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    首页 分子通 按分子结构分类 有机化合物 有机聚合物 多肽

    多肽

    肽是由两个或两个以上氨基酸通过脱水缩合形成的化合物。最简单的肽由两个氨基酸构成，称为二肽；包含多个氨基酸的肽则被称为多肽。通常情况下，含有50个及以上氨基酸单位的多肽，则归类为蛋白质。肽广泛存在于动物、植物和微生物中，在生物体内的生长发育、细胞分化、大脑活动、肿瘤病变、免疫防御、生殖控制以及抗衰老等方面都扮演着重要角色。

    例如，谷胱甘肽是某些酶的重要辅基，参与体内氧化还原反应；多种激素如催产素、加压素、胰高血糖素及促肾上腺皮质激素等，均属于多肽类，通过调节机体代谢发挥作用。下丘脑分泌的激素调节因子也是由多肽构成，控制着其他内分泌腺释放激素的过程。

    近年来，在高等动物的大脑中发现了具有镇痛作用的脑啡肽（五肽）。许多抗生素如多粘菌素、短杆菌肽等也是肽类物质，具备强大的抗菌能力。此外，多肽是指通过肽键连接形成的一系列氨基酸单位构成的长链结构。一般而言，含有数十个或更少氨基酸单位的多肽称为肽；而更多氨基酸单位组成的则被称为蛋白质。

    在命名时，通常按照从氨基末端（N端）到羧基末端（C端）的顺序书写。如Ser·Gly·Try·Ala·Leu这个五肽由5个氨基酸残基和4个肽键组成，命名为丝氨酰甘氨酰酪氨酰丙氨酰亮氨酸。

    肽广泛存在于动植物组织中，并且其中许多具有特殊生物活性的功能性肽统称为生物活性肽。近年来的研究表明，几乎所有重大生命科学理论——包括免疫防御、生殖控制、肿瘤病变和抗衰防老等——均涉及相关的活性肽，这些理论与临床医学实践密切相关，因此生物活性肽在实际应用中也具有重要价值。

    生物活性肽种类繁多，例如促肾上腺皮质激素为39肽，催产素为九肽，而两种重要的脑啡肽均为五肽。许多抗菌素也是由肽类物质构成的。生长因子则受控于基因，在细胞发育过程中起到调节和控制作用。表皮生长因子含有50个氨基酸残基，神经生长因子则由118个氨基酸组成。

    相关化合物

    中文名称 英文名称 CAS号 化学式 结构式图片
    新抑肌肽 Neomyosuppressin 143458-86-0 C58H86N16O15
    新抑肌肽
    拮抗剂多肽BALIXAFORTIDE Balixafortide 1051366-32-5 C84H118N24O21S2
    拮抗剂多肽BALIXAFORTIDE
    拮抗剂 Lys-pro-asn-pro-glu-arg-phe-tyr-gly-leu-met-NH2 139446-71-2 C62H95N17O15S
    拮抗剂
    拟态弧菌肠毒素 (4S)-5-[[(2S,3S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-4-amino-1-[(2S)-2-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[2-[[(2R)-1-[[(2S)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,4-dioxobutan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-5-oxopentanoic acid 100007-57-6 C72H113N19O24S6
    拟态弧菌肠毒素
    抗菌肽POLYBIA-MP1 IDWKKLLDAAKQIL-NH2 872043-01-1 C78H132N20O19
    抗菌肽POLYBIA-MP1
    抗菌肽A (4S)-4-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2,6-diamino-1-hydroxyhexylidene]amino]-1-hydroxy-3-(1H-indol-3-yl)propylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-3-methylpentylidene]amino]-5-[(2S)-6-amino-1-[(2S)-1-[2-[(2S)-1-[(2S)-1-[(2S,3S)-1-[(2S)-1-[(2S)-1-[2-[(2S,3S)-1-[(2S,3S)-1-[(2S)-6-amino-1-[(2S)-1-[2-[(2S)-2-[N-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[2-[(2S)-1-[(2S)-1-[(2S,3R)-1-[(2S)-1-[(2S,3S)-1-[(2S)-1-[(2S)-6-amino-1-hydroxy-1-iminohexan-2-yl]imino-1-hydroxypropan-2-yl]imino-1-hydroxy-3-methylpentan-2-yl]imino-1,5-dihydroxy-5-iminopentan-2-yl]imino-1,3-dihydroxybutan-2-yl]imino-1-hydroxypropan-2-yl]imino-1,5-dihydroxy-5-iminopentan-2-yl]imino-2-hydroxyethyl]imino-1-hydroxy-3-methylbutan-2-yl]imino-1-hydroxy-3-methylbutan-2-yl]imino-1-hydroxypropan-2-yl]imino-1-hydroxy-3-methylbutan-2-yl]imino-1-hydroxypropan-2-yl]-C-hydroxycarbonimidoyl]pyrrolidin-1-yl]-2-oxoethyl]imino-1-hydroxypropan-2-yl]imino-1-hydroxyhexan-2-yl]imino-1-hydroxy-3-methylpentan-2-yl]imino-1-hydroxy-3-methylpentan-2-yl]imino-2-hydroxyethyl]imino-3-carboxy-1-hydroxypropan-2-yl]imino-5-carbamimidamido-1-hydroxypentan-2-yl]imino-1-hydroxy-3-methylpentan-2-yl]imino-1,4-dihydroxy-4-iminobutan-2-yl]imino-1,5-dihydroxy-5-iminopentan-2-yl]imino-2-hydroxyethyl]imino-1-hydroxy-3-methylbutan-2-yl]imino-1-hydroxyhexan-2-yl]imino-5-hydroxypentanoic acid —— C184H313N53O46
    抗菌肽A
    抗敌素 Colistin 1066-17-7 C52H98N16O13
    抗敌素
    抗利尿激素,N-[N-(N-L-苏氨酰-L-丝氨酰)-L-丙氨酰]-8-L-精氨酸-(9CI) 10-Thr-11-ser-12-ala-argipressin 115820-14-9 C56H82N18O17S2
    抗利尿激素,N-[N-(N-L-苏氨酰-L-丝氨酰)-L-丙氨酰]-8-L-精氨酸-(9CI)
    抑胃肽 5-amino-2-[[2-[[2-[[4-amino-2-[[2-[[6-amino-2-[[2-[[2-[[4-amino-2-[[6-amino-2-[[6-amino-2-[[2-[[6-amino-2-[[5-amino-2-[2-[[2-[[2-[[2-[[4-amino-2-[[2-[[2-[[2-[[5-amino-2-[[5-amino-2-[[2-[[2-[[6-amino-2-[[2-[[2-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]propanoylamino]-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoylamino]-5-oxopentanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoic acid —— C226H338N60O66S
    抑胃肽
    成骨生长肽 ALKRQGRTLYGFGG 132996-61-3 C68H110N22O18
    成骨生长肽
    戈那瑞林 Pacap-38 —— C203H331N63O53S
    戈那瑞林
    心钠素II atriopeptin II 89139-54-8 C98H156N34O32S2
    心钠素II
    心房肽II,大鼠,兔,小鼠 Atriopeptin II 98084-69-6 C141H227N51O42S2
    心房肽II,大鼠,兔,小鼠
    心房利尿钠因子(1-11) SLRRSSCFGGR 98897-21-3 C49H84N20O15S
    心房利尿钠因子(1-11)
    心房利尿钠因子 Peptide, atrial natriuretic 88898-17-3 C128H207N45O39S2
    心房利尿钠因子
    德谷胰岛素 16-[[(1S)-4-[[(5S)-5-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(1R,6R,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,50S,53S,56S,59S,62S,65S,68S,71S,74R,77S,80S,83S,88R)-88-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]-6-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-47-[[(1S)-3-amino-1-carboxy-3-oxopropyl]carbamoyl]-53-(2-amino-2-oxoethyl)-62-(3-amino-3-oxopropyl)-77-[(2S)-butan-2-yl]-24,56-bis(2-carboxyethyl)-83-[(1R)-1-hydroxyethyl]-12,71,80-tris(hydroxymethyl)-33,50,65-tris[(4-hydroxyphenyl)methyl]-15-(1H-imidazol-4-ylmethyl)-27-methyl-18,30,36,59,68-pentakis(2-methylpropyl)-7,10,13,16,19,22,25,28,31,34,37,40,49,52,55,58,61,64,67,70,73,76,79,82,85,87-hexacosaoxo-21,39-di(propan-2-yl)-3,4,44,45,90,91-hexathia-8,11,14,17,20,23,26,29,32,35,38,41,48,51,54,57,60,63,66,69,72,75,78,81,84,86-hexacosazabicyclo[72.11.7]dononacontane-42-carbonyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-carboxypentyl]amino]-1-carboxy-4-oxobutyl]amino]-16-oxohexadecanoic acid 844439-96-9 C274H411N65O81S6
    德谷胰岛素
    强啡肽B(1-29) Dynorphin B (1-29) 84376-30-7 C161H236N42O48
    强啡肽B(1-29)
    强啡肽(1-11) dynorphin(1-11) 79985-34-5 C63H103N21O13
    强啡肽(1-11)
    异噻唑并[5,4-d]嘧啶-4(5H)-酮,3-乙基-(9CI) Cdc2 peptide (9-19) 142570-54-5 C55H84N12O16
    异噻唑并[5,4-d]嘧啶-4(5H)-酮,3-乙基-(9CI)
    度莫瑞林 Dumorelin 105953-59-1 C218H362N72O68
    度莫瑞林
    己醛,2-甲基-5-羰基-,(2R)- 55-Tyr-pth (42-55) 97613-65-5 C69H116N26O20
    己醛,2-甲基-5-羰基-,(2R)-
    尾加压素II Urotensin II-alpha 9047-55-6 C62H84N14O17S2
    尾加压素II
    小脑肽 Cerebellin 94071-26-8 C69H113N23O23
    小脑肽
    寡肽-10 Oligopeptide-10 466691-40-7 C78H140N20O15
    寡肽-10
    安替肽 antide 112568-12-4 C82H108ClN17O14
    安替肽
    奈西利肽 Brain Natriuretic Peptide (1-32), human —— C143H244N50O42S4
    奈西利肽
    天蚕丝抗菌肽 Cecropin B 80451-05-4 C176H302N52O41S
    天蚕丝抗菌肽
    大鼠 Histidylseryl-alpha-aspartylalanylvalylphenylalanylthreonyl-alpha-aspartylasparaginyltyrosylthreonyl-N~5~-(diaminomethylidene)ornithine 120928-03-2 C61H88N18O22
    大鼠
    多黏菌素T1 N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3,12-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide 63700-39-0 C58H102N16O12
    多黏菌素T1
    多黏菌素S1 N-[(2S)-4-amino-1-[[(2S,3R)-3-hydroxy-1-[[(2R)-3-hydroxy-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3,12-bis[(1R)-1-hydroxyethyl]-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]propan-2-yl]amino]-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide —— C53H91N15O15
    多黏菌素S1
    多肽物质P substance P 33507-63-0 C63H98N18O13S
    多肽物质P
    多粘菌素 [(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]carbamic acid 1406-11-7 C48H82N16O14
    多粘菌素
    多粘环素 Colimecycline 58298-92-3 C122H172N22O40
    多粘环素
    培西加南醋酸盐 Pexiganan acetate 172820-23-4 C124H214N32O24
    培西加南醋酸盐
    埃皮德明 Epidermin 99165-17-0 C98H141N25O23S4
    埃皮德明
    地西卢定 (2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S,3R)-2-[[2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(1R,6R,9S,12S,15S,18S,24S,27S,33S,36S,39R,44R,47S,53S,56S,59S,67S,73S,76S)-15,76-bis(4-aminobutyl)-44-[[(2S)-2-[[(4R,7S,10S,13S,19S,22S,25S,28R)-28-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-10-(2-amino-2-oxoethyl)-13-(3-amino-3-oxopropyl)-22-(2-carboxyethyl)-25-[(1R)-1-hydroxyethyl]-19-(hydroxymethyl)-7-(2-methylpropyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octazacyclononacosane-4-carbonyl]amino]-4-methylpentanoyl]amino]-12,56,73-tris(2-amino-2-oxoethyl)-9,67-bis(3-amino-3-oxopropyl)-36-[(2S)-butan-2-yl]-18,47-bis(2-carboxyethyl)-24-(carboxymethyl)-27,53-bis(hydroxymethyl)-33-(2-methylpropyl)-8,11,14,17,20,23,26,29,32,35,38,45,48,51,54,57,60,62,65,68,71,74,77-tricosaoxo-59-propan-2-yl-3,4,41,42-tetrathia-7,10,13,16,19,22,25,28,31,34,37,46,49,52,55,58,61,63,66,69,72,75,78-tricosazabicyclo[37.22.17]octaheptacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acid —— C287H440N80O110S6
    地西卢定
    地毯海葵毒素 H-Arg-Ser-Cys(1)-Ile-Asp-aThr-Ile-Pro-Lys-Ser-Arg-Cys(2)-Thr-Ala-Phe-Gln-Cys(3)-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys(2)-D-Arg-D-Lys-aThr-Cys(3)-Gly-Thr-Cys(1)-OH 172450-46-3 C169H274N54O48S7
    地毯海葵毒素
    地司特泰 TSLDASIIWAMMQN 272105-42-7 C68H109N17O22S2
    地司特泰
    地加瑞克杂质 degarelix acetate 934016-19-0 C2H4O2*C82H103ClN18O16
    地加瑞克杂质
    噻唑并[5,4-c]吡啶,4,5,6,7-四氢-2-苯基- Substance P, C-terminal glycine extended 98093-85-7 C65H100N18O15S
    噻唑并[5,4-c]吡啶,4,5,6,7-四氢-2-苯基-
    噻唑并[4,5-c]吡啶,2-甲基- Circulin A 5854-98-8 C53H100N16O13
    噻唑并[4,5-c]吡啶,2-甲基-
    噻唑并[4,5-b]吡啶-2(3H)-酮,7-甲氧基-,腙(9CI) Harpin —— C38H68N12O14S
    噻唑并[4,5-b]吡啶-2(3H)-酮,7-甲氧基-,腙(9CI)
    噻唑-5-甲酰胺 psbF protein, Chlamydomonas reinhardti 147651-80-7 C246H378N58O61S2
    噻唑-5-甲酰胺
    噻唑,4-(2-乙基四氢-2-甲基-2H-吡喃-4-基)-2-苯基- Neurotensin, iodo-tyr(3)- 88096-15-5 C78H120IN21O20
    噻唑,4-(2-乙基四氢-2-甲基-2H-吡喃-4-基)-2-苯基-
    噬菌体M2终点蛋白质 Insulin-like growth factor I (57-70) 123618-03-1 C71H119N17O19S
    噬菌体M2终点蛋白质
    噁丙环,2-甲基-,聚合噁丙环,单(2-丙基庚基)醚 Toxin C(13)S(1)C(3) 74504-52-2 C296H458N82O76S6
    噁丙环,2-甲基-,聚合噁丙环,单(2-丙基庚基)醚
    嗜铬粒蛋白A-衍生肽 Trp-ser-lys-met-asp-gln-leu-ala-lys-glu-leu-thr-ala-glu 115136-18-0 C72H116N18O24S
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    咽侧体抑制素VI Ala-pro-ser-gly-ala-gln-arg-leu-tyr-gly-phe-gly-leu-NH2 123209-95-0 C61H94N18O16
    咽侧体抑制素VI
    吡啶,2-[2-(4,5-二氢-1H-咪唑-2-基)肼基]- 2-[[2-[[2-[[2-[[2-[[[1-[2-[[2-[[2-[[2-[[2-[[2-[[1,5-dihydroxy-2-[[1-hydroxy-2-[[1-hydroxy-2-[[1-hydroxy-2-[[1-hydroxy-2-[[1-hydroxy-2-(1-hydroxyethylideneamino)-2-methylpropylidene]amino]propylidene]amino]propylidene]amino]-2-methylpropylidene]amino]-2-methylpropylidene]amino]-5-iminopentylidene]amino]-1-hydroxy-2-methylpropylidene]amino]-1-hydroxy-2-methylpropylidene]amino]-1-hydroxy-2-methylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-2-methylpropanoyl]pyrrolidin-2-yl]-hydroxymethylidene]amino]-1-hydroxy-3-methylbutylidene]amino]-1-hydroxy-2-methylpropylidene]amino]-1-hydroxy-3-methylpentylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-N-[1-hydroxy-3-(1H-indol-3-yl)propan-2-yl]pentanediimidic acid —— C91H149N23O24
    吡啶,2-[2-(4,5-二氢-1H-咪唑-2-基)肼基]-
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