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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-benzyl-5-[(1R)-1-(2H-triazol-4-ylsulfanyl)ethyl]-1,2,4-oxadiazole —— C13H13N5OS
    3-benzyl-5-[(1R)-1-(2H-triazol-4-ylsulfanyl)ethyl]-1,2,4-oxadiazole
    —— (2S)-1-[4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(4-methylphenyl)sulfanylpropan-1-one —— C19H25N3O4S2
    (2S)-1-[4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(4-methylphenyl)sulfanylpropan-1-one
    —— 1-[(3R,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone —— C20H20N6OS3
    1-[(3R,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone
    —— 1-[(3S,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone —— C20H20N6OS3
    1-[(3S,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone
    —— 1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone —— C18H23N3O4S2
    1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone
    —— 1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(2,4-dimethylphenyl)sulfanylethanone —— C19H25N3O4S2
    1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(2,4-dimethylphenyl)sulfanylethanone
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]propanamide —— C22H30N4O2S
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]propanamide
    —— 1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(2-methylphenyl)sulfanylethanone —— C18H23N3O4S2
    1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]piperazin-1-yl]-2-(2-methylphenyl)sulfanylethanone
    —— 6-ethylsulfanyl-N-[[(3R)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]methyl]pyrazin-2-amine —— C13H19F3N4S
    6-ethylsulfanyl-N-[[(3R)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]methyl]pyrazin-2-amine
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1R)-2-morpholin-4-yl-1-phenylethyl]propanamide —— C22H30N4O2S
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1R)-2-morpholin-4-yl-1-phenylethyl]propanamide
    —— 6-ethylsulfanyl-N-[[(3S)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]methyl]pyrazin-2-amine —— C13H19F3N4S
    6-ethylsulfanyl-N-[[(3S)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]methyl]pyrazin-2-amine
    —— 2-(2,5-difluorophenyl)sulfanyl-N-[(1R)-2-morpholin-4-yl-1-phenylethyl]acetamide —— C20H22F2N2O2S
    2-(2,5-difluorophenyl)sulfanyl-N-[(1R)-2-morpholin-4-yl-1-phenylethyl]acetamide
    —— 2-(4-methylphenyl)sulfanyl-N-[(1R)-2-morpholin-4-yl-1-phenylethyl]acetamide —— C21H26N2O2S
    2-(4-methylphenyl)sulfanyl-N-[(1R)-2-morpholin-4-yl-1-phenylethyl]acetamide
    —— 2-(4-methylphenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]acetamide —— C21H26N2O2S
    2-(4-methylphenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]acetamide
    —— 3-[(2-Benzylsulfanyl-6-methylpyrimidin-4-yl)amino]phenol —— C18H17N3OS
    3-[(2-Benzylsulfanyl-6-methylpyrimidin-4-yl)amino]phenol
    —— (2S)-3-(4-fluorophenyl)sulfanyl-N-(2-hydroxy-2-methylpropyl)-2-methylpropanamide —— C14H20FNO2S
    (2S)-3-(4-fluorophenyl)sulfanyl-N-(2-hydroxy-2-methylpropyl)-2-methylpropanamide
    —— 2-(4-fluorophenyl)sulfanyl-N-[(1S)-2-morpholin-4-ium-4-yl-1-phenylethyl]acetamide —— C20H24FN2O2S+
    2-(4-fluorophenyl)sulfanyl-N-[(1S)-2-morpholin-4-ium-4-yl-1-phenylethyl]acetamide
    —— N-[(R)-cyano-(2,4-difluorophenyl)methyl]-3-pyridin-2-ylsulfanylpropanamide —— C16H13F2N3OS
    N-[(R)-cyano-(2,4-difluorophenyl)methyl]-3-pyridin-2-ylsulfanylpropanamide
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[(1R)-2-morpholin-4-ium-4-yl-1-phenylethyl]acetamide —— C22H29N2O2S+
    2-(3,4-dimethylphenyl)sulfanyl-N-[(1R)-2-morpholin-4-ium-4-yl-1-phenylethyl]acetamide
    —— 2-(2-methylphenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]acetamide —— C21H26N2O2S
    2-(2-methylphenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]acetamide
    —— 2-(4-fluorophenyl)sulfanyl-N-[(1R)-2-morpholin-4-ium-4-yl-1-phenylethyl]acetamide —— C20H24FN2O2S+
    2-(4-fluorophenyl)sulfanyl-N-[(1R)-2-morpholin-4-ium-4-yl-1-phenylethyl]acetamide
    —— N-[(1S)-2-morpholin-4-yl-1-phenylethyl]-2-phenylsulfanylacetamide —— C20H24N2O2S
    N-[(1S)-2-morpholin-4-yl-1-phenylethyl]-2-phenylsulfanylacetamide
    —— 3-(4-chlorophenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]propanamide —— C21H25ClN2O2S
    3-(4-chlorophenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]propanamide
    —— (6E)-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C16H16N4O3S3
    (6E)-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— 1-[(3R,4S)-1,3-dimethylpiperidin-4-yl]-1-methyl-3-[(1S)-1-(4-methylsulfanylphenyl)ethyl]urea —— C18H29N3OS
    1-[(3R,4S)-1,3-dimethylpiperidin-4-yl]-1-methyl-3-[(1S)-1-(4-methylsulfanylphenyl)ethyl]urea
    —— (6E)-6-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-5-imino-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C19H15ClN4O4S3
    (6E)-6-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-5-imino-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— 1-[(3S,3aS,7Z)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone —— C22H22N4O3S
    1-[(3S,3aS,7Z)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone
    —— 2-(4-fluorophenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]acetamide —— C20H23FN2O2S
    2-(4-fluorophenyl)sulfanyl-N-[(1S)-2-morpholin-4-yl-1-phenylethyl]acetamide
    —— (2R)-N-methyl-N-(2-pyridin-2-ylethyl)-2-pyridin-2-ylsulfanylpropanamide —— C16H19N3OS
    (2R)-N-methyl-N-(2-pyridin-2-ylethyl)-2-pyridin-2-ylsulfanylpropanamide
    —— (3S)-3-[(1-ethylimidazol-2-yl)sulfanylmethyl]-1-methylsulfonylpiperidine —— C12H21N3O2S2
    (3S)-3-[(1-ethylimidazol-2-yl)sulfanylmethyl]-1-methylsulfonylpiperidine
    —— (2R)-3-(4-fluorophenyl)sulfanyl-N-(2-hydroxy-2-methylpropyl)-2-methylpropanamide —— C14H20FNO2S
    (2R)-3-(4-fluorophenyl)sulfanyl-N-(2-hydroxy-2-methylpropyl)-2-methylpropanamide
    —— 1-[(3S,4S)-1,3-dimethylpiperidin-4-yl]-1-methyl-3-[(1S)-1-(4-methylsulfanylphenyl)ethyl]urea —— C18H29N3OS
    1-[(3S,4S)-1,3-dimethylpiperidin-4-yl]-1-methyl-3-[(1S)-1-(4-methylsulfanylphenyl)ethyl]urea
    —— (2R)-2-pyridin-2-ylsulfanyl-1-[(2S)-2-(1H-pyrrol-2-yl)pyrrolidin-1-yl]propan-1-one —— C16H19N3OS
    (2R)-2-pyridin-2-ylsulfanyl-1-[(2S)-2-(1H-pyrrol-2-yl)pyrrolidin-1-yl]propan-1-one
    —— 1-[(3R,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone —— C22H22N4OS3
    1-[(3R,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone
    —— (3R)-3-[(1-ethylimidazol-2-yl)sulfanylmethyl]-1-methylsulfonylpiperidine —— C12H21N3O2S2
    (3R)-3-[(1-ethylimidazol-2-yl)sulfanylmethyl]-1-methylsulfonylpiperidine
    —— (2S)-2-pyridin-2-ylsulfanyl-1-[(2R)-2-(1H-pyrrol-2-yl)pyrrolidin-1-yl]propan-1-one —— C16H19N3OS
    (2S)-2-pyridin-2-ylsulfanyl-1-[(2R)-2-(1H-pyrrol-2-yl)pyrrolidin-1-yl]propan-1-one
    —— (2R)-2-pyridin-2-ylsulfanyl-1-[(2R)-2-(1H-pyrrol-2-yl)pyrrolidin-1-yl]propan-1-one —— C16H19N3OS
    (2R)-2-pyridin-2-ylsulfanyl-1-[(2R)-2-(1H-pyrrol-2-yl)pyrrolidin-1-yl]propan-1-one
    —— (6E)-5-imino-6-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C20H18N4O4S3
    (6E)-5-imino-6-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-propan-2-ylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— (6E)-6-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-3-ethylsulfonyl-5-imino-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C18H13ClN4O4S3
    (6E)-6-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-3-ethylsulfonyl-5-imino-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— (6E)-3-ethylsulfonyl-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C15H14N4O3S3
    (6E)-3-ethylsulfonyl-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— (6E)-3-ethylsulfonyl-5-imino-6-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C19H16N4O4S3
    (6E)-3-ethylsulfonyl-5-imino-6-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— (6E)-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C14H12N4O3S3
    (6E)-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— (6E)-5-imino-3-methylsulfonyl-6-[(5-phenylsulfanylfuran-2-yl)methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C17H12N4O4S3
    (6E)-5-imino-3-methylsulfonyl-6-[(5-phenylsulfanylfuran-2-yl)methylidene]-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— 3-(2,2-dimethoxyethylsulfanyl)-1H-1,2,4-triazol-5-amine —— C6H12N4O2S
    3-(2,2-dimethoxyethylsulfanyl)-1H-1,2,4-triazol-5-amine
    —— (6E)-5-imino-6-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C18H14N4O4S3
    (6E)-5-imino-6-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— (6E)-6-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-5-imino-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C17H11ClN4O4S3
    (6E)-6-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-5-imino-3-methylsulfonyl-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— 4-Benzyl-5-(2-phenylethylsulfanyl)-1,2,4-triazol-3-amine —— C17H18N4S
    4-Benzyl-5-(2-phenylethylsulfanyl)-1,2,4-triazol-3-amine
    —— 2-[3-Amino-5-(cyanomethylsulfanyl)-1,2,4-triazol-4-yl]acetonitrile —— C6H6N6S
    2-[3-Amino-5-(cyanomethylsulfanyl)-1,2,4-triazol-4-yl]acetonitrile
    —— Methyl 2-[(5-amino-4-benzyl-1,2,4-triazol-3-yl)sulfanyl]acetate —— C12H14N4O2S
    Methyl 2-[(5-amino-4-benzyl-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— 2-[3-Amino-5-(2-phenylethylsulfanyl)-1,2,4-triazol-4-yl]acetonitrile —— C12H13N5S
    2-[3-Amino-5-(2-phenylethylsulfanyl)-1,2,4-triazol-4-yl]acetonitrile