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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(3,5-Dimethoxyphenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C16H13N3O5S
    2-(3,5-Dimethoxyphenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 4,5,6-Trimethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylpyridine-3-carbonitrile —— C15H12N4S2
    4,5,6-Trimethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylpyridine-3-carbonitrile
    —— 2-[[5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C15H15N5OS4
    2-[[5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(2-chloro-4-nitrophenyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide —— C13H13ClN4O3S3
    2-[[5-(2-chloro-4-nitrophenyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— 10-Methyl-12-[(5-propylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene —— C15H16N4S4
    10-Methyl-12-[(5-propylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene
    —— N-propyl-2-[(5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H13N5OS4
    N-propyl-2-[(5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-prop-2-enyl-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C11H9N5S3
    N-prop-2-enyl-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 2-[[5-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H13N5OS4
    2-[[5-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 4-[[5-(2-Methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C16H18N4S4
    4-[[5-(2-Methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— 5,6-Dimethyl-4-[[5-(2-methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]thieno[2,3-d]pyrimidine —— C14H16N4S4
    5,6-Dimethyl-4-[[5-(2-methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]thieno[2,3-d]pyrimidine
    —— 2-[[5-(2-Methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C13H12N4O2S3
    2-[[5-(2-Methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 1-[[5-(6-Phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one —— C19H15N5O2S2
    1-[[5-(6-Phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one
    —— 1-[[5-(7-Thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one —— C16H15N5O2S2
    1-[[5-(7-Thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one
    —— 2-(2-Methylpropylsulfanyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-thiadiazole —— C12H13N3O2S3
    2-(2-Methylpropylsulfanyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-thiadiazole
    —— 1-[(5-Thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-2-one —— C13H11N5O2S2
    1-[(5-Thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-2-one
    —— 3-[[5-Benzyl-4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5-(furan-2-yl)-1,2-oxazole —— C20H20N4O3S
    3-[[5-Benzyl-4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5-(furan-2-yl)-1,2-oxazole
    —— N-(2-methoxyethyl)-5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-thiadiazol-2-amine —— C16H19N5OS3
    N-(2-methoxyethyl)-5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(2-methoxyethyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C11H11N5OS3
    N-(2-methoxyethyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— N-(2-methoxyethyl)-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-thiadiazol-2-amine —— C18H17N5OS3
    N-(2-methoxyethyl)-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-thiadiazol-2-amine
    —— 2-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole —— C17H19N5OS2
    2-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole
    —— 2-(6-Phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole —— C19H17N5OS2
    2-(6-Phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole
    —— 2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazole —— C19H17FN5OS2+
    2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazole
    —— N-(2-methoxyethyl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-thiadiazol-2-amine —— C15H17N5OS3
    N-(2-methoxyethyl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-thiadiazol-2-amine
    —— 2-(2-Methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazole —— C20H20N5OS2+
    2-(2-Methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazole
    —— 2-(4-Chloro-2-nitrophenyl)sulfanyl-5-ethylsulfanyl-1,3,4-thiadiazole —— C10H8ClN3O2S3
    2-(4-Chloro-2-nitrophenyl)sulfanyl-5-ethylsulfanyl-1,3,4-thiadiazole
    —— 2-(3,4-Dimethylphenyl)-5-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C17H15N3O5S2
    2-(3,4-Dimethylphenyl)-5-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-(2-Methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole —— C20H19N5OS2
    2-(2-Methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole
    —— 2-(Pyrrolidin-1-ium-1-ylmethyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole —— C13H14N5OS2+
    2-(Pyrrolidin-1-ium-1-ylmethyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole
    —— 5,6-Dimethyl-3-(2-methylpropyl)-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one —— C18H18N4OS3
    5,6-Dimethyl-3-(2-methylpropyl)-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one
    —— 2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole —— C13H13ClN4O3S
    2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole
    —— N-(2-methoxyethyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-amine —— C15H17N5OS3
    N-(2-methoxyethyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-(6-Phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazole —— C19H18N5OS2+
    2-(6-Phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazole
    —— 2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole —— C19H16FN5OS2
    2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole
    —— 2-(2-Methylphenyl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole —— C19H16N4OS2
    2-(2-Methylphenyl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole
    —— 4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine —— C10H8N4S4
    4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine
    —— 4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5-(4-methylphenyl)thieno[2,3-d]pyrimidine —— C17H14N4S4
    4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5-(4-methylphenyl)thieno[2,3-d]pyrimidine
    —— 4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5,6-dimethylthieno[2,3-d]pyrimidine —— C12H12N4S4
    4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5,6-dimethylthieno[2,3-d]pyrimidine
    —— 2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(3,4-dimethylphenyl)-1,3,4-oxadiazole —— C16H12ClN3O3S
    2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(3,4-dimethylphenyl)-1,3,4-oxadiazole
    —— 2-(2-Chloro-4-nitrophenyl)sulfanyl-5-ethylsulfanyl-1,3,4-thiadiazole —— C10H8ClN3O2S3
    2-(2-Chloro-4-nitrophenyl)sulfanyl-5-ethylsulfanyl-1,3,4-thiadiazole
    —— 2-(4-Methylphenyl)-5-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-oxadiazole —— C18H14N4OS2
    2-(4-Methylphenyl)-5-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1,3,4-oxadiazole
    —— 2-(3-Methylphenyl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C21H14N4OS2
    2-(3-Methylphenyl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 5-(4-Methylphenyl)-4-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine —— C16H12N4S4
    5-(4-Methylphenyl)-4-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine
    —— 4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-2,5,6-trimethylthieno[2,3-d]pyrimidine —— C13H14N4S4
    4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-2,5,6-trimethylthieno[2,3-d]pyrimidine
    —— 5,6-Dimethyl-2-(2-nitrophenyl)sulfanyl-3-propan-2-ylthieno[2,3-d]pyrimidin-4-one —— C17H17N3O3S2
    5,6-Dimethyl-2-(2-nitrophenyl)sulfanyl-3-propan-2-ylthieno[2,3-d]pyrimidin-4-one
    —— (7S)-4-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C15H16N4S4
    (7S)-4-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— 4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-6-phenylthieno[2,3-d]pyrimidine —— C16H12N4S4
    4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-6-phenylthieno[2,3-d]pyrimidine
    —— (7R)-4-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C15H16N4S4
    (7R)-4-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— 2-(2-Methylphenyl)-5-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C16H13N3O5S2
    2-(2-Methylphenyl)-5-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 4,8-Dimethyl-2-(4-methylsulfonyl-2-nitrophenyl)sulfanylquinoline —— C18H16N2O4S2
    4,8-Dimethyl-2-(4-methylsulfonyl-2-nitrophenyl)sulfanylquinoline
    —— (7S)-7-methyl-4-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C14H14N4S4
    (7S)-7-methyl-4-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine