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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-(2,3-dimethylphenyl)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C20H19N5OS2
    N-(2,3-dimethylphenyl)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(furan-2-ylmethyl)-2-[[5-(5-methyl-1,2-oxazol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C13H12N4O4S
    N-(furan-2-ylmethyl)-2-[[5-(5-methyl-1,2-oxazol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-(2,3-dimethylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H19N7S2
    N-(2,3-dimethylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-butyl-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C17H24N4OS2
    N-butyl-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 1-(Azocan-1-yl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H24N4OS2
    1-(Azocan-1-yl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(furan-2-yl)ethyl]acetamide —— C18H20N4O2S2
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(furan-2-yl)ethyl]acetamide
    —— 2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide —— C20H22N4OS2
    2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(3-methylthiophen-2-yl)methyl]acetamide —— C19H22N4OS3
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(3-methylthiophen-2-yl)methyl]acetamide
    —— 1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C20H19N3O3S2
    1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide —— C17H24N4OS2
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide
    —— 2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide —— C19H20N4OS2
    2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide
    —— N-(2-cyanoethyl)-N-(furan-2-ylmethyl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H19N5O2S2
    N-(2-cyanoethyl)-N-(furan-2-ylmethyl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-5-methylhexan-2-yl]acetamide —— C18H26N4OS2
    2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-5-methylhexan-2-yl]acetamide
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide —— C20H22N4OS2
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide
    —— 2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dipropylacetamide —— C17H24N4OS2
    2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dipropylacetamide
    —— N-(4-methylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H17N7S2
    N-(4-methylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-5-methylhexan-2-yl]acetamide —— C18H26N4OS2
    2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-5-methylhexan-2-yl]acetamide
    —— 2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide —— C16H22N4OS2
    2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide
    —— Ethyl 2,5-dimethyl-1-[2-oxo-2-(2-phenylsulfanylethylamino)ethyl]pyrrole-3-carboxylate —— C19H24N2O3S
    Ethyl 2,5-dimethyl-1-[2-oxo-2-(2-phenylsulfanylethylamino)ethyl]pyrrole-3-carboxylate
    —— N-[(1S)-1-cyclopropylethyl]-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H22N4OS2
    N-[(1S)-1-cyclopropylethyl]-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3-methylthiophen-2-yl)methyl]acetamide —— C18H20N4OS3
    N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3-methylthiophen-2-yl)methyl]acetamide
    —— 2-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-4-yl]-N-(2-phenylsulfanylethyl)acetamide —— C17H19N3O2S2
    2-[2-(2-oxopyrrolidin-1-yl)-1,3-thiazol-4-yl]-N-(2-phenylsulfanylethyl)acetamide
    —— 2-(3-benzyl-2,6-dioxopyrimidin-1-yl)-N-(2-phenylsulfanylethyl)acetamide —— C21H21N3O3S
    2-(3-benzyl-2,6-dioxopyrimidin-1-yl)-N-(2-phenylsulfanylethyl)acetamide
    —— (E)-3-[5-chloro-3-methyl-1-(2-methylpropyl)pyrazol-4-yl]-N-(2-phenylsulfanylethyl)prop-2-enamide —— C19H24ClN3OS
    (E)-3-[5-chloro-3-methyl-1-(2-methylpropyl)pyrazol-4-yl]-N-(2-phenylsulfanylethyl)prop-2-enamide
    —— 4-morpholin-4-yl-4-oxo-N-(2-phenylsulfanylethyl)butanamide —— C16H22N2O3S
    4-morpholin-4-yl-4-oxo-N-(2-phenylsulfanylethyl)butanamide
    —— (Z)-N-cyclopropyl-3-phenylsulfanylprop-2-enamide —— C12H13NOS
    (Z)-N-cyclopropyl-3-phenylsulfanylprop-2-enamide
    —— 5-[[5-(furan-2-yl)-1,2-oxazol-3-yl]methylsulfanyl]-N-(2-methylphenyl)-1,3,4-thiadiazol-2-amine —— C17H14N4O2S2
    5-[[5-(furan-2-yl)-1,2-oxazol-3-yl]methylsulfanyl]-N-(2-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-fluorophenyl)methyl]-N-methylacetamide —— C20H21FN4OS2
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-fluorophenyl)methyl]-N-methylacetamide
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide —— C17H24N4OS2
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide
    —— N-(2-methylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H17N7S2
    N-(2-methylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[(3R)-1,1-dioxothiolan-3-yl]sulfanyl-N-(2-phenylsulfanylethyl)acetamide —— C14H19NO3S3
    2-[(3R)-1,1-dioxothiolan-3-yl]sulfanyl-N-(2-phenylsulfanylethyl)acetamide
    —— (Z)-N-(furan-2-ylmethyl)-3-phenylsulfanylprop-2-enamide —— C14H13NO2S
    (Z)-N-(furan-2-ylmethyl)-3-phenylsulfanylprop-2-enamide
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(5-methylfuran-2-yl)methyl]acetamide —— C19H22N4O2S2
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(5-methylfuran-2-yl)methyl]acetamide
    —— 2-(2,5-difluorophenyl)sulfanyl-N-(2-phenylsulfanylethyl)acetamide —— C16H15F2NOS2
    2-(2,5-difluorophenyl)sulfanyl-N-(2-phenylsulfanylethyl)acetamide
    —— 3-(5-phenylfuran-2-yl)-N-(2-phenylsulfanylethyl)propanamide —— C21H21NO2S
    3-(5-phenylfuran-2-yl)-N-(2-phenylsulfanylethyl)propanamide
    —— (E)-N-(2-phenylsulfanylethyl)-3-thiophen-2-ylprop-2-enamide —— C15H15NOS2
    (E)-N-(2-phenylsulfanylethyl)-3-thiophen-2-ylprop-2-enamide
    —— 3-(2-chloro-6-fluorophenyl)-5-methyl-N-(2-phenylsulfanylethyl)-1,2-oxazole-4-carboxamide —— C19H16ClFN2O2S
    3-(2-chloro-6-fluorophenyl)-5-methyl-N-(2-phenylsulfanylethyl)-1,2-oxazole-4-carboxamide
    —— 5-(carbamoylamino)-N-(2-phenylsulfanylethyl)pentanamide —— C14H21N3O2S
    5-(carbamoylamino)-N-(2-phenylsulfanylethyl)pentanamide
    —— (E)-3-(furan-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide —— C15H15NO2S
    (E)-3-(furan-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide
    —— 3-(3,5-dimethyl-1,2-oxazol-4-yl)-N-(2-phenylsulfanylethyl)propanamide —— C16H20N2O2S
    3-(3,5-dimethyl-1,2-oxazol-4-yl)-N-(2-phenylsulfanylethyl)propanamide
    —— 5-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)-N-(2-phenylsulfanylethyl)pentanamide —— C16H20N2O2S3
    5-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)-N-(2-phenylsulfanylethyl)pentanamide
    —— 1-methyl-N-(2-phenylsulfanylethyl)pyrazole-4-carboxamide —— C13H15N3OS
    1-methyl-N-(2-phenylsulfanylethyl)pyrazole-4-carboxamide
    —— N-[(1R)-1-(furan-2-yl)ethyl]-2-phenylsulfanylacetamide —— C14H15NO2S
    N-[(1R)-1-(furan-2-yl)ethyl]-2-phenylsulfanylacetamide
    —— 3-(4-chlorophenyl)sulfanyl-N-[(1R)-1-(furan-2-yl)ethyl]propanamide —— C15H16ClNO2S
    3-(4-chlorophenyl)sulfanyl-N-[(1R)-1-(furan-2-yl)ethyl]propanamide
    —— N-[(1S)-1-(furan-2-yl)ethyl]-2-phenylsulfanylacetamide —— C14H15NO2S
    N-[(1S)-1-(furan-2-yl)ethyl]-2-phenylsulfanylacetamide
    —— 3-(4-fluorophenyl)sulfanyl-N-[(1R)-1-(furan-2-yl)ethyl]propanamide —— C15H16FNO2S
    3-(4-fluorophenyl)sulfanyl-N-[(1R)-1-(furan-2-yl)ethyl]propanamide
    —— N-[(1R)-1-(furan-2-yl)ethyl]-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrobenzamide —— C16H15N5O4S
    N-[(1R)-1-(furan-2-yl)ethyl]-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrobenzamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(1R)-1-(furan-2-yl)ethyl]acetamide —— C15H16BrNO2S
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(1R)-1-(furan-2-yl)ethyl]acetamide
    —— N-[[5-(4-chlorophenyl)furan-2-yl]methyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide —— C21H22ClN3O2S
    N-[[5-(4-chlorophenyl)furan-2-yl]methyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide
    —— 1-(3-Chlorophenyl)-3-[[2-(2-methylphenyl)sulfanylacetyl]amino]thiourea —— C16H16ClN3OS2
    1-(3-Chlorophenyl)-3-[[2-(2-methylphenyl)sulfanylacetyl]amino]thiourea