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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 10-[(4-Methylpiperidin-1-yl)methyl]-12-pyrimidin-2-ylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C20H23N5S2
    10-[(4-Methylpiperidin-1-yl)methyl]-12-pyrimidin-2-ylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— 10-(Phenylsulfanylmethyl)-12-pyrimidin-2-ylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C20H16N4S3
    10-(Phenylsulfanylmethyl)-12-pyrimidin-2-ylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— 2,5,6-Trimethyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C13H12N4S2
    2,5,6-Trimethyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 2-(4-Methylpyrimidin-2-yl)sulfanyl-5-nitrobenzonitrile —— C12H8N4O2S
    2-(4-Methylpyrimidin-2-yl)sulfanyl-5-nitrobenzonitrile
    —— N,N-diethyl-4-(4-methylpyrimidin-2-yl)sulfanyl-3-nitrobenzenesulfonamide —— C15H18N4O4S2
    N,N-diethyl-4-(4-methylpyrimidin-2-yl)sulfanyl-3-nitrobenzenesulfonamide
    —— 2-(2-Nitro-4-piperidin-1-ylsulfonylphenyl)sulfanylpyrimidine —— C15H16N4O4S2
    2-(2-Nitro-4-piperidin-1-ylsulfonylphenyl)sulfanylpyrimidine
    —— 1-[4-(4-Methylpyrimidin-2-yl)sulfanyl-3-nitrophenyl]sulfonylazepane —— C17H20N4O4S2
    1-[4-(4-Methylpyrimidin-2-yl)sulfanyl-3-nitrophenyl]sulfonylazepane
    —— 4-[[5,6-Dimethyl-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidin-2-yl]methyl]morpholine —— C18H21N5OS2
    4-[[5,6-Dimethyl-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidin-2-yl]methyl]morpholine
    —— 10-[(4-Methylpiperidin-1-yl)methyl]-12-(4-methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C21H25N5S2
    10-[(4-Methylpiperidin-1-yl)methyl]-12-(4-methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— 10-[(4-Methylpiperidin-1-ium-1-yl)methyl]-12-(4-methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C21H26N5S2+
    10-[(4-Methylpiperidin-1-ium-1-yl)methyl]-12-(4-methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— [5,6-Dimethyl-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidin-2-yl]methyl-diethylazanium —— C18H24N5S2+
    [5,6-Dimethyl-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidin-2-yl]methyl-diethylazanium
    —— 4,6-Dimethyl-2-(2-nitro-4-piperidin-1-ylsulfonylphenyl)sulfanylpyrimidine —— C17H20N4O4S2
    4,6-Dimethyl-2-(2-nitro-4-piperidin-1-ylsulfonylphenyl)sulfanylpyrimidine
    —— (7R)-4-(4,6-dimethylpyrimidin-2-yl)sulfanyl-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C17H18N4S2
    (7R)-4-(4,6-dimethylpyrimidin-2-yl)sulfanyl-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— 4-(4,6-Dimethylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine —— C12H10N4S2
    4-(4,6-Dimethylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine
    —— 4-[[4-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl]methyl]morpholine —— C19H23N5OS2
    4-[[4-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl]methyl]morpholine
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C18H16ClN3O2S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— 4-benzyl-3-[(3S,5S)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H15N3O3S
    4-benzyl-3-[(3S,5S)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 4-benzyl-3-[(3R,5R)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H15N3O3S
    4-benzyl-3-[(3R,5R)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 4-benzyl-3-[(3R,5S)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H15N3O3S
    4-benzyl-3-[(3R,5S)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 1-[[2-(4-Bromo-2-methylphenyl)sulfanylacetyl]amino]-3-(3-methoxypropyl)-1-methylthiourea —— C15H22BrN3O2S2
    1-[[2-(4-Bromo-2-methylphenyl)sulfanylacetyl]amino]-3-(3-methoxypropyl)-1-methylthiourea
    —— 1-[3-(4-Chlorophenyl)sulfanylpropanoylamino]-3-(3-methoxypropyl)-1-methylthiourea —— C15H22ClN3O2S2
    1-[3-(4-Chlorophenyl)sulfanylpropanoylamino]-3-(3-methoxypropyl)-1-methylthiourea
    —— N-benzyl-5-(3-methylbut-2-enylsulfanyl)-1,3,4-thiadiazol-2-amine —— C14H17N3S2
    N-benzyl-5-(3-methylbut-2-enylsulfanyl)-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide —— C17H18N4OS3
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide
    —— (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-2-cyano-3-methylbutan-2-yl]propanamide —— C18H23N5OS2
    (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-2-cyano-3-methylbutan-2-yl]propanamide
    —— methyl (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate —— C13H15N3O2S2
    methyl (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate
    —— (2S)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-2-cyano-3-methylbutan-2-yl]propanamide —— C18H23N5OS2
    (2S)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-2-cyano-3-methylbutan-2-yl]propanamide
    —— (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[2-(4-fluorophenyl)ethyl]propanamide —— C20H21FN4OS2
    (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]propanamide —— C19H26N4OS2
    (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]propanamide
    —— (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclohexyl-N-ethylpropanamide —— C20H28N4OS2
    (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclohexyl-N-ethylpropanamide
    —— 4-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-diethylbutanamide —— C17H24N4OS2
    4-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-diethylbutanamide
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethyl-N-(2-methylprop-2-enyl)acetamide —— C17H22N4OS2
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethyl-N-(2-methylprop-2-enyl)acetamide
    —— N-benzyl-5-[(1R)-1-phenylethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C17H17N3S2
    N-benzyl-5-[(1R)-1-phenylethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— (2S)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]cyclohexan-1-one —— C15H17N3OS2
    (2S)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]cyclohexan-1-one
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide —— C21H24N4OS2
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide
    —— 1-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C20H21N5O3S
    1-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 3-[[2-(4-Fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazol-4-amine —— C16H12FN5S3
    3-[[2-(4-Fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazol-4-amine
    —— N'-acetyl-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetohydrazide —— C13H15N5O2S2
    N'-acetyl-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetohydrazide
    —— N'-[3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoyl]cyclohexanecarbohydrazide —— C17H26N4O2S
    N'-[3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoyl]cyclohexanecarbohydrazide
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C17H18N4OS3
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(3,4-dimethylphenyl)ethyl]acetamide —— C21H24N4OS2
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(3,4-dimethylphenyl)ethyl]acetamide
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(1-cyanocyclohexyl)-N-methylacetamide —— C19H23N5OS2
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(1-cyanocyclohexyl)-N-methylacetamide
    —— 2-[[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(1-ethyl-2,5-dimethylpyrrol-3-yl)ethanone —— C19H22N4OS2
    2-[[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(1-ethyl-2,5-dimethylpyrrol-3-yl)ethanone
    —— 2-[[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)ethanone —— C20H24N4OS2
    2-[[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)ethanone
    —— N'-[2-(1-adamantyl)acetyl]-3-(3,4-difluorophenyl)sulfanylpropanehydrazide —— C21H26F2N2O2S
    N'-[2-(1-adamantyl)acetyl]-3-(3,4-difluorophenyl)sulfanylpropanehydrazide
    —— 2-(1-adamantyl)-N'-[2-(2,5-difluorophenyl)sulfanylacetyl]acetohydrazide —— C20H24F2N2O2S
    2-(1-adamantyl)-N'-[2-(2,5-difluorophenyl)sulfanylacetyl]acetohydrazide
    —— methyl (2S)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanoate —— C17H17N3O2S2
    methyl (2S)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanoate
    —— 6-Amino-5-[2-[(4,5-dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione —— C19H26N6O3S
    6-Amino-5-[2-[(4,5-dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione
    —— methyl (2R)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanoate —— C17H17N3O2S2
    methyl (2R)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanoate
    —— 3-(3,4-difluorophenyl)sulfanyl-N-[(4-methylphenyl)methyl]propanamide —— C17H17F2NOS
    3-(3,4-difluorophenyl)sulfanyl-N-[(4-methylphenyl)methyl]propanamide
    —— 2-(5-Ethyl-4-methylthiophen-2-yl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole —— C16H14N4O3S2
    2-(5-Ethyl-4-methylthiophen-2-yl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole