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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide —— C14H14F3N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methyl-N-(4-methylcyclohexyl)acetamide —— C20H27N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methyl-N-(4-methylcyclohexyl)acetamide
    —— 2-(3,5-Dimethylphenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-oxadiazole —— C17H14N4O3S
    2-(3,5-Dimethylphenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-oxadiazole
    —— (4-Oxo-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-2-yl)methyl 3-(4-methylphenyl)sulfanylpropanoate —— C21H22N2O3S2
    (4-Oxo-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-2-yl)methyl 3-(4-methylphenyl)sulfanylpropanoate
    —— (1R,2S,3S,4R)-3-(2-methylsulfonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid —— C12H17NO5S
    (1R,2S,3S,4R)-3-(2-methylsulfonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
    —— N,N-dibenzyl-2-[[5-[(5S)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C31H36N4OS2
    N,N-dibenzyl-2-[[5-[(5S)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 6-amino-5-[(2R)-2-[[5-[(5S)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1,3-dimethylpyrimidine-2,4-dione —— C26H34N6O3S2
    6-amino-5-[(2R)-2-[[5-[(5S)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1,3-dimethylpyrimidine-2,4-dione
    —— (1R,2S,3R,4R)-3-(2-methylsulfonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid —— C12H17NO5S
    (1R,2S,3R,4R)-3-(2-methylsulfonylethylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
    —— 6-amino-5-[(2S)-2-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1,3-dimethylpyrimidine-2,4-dione —— C26H34N6O3S2
    6-amino-5-[(2S)-2-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1,3-dimethylpyrimidine-2,4-dione
    —— N,N-dibenzyl-2-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C31H36N4OS2
    N,N-dibenzyl-2-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— (1'S,5'S)-N-[(1S)-1-thiophen-2-ylethyl]spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxamide —— C18H25NOS3
    (1'S,5'S)-N-[(1S)-1-thiophen-2-ylethyl]spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxamide
    —— N-[(4-fluorophenyl)methyl]-2-[(4-methylsulfanylphenyl)methylsulfanyl]acetamide —— C17H18FNOS2
    N-[(4-fluorophenyl)methyl]-2-[(4-methylsulfanylphenyl)methylsulfanyl]acetamide
    —— (1'S,5'S)-N-[(1R)-1-thiophen-2-ylethyl]spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxamide —— C18H25NOS3
    (1'S,5'S)-N-[(1R)-1-thiophen-2-ylethyl]spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxamide
    —— (Z)-3-amino-2-[2-[3-methyl-7-(2-methylpropyl)-2,4-dioxo-1-propylpyrimido[4,5-d]pyrimidin-5-yl]sulfanylacetyl]but-2-enenitrile —— C20H26N6O3S
    (Z)-3-amino-2-[2-[3-methyl-7-(2-methylpropyl)-2,4-dioxo-1-propylpyrimido[4,5-d]pyrimidin-5-yl]sulfanylacetyl]but-2-enenitrile
    —— [(3R)-3-cyano-4-imino-2-oxopentyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C17H20N2O3S
    [(3R)-3-cyano-4-imino-2-oxopentyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— (2S)-2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C13H14BrN3O2S
    (2S)-2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide
    —— (5-Oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methyl 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C18H18N2O3S2
    (5-Oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methyl 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— (5-Phenyl-1,3,4-oxadiazol-2-yl)methyl 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C20H20N2O3S
    (5-Phenyl-1,3,4-oxadiazol-2-yl)methyl 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— 2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxyethyl)acetamide —— C15H27N5O2S
    2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxyethyl)acetamide
    —— (4R)-N,N,6-trimethyl-4-(4-methylsulfanylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide —— C15H19N3O2S
    (4R)-N,N,6-trimethyl-4-(4-methylsulfanylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
    —— (2R)-N-(1-adamantyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide —— C19H22ClF3N2OS
    (2R)-N-(1-adamantyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide
    —— 2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C20H29N5OS
    2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— 2-Ethyl-7-[(4-methylsulfanylphenyl)methylsulfanylmethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C16H17N3OS3
    2-Ethyl-7-[(4-methylsulfanylphenyl)methylsulfanylmethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— 2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C17H24N4OS
    2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— (2R)-2-(6-methyl-2-nitropyridin-3-yl)oxy-N-(2-phenylsulfanylphenyl)propanamide —— C21H19N3O4S
    (2R)-2-(6-methyl-2-nitropyridin-3-yl)oxy-N-(2-phenylsulfanylphenyl)propanamide
    —— 2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide —— C19H33N5OS
    2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide
    —— methyl (1S,3R,6S)-3-(4-chlorophenyl)sulfanyl-2,4-dioxo-6-phenylcyclohexane-1-carboxylate —— C20H17ClO4S
    methyl (1S,3R,6S)-3-(4-chlorophenyl)sulfanyl-2,4-dioxo-6-phenylcyclohexane-1-carboxylate
    —— (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]pentanedinitrile —— C15H15N5S2
    (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]pentanedinitrile
    —— 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C18H23N3O3S2
    2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— (2S)-1-(4-ethylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one —— C20H28N4O2S2
    (2S)-1-(4-ethylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one
    —— (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one —— C20H29N4O2S2+
    (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one
    —— 3,3-dimethyl-1-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]butan-2-one —— C17H22N2O2S2
    3,3-dimethyl-1-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]butan-2-one
    —— 2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C13H15N3O2S2
    2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-(azepan-1-yl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H25N3O2S2
    1-(azepan-1-yl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C13H15N3O2S2
    2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide —— C14H19N5OS2
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
    —— 2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-1-morpholin-4-ylethanone —— C17H21N3O3S2
    2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-1-morpholin-4-ylethanone
    —— 1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H25N3O3S2
    1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— (2S)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanenitrile —— C14H15N3OS2
    (2S)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanenitrile
    —— 2-benzylsulfanyl-5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazole —— C18H18N2OS2
    2-benzylsulfanyl-5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazole
    —— 1-(4-acetylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H24N4O3S2
    1-(4-acetylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— tert-butyl 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetate —— C17H22N2O3S2
    tert-butyl 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
    —— 5-[[5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C11H11N5O2S2
    5-[[5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— [(2R)-1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate —— C17H18ClNO3S2
    [(2R)-1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— N,N-dimethyl-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C15H19N3O2S2
    N,N-dimethyl-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(4-fluorophenyl)methyl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H20FN3O2S2
    N-[(4-fluorophenyl)methyl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N,N-bis(2-methoxyethyl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H27N3O4S2
    N,N-bis(2-methoxyethyl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N'-acetyl-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetohydrazide —— C15H18N4O3S2
    N'-acetyl-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetohydrazide
    —— [(2R)-1-[[(3R)-1,1-dioxothiolan-3-yl]-methylamino]-1-oxopropan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate —— C17H22ClNO5S2
    [(2R)-1-[[(3R)-1,1-dioxothiolan-3-yl]-methylamino]-1-oxopropan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— (2S)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-tert-butylpropanamide —— C24H28N4OS
    (2S)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-tert-butylpropanamide