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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— Tert-butyl 2-(1-methyltetrazol-5-yl)sulfanylacetate —— C8H14N4O2S
    Tert-butyl 2-(1-methyltetrazol-5-yl)sulfanylacetate
    —— 4-[(2S,5R)-5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]-N,N-dimethylaniline —— C18H19ClF3N3OS
    4-[(2S,5R)-5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]-N,N-dimethylaniline
    —— 4-[(2R,5R)-5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline —— C18H20ClF3N3OS+
    4-[(2R,5R)-5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline
    —— 4-[(2S,5S)-5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline —— C18H20ClF3N3OS+
    4-[(2S,5S)-5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline
    —— [2-[[(2S)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] 2-(4-fluorophenyl)sulfanylacetate —— C16H19FN2O3S
    [2-[[(2S)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] 2-(4-fluorophenyl)sulfanylacetate
    —— [2-[[(2R)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] 2-(4-fluorophenyl)sulfanylacetate —— C16H19FN2O3S
    [2-[[(2R)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] 2-(4-fluorophenyl)sulfanylacetate
    —— 2-(2-chlorophenyl)sulfanyl-N-pentylpyridine-3-carboxamide —— C17H19ClN2OS
    2-(2-chlorophenyl)sulfanyl-N-pentylpyridine-3-carboxamide
    —— 4-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-[1]benzofuro[3,2-d]pyrimidine —— C18H10N4O2S
    4-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-[1]benzofuro[3,2-d]pyrimidine
    —— N-(2-methylbutan-2-yl)-2-[2-nitro-4-(trifluoromethyl)phenyl]sulfanylbenzamide —— C19H19F3N2O3S
    N-(2-methylbutan-2-yl)-2-[2-nitro-4-(trifluoromethyl)phenyl]sulfanylbenzamide
    —— (2S)-2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-3-phenylpropanenitrile —— C20H24N4S
    (2S)-2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-3-phenylpropanenitrile
    —— [2-oxo-2-[[(2S)-oxolan-2-yl]methylamino]ethyl] 2-(4-methylphenyl)sulfanylacetate —— C16H21NO4S
    [2-oxo-2-[[(2S)-oxolan-2-yl]methylamino]ethyl] 2-(4-methylphenyl)sulfanylacetate
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]pyridine-3-carboxamide —— C23H22N4O2S
    2-(3,4-dimethylphenyl)sulfanyl-N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]pyridine-3-carboxamide
    —— 4-Methyl-2-[2-nitro-4-(trifluoromethylsulfonyl)phenyl]sulfanyl-1,3-thiazole —— C11H7F3N2O4S3
    4-Methyl-2-[2-nitro-4-(trifluoromethylsulfonyl)phenyl]sulfanyl-1,3-thiazole
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-[2-(pyridin-3-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide —— C23H21N5OS
    2-(2,4-dimethylphenyl)sulfanyl-N-[2-(pyridin-3-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(3S)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone —— C15H14N6O2S2
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(3S)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]pyridine-3-carboxamide —— C23H22N4O2S
    2-(2,5-dimethylphenyl)sulfanyl-N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]pyridine-3-carboxamide
    —— 3-[(2R)-1-(1-adamantyl)-1-oxopropan-2-yl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one —— C18H27N3O2S
    3-[(2R)-1-(1-adamantyl)-1-oxopropan-2-yl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-[2-(pyridin-4-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide —— C23H21N5OS
    2-(2,4-dimethylphenyl)sulfanyl-N-[2-(pyridin-4-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide
    —— 2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]acetamide —— C13H16FN5OS
    2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]acetamide
    —— Methyl 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbenzoate —— C16H14N2O2S2
    Methyl 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbenzoate
    —— N-methyl-N-[(2-methylphenyl)methyl]-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C15H18N2OS2
    N-methyl-N-[(2-methylphenyl)methyl]-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— (3,5-Dimethyl-1,2-oxazol-4-yl)methyl 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate —— C16H14ClN3O4S
    (3,5-Dimethyl-1,2-oxazol-4-yl)methyl 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]pyridine-3-carboxamide —— C23H22N4O2S
    2-(2,4-dimethylphenyl)sulfanyl-N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]pyridine-3-carboxamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[2-(1-methylpiperidin-4-yl)pyrazol-3-yl]pyridine-3-carboxamide —— C23H27N5OS
    2-(2,5-dimethylphenyl)sulfanyl-N-[2-(1-methylpiperidin-4-yl)pyrazol-3-yl]pyridine-3-carboxamide
    —— 4-Methyl-2-(2-methylpyrazolo[1,5-a]quinazolin-5-yl)sulfanyl-1,3-thiazole —— C15H12N4S2
    4-Methyl-2-(2-methylpyrazolo[1,5-a]quinazolin-5-yl)sulfanyl-1,3-thiazole
    —— (5-Phenyl-1,3,4-oxadiazol-2-yl)methyl 3-(4-methylphenyl)sulfanylpropanoate —— C19H18N2O3S
    (5-Phenyl-1,3,4-oxadiazol-2-yl)methyl 3-(4-methylphenyl)sulfanylpropanoate
    —— ethyl N-[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]carbamate —— C11H10ClF3N2O3S
    ethyl N-[2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]carbamate
    —— N'-[[5-(hydroxymethyl)-2-methyl-3-oxopyridin-4-ylidene]methyl]-3-(4-methylphenyl)sulfanylpropanehydrazide —— C18H21N3O3S
    N'-[[5-(hydroxymethyl)-2-methyl-3-oxopyridin-4-ylidene]methyl]-3-(4-methylphenyl)sulfanylpropanehydrazide
    —— N-[[4-[(2-phenylsulfanylphenyl)sulfamoyl]phenyl]methyl]acetamide —— C21H20N2O3S2
    N-[[4-[(2-phenylsulfanylphenyl)sulfamoyl]phenyl]methyl]acetamide
    —— N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]-2-phenylsulfanylpyridine-3-carboxamide —— C21H18N4O2S
    N-[2-[(5-methylfuran-2-yl)methyl]pyrazol-3-yl]-2-phenylsulfanylpyridine-3-carboxamide
    —— N-[2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-1-methylpyrrole-2-carboxamide —— C18H19N5O2S
    N-[2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-1-methylpyrrole-2-carboxamide
    —— Ethyl 2-[2-[2-(1-adamantyl)-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C19H25NO3S2
    Ethyl 2-[2-[2-(1-adamantyl)-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— 2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C15H24N4O4S2
    2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— [2-[[(2R)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] (1'R,5'S)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate —— C20H30N2O3S2
    [2-[[(2R)-2-cyano-3-methylbutan-2-yl]amino]-2-oxoethyl] (1'R,5'S)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate
    —— 2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C15H24N4O4S2
    2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— (2S)-N,N-dimethyl-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C15H27N5O2S
    (2S)-N,N-dimethyl-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— (2S)-N-[(4-methylphenyl)methyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C14H17N3OS2
    (2S)-N-[(4-methylphenyl)methyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 2-Methyl-5-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)pyrazolo[1,5-a]quinazoline —— C17H12N6S
    2-Methyl-5-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)pyrazolo[1,5-a]quinazoline
    —— (2R)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-phenylethyl)propanamide —— C14H17N3OS2
    (2R)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-phenylethyl)propanamide
    —— (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C11H17N3O3S3
    (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-(1-cyanocyclohexyl)-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C14H20N4OS2
    (2S)-N-(1-cyanocyclohexyl)-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-N-[(4-fluorophenyl)methyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C13H14FN3OS2
    (2R)-N-[(4-fluorophenyl)methyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C10H15N3O3S3
    (2S)-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— N-[2-(3,4-dimethylphenyl)sulfanylacetyl]-2-methylpropanamide —— C14H19NO2S
    N-[2-(3,4-dimethylphenyl)sulfanylacetyl]-2-methylpropanamide
    —— 5-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-thiophen-3-yl-1,2,4-oxadiazole —— C10H8N4OS3
    5-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-thiophen-3-yl-1,2,4-oxadiazole
    —— (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C12H19N3O3S3
    (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide —— C20H20FN3O2S
    2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide
    —— (2R)-N-(1-cyanocyclohexyl)-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C14H20N4OS2
    (2R)-N-(1-cyanocyclohexyl)-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C10H15N3O3S3
    (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C11H17N3O3S3
    (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide