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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— phenyl 1-trimethylsilylcrotyl sulfide 78905-12-1 C13H20SSi
    phenyl 1-trimethylsilylcrotyl sulfide
    —— (3S,5S,2'R,6'S)-3-(2',6'-oxido-8'-oxo-9'-decenyl)-5-methyl-3-(phenylthio)tetrahydrofuran-2-one 1064039-15-1 C21H26O4S
    (3S,5S,2'R,6'S)-3-(2',6'-oxido-8'-oxo-9'-decenyl)-5-methyl-3-(phenylthio)tetrahydrofuran-2-one
    —— phenyl α-trimethylsilyl-1-cycloheptenylmethyl sulfide 110362-96-4 C17H26SSi
    phenyl α-trimethylsilyl-1-cycloheptenylmethyl sulfide
    —— phenyl α-trimethylsilyl-1-cyclopentenylmethyl sulfide 110372-04-8 C15H22SSi
    phenyl α-trimethylsilyl-1-cyclopentenylmethyl sulfide
    —— methyl 3-{3-[(2,5-dimethylphenyl)thio]-5-isopropyl-1H-indol-2-yl}-2,2-dimethylpropanoate 854279-83-7 C25H31NO2S
    methyl 3-{3-[(2,5-dimethylphenyl)thio]-5-isopropyl-1H-indol-2-yl}-2,2-dimethylpropanoate
    —— 3-phenylthio-3-trimethylsilyl-2-methylpropene 78905-11-0 C13H20SSi
    3-phenylthio-3-trimethylsilyl-2-methylpropene
    —— [(Diethyl-methyl-silanyl)-methylsulfanylmethyl]-diethyl-amine 81633-91-2 C11H27NSSi
    [(Diethyl-methyl-silanyl)-methylsulfanylmethyl]-diethyl-amine
    —— 5,6-dihydro-5-ethoxymethyl-1,3-dithiolo[4,5-b]1,4-dithiin-2-one 355117-93-0 C8H10O2S4
    5,6-dihydro-5-ethoxymethyl-1,3-dithiolo[4,5-b]1,4-dithiin-2-one
    —— 5,6-dihydro-5-ethoxymethyl-1,3-dithiolo[4,5-b]1,4-dithiin-2-thione 355117-91-8 C8H10OS5
    5,6-dihydro-5-ethoxymethyl-1,3-dithiolo[4,5-b]1,4-dithiin-2-thione
    —— 7-benzylthio-3-(2-chlorophenyl)-1-(2-ethoxy-1-ethoxymethylethyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 335653-51-5 C26H29ClN4O3S
    7-benzylthio-3-(2-chlorophenyl)-1-(2-ethoxy-1-ethoxymethylethyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
    —— 2-(4-Phenyl-1,2,3-selenadiazol-5-yl)-5-methylmercapto-1,3,4-oxadiazol 64369-35-3 C11H8N4OSSe
    2-(4-Phenyl-1,2,3-selenadiazol-5-yl)-5-methylmercapto-1,3,4-oxadiazol
    —— 2-methylsulfanyl-5-phenylethynyl-[1,3,4]oxadiazole 64369-39-7 C11H8N2OS
    2-methylsulfanyl-5-phenylethynyl-[1,3,4]oxadiazole
    —— 1-ethylsulfonyl-2-propanone 135102-50-0 C5H10O2S
    1-ethylsulfonyl-2-propanone
    —— 1,2-bis-ethylsulfanyl-propene 38091-85-9 C7H14S2
    1,2-bis-ethylsulfanyl-propene
    —— trans-1,2-di(ethylthio)-1-propene 114232-68-7 C7H14S2
    trans-1,2-di(ethylthio)-1-propene
    —— (3RS)-2-methyl-2-phenylsulfanylhex-5-en-3-ol 311806-85-6 C13H18OS
    (3RS)-2-methyl-2-phenylsulfanylhex-5-en-3-ol
    —— thiocarbonic acid <i>O</i>-ethyl ester 28953-98-2 C3H6O2S
    thiocarbonic acid <i>O</i>-ethyl ester
    —— 2,6-Dimethyl-2-(phenylthio)-heptan-3-ol 63996-44-1 C15H24OS
    2,6-Dimethyl-2-(phenylthio)-heptan-3-ol
    —— ethyl 5-(5-cyclopropylpyridin-3-ylamino)-3-(methylthio)-1,2,4-triazine-6-carboxylate 1429042-11-4 C15H17N5O2S
    ethyl 5-(5-cyclopropylpyridin-3-ylamino)-3-(methylthio)-1,2,4-triazine-6-carboxylate
    —— 5,5-dimethyl-4-(phenylthio)-4,5-dihydrofuran-2(3H)-one 79749-96-5 C12H14O2S
    5,5-dimethyl-4-(phenylthio)-4,5-dihydrofuran-2(3H)-one
    —— 3-hydroxy-4-methyl-4-phenylsulfanyl-pentanamide 910865-12-2 C12H17NO2S
    3-hydroxy-4-methyl-4-phenylsulfanyl-pentanamide
    —— (2RS)-3-methyl-3-phenylsulfanylbutan-2-ol 58468-92-1 C11H16OS
    (2RS)-3-methyl-3-phenylsulfanylbutan-2-ol
    —— [(2,6-Dimethylhept-1-EN-3-YL)sulfanyl]benzene 61737-13-1 C15H22S
    [(2,6-Dimethylhept-1-EN-3-YL)sulfanyl]benzene
    —— 2-methyl-2-(phenylsulfanyl)-1-propanol 66164-89-4 C10H14OS
    2-methyl-2-(phenylsulfanyl)-1-propanol
    —— 1,4-Anhydro-3,5-dideoxy-1,1-dimethyl-2-S-phenyl-2-thio-D-threo-pentitol 178753-35-0 C13H18OS
    1,4-Anhydro-3,5-dideoxy-1,1-dimethyl-2-S-phenyl-2-thio-D-threo-pentitol
    —— 2,4-bis-benzylsulfanyl-6-(3-methyl-butyl)-pyrimidine 1067679-27-9 C23H26N2S2
    2,4-bis-benzylsulfanyl-6-(3-methyl-butyl)-pyrimidine
    —— 3-hydroxy-4-phenylsulfanyl-4-methylpentanenitrile 499776-31-7 C12H15NOS
    3-hydroxy-4-phenylsulfanyl-4-methylpentanenitrile
    —— 2,5-Dimethyl-5-phenylsulfanylhexane-2,4-diol 179806-67-8 C14H22O2S
    2,5-Dimethyl-5-phenylsulfanylhexane-2,4-diol
    —— (5S,6S)-2-methyl-2-phenylsulfanyl-5-hydroxy-6-(tert-butyldimethylsilyloxy)heptan-3-one 312326-74-2 C20H34O3SSi
    (5S,6S)-2-methyl-2-phenylsulfanyl-5-hydroxy-6-(tert-butyldimethylsilyloxy)heptan-3-one
    —— Ethyl 3-hydroxy-4-methyl-4-phenylsulfanylpentanedithioate 174784-05-5 C14H20OS3
    Ethyl 3-hydroxy-4-methyl-4-phenylsulfanylpentanedithioate
    —— (3'aS,7'aS)-7'a-methylspiro[1,3-dithiolane-2,5'-2,3,3a,4,6,7-hexahydroindene]-1'-one 195211-54-2 C12H18OS2
    (3'aS,7'aS)-7'a-methylspiro[1,3-dithiolane-2,5'-2,3,3a,4,6,7-hexahydroindene]-1'-one
    —— 2-methyl-2-phenylsulfanylhex-5-en-3-one 311806-87-8 C13H16OS
    2-methyl-2-phenylsulfanylhex-5-en-3-one
    —— 4-hydroxy-5-methyl-5-phenylsulfanylhexan-2-one 179806-58-7 C13H18O2S
    4-hydroxy-5-methyl-5-phenylsulfanylhexan-2-one
    —— 2-[(4-Chlorophenyl)sulfanyl]-2-nitropropane-1,3-diol 90691-69-3 C9H10ClNO4S
    2-[(4-Chlorophenyl)sulfanyl]-2-nitropropane-1,3-diol
    —— (<i>R</i>)-3-methanesulfinyl-propylamine 15813-61-3 C4H11NOS
    (<i>R</i>)-3-methanesulfinyl-propylamine
    —— 4,4'-thiobis<3-isopropyl-6-trifluoromethyl)-2-benzothiazolinethione> 81587-64-6 C22H18F6N2S5
    4,4'-thiobis<3-isopropyl-6-trifluoromethyl)-2-benzothiazolinethione>
    —— 5-<(ethoxycarbonyl)(phenylthio)methyl>-4-methoxy-6-methyl-2H-pyran-2-one 93338-84-2 C17H18O5S
    5-<(ethoxycarbonyl)(phenylthio)methyl>-4-methoxy-6-methyl-2H-pyran-2-one
    —— 1,4-bis-carbamimidoylmercapto-but-2-yne 98485-20-2 C6H10N4S2
    1,4-bis-carbamimidoylmercapto-but-2-yne
    —— 4-butyl-1-(4-chlorophenyl)-5-(phenylthio)-1H-1,2,3-triazole 1605324-38-6 C18H18ClN3S
    4-butyl-1-(4-chlorophenyl)-5-(phenylthio)-1H-1,2,3-triazole
    —— 2-(4-bromomethylthio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole 1404052-58-9 C13H9BrN4S2
    2-(4-bromomethylthio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole
    —— 1,4-Bis-(4-chlorophenylthio)-2-butin 56163-27-0 C16H12Cl2S2
    1,4-Bis-(4-chlorophenylthio)-2-butin
    —— (Z)-1-phenylthio-3-(tetrahydropyran-2-yl)oxy-1-propene 1094758-68-5 C14H18O2S
    (Z)-1-phenylthio-3-(tetrahydropyran-2-yl)oxy-1-propene
    —— 1,4-Bis-(2-methylphenylthio)-2-butin 56163-31-6 C18H18S2
    1,4-Bis-(2-methylphenylthio)-2-butin
    —— 1,4-Bis-(4-bromphenylthio)-2-butin 56163-30-5 C16H12Br2S2
    1,4-Bis-(4-bromphenylthio)-2-butin
    —— 1,4-bis(p-tolylthio)but-2-yne 56163-32-7 C18H18S2
    1,4-bis(p-tolylthio)but-2-yne
    —— 3-[(4-chlorophenyl)thio]-2-methyl-6-(methylsulfonyl)-1H-indole 507271-46-7 C16H14ClNO2S2
    3-[(4-chlorophenyl)thio]-2-methyl-6-(methylsulfonyl)-1H-indole
    —— 5-bromo-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole 336186-27-7 C15H11BrClNS
    5-bromo-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole
    —— (R)-4-hydroxy-4-(1-(phenylthio)cyclobutyl)butan-2-one 928161-65-3 C14H18O2S
    (R)-4-hydroxy-4-(1-(phenylthio)cyclobutyl)butan-2-one
    —— 3-[(4-chlorophenyl)thio]-2,5-dimethyl-1H-indole 336186-33-5 C16H14ClNS
    3-[(4-chlorophenyl)thio]-2,5-dimethyl-1H-indole
    —— 3-(4-chlorophenylsulfanylmethyl)-3-methyl-1,2,5-trioxaspiro[5.5]undecane 869661-08-5 C16H21ClO3S
    3-(4-chlorophenylsulfanylmethyl)-3-methyl-1,2,5-trioxaspiro[5.5]undecane