlorothiophen-2-yl)-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C12H14ClN3OS3
    1-(5-Chlorothiophen-2-yl)-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— (2S)-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide —— C14H17FN4OS2
    (2S)-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide
    —— (2R)-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)propanamide —— C15H20N4OS2
    (2R)-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)propanamide
    —— 2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C16H22N4OS2
    2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— (2S)-N-(1-cyanocyclohexyl)-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide —— C15H23N5OS2
    (2S)-N-(1-cyanocyclohexyl)-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide
    —— 2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide —— C14H17FN4OS2
    2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide
    —— N-[(2R)-butan-2-yl]-N-[(2S)-butan-2-yl]-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H26N4OS2
    N-[(2R)-butan-2-yl]-N-[(2S)-butan-2-yl]-2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-(2,2,2-trifluoroethyl)acetamide —— C13H15F3N4O2S2
    2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-(2,2,2-trifluoroethyl)acetamide