Organic nitriles are converted into cyanide ions through the action of cytochrome P450 enzymes in the liver. Cyanide is rapidly absorbed and distributed throughout the body. Cyanide is mainly metabolized into thiocyanate by either rhodanese or 3-mercaptopyruvate sulfur transferase. Cyanide metabolites are excreted in the urine. (L96)
Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
致癌性证据
癌症分类：B2组可能的人类致癌物（基于Meta分析数据）
Cancer Classification: Group B2 Probable Human Carcinogen (Based on Metam Sodiam Data)
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌物分类
对人类不具有致癌性（未被国际癌症研究机构IARC列名）。
No indication of carcinogenicity to humans (not listed by IARC).
Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
暴露途径
该物质可以通过吸入其气溶胶和通过吞食被吸收进人体。
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
... Chemical disposition studies of (14)C labeled methylene bis(thiocyanate) were conducted in male F344/N rats. In these studies more than 90% of the admin radioactivity was eliminated in 48 hr. ... As the dose was incr from 0.2 to 1 to 10 mg/kg, greater percentages of the admin radioactivity remained in the tissues. Blood cyanide concn were incr shortly after the admin of 10 mg/kg (14)C methylene bis(thiocyanate) but were similar to control values 2 hr after dosing.
对来自香菇的提取物/馏出物进行的香气提取物稀释分析（AEDA）应用显示32种气味，其中3-（甲硫基）丙醛（煮熟的马铃薯），1-辛烯-3-酮和1-辛烯-3-醇（均为蘑菇状）具有最高的风味稀释度（FD）因子。用原始香菇组织和13 C 18亚油酸或2 H 4 -1-辛烯-3-醇进行同位素富集实验，证实1-辛烯-3-醇和1-辛烯-3-酮均为直接降解产物脂肪酸，但首次证明酮不是由醇的氧化形成的。煎炸后，出现42种气味活性化合物，其中3-羟基-4,5-二甲基呋喃-2（5 H）-一（咸），1,2,4,5-四硫烷（燃烧，硫磺），4-羟基-2,5-二甲基呋喃-3（2 H）-一（焦糖状），苯乙酸（蜂蜜-如），3-（甲硫基）-丙醛和反式-4,5-环氧-（E）-2-癸烯（金属）显示出最高的FD因子。为了更深入地了解其香气的贡献，通过稳定的同位素稀释法对生香菇中的19种主要香精进行定量，而在香菇中对21种主要香精进
The four-component cyclization of dilithium acetylide with dithiocyanatoalkanes yielded the hitherto unknown tetrathiacyclodiynes 34, 38, 41, and 43 in moderate yields. The use of the trimethylsilyl protecting group allowed a more efficient and flexible stepwise approach with good yields. The resulting tetrathiacyclodiynes 25−44 were investigated by X-ray analysis. For ring systems with a twist-chair
[EN] PROCESS FOR MANUFACTURING METHYLENE BIS(THIOCYANATE)<br/>[FR] PROCÉDÉ DE FABRICATION DE BIS(THIOCYANATE) DE MÉTHYLÈNE
申请人：BROMINE COMPOUNDS LTD
公开号：WO2014167560A1
公开（公告）日：2014-10-16
This invention provides pure methylene bis(thiocyanate) in an ecor industrial process. The product is practically free of insolubles (<0.1%) after prolonged storage.
