番石榴苷 | 6743-88-0

• 物质功能分类: 天然产物 - 黄酮类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 番石榴苷
• 中文别名: 番石榴甙；槲皮素-3-O-Alpha-L-吡喃阿拉伯糖苷；扁蓄苷
• 英文名称: quercetin-3-arabinoside
• 英文别名: 3-O-quercetin α-L-arabinopyranoside；quercetin 3-O-α-L-arabinopyranoside；quercetin-3-O-α-L-arabinopyranoside；quercetin-3-O-β-D-arabinopyranoside；quercetin-3-O-β-L-arabinopyranoside；quercetin 3-O-α-L-arabinoside；2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2R,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxychromen-4-one
• CAS: 6743-88-0；22255-13-6；72581-59-0；94131-44-9
• 化学式: C₂₀H₁₈O₁₁
• 分子量: 434.356
• InChiKey: PZZRDJXEMZMZFD-JNEVDQRJSA-N

物化性质

• 熔点：
  237-239 °C
• 沸点：
  828.1±65.0 °C(Predicted)
• 密度：
  1.86
• 溶解度：
  DMSO（轻微）、乙醇（轻微、超声处理）、甲醇（轻微）
• LogP：
  1.680 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  11

制备方法与用途

番石榴叶

番石榴叶为桃金娘科植物番石榴（Psidium guajava L.）的叶子。其性味甘、涩，平。具有消食、止泻、收敛和止血的功效。

• ① 治疗消化不良、肠炎及痢疾：煎服 2.4～4.5g（鲜品 15～30g）。
• ② 治疗牙痛、牙龈脓肿，可煎水含漱；小儿盗汗、皮肤瘙痒及热痱，可用煎水洗浴；治疗湿疹和创伤出血，研末撒敷；跌打损伤，用叶子捣敷。

番石榴叶含有 β-谷甾醇、三萜类化合物及挥发油。还包含槲皮素、番石榴苷、扁蓄苷、番石榴鞣花苷（Amritoside）以及番石榴酸（Psidiolic acid）。通过醇浸出物和水煎剂，对金黄色葡萄球菌有体外抗菌作用，并且饮用叶浸剂可以降低血糖。

应用

• 饮料 | 冷饮 | 乳制品

• 生物活性

  • Guaijaverin 是一种尿素酶抑制剂（IC50 值为 120 μM），具有抗氧化和抗变形链球菌活性。

• 靶点

  • IC50: 120 μM (Urease)

• 体外研究

  • Guaijaverin 对变形链球菌（Strep. mutans）有抗菌作用，MIC 值分别为 MTCC 1943 和 CLSM 001 菌株的 4 mg/ml 和 2 mg/ml。

反应信息

• 作为反应物：
  描述：

  番石榴苷 在 盐酸 作用下， 生成 L-(+)-arabinose 、 槲皮素
  参考文献：
  名称：

  Flavonols of the fruit of various seeds of the genusAmelanchier

  摘要：

  DOI：

  10.1007/bf00577214

文献信息

• Chemical Constituents of Curatella Americana (Dilleniaceae)
  作者：M.M. El-Azizi、A.M. Ateya、G.H. Svoboda、P.L. Schiff、D.J. Slatkin、J.E. Knapp

  DOI：10.1002/jps.2600690333

  日期：1980.3

  A phytochemical investigation of an ethanolic extract of the leaves of Curatella americana Linn. (Dilleniaceae) resulted in the isolation and identification of the flavonol glycoside avicularin and gallic acid.

  美国Curatella Lina Linn叶片的乙醇提取物的植物化学研究。（Dilleniaceae）导致了黄酮醇苷avicularin和没食子酸的分离和鉴定。
• TISSUE-PRESERVING LIQUID AND TISSUE-PRESERVING METHOD
  申请人：Osaka University

  公开号：EP2878197A1

  公开（公告）日：2015-06-03

  The present invention provides a tissue preservation sol ution that has good quality for preservation of tissues, org ans and cells, and is useful in the fields of regenerative m edicine, transplantation medicine, etc. The tissue preserva tion solution of the present invention comprises a compound having a Nrf2 activating effect. Preferable compounds havin g a Nrf2 activating effect are electrophiles, and in particu lar, ebselen and tert-butylhydroquinone. A preferable basal solution of the tissue preservation solution is Hank's bala nced salt solution.

  本发明提供了一种组织保存液，它具有良好的组织、器官和细胞保存质量，可用于再生医学、移植医学等领域。本发明的组织保存液包含一种具有 Nrf2 激活作用的化合物。具有 Nrf2 激活作用的化合物最好是嗜电化合物，特别是依布硒和叔丁基对苯二酚。组织保存溶液的基质溶液最好是汉克巴尔德盐溶液。
• TISSUE PRESERVATION SOLUTION AND TISSUE PRESERVATION METHOD
  申请人：Osaka University

  公开号：EP2878197B1

  公开（公告）日：2018-12-26
• NRF2 Deficiency Influences Susceptibility to Steroid Resistance via HDAC2 Reduction
  申请人：Rahman Irfan

  公开号：US20140080795A1

  公开（公告）日：2014-03-20

  Methods for the treatment or prevention of diseases which are caused by the decreased concentrations of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by the methods of the invention include chronic obstructive pulmonary disease (COPD) and asthma, including steroid resistant COPD and asthma. The invention provides methods for treating or preventing of diseases caused by the degradation of HDAC2 by providing to the subject in need of treatment or prevention a molecular compound capable of preventing the degradation of HDAC2. Such molecular compounds include Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activators. Methods are further provided for the treatment and prevention of COPD and asthma by providing to a subject in need of such treatment and prevention a nucleic acid which causes expression of HDAC2 in lung cells and/or a nucleic acid which causes expression of Nrf2 in lung cells.
• COMPOSITIONS AND METHODS FOR THE STUDY AND TREATMENT OF ACUTE KIDNEY INJURY
  申请人：The Johns Hopkins University

  公开号：US20160120158A1

  公开（公告）日：2016-05-05

  The present invention relates to the field of nephrology. More specifically, the present invention provides compositions and methods useful for the study and treatment of acute kidney injury. In one embodiment, the present invention provides a knockout animal whose genome comprises a deletion of exon 2 and exon 3 of kelch-like ECH-associated protein 1 (KEAP1) in T-cells. In another embodiment, a method for treating a subject diagnosed with AKI comprising the steps of (a) isolating T-cells from the subject; (b) activating Nrf2 expression in the isolated T-cells; and (c) administering the T-cells back to the subject.