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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(3-phenylsulfanylpropyl)acetamide —— C18H19N3O3S2
    2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(3-phenylsulfanylpropyl)acetamide
    —— 2-(2-Methylfuran-3-yl)-5-[(5-phenyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-oxadiazole —— C17H13N3O3S
    2-(2-Methylfuran-3-yl)-5-[(5-phenyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— N-cyclopropyl-N-[(2-fluorophenyl)methyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H18FN3O3S
    N-cyclopropyl-N-[(2-fluorophenyl)methyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,4,4-trimethylpentan-2-yl)acetamide —— C17H25N3O3S
    2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,4,4-trimethylpentan-2-yl)acetamide
    —— N-[(4-ethylphenyl)methyl]-N-methyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H21N3O3S
    N-[(4-ethylphenyl)methyl]-N-methyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(2S)-2-ethylhexyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C17H25N3O3S
    N-[(2S)-2-ethylhexyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C18H16N2O5S
    1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— N-[(5-chlorothiophen-2-yl)methyl]-N-ethyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H16ClN3O3S2
    N-[(5-chlorothiophen-2-yl)methyl]-N-ethyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-ethyl-N-[(3-fluorophenyl)methyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H18FN3O3S
    N-ethyl-N-[(3-fluorophenyl)methyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-oxo-4-(2-phenylethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide —— C20H22N4O2S
    2-[[5-oxo-4-(2-phenylethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide
    —— 3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-[2-(4-fluorophenyl)ethyl]propanamide —— C19H23FN4O2S
    3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— 3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]-N-[2-(4-fluorophenyl)ethyl]propanamide —— C18H20F3N3OS
    3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— 2-(4-methylphenyl)-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole —— C17H14N4S3
    2-(4-methylphenyl)-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole
    —— N-[(3-chlorophenyl)methyl]-3-(2-fluorophenyl)sulfanylpropanamide —— C16H15ClFNOS
    N-[(3-chlorophenyl)methyl]-3-(2-fluorophenyl)sulfanylpropanamide
    —— 3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-[(2-chlorophenyl)methyl]propanamide —— C18H21ClN4O2S
    3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-[(2-chlorophenyl)methyl]propanamide
    —— N-[(2-chlorophenyl)methyl]-3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]propanamide —— C17H18ClF2N3OS
    N-[(2-chlorophenyl)methyl]-3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]propanamide
    —— 2-[[4-Cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole —— C19H17N5OS2
    2-[[4-Cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole
    —— (3S)-1-butyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide —— C21H24N2O2S
    (3S)-1-butyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide
    —— (Z)-N-(2-hydroxyethyl)-N-[(4-methylsulfanylphenyl)methyl]pent-3-enamide —— C15H21NO2S
    (Z)-N-(2-hydroxyethyl)-N-[(4-methylsulfanylphenyl)methyl]pent-3-enamide
    —— 2-[[4-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C18H18N4O4S
    2-[[4-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— 2-[[4-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C18H18N4O4S
    2-[[4-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— 2-[[4-[(Z)-[5-[(1R,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C18H17N4O4S-
    2-[[4-[(Z)-[5-[(1R,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— N-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-2-(4-methylphenyl)sulfanylacetamide —— C18H20N2O2S
    N-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-2-(4-methylphenyl)sulfanylacetamide
    —— 2-(2-fluorophenyl)sulfanyl-N-[(Z)-[5-[(1R,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide —— C17H17FN2O2S
    2-(2-fluorophenyl)sulfanyl-N-[(Z)-[5-[(1R,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide
    —— ethyl N-[4-[1-[2-[2-(2-fluorophenyl)sulfanylacetyl]hydrazinyl]ethylidene]-3-methyl-1,2-thiazol-5-ylidene]carbamate —— C17H19FN4O3S2
    ethyl N-[4-[1-[2-[2-(2-fluorophenyl)sulfanylacetyl]hydrazinyl]ethylidene]-3-methyl-1,2-thiazol-5-ylidene]carbamate
    —— (Z)-N-[3-[(4-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-[5-[(1R,2S)-2-methylcyclopropyl]furan-2-yl]methanimine —— C18H17ClN4OS
    (Z)-N-[3-[(4-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-[5-[(1R,2S)-2-methylcyclopropyl]furan-2-yl]methanimine
    —— N-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-2-(4-methylphenyl)sulfanylacetamide —— C18H20N2O2S
    N-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-2-(4-methylphenyl)sulfanylacetamide
    —— 2-[[5-cyclohexyl-4-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetate —— C19H23N4O3S-
    2-[[5-cyclohexyl-4-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 2-[[5-cyclohexyl-4-[(Z)-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C19H24N4O3S
    2-[[5-cyclohexyl-4-[(Z)-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— N-[(Z)-1-(5-amino-3-methyl-1,2-thiazol-4-yl)ethylideneamino]-3-(4-fluorophenyl)sulfanylpropanamide —— C15H17FN4OS2
    N-[(Z)-1-(5-amino-3-methyl-1,2-thiazol-4-yl)ethylideneamino]-3-(4-fluorophenyl)sulfanylpropanamide
    —— 2-[[5-cyclohexyl-4-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C19H24N4O3S
    2-[[5-cyclohexyl-4-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— ethyl N-[3-methyl-4-[1-[2-[2-(4-methylphenyl)sulfanylacetyl]hydrazinyl]ethylidene]-1,2-thiazol-5-ylidene]carbamate —— C18H22N4O3S2
    ethyl N-[3-methyl-4-[1-[2-[2-(4-methylphenyl)sulfanylacetyl]hydrazinyl]ethylidene]-1,2-thiazol-5-ylidene]carbamate
    —— (Z)-N-[3-[(4-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methanimine —— C18H17ClN4OS
    (Z)-N-[3-[(4-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methanimine
    —— 2-[[5-cyclohexyl-4-[(Z)-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetate —— C19H23N4O3S-
    2-[[5-cyclohexyl-4-[(Z)-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 2-[[5-cyclohexyl-4-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C19H24N4O3S
    2-[[5-cyclohexyl-4-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— 1-[2-[[5-(3-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]imidazolidin-2-one 924015-71-4 C13H11BrN4O3S
    1-[2-[[5-(3-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]imidazolidin-2-one
    —— 2-(4-chlorophenyl)sulfanyl-N-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide —— C17H17ClN2O2S
    2-(4-chlorophenyl)sulfanyl-N-[(Z)-[5-[(1R,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide —— C17H17ClN2O2S
    2-(4-chlorophenyl)sulfanyl-N-[(Z)-[5-[(1S,2R)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(Z)-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide —— C17H17ClN2O2S
    2-(4-chlorophenyl)sulfanyl-N-[(Z)-[5-[(1S,2S)-2-methylcyclopropyl]furan-2-yl]methylideneamino]acetamide
    —— (2S)-2-[[5-[(3S)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide —— C12H20N4O3S2
    (2S)-2-[[5-[(3S)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide
    —— (2R)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-enylpropanamide —— C13H20N4O3S2
    (2R)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-enylpropanamide
    —— (2R)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-propylpropanamide —— C13H22N4O3S2
    (2R)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-propylpropanamide
    —— (2R)-2-[[5-[(3S)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-enylpropanamide —— C13H20N4O3S2
    (2R)-2-[[5-[(3S)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-enylpropanamide
    —— (2R)-3-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-2-methylpropanenitrile —— C11H16N4O2S2
    (2R)-3-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-2-methylpropanenitrile
    —— 2-[[5-[(3S)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-ynylacetamide —— C12H16N4O3S2
    2-[[5-[(3S)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-ynylacetamide
    —— [(1R)-1-cyanoethyl] 2-phenylsulfanylpyridine-3-carboxylate —— C15H12N2O2S
    [(1R)-1-cyanoethyl] 2-phenylsulfanylpyridine-3-carboxylate
    —— (3S)-3-[4-methyl-5-[2-[(2S)-1-methylpiperidin-2-yl]ethylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C15H26N4O2S2
    (3S)-3-[4-methyl-5-[2-[(2S)-1-methylpiperidin-2-yl]ethylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— (2R)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide —— C12H20N4O3S2
    (2R)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide
    —— (2S)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-enylpropanamide —— C13H20N4O3S2
    (2S)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-prop-2-enylpropanamide
    —— 1-(2,5-dimethylthiophen-3-yl)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C15H19N3O3S3
    1-(2,5-dimethylthiophen-3-yl)-2-[[5-[(3R)-1,1-dioxothiolan-3-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone