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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-(1-adamantyl)-N-[(4-chlorophenyl)methyl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide —— C21H25ClN4OS
    N-(1-adamantyl)-N-[(4-chlorophenyl)methyl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
    —— N-[(2S)-2-phenylpropyl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide —— C13H16N4OS
    N-[(2S)-2-phenylpropyl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
    —— (E)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-(5-piperidin-1-ylfuran-2-yl)prop-2-enoic acid —— C15H17N3O4S
    (E)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-(5-piperidin-1-ylfuran-2-yl)prop-2-enoic acid
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-(2-methylpropyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide —— C12H20N4O3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-(2-methylpropyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
    —— (Z)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-(5-phenylsulfanylfuran-2-yl)prop-2-enoic acid —— C16H12N2O4S2
    (Z)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-(5-phenylsulfanylfuran-2-yl)prop-2-enoic acid
    —— N-(1-adamantyl)-N-(furan-2-ylmethyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide —— C19H24N4O2S
    N-(1-adamantyl)-N-(furan-2-ylmethyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
    —— (E)-3-(5-bromofuran-2-yl)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]prop-2-enoic acid —— C10H7BrN2O4S
    (E)-3-(5-bromofuran-2-yl)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]prop-2-enoic acid
    —— N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide —— C10H15N5OS
    N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
    —— [5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]methyl 2-(4-bromo-2-methylphenyl)sulfanylacetate —— C16H13BrN2O4S
    [5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]methyl 2-(4-bromo-2-methylphenyl)sulfanylacetate
    —— [2-[[(2R)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate —— C17H21BrN2O3S
    [2-[[(2R)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate
    —— (E)-2-(1,3-benzoxazol-2-ylsulfanyl)-3-(5-phenylsulfanylfuran-2-yl)prop-2-enoate —— C20H12NO4S2-
    (E)-2-(1,3-benzoxazol-2-ylsulfanyl)-3-(5-phenylsulfanylfuran-2-yl)prop-2-enoate
    —— (Z)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-(1,2,5-trimethylpyrrol-3-yl)prop-2-enoate —— C18H15ClN3O3S-
    (Z)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-(1,2,5-trimethylpyrrol-3-yl)prop-2-enoate
    —— (E)-3-[5-(5-chloro-2-methylphenyl)furan-2-yl]-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]prop-2-enoic acid —— C17H13ClN2O4S
    (E)-3-[5-(5-chloro-2-methylphenyl)furan-2-yl]-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]prop-2-enoic acid
    —— (Z)-2-[(5-ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-(3-methylthiophen-2-yl)prop-2-enoic acid —— C12H12N2O3S2
    (Z)-2-[(5-ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-(3-methylthiophen-2-yl)prop-2-enoic acid
    —— (Z)-2-[(5-ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-[(4S)-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl]prop-2-enoate —— C17H15N4O4S-
    (Z)-2-[(5-ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-3-[(4S)-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl]prop-2-enoate
    —— [2-(Methylamino)-2-oxoethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate —— C12H14BrNO3S
    [2-(Methylamino)-2-oxoethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate
    —— N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)sulfanylpyridine-3-carboxamide —— C21H18N2O3S
    N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)sulfanylpyridine-3-carboxamide
    —— 2-[2-[(4-fluorophenyl)sulfanylmethyl]-5-methoxy-4-oxopyridin-1-yl]-N-(furan-2-ylmethyl)acetamide —— C20H19FN2O4S
    2-[2-[(4-fluorophenyl)sulfanylmethyl]-5-methoxy-4-oxopyridin-1-yl]-N-(furan-2-ylmethyl)acetamide
    —— Ethyl 2-[2-[(5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]-1,3-thiazol-4-yl]acetate —— C14H13N3O3S3
    Ethyl 2-[2-[(5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]-1,3-thiazol-4-yl]acetate
    —— 1-(2,5-Dimethylphenyl)-3-[3-(4-fluorophenyl)sulfanylpropanoylamino]thiourea —— C18H20FN3OS2
    1-(2,5-Dimethylphenyl)-3-[3-(4-fluorophenyl)sulfanylpropanoylamino]thiourea
    —— 1-[4-[(3S)-1,1-dioxothiolan-3-yl]piperazin-4-ium-1-yl]-2-(2,4,6-trimethylphenyl)sulfanylethanone —— C19H29N2O3S2+
    1-[4-[(3S)-1,1-dioxothiolan-3-yl]piperazin-4-ium-1-yl]-2-(2,4,6-trimethylphenyl)sulfanylethanone
    —— N-[(3S,4R)-4-chloro-1,1-dioxothiolan-3-yl]-2-(2,4,6-trimethylphenyl)sulfanylacetamide —— C15H20ClNO3S2
    N-[(3S,4R)-4-chloro-1,1-dioxothiolan-3-yl]-2-(2,4,6-trimethylphenyl)sulfanylacetamide
    —— 1-(2,5-Dimethylphenyl)-3-[[2-(4-methylphenyl)sulfanylacetyl]amino]thiourea —— C18H21N3OS2
    1-(2,5-Dimethylphenyl)-3-[[2-(4-methylphenyl)sulfanylacetyl]amino]thiourea
    —— (2S)-N-benzyl-2-(2,4,6-trimethylphenyl)sulfanylpropanamide —— C19H23NOS
    (2S)-N-benzyl-2-(2,4,6-trimethylphenyl)sulfanylpropanamide
    —— N-(furan-2-ylmethyl)-2-(2,4,6-trimethylphenyl)sulfanylacetamide —— C16H19NO2S
    N-(furan-2-ylmethyl)-2-(2,4,6-trimethylphenyl)sulfanylacetamide
    —— (2S)-N-cyclopentyl-2-(2,4,6-trimethylphenyl)sulfanylpropanamide —— C17H25NOS
    (2S)-N-cyclopentyl-2-(2,4,6-trimethylphenyl)sulfanylpropanamide
    —— 2-(3-chloro-4-fluorophenyl)sulfanyl-N-[2-(2-fluorophenyl)ethyl]acetamide —— C16H14ClF2NOS
    2-(3-chloro-4-fluorophenyl)sulfanyl-N-[2-(2-fluorophenyl)ethyl]acetamide
    —— (2R)-N-benzyl-2-(2,4,6-trimethylphenyl)sulfanylpropanamide —— C19H23NOS
    (2R)-N-benzyl-2-(2,4,6-trimethylphenyl)sulfanylpropanamide
    —— (2R)-2-(3-chloro-4-fluorophenyl)sulfanyl-N-cyclopropylpropanamide —— C12H13ClFNOS
    (2R)-2-(3-chloro-4-fluorophenyl)sulfanyl-N-cyclopropylpropanamide
    —— 7-[(3-Chloro-4-fluorophenyl)sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C13H8ClFN2OS2
    7-[(3-Chloro-4-fluorophenyl)sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 1-[4-(2,4-Dimethylphenyl)sulfanylphenyl]-3-(2-morpholin-4-ylethyl)thiourea —— C21H27N3OS2
    1-[4-(2,4-Dimethylphenyl)sulfanylphenyl]-3-(2-morpholin-4-ylethyl)thiourea
    —— 1-[4-(2,5-Dimethylphenyl)sulfanylphenyl]-3-(3-morpholin-4-ylpropyl)thiourea —— C22H29N3OS2
    1-[4-(2,5-Dimethylphenyl)sulfanylphenyl]-3-(3-morpholin-4-ylpropyl)thiourea
    —— 1-[4-(2,4-Dimethylphenyl)sulfanylphenyl]-3-(2-morpholin-4-ium-4-ylethyl)thiourea —— C21H28N3OS2+
    1-[4-(2,4-Dimethylphenyl)sulfanylphenyl]-3-(2-morpholin-4-ium-4-ylethyl)thiourea
    —— 1-[4-(2,4-Dimethylphenyl)sulfanylphenyl]-3-(3-morpholin-4-ylpropyl)thiourea —— C22H29N3OS2
    1-[4-(2,4-Dimethylphenyl)sulfanylphenyl]-3-(3-morpholin-4-ylpropyl)thiourea
    —— (2S)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one —— C17H23ClN5OS2+
    (2S)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one
    —— (2S)-N-benzyl-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide —— C19H19ClN4OS2
    (2S)-N-benzyl-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide
    —— 1-[2-[[5-(3-Chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrrolidin-2-one —— C14H13ClN4O2S2
    1-[2-[[5-(3-Chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrrolidin-2-one
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(cyclohexylmethyl)acetamide —— C17H21ClN4OS2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(cyclohexylmethyl)acetamide
    —— N-(3-chlorophenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H10ClN5OS3
    N-(3-chlorophenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)acetamide —— C18H17ClN4OS2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)acetamide
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(cyclopropylmethyl)-N-propylacetamide —— C17H21ClN4OS2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(cyclopropylmethyl)-N-propylacetamide
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H19ClN4O2S2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide —— C16H15ClN4OS3
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide
    —— 4-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-diethylbutanamide —— C16H21ClN4OS2
    4-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-diethylbutanamide
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(1S)-1-phenylethyl]acetamide —— C19H19ClN4OS2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(1S)-1-phenylethyl]acetamide
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H19ClN4O2S2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-3-methylbutan-2-yl]acetamide —— C15H19ClN4OS2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-3-methylbutan-2-yl]acetamide
    —— 2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide —— C17H21ClN4OS2
    2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide
    —— (2R)-N-benzyl-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide —— C19H19ClN4OS2
    (2R)-N-benzyl-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide
    —— (2R)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-1-yl)propan-1-one —— C17H22ClN5OS2
    (2R)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-1-yl)propan-1-one