戊氧基二硫代甲酸钾 | 123-97-7

• 分子结构分类: 有机化合物 - 有机硫化合物
• 中文名称: 戊氧基二硫代甲酸钾
• 中文别名: 二硫代乙酸O-戊酯
• 英文名称: n-Propylxanthate
• 英文别名: dithiocarbonic acid O-pentyl ester；Dithiokohlensaeure-O-pentylester；O-Pentyl-dithiokohlensaeure；Pentylxanthogensaeure；Dithiokohlensaeure-O-n-amylester；n-Amylxanthogensaeure；Pentoxymethanedithioic acid
• CAS: 123-97-7
• 化学式: C₆H₁₂OS₂
• 分子量: 164.293
• InChiKey: QWENMOXLTHDKDL-UHFFFAOYSA-N

物化性质

• 熔点：
  131 °C (decomp)
• 沸点：
  190.7±23.0 °C(Predicted)
• 密度：
  1.073±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  42.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2905199090

反应信息

• 作为反应物：
  描述：

  戊氧基二硫代甲酸钾 、 三氯硫氯甲烷 在 乙醚 作用下， 生成 pentyloxythiocarbonyl-trichloromethyl-disulfane
  参考文献：
  名称：

  Ettel; Zbirovsky, Collection of Czechoslovak Chemical Communications, 1956, vol. 21, p. 1654

  摘要：

  DOI：

文献信息

• [EN] 1-'(E)-2-(PHENYL) ETHENYL-4-(ARYLALKOXY)-OXAZOLE OR - THIAZOLE COMPOUNDS AS HER-2 TYROSINE KINASES INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER<br/>[FR] COMPOSES DE 1-'(E)-2-(PHENYL) ETHENYL-4-(ARYLALKOXY)-OXAZOLE OU -THIAZOLE SERVANT D'INHIBITEURS DE HER-2 TYROSINE KINASES ET LEUR UTILISATION POUR TRAITER UN CANCER
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005040158A1

  公开（公告）日：2005-05-06

  Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式(I)的化合物，它们的药用盐，对映体形式，二对映异构体和外消旋体，上述化合物的制备，含有它们的药物以及其制造，以及上述化合物在控制或预防癌症等疾病中的应用。
• Process and novel intermediates for preparing isoxazolin-3-ylacyl benzenes
  申请人：——

  公开号：US20030028033A1

  公开（公告）日：2003-02-06

  The present invention describes a process for preparing isoxazoles of the formula I 1 where: R 1 is hydrogen, C 1 -C 6 -alkyl, R 2 is hydrogen, C 1 -C 6 -alkyl, R 3 , R 4 , R 5 are each hydrogen, C 1 -C 6 -alkyl or R 4 and R 5 together form a bond, R 6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI 2 where R 1 , R 3 , R 4 and R 5 are each as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Furthermore, the invention describes novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates.

  本发明描述了一种制备式I1异构体的过程，其中：R1为氢、C1-C6烷基，R2为氢、C1-C6烷基，R3、R4、R5分别为氢、C1-C6烷基或R4和R5共同形成键，R6为杂环环，n为0、1或2；该过程包括制备式VI2的中间体，其中R1、R3、R4和R5均如上所述，随后进行卤代反应、硫代甲基化、氧化和酰化，以得到式I的化合物。此外，本发明还描述了制备式I化合物的新型中间体和制备中间体的新型过程。
• Novel arylazole derivatives, their manufacture and use as pharmaceutical agents
  申请人：Bossenmaier Birgit

  公开号：US20050124670A1

  公开（公告）日：2005-06-09

  There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本文介绍了公式(I)的化合物及其药学上可接受的盐、对映体、非对映异构体和外消旋体，上述化合物的制备，包含它们的药物和制造方法，以及上述化合物在控制或预防诸如癌症等疾病中的应用。
• Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0123254A1

  公开（公告）日：1984-10-31

  New triazine derivatives represented by the formula: wherein R' is hydrogen or halogen; R2 is a hydroxy, protected hydroxy, amino, cyano, mercapto, lower alkylthio, arylthio, sulfamoyl, lower alkylsulfonylamino, lower alkylureido, arylureido, lower alkyl-thioureido, aryl-thioureido, lower alkenoylamino, lower alkoxycarbonylamino, lower alkoxy (thiocarbonyl) thio, or cyclic or acyclic alkanoylamino in which the cyclic and acyclic alkanoylamino group may have a substituent selected from lower alkoxy, aryl, hydroxyaryl; and protected hydroxyaryl; and X is O or S; and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals.

  由以下式子表示的新型三嗪衍生物 其中 R' 是氢或卤素； R2是羟基、受保护的羟基、氨基、氰基、巯基、低级烷硫基、芳基硫基、氨基磺酰基、低级烷基磺酰基氨基、低级烷基脲基、芳基脲基、低级烷基硫脲基、芳基硫脲基、低级烯酰胺基、低级烷氧基羰基氨基、低级烷氧基（硫代羰基）硫基或环状或无环状烷酰胺基。 其中环状和非环状烷酰基氨基可具有选自低级烷氧基、芳基、羟基芳基和受保护羟基芳基的取代基；以及 X 是 O 或 S； 及其药学上可接受的盐，可用于治疗人类和动物的高血压、血栓和溃疡。
• Polymer particles and process for producing the same
  申请人：JAPAN SYNTHETIC RUBBER CO., LTD.

  公开号：EP0170456A1

  公开（公告）日：1986-02-05

  An aqueous dispersion of polymer articles each comprising (a) a syndiotactic 1,2-polybutadiene having 70% or more of its unsaturated hydrocarbon groups in the side chains and having a melting point of 70°C or higher, (b) a polymer mixture of said polybutadiene (a) and other polymer such that (a) and (b) co-exist in the same particle, or (c) a copolymer obtained by graft-polymerizing a conjugated diene and/or other polymerizable monomer on said polybutadiene (a), each of said particles having an average diameter of 10µm or less. Said aqueous dispersion can be produced by adding, to an aqueous dispersion of a first catalyst component solution, a conjugated diene monomer and a second catalyst component and polymerizing said conjugated diene monomer; the first catalyst component solution contains (A) a cobalt compound, (B) an alkali metal, an organometallic compound of a metal of Group I to III of the Periodic Table or a hydride of a metal of Group I to III of the Periodic Table, and (C) 1 to 1,000 moles, per mole of the cobalt compound (A), of a conjugated diene compound; and the second catalyst component is carbon disulfide, phenyli- bothiocyanic acid or a xanthogen compound.

  一种聚合物制品的水分散液，每种聚合物制品均包含 (a) 侧链中不饱和烃基含量为 70%或以上且熔点为 70°C 或更高的辛二碳 1，2-聚丁二烯、(b) 聚丁二烯（a）和其他聚合物的混合物，使（a）和（b）在同一颗粒中共存；或 (c) 通过在聚丁二烯（a）上接枝聚合共轭二烯和/或其他可聚合单体而得到的共聚物，每个所述颗粒的平均直径为 10 微米或更小。在第一催化剂组分溶液的水分散液中加入共轭二烯烃单体和第二催化剂组分，并聚合所述共轭二烯烃单体，即可制得所述水分散液；第一催化剂组分溶液含有 (A) 钴化合物，(B) 碱金属、元素周期表第 I 至 III 族金属的有机金属化合物或元素周期表第 I 至 III 族金属的氢化物，以及 (C) 每摩尔钴化合物 (A) 含 1 至 1,000 摩尔共轭二烯化合物；以及 第二催化剂组分为二硫化碳、苯基二硫代氰酸或黄原酸化合物。