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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide —— C18H23FN4OS2
    (2R)-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide
    —— N-benzyl-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C18H17FN4OS2
    N-benzyl-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 5-(2-ethoxyethylsulfanyl)-N-(3-fluorophenyl)-1,3,4-thiadiazol-2-amine —— C12H14FN3OS2
    5-(2-ethoxyethylsulfanyl)-N-(3-fluorophenyl)-1,3,4-thiadiazol-2-amine
    —— 1-Cycloheptyl-3-[2-(dimethylamino)ethyl]thiourea —— C12H25N3S
    1-Cycloheptyl-3-[2-(dimethylamino)ethyl]thiourea
    —— 1-cyclopentyl-3-[(1R,2S)-2-methylcyclohexyl]thiourea —— C13H24N2S
    1-cyclopentyl-3-[(1R,2S)-2-methylcyclohexyl]thiourea
    —— [5-(3-Methylphenyl)-1,3,4-oxadiazol-2-yl]methyl 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate —— C20H22N4O3S
    [5-(3-Methylphenyl)-1,3,4-oxadiazol-2-yl]methyl 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate
    —— 1-methyl-3-[(3R)-1-(methylcarbamothioylamino)pentan-3-yl]thiourea —— C9H20N4S2
    1-methyl-3-[(3R)-1-(methylcarbamothioylamino)pentan-3-yl]thiourea
    —— 1-Cyclopentyl-3-[2-(dimethylamino)ethyl]thiourea —— C10H21N3S
    1-Cyclopentyl-3-[2-(dimethylamino)ethyl]thiourea
    —— 1-Cyclooctyl-3-[2-(dimethylamino)ethyl]thiourea —— C13H27N3S
    1-Cyclooctyl-3-[2-(dimethylamino)ethyl]thiourea
    —— [2-[Methyl(thiophen-3-ylmethyl)amino]-2-oxoethyl] 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate —— C18H23N3O3S2
    [2-[Methyl(thiophen-3-ylmethyl)amino]-2-oxoethyl] 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate
    —— (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C15H18N4O3S
    (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— N-butyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H21N3O5S2
    N-butyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H19N3O3S
    N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-(Furan-2-yl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-oxadiazole —— C13H8N4O4S
    2-(Furan-2-yl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-oxadiazole
    —— N-butyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H21N3O5S2
    N-butyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1R)-1-(4-bromophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H14BrN3O3S
    N-[(1R)-1-(4-bromophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1S)-1-(4-bromophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H14BrN3O3S
    N-[(1S)-1-(4-bromophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-[2,5-dimethyl-1-[(1R)-1-phenylethyl]pyrrol-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C22H21N3O3S
    1-[2,5-dimethyl-1-[(1R)-1-phenylethyl]pyrrol-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[2-(2-Chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(furan-2-yl)-1,3,4-oxadiazole —— C16H10ClN3O2S2
    2-[[2-(2-Chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(furan-2-yl)-1,3,4-oxadiazole
    —— N-benzyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methylacetamide —— C16H15N3O3S
    N-benzyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 1-[4-(4-Bromophenyl)sulfanylphenyl]-3-[2-(dimethylamino)ethyl]thiourea —— C17H20BrN3S2
    1-[4-(4-Bromophenyl)sulfanylphenyl]-3-[2-(dimethylamino)ethyl]thiourea
    —— 1-[4-(3,4-dimethylphenyl)sulfanylphenyl]-3-[[(2S)-oxolan-2-yl]methyl]thiourea —— C20H24N2OS2
    1-[4-(3,4-dimethylphenyl)sulfanylphenyl]-3-[[(2S)-oxolan-2-yl]methyl]thiourea
    —— 1-[4-(4-Bromophenyl)sulfanylphenyl]-3-cyclopropylthiourea —— C16H15BrN2S2
    1-[4-(4-Bromophenyl)sulfanylphenyl]-3-cyclopropylthiourea
    —— 2-[[4-(4-Bromophenyl)sulfanylphenyl]carbamothioylamino]ethyl-dimethylazanium —— C17H21BrN3S2+
    2-[[4-(4-Bromophenyl)sulfanylphenyl]carbamothioylamino]ethyl-dimethylazanium
    —— 1-[4-(4-Bromophenyl)sulfanylphenyl]-3-prop-2-enylthiourea —— C16H15BrN2S2
    1-[4-(4-Bromophenyl)sulfanylphenyl]-3-prop-2-enylthiourea
    —— 1-[4-(4-Bromophenyl)sulfanylphenyl]-3-ethylthiourea —— C15H15BrN2S2
    1-[4-(4-Bromophenyl)sulfanylphenyl]-3-ethylthiourea
    —— 1-[4-(3,4-dimethylphenyl)sulfanylphenyl]-3-[[(2R)-oxolan-2-yl]methyl]thiourea —— C20H24N2OS2
    1-[4-(3,4-dimethylphenyl)sulfanylphenyl]-3-[[(2R)-oxolan-2-yl]methyl]thiourea
    —— 2-[[4-(3,4-Dimethylphenyl)sulfanylphenyl]carbamothioylamino]ethyl-dimethylazanium —— C19H26N3S2+
    2-[[4-(3,4-Dimethylphenyl)sulfanylphenyl]carbamothioylamino]ethyl-dimethylazanium
    —— 1-[4-(3,4-Dimethylphenyl)sulfanylphenyl]-3-ethylthiourea —— C17H20N2S2
    1-[4-(3,4-Dimethylphenyl)sulfanylphenyl]-3-ethylthiourea
    —— 1-(1-Adamantyl)-3-[2-(dimethylamino)ethyl]thiourea —— C15H27N3S
    1-(1-Adamantyl)-3-[2-(dimethylamino)ethyl]thiourea
    —— (2S)-N-(2-methoxyethyl)-2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C14H20N4O3S
    (2S)-N-(2-methoxyethyl)-2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— [(3R)-1,1-dioxothiolan-3-yl] 2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C14H17N3O5S2
    [(3R)-1,1-dioxothiolan-3-yl] 2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— (2E)-2-(2,5,6,7,8,9-hexahydro-[1,2,4]triazolo[4,3-a]azepin-3-ylidene)-4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxobutanenitrile —— C19H21N7O2S
    (2E)-2-(2,5,6,7,8,9-hexahydro-[1,2,4]triazolo[4,3-a]azepin-3-ylidene)-4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxobutanenitrile
    —— [2-Oxo-2-(2-oxo-1,3-oxazolidin-3-yl)ethyl] 2-(2-cyanophenyl)sulfanylbenzoate —— C19H14N2O5S
    [2-Oxo-2-(2-oxo-1,3-oxazolidin-3-yl)ethyl] 2-(2-cyanophenyl)sulfanylbenzoate
    —— (2S)-2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)propanamide —— C19H22N4O2S
    (2S)-2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)propanamide
    —— 2-[(5Z)-3-(4-methylphenyl)-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]propanedinitrile —— C21H15N3OS2
    2-[(5Z)-3-(4-methylphenyl)-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]propanedinitrile
    —— (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)propan-1-one —— C13H16N4O2S
    (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)propan-1-one
    —— 5-(4-fluorophenyl)-4-methyl-3-(1H-1,2,4-triazol-5-ylsulfanylmethyl)-1,2-oxazole —— C13H11FN4OS
    5-(4-fluorophenyl)-4-methyl-3-(1H-1,2,4-triazol-5-ylsulfanylmethyl)-1,2-oxazole
    —— (2R)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-(4-bromophenyl)sulfanylpropan-1-one —— C17H18BrNO2S
    (2R)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-(4-bromophenyl)sulfanylpropan-1-one
    —— 5-(((5-(Thiophen-2-yl)isoxazol-3-yl)methyl)thio)-1,3,4-thiadiazol-2-amine —— C10H8N4OS3
    5-(((5-(Thiophen-2-yl)isoxazol-3-yl)methyl)thio)-1,3,4-thiadiazol-2-amine
    —— 5-[(2-Thiophen-3-yl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C10H8N4S4
    5-[(2-Thiophen-3-yl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— (2R)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one —— C13H16N4O2S2
    (2R)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one
    —— 3-[(2-thiophen-3-yl-1,3-thiazol-4-yl)methylsulfanyl]-1H-1,2,4-triazol-5-amine —— C10H9N5S3
    3-[(2-thiophen-3-yl-1,3-thiazol-4-yl)methylsulfanyl]-1H-1,2,4-triazol-5-amine
    —— 3-[5-[2-(Azocan-1-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C16H27N5O2S
    3-[5-[2-(Azocan-1-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— 2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2R)-5-methylhexan-2-yl]acetamide —— C19H28N4OS2
    2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2R)-5-methylhexan-2-yl]acetamide
    —— 3-[(4-Cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-5-(furan-2-yl)-1,2-oxazole —— C17H14N4O2S2
    3-[(4-Cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-5-(furan-2-yl)-1,2-oxazole
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2-methylphenyl)methyl]acetamide —— C19H20N4OS2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2-methylphenyl)methyl]acetamide
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(3-propan-2-yloxypropyl)acetamide —— C16H20ClN3O3S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(3-propan-2-yloxypropyl)acetamide
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-pentylacetamide —— C16H22N4OS2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-pentylacetamide
    —— 2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide —— C20H21FN4OS2
    2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide