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黄酮类化合物

黄酮类化合物 定义与结构特征

黄酮类化合物是一大类天然存在的有机化合物,属于酚类衍生物。它们的分子结构通常包含两个苯环(A和B环)和一个三碳环(C环),形成一个基本骨架。该骨架由多个亚结构组成,包括黄烷醇、黄酮、黄酮醇等。

生物来源

黄酮类化合物广泛存在于植物界中,常见于许多蔬菜、水果及中药中。例如,在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

化学性质 亲水性与溶解度

由于其分子结构中含有多个酚羟基,因此具有一定的亲水性和良好的溶解性,这使得黄酮类化合物在药物设计中扮演重要角色。

稳定性与光敏性

大多数黄酮类化合物相对稳定,在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感,容易被氧化,导致颜色变化。

生理活性与药用价值

黄酮类化合物因其丰富的生理活性而备受关注,主要包括:

  • 抗氧化作用:可有效清除体内自由基,保护细胞免受损伤。
  • 抗炎效应:有助于减轻炎症反应,缓解症状。
  • 心血管保护:可能通过多种机制改善心脑血管健康。
  • 抗癌潜力:研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
应用领域 食品工业

作为一种天然色素和抗氧化剂,被广泛应用于食品加工中以提高其保质期及营养价值。

化妆品行业

利用其良好的生物相容性和抗衰老特性,在化妆品配方中应用广泛。

药物开发

由于黄酮类化合物展现出广泛的药理活性,已成为新药研发的重要候选目标之一。

中文名称 英文名称 CAS号 化学式 结构式图片
—— 2-[6-Chloro-2-(4-methoxyphenyl)-4-oxochromen-3-yl]oxyacetic acid —— C18H13ClO6
2-[6-Chloro-2-(4-methoxyphenyl)-4-oxochromen-3-yl]oxyacetic acid
—— 6-Chloro-3-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-2-(4-methylphenyl)chromen-4-one —— C22H18ClNO4
6-Chloro-3-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-2-(4-methylphenyl)chromen-4-one
—— 6-Chloro-2-(2-chlorophenyl)-7-methyl-3-(2-oxopropoxy)chromen-4-one —— C19H14Cl2O4
6-Chloro-2-(2-chlorophenyl)-7-methyl-3-(2-oxopropoxy)chromen-4-one
—— (6-Chloro-7-methyl-4-oxo-2-phenylchromen-3-yl) thiophene-2-carboxylate —— C21H13ClO4S
(6-Chloro-7-methyl-4-oxo-2-phenylchromen-3-yl) thiophene-2-carboxylate
—— 2-(6-Chloro-7-methyl-4-oxo-2-phenylchromen-3-yl)oxyacetamide —— C18H14ClNO4
2-(6-Chloro-7-methyl-4-oxo-2-phenylchromen-3-yl)oxyacetamide
—— 2-[6-Chloro-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetonitrile —— C18H12ClNO3
2-[6-Chloro-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetonitrile
—— 6-Chloro-2-(3,4-dimethoxyphenyl)-3-propan-2-yloxychromen-4-one —— C20H19ClO5
6-Chloro-2-(3,4-dimethoxyphenyl)-3-propan-2-yloxychromen-4-one
—— 6-Chloro-3-(2-oxopropoxy)-2-phenylchromen-4-one —— C18H13ClO4
6-Chloro-3-(2-oxopropoxy)-2-phenylchromen-4-one
—— 5-[(6-Chloro-4-oxo-2-phenylchromen-3-yl)oxymethyl]furan-2-carboxylic acid —— C21H13ClO6
5-[(6-Chloro-4-oxo-2-phenylchromen-3-yl)oxymethyl]furan-2-carboxylic acid
—— 6-Chloro-2-(4-methylphenyl)-3-[(1-methylpyrazol-4-yl)methoxy]chromen-4-one —— C21H17ClN2O3
6-Chloro-2-(4-methylphenyl)-3-[(1-methylpyrazol-4-yl)methoxy]chromen-4-one
—— 2-(6-chloro-4-oxo-2-phenylchromen-3-yl)oxy-N,N-diethylacetamide —— C21H20ClNO4
2-(6-chloro-4-oxo-2-phenylchromen-3-yl)oxy-N,N-diethylacetamide
—— 6-Chloro-2-(4-chlorophenyl)-3-(2-phenylethoxy)chromen-4-one —— C23H16Cl2O3
6-Chloro-2-(4-chlorophenyl)-3-(2-phenylethoxy)chromen-4-one
—— 2-(2-Chlorophenyl)-6,7-dimethyl-3-[(2-methylphenyl)methoxy]chromen-4-one —— C25H21ClO3
2-(2-Chlorophenyl)-6,7-dimethyl-3-[(2-methylphenyl)methoxy]chromen-4-one
—— (2S)-2-[2-(3,4-dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate —— C22H21O7-
(2S)-2-[2-(3,4-dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate
—— 3-[(4-Chlorophenyl)methoxy]-2-(4-methoxyphenyl)-6,7-dimethylchromen-4-one —— C25H21ClO4
3-[(4-Chlorophenyl)methoxy]-2-(4-methoxyphenyl)-6,7-dimethylchromen-4-one
—— [2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl] 2,2-dimethylpropanoate —— C24H26O6
[2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl] 2,2-dimethylpropanoate
—— [2-(2-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl] 2-methylpropanoate —— C21H19ClO4
[2-(2-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl] 2-methylpropanoate
—— [2-(4-Methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl] prop-2-enyl carbonate —— C22H20O6
[2-(4-Methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl] prop-2-enyl carbonate
—— methyl (2S)-2-[2-(4-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate —— C21H19ClO5
methyl (2S)-2-[2-(4-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate
—— 2-(3,4-Dimethoxyphenyl)-3-methoxy-6,7-dimethylchromen-4-one —— C20H20O5
2-(3,4-Dimethoxyphenyl)-3-methoxy-6,7-dimethylchromen-4-one
—— 3-(Methoxymethoxy)-2-(4-methoxyphenyl)-6,7-dimethylchromen-4-one —— C20H20O5
3-(Methoxymethoxy)-2-(4-methoxyphenyl)-6,7-dimethylchromen-4-one
—— [2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl] acetate —— C21H20O6
[2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl] acetate
—— 2-(4-Methoxyphenyl)-6,7-dimethyl-3-phenacyloxychromen-4-one —— C26H22O5
2-(4-Methoxyphenyl)-6,7-dimethyl-3-phenacyloxychromen-4-one
—— methyl (2R)-2-[2-(4-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate —— C21H19ClO5
methyl (2R)-2-[2-(4-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate
—— (2S)-2-[2-(2-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoic acid —— C20H17ClO5
(2S)-2-[2-(2-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoic acid
—— (2R)-2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate —— C21H19O6-
(2R)-2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate
—— [2-(4-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl] butanoate —— C21H19ClO4
[2-(4-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl] butanoate
—— ethyl (2S)-2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate —— C23H24O6
ethyl (2S)-2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate
—— methyl (2S)-2-[2-(3,4-dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate —— C23H24O7
methyl (2S)-2-[2-(3,4-dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate
—— (2R)-2-[2-(2-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate —— C20H16ClO5-
(2R)-2-[2-(2-chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoate
—— 2-(4-Chlorophenyl)-3-ethoxy-6,7-dimethylchromen-4-one —— C19H17ClO3
2-(4-Chlorophenyl)-3-ethoxy-6,7-dimethylchromen-4-one
—— 2-[2-(2-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetonitrile —— C19H14ClNO3
2-[2-(2-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetonitrile
—— 2-(2-Chlorophenyl)-6,7-dimethyl-3-[(3-methylphenyl)methoxy]chromen-4-one —— C25H21ClO3
2-(2-Chlorophenyl)-6,7-dimethyl-3-[(3-methylphenyl)methoxy]chromen-4-one
—— 2-(2-Chlorophenyl)-6,7-dimethyl-3-(2-oxo-2-pyrrolidin-1-ylethoxy)chromen-4-one —— C23H22ClNO4
2-(2-Chlorophenyl)-6,7-dimethyl-3-(2-oxo-2-pyrrolidin-1-ylethoxy)chromen-4-one
—— 2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-3-phenylmethoxychromen-4-one —— C26H24O5
2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-3-phenylmethoxychromen-4-one
—— 2-[2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetonitrile —— C21H19NO5
2-[2-(3,4-Dimethoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetonitrile
—— 2-(4-Methoxyphenyl)-6,7-dimethyl-3-[(1-methylpyrazol-4-yl)methoxy]chromen-4-one —— C23H22N2O4
2-(4-Methoxyphenyl)-6,7-dimethyl-3-[(1-methylpyrazol-4-yl)methoxy]chromen-4-one
—— Pentyl 2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetate —— C25H28O6
Pentyl 2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetate
—— 2-(4-Methoxyphenyl)-6,7-dimethyl-3-(thiophen-2-ylmethoxy)chromen-4-one —— C23H20O4S
2-(4-Methoxyphenyl)-6,7-dimethyl-3-(thiophen-2-ylmethoxy)chromen-4-one
—— [2-(4-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl] cyclohexanecarboxylate —— C24H23ClO4
[2-(4-Chlorophenyl)-6,7-dimethyl-4-oxochromen-3-yl] cyclohexanecarboxylate
—— Ethyl 2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetate —— C22H22O6
Ethyl 2-[2-(4-methoxyphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetate
—— 4-[(E)-[6-methoxy-2-(4-methylphenyl)chromen-4-ylidene]methyl]-1-methylpyridin-1-ium —— C24H22NO2+
4-[(E)-[6-methoxy-2-(4-methylphenyl)chromen-4-ylidene]methyl]-1-methylpyridin-1-ium
—— Methyl 2-[6,7-dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetate —— C21H20O5
Methyl 2-[6,7-dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetate
—— 2-[6,7-Dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetate —— C20H17O5-
2-[6,7-Dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetate
—— 6,7-Dimethyl-2-(4-methylphenyl)-3-(thiophen-2-ylmethoxy)chromen-4-one —— C23H20O3S
6,7-Dimethyl-2-(4-methylphenyl)-3-(thiophen-2-ylmethoxy)chromen-4-one
—— 3-[[6,7-Dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxymethyl]benzoic acid —— C26H22O5
3-[[6,7-Dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxymethyl]benzoic acid
—— 2-[2-(4-Tert-butylphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetate —— C23H23O5-
2-[2-(4-Tert-butylphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxyacetate
—— [6,7-Dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl] 3-chlorobenzoate —— C25H19ClO4
[6,7-Dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl] 3-chlorobenzoate
—— N-cyclohexyl-2-[6,7-dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetamide —— C26H29NO4
N-cyclohexyl-2-[6,7-dimethyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxyacetamide
—— (2S)-2-[2-(4-tert-butylphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoic acid —— C24H26O5
(2S)-2-[2-(4-tert-butylphenyl)-6,7-dimethyl-4-oxochromen-3-yl]oxypropanoic acid