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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-2-(1-benzyltetrazol-5-yl)sulfanyl-1-(4-ethylpiperazin-1-yl)propan-1-one —— C17H24N6OS
    (2S)-2-(1-benzyltetrazol-5-yl)sulfanyl-1-(4-ethylpiperazin-1-yl)propan-1-one
    —— (3R,4S)-4-[2-(4-methylphenyl)sulfanylethylamino]-1,1-dioxothiolan-3-ol —— C13H19NO3S2
    (3R,4S)-4-[2-(4-methylphenyl)sulfanylethylamino]-1,1-dioxothiolan-3-ol
    —— 1-[4-[(1S)-1-phenylethyl]piperazin-1-yl]-2-(1-propan-2-yltetrazol-5-yl)sulfanylethanone —— C18H26N6OS
    1-[4-[(1S)-1-phenylethyl]piperazin-1-yl]-2-(1-propan-2-yltetrazol-5-yl)sulfanylethanone
    —— N-cyclopropyl-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C10H12N4OS2
    N-cyclopropyl-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 5-(4-Chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine 920857-27-8 C14H9ClN6S2
    5-(4-Chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine
    —— (2R)-N-(cyclohexylmethyl)-2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C22H32N4O2S
    (2R)-N-(cyclohexylmethyl)-2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— 2-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazole —— C19H19N7O2S
    2-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazole
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-(1-propylpiperidin-1-ium-4-yl)acetamide —— C18H28BrN2OS+
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-(1-propylpiperidin-1-ium-4-yl)acetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-(1-propylpiperidin-1-ium-4-yl)acetamide —— C17H26BrN2OS+
    2-(4-bromo-2-methylphenyl)sulfanyl-N-(1-propylpiperidin-1-ium-4-yl)acetamide
    —— 3-Methyl-7-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C15H13N5O2S3
    3-Methyl-7-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-(1-methyltetrazol-5-yl)sulfanylacetamide —— C10H17N5O3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-(1-methyltetrazol-5-yl)sulfanylacetamide
    —— (5E)-2-cyclohexylimino-5-[(4-methylsulfanylphenyl)methylidene]-1,3-thiazolidin-4-one —— C17H20N2OS2
    (5E)-2-cyclohexylimino-5-[(4-methylsulfanylphenyl)methylidene]-1,3-thiazolidin-4-one
    —— [(3S)-3-methylsulfonylbutyl]hydrazine —— C5H14N2O2S
    [(3S)-3-methylsulfonylbutyl]hydrazine
    —— 4-[(Difluoromethyl)thio]benzene-1,2-diamine —— C7H8F2N2S
    4-[(Difluoromethyl)thio]benzene-1,2-diamine
    —— [(3R)-3-methylsulfonylbutyl]hydrazine —— C5H14N2O2S
    [(3R)-3-methylsulfonylbutyl]hydrazine
    —— 6-(carbamoylamino)-N-[2-(4-chlorophenyl)sulfanylethyl]hexanamide —— C15H22ClN3O2S
    6-(carbamoylamino)-N-[2-(4-chlorophenyl)sulfanylethyl]hexanamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-2,5-dimethyl-1-propan-2-ylpyrrole-3-carboxamide —— C18H23ClN2OS
    N-[2-(4-chlorophenyl)sulfanylethyl]-2,5-dimethyl-1-propan-2-ylpyrrole-3-carboxamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide —— C18H22ClN3OS2
    N-[2-(4-chlorophenyl)sulfanylethyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-3,5-dimethyl-1-[(4-methylphenyl)methyl]pyrazole-4-carboxamide —— C22H24ClN3OS
    N-[2-(4-chlorophenyl)sulfanylethyl]-3,5-dimethyl-1-[(4-methylphenyl)methyl]pyrazole-4-carboxamide
    —— (E)-3-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]-2-pyridin-2-ylprop-2-enenitrile —— C18H13N5O2S
    (E)-3-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]-2-pyridin-2-ylprop-2-enenitrile
    —— 3-(2-chlorophenyl)-N-[2-(4-chlorophenyl)sulfanylethyl]-5-methyl-1,2-oxazole-4-carboxamide —— C19H16Cl2N2O2S
    3-(2-chlorophenyl)-N-[2-(4-chlorophenyl)sulfanylethyl]-5-methyl-1,2-oxazole-4-carboxamide
    —— 4-bromo-N'-[3-(4-fluorophenyl)sulfanylpropanoyl]-1H-pyrrole-2-carbohydrazide —— C14H13BrFN3O2S
    4-bromo-N'-[3-(4-fluorophenyl)sulfanylpropanoyl]-1H-pyrrole-2-carbohydrazide
    —— 4-bromo-N'-[2-(3,4-dimethylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide —— C15H16BrN3O2S
    4-bromo-N'-[2-(3,4-dimethylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide
    —— 4-bromo-N'-[3-(4-chlorophenyl)sulfanylpropanoyl]-1H-pyrrole-2-carbohydrazide —— C14H13BrClN3O2S
    4-bromo-N'-[3-(4-chlorophenyl)sulfanylpropanoyl]-1H-pyrrole-2-carbohydrazide
    —— 4-bromo-N'-[2-(4-fluorophenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide —— C13H11BrFN3O2S
    4-bromo-N'-[2-(4-fluorophenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide
    —— 4-bromo-N'-[2-(2,5-dimethylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide —— C15H16BrN3O2S
    4-bromo-N'-[2-(2,5-dimethylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide
    —— (Z)-3-(5-methylfuran-2-yl)-N-(3-phenylsulfanylpropyl)prop-2-enamide —— C17H19NO2S
    (Z)-3-(5-methylfuran-2-yl)-N-(3-phenylsulfanylpropyl)prop-2-enamide
    —— (Z)-N-(3-phenylsulfanylpropyl)-3-thiophen-2-ylprop-2-enamide —— C16H17NOS2
    (Z)-N-(3-phenylsulfanylpropyl)-3-thiophen-2-ylprop-2-enamide
    —— (7E)-3-[chloro(difluoro)methyl]-7-[(5-methylthiophen-2-yl)methylidene]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C17H11ClF2N4S2
    (7E)-3-[chloro(difluoro)methyl]-7-[(5-methylthiophen-2-yl)methylidene]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— methyl (2R)-3-[1-(benzenesulfonyl)-3-phenylsulfanylindol-2-yl]-2-cyanopropanoate —— C25H20N2O4S2
    methyl (2R)-3-[1-(benzenesulfonyl)-3-phenylsulfanylindol-2-yl]-2-cyanopropanoate
    —— 4-(4-Methylphenyl)-2-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-1,3-thiazole —— C17H14N2O4S3
    4-(4-Methylphenyl)-2-(4-methylsulfonyl-2-nitrophenyl)sulfanyl-1,3-thiazole
    —— methyl (2S)-3-[1-(benzenesulfonyl)-3-phenylsulfanylindol-2-yl]-2-cyanopropanoate —— C25H20N2O4S2
    methyl (2S)-3-[1-(benzenesulfonyl)-3-phenylsulfanylindol-2-yl]-2-cyanopropanoate
    —— 11-Methyl-10-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one —— C19H18N4OS3
    11-Methyl-10-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one
    —— 10-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-11-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one —— C18H16N4OS3
    10-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-11-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one
    —— 5-Nitro-2-(4-oxo-3-phenylthieno[2,3-d]pyrimidin-2-yl)sulfanylbenzonitrile —— C19H10N4O3S2
    5-Nitro-2-(4-oxo-3-phenylthieno[2,3-d]pyrimidin-2-yl)sulfanylbenzonitrile
    —— 2-[(11-Methyl-12-oxo-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-10-yl)sulfanyl]-5-nitrobenzonitrile —— C17H12N4O3S2
    2-[(11-Methyl-12-oxo-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-10-yl)sulfanyl]-5-nitrobenzonitrile
    —— 3-(2-Methoxyethyl)-5,6-dimethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one —— C17H16N4O2S3
    3-(2-Methoxyethyl)-5,6-dimethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one
    —— 10-(2-Chloro-4-nitrophenyl)sulfanyl-11-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one —— C16H12ClN3O3S2
    10-(2-Chloro-4-nitrophenyl)sulfanyl-11-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one
    —— 3-Methyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one —— C17H14N4OS3
    3-Methyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
    —— 2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-3-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one —— C19H18N4OS3
    2-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-3-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
    —— 11-Propyl-10-thieno[2,3-d]pyrimidin-4-ylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one —— C18H16N4OS3
    11-Propyl-10-thieno[2,3-d]pyrimidin-4-ylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one
    —— 2-[(3-Ethyl-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanyl]-5-nitrobenzonitrile —— C19H16N4O3S2
    2-[(3-Ethyl-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanyl]-5-nitrobenzonitrile
    —— N-[2-[(5E)-5-[(3-bromophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-phenylsulfanylacetamide —— C20H17BrN2O3S2
    N-[2-[(5E)-5-[(3-bromophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-phenylsulfanylacetamide
    —— N-[(S)-(4-chlorophenyl)-(1-methylimidazol-2-yl)methyl]-3-(4-fluorophenyl)sulfanylpropanamide —— C20H19ClFN3OS
    N-[(S)-(4-chlorophenyl)-(1-methylimidazol-2-yl)methyl]-3-(4-fluorophenyl)sulfanylpropanamide
    —— N-[(S)-(4-chlorophenyl)-(1-methylimidazol-2-yl)methyl]-2-(2-methylphenyl)sulfanylacetamide —— C20H20ClN3OS
    N-[(S)-(4-chlorophenyl)-(1-methylimidazol-2-yl)methyl]-2-(2-methylphenyl)sulfanylacetamide
    —— ethyl (4S)-6-amino-4-(2-chlorophenyl)-5-cyano-2-[(3-cyano-4,6-dimethylpyridin-2-yl)sulfanylmethyl]-4H-thiopyran-3-carboxylate —— C24H21ClN4O2S2
    ethyl (4S)-6-amino-4-(2-chlorophenyl)-5-cyano-2-[(3-cyano-4,6-dimethylpyridin-2-yl)sulfanylmethyl]-4H-thiopyran-3-carboxylate
    —— N,N'-dimethyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]-N'-[(Z)-(4-methylsulfanylphenyl)methylideneamino]ethane-1,2-diamine —— C20H26N4S2
    N,N'-dimethyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]-N'-[(Z)-(4-methylsulfanylphenyl)methylideneamino]ethane-1,2-diamine
    —— ethyl (4R)-6-amino-4-(2-chlorophenyl)-5-cyano-2-[(3-cyano-4,6-dimethylpyridin-2-yl)sulfanylmethyl]-4H-thiopyran-3-carboxylate —— C24H21ClN4O2S2
    ethyl (4R)-6-amino-4-(2-chlorophenyl)-5-cyano-2-[(3-cyano-4,6-dimethylpyridin-2-yl)sulfanylmethyl]-4H-thiopyran-3-carboxylate
    —— ethyl (7S,8S)-4-methoxy-9-oxo-8-phenyl-5,6,7,8-tetrahydropyrimido[4,5-b][1,4]benzothiazine-7-carboxylate —— C20H19N3O4S
    ethyl (7S,8S)-4-methoxy-9-oxo-8-phenyl-5,6,7,8-tetrahydropyrimido[4,5-b][1,4]benzothiazine-7-carboxylate
    —— ethyl (7R,8R)-4-methoxy-9-oxo-8-phenyl-5,6,7,8-tetrahydropyrimido[4,5-b][1,4]benzothiazine-7-carboxylate —— C20H19N3O4S
    ethyl (7R,8R)-4-methoxy-9-oxo-8-phenyl-5,6,7,8-tetrahydropyrimido[4,5-b][1,4]benzothiazine-7-carboxylate