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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(4-fluorophenyl)-4-methyl-1,2-oxazole —— C17H18FN5OS
    3-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(4-fluorophenyl)-4-methyl-1,2-oxazole
    —— 5-[(4-Prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]pentanenitrile —— C10H14N4S
    5-[(4-Prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]pentanenitrile
    —— 3-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-5-thiophen-2-yl-1H-1,2,4-triazole —— C14H12ClN3S2
    3-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-5-thiophen-2-yl-1H-1,2,4-triazole
    —— 2-methyl-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C10H9N5OS2
    2-methyl-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— (2R)-N-cyclopropyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C12H14N4OS2
    (2R)-N-cyclopropyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— methyl (2S)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoate —— C10H11N3O2S2
    methyl (2S)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoate
    —— (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C15H22N5OS2+
    (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— 1-[2-(Cyclohexen-1-yl)ethyl]-3-(2-methoxyethyl)thiourea —— C12H22N2OS
    1-[2-(Cyclohexen-1-yl)ethyl]-3-(2-methoxyethyl)thiourea
    —— (2R)-N-(1-cyanocyclohexyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H19N5OS2
    (2R)-N-(1-cyanocyclohexyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2S)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C15H22N5OS2+
    (2S)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— N-[(3-fluorophenyl)methyl]-N-methyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H15FN4OS2
    N-[(3-fluorophenyl)methyl]-N-methyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C20H20N4O2S2
    (2R)-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— 6-Amino-1-cyclopropyl-5-[2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione —— C18H17N5O4S
    6-Amino-1-cyclopropyl-5-[2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione
    —— 1-[4-(2,4-dimethylphenyl)sulfanylphenyl]-3-[[(2R)-oxolan-2-yl]methyl]thiourea —— C20H24N2OS2
    1-[4-(2,4-dimethylphenyl)sulfanylphenyl]-3-[[(2R)-oxolan-2-yl]methyl]thiourea
    —— 2-[2-[2,5-dimethyl-1-(1H-1,2,4-triazol-5-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile —— C18H18N6OS
    2-[2-[2,5-dimethyl-1-(1H-1,2,4-triazol-5-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
    —— 3-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole —— C11H13N3O2S2
    3-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole
    —— 3-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole —— C11H13N3O2S2
    3-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole
    —— methyl 4-[2,5-dimethyl-3-[2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetyl]pyrrol-1-yl]butanoate —— C19H22N4O3S2
    methyl 4-[2,5-dimethyl-3-[2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetyl]pyrrol-1-yl]butanoate
    —— N-[(3-chlorophenyl)methyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H13ClN4OS2
    N-[(3-chlorophenyl)methyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 6-Amino-1-cyclopropyl-5-[2-[[5-(4-ethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione —— C19H19N5O4S
    6-Amino-1-cyclopropyl-5-[2-[[5-(4-ethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione
    —— (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H22N4OS2
    (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 3-(3-phenylpropylsulfanyl)-5-thiophen-2-yl-1H-1,2,4-triazole —— C15H15N3S2
    3-(3-phenylpropylsulfanyl)-5-thiophen-2-yl-1H-1,2,4-triazole
    —— 1-(5-chlorothiophen-2-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C12H8ClN3OS3
    1-(5-chlorothiophen-2-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (2S)-N-(1-adamantyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C19H24N4OS2
    (2S)-N-(1-adamantyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(1R)-1-(2,4-difluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H14F2N4OS2
    N-[(1R)-1-(2,4-difluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C20H20N4O2S2
    (2S)-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H22N4OS2
    (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C18H20N4OS2
    N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 6-Amino-1-cyclopropyl-5-[2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetyl]pyrimidine-2,4-dione —— C13H14N4O3S2
    6-Amino-1-cyclopropyl-5-[2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetyl]pyrimidine-2,4-dione
    —— 6-Amino-5-[2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-1-cyclopropylpyrimidine-2,4-dione —— C18H17N5O4S
    6-Amino-5-[2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-1-cyclopropylpyrimidine-2,4-dione
    —— 2-(4-chlorophenyl)-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C15H10ClN5OS2
    2-(4-chlorophenyl)-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— N-[2-(4-methoxyphenoxy)ethyl]-N-methyl-2-phenylsulfanylpyridine-3-carboxamide —— C22H22N2O3S
    N-[2-(4-methoxyphenoxy)ethyl]-N-methyl-2-phenylsulfanylpyridine-3-carboxamide
    —— 3-[(3-fluorophenyl)methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole —— C13H10FN3S2
    3-[(3-fluorophenyl)methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole
    —— N-[(1S)-1-(4-ethylphenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C18H20N4OS2
    N-[(1S)-1-(4-ethylphenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(3-methylphenyl)-1,3,4-oxadiazole —— C16H18N6OS
    2-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(3-methylphenyl)-1,3,4-oxadiazole
    —— N-[2-(cyclohexen-1-yl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H20N4OS2
    N-[2-(cyclohexen-1-yl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 1-(1-ethyl-2,5-dimethylpyrrol-3-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C16H18N4OS2
    1-(1-ethyl-2,5-dimethylpyrrol-3-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 5-(3,4-Dimethoxyphenyl)-2-methyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C19H16N4O2S2
    5-(3,4-Dimethoxyphenyl)-2-methyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 5-(4-Chlorophenyl)-4-(1-cyclopropyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine —— C16H11ClN6S2
    5-(4-Chlorophenyl)-4-(1-cyclopropyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine
    —— 6-Amino-1-cyclopropyl-5-[2-(1-methylimidazol-2-yl)sulfanylacetyl]pyrimidine-2,4-dione —— C13H15N5O3S
    6-Amino-1-cyclopropyl-5-[2-(1-methylimidazol-2-yl)sulfanylacetyl]pyrimidine-2,4-dione
    —— 6-Amino-1-cyclopropyl-5-(2-pyrimidin-2-ylsulfanylacetyl)pyrimidine-2,4-dione —— C13H13N5O3S
    6-Amino-1-cyclopropyl-5-(2-pyrimidin-2-ylsulfanylacetyl)pyrimidine-2,4-dione
    —— 6-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)pyridine-3-sulfonamide —— C13H12N2O4S2
    6-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)pyridine-3-sulfonamide
    —— (4-methylsulfanylphenyl)methyl N'-propan-2-ylcarbamimidothioate —— C12H18N2S2
    (4-methylsulfanylphenyl)methyl N'-propan-2-ylcarbamimidothioate
    —— N-[2-(4-methylphenyl)sulfanylethyl]-2-(1-oxidopyridin-1-ium-2-yl)oxyacetamide —— C16H18N2O3S
    N-[2-(4-methylphenyl)sulfanylethyl]-2-(1-oxidopyridin-1-ium-2-yl)oxyacetamide
    —— N-[2-(4-chlorophenyl)sulfanylphenyl]-2-([1,2,4]triazolo[4,3-a]pyridin-3-yloxy)acetamide —— C20H15ClN4O2S
    N-[2-(4-chlorophenyl)sulfanylphenyl]-2-([1,2,4]triazolo[4,3-a]pyridin-3-yloxy)acetamide
    —— 1-[2-(4-Chlorophenyl)sulfanylethyl]-3,5-dimethyl-4-nitropyrazole —— C13H14ClN3O2S
    1-[2-(4-Chlorophenyl)sulfanylethyl]-3,5-dimethyl-4-nitropyrazole
    —— N-[2-(4-chlorophenyl)sulfanylphenyl]-2-(1-oxidopyridin-1-ium-2-yl)oxyacetamide —— C19H15ClN2O3S
    N-[2-(4-chlorophenyl)sulfanylphenyl]-2-(1-oxidopyridin-1-ium-2-yl)oxyacetamide
    —— (3S)-1-tert-butyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide —— C21H24N2O2S
    (3S)-1-tert-butyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide
    —— (3R)-1-tert-butyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide —— C21H24N2O2S
    (3R)-1-tert-butyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide
    —— 4-cyclopropyl-3-(2-methylprop-2-enylsulfanyl)-1H-1,2,4-triazol-5-one —— C9H13N3OS
    4-cyclopropyl-3-(2-methylprop-2-enylsulfanyl)-1H-1,2,4-triazol-5-one