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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-[(1-methyl-1H-imidazol-2-yl)thio]-4 [(methylsulfonyl)-amino]benzenesulfonamide 187846-16-8 C11H14N4O4S3
    3-[(1-methyl-1H-imidazol-2-yl)thio]-4 [(methylsulfonyl)-amino]benzenesulfonamide
    —— N-[4-(4-methoxy-3-propan-2-ylphenyl)sulfanyl-3,5-dimethylphenyl]acetamide —— C20H25NO2S
    N-[4-(4-methoxy-3-propan-2-ylphenyl)sulfanyl-3,5-dimethylphenyl]acetamide
    —— 2-amino-5-(4-methyl-4H-(1,2,4)-triazole-3-yl)sulfanyl-N-(4-methylthiazole-2-yl)benzamide —— C14H14N6OS2
    2-amino-5-(4-methyl-4H-(1,2,4)-triazole-3-yl)sulfanyl-N-(4-methylthiazole-2-yl)benzamide
    —— (Z)-hydroxy-propyl-[[5-[4-(trifluoromethoxy)phenyl]sulfanylfuran-2-yl]methylidene]azanium —— C15H15F3NO3S+
    (Z)-hydroxy-propyl-[[5-[4-(trifluoromethoxy)phenyl]sulfanylfuran-2-yl]methylidene]azanium
    —— [(E)-3-chlorobut-2-enyl] carbamimidothioate —— C5H9ClN2S
    [(E)-3-chlorobut-2-enyl] carbamimidothioate
    —— 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylthio)benzaldehyde —— C22H26OS
    4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylthio)benzaldehyde
    —— 2-[(1-Methylimidazol-2-yl)sulfanylmethyl]-6-(pyridin-4-ylsulfanylmethyl)pyridine —— C16H16N4S2
    2-[(1-Methylimidazol-2-yl)sulfanylmethyl]-6-(pyridin-4-ylsulfanylmethyl)pyridine
    —— 6-Phenyl-8-propan-2-ylsulfanyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine —— C15H13F3N4S
    6-Phenyl-8-propan-2-ylsulfanyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
    —— 2-[4-(4-Methylphenyl)sulfanylthieno[2,3-c]pyridin-2-yl]prop-2-enamide —— C17H14N2OS2
    2-[4-(4-Methylphenyl)sulfanylthieno[2,3-c]pyridin-2-yl]prop-2-enamide
    —— 3-(4-chloro-anilino)-5-(pyridin-2-ylmethylthio)-1,2,4-triazole 334539-42-3 C14H12ClN5S
    3-(4-chloro-anilino)-5-(pyridin-2-ylmethylthio)-1,2,4-triazole
    —— (2R)-4-[(2-butylsulfanylpyrimidin-5-yl)methyl]-2-pyridin-3-ylmorpholine —— C18H24N4OS
    (2R)-4-[(2-butylsulfanylpyrimidin-5-yl)methyl]-2-pyridin-3-ylmorpholine
    —— (2S)-4-[(2-butylsulfanylpyrimidin-5-yl)methyl]-2-pyridin-3-ylmorpholine —— C18H24N4OS
    (2S)-4-[(2-butylsulfanylpyrimidin-5-yl)methyl]-2-pyridin-3-ylmorpholine
    —— 1-hydroxy-1-[5-(4-methoxyphenylthio)thien-2-ylmethyl]urea —— C13H14N2O3S2
    1-hydroxy-1-[5-(4-methoxyphenylthio)thien-2-ylmethyl]urea
    —— 3-(1-Azatricyclo[3.3.1.13,7]decan-4-yl)-4-butylsulfanyl-1,2,5-thiadiazole —— C15H23N3S2
    3-(1-Azatricyclo[3.3.1.13,7]decan-4-yl)-4-butylsulfanyl-1,2,5-thiadiazole
    —— N-(4-methylphenyl)-3-(3-methylthiophen-2-yl)sulfanyl-1H-1,2,4-triazol-5-amine —— C14H14N4S2
    N-(4-methylphenyl)-3-(3-methylthiophen-2-yl)sulfanyl-1H-1,2,4-triazol-5-amine
    —— 2-(4-tert-butylphenyl)sulfanyl-4,5-dichloro-1H-imidazole —— C13H14Cl2N2S
    2-(4-tert-butylphenyl)sulfanyl-4,5-dichloro-1H-imidazole
    —— 3-(4-chloro-anilino)-5-benzylthio-1,2,4-triazole 334539-31-0 C15H13ClN4S
    3-(4-chloro-anilino)-5-benzylthio-1,2,4-triazole
    —— N-(4-chlorophenyl)-3-[(Z)-2-methylpent-2-enyl]sulfanyl-1H-1,2,4-triazol-5-amine —— C14H17ClN4S
    N-(4-chlorophenyl)-3-[(Z)-2-methylpent-2-enyl]sulfanyl-1H-1,2,4-triazol-5-amine
    —— N-(cyanomethyl)-2-[(4-fluorophenyl)sulfanylmethyl]cyclohexane-1-carboxamide —— C16H19FN2OS
    N-(cyanomethyl)-2-[(4-fluorophenyl)sulfanylmethyl]cyclohexane-1-carboxamide
    —— 3-anilino-5-(cyclohexylmethylthio)-1,2,4-triazole 334538-57-7 C15H20N4S
    3-anilino-5-(cyclohexylmethylthio)-1,2,4-triazole
    —— N,N-dimethyl-N-[(4-{[4-(methylsulfanyl)phenyl]sulfanyl}-3-pyridinyl)methyl]amine 662150-37-0 C15H18N2S2
    N,N-dimethyl-N-[(4-{[4-(methylsulfanyl)phenyl]sulfanyl}-3-pyridinyl)methyl]amine
    —— (Z,Z)-2-chloro-N-(3-methyl-5-methylsulfanyl-1,2,4-triazol-4-yl)-3-phenylprop-2-en-1-imine —— C13H13ClN4S
    (Z,Z)-2-chloro-N-(3-methyl-5-methylsulfanyl-1,2,4-triazol-4-yl)-3-phenylprop-2-en-1-imine
    —— 3-(pyridin-4-yl)thio-2,3-dihydro-1,1-dioxidebenzo[b]thiophene 246169-09-5 C13H11NO2S2
    3-(pyridin-4-yl)thio-2,3-dihydro-1,1-dioxidebenzo[b]thiophene
    —— (5S,6S)-6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C12H19N3S2
    (5S,6S)-6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 3-[(Z)-2-methylbut-2-enyl]sulfanyl-N-phenyl-1H-1,2,4-triazol-5-amine —— C13H16N4S
    3-[(Z)-2-methylbut-2-enyl]sulfanyl-N-phenyl-1H-1,2,4-triazol-5-amine
    —— 2-(2-butoxyethylsulfanyl)-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C17H24N2O2S
    2-(2-butoxyethylsulfanyl)-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-(2-butoxyethylsulfanyl)-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C17H24N2O2S
    2-(2-butoxyethylsulfanyl)-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 3-[(2R)-1-[(2-butylsulfanylpyrimidin-5-yl)methyl]piperidin-2-yl]-5-methyl-1,2-oxazole —— C18H26N4OS
    3-[(2R)-1-[(2-butylsulfanylpyrimidin-5-yl)methyl]piperidin-2-yl]-5-methyl-1,2-oxazole
    —— 5-[(2S)-1-[(2-benzylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-methyl-1,2-oxazole —— C20H22N4OS
    5-[(2S)-1-[(2-benzylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-methyl-1,2-oxazole
    —— N-phenyl-3-thiophen-2-ylsulfanyl-1H-1,2,4-triazol-5-amine —— C12H10N4S2
    N-phenyl-3-thiophen-2-ylsulfanyl-1H-1,2,4-triazol-5-amine
    —— 3-[(2S)-1-[(2-butylsulfanylpyrimidin-5-yl)methyl]piperidin-2-yl]-5-methyl-1,2-oxazole —— C18H26N4OS
    3-[(2S)-1-[(2-butylsulfanylpyrimidin-5-yl)methyl]piperidin-2-yl]-5-methyl-1,2-oxazole
    —— N-benzyl-N-cyclopropyl-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C23H25N3O2S
    N-benzyl-N-cyclopropyl-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 5-[(2R)-1-[(2-benzylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-methyl-1,2-oxazole —— C20H22N4OS
    5-[(2R)-1-[(2-benzylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-methyl-1,2-oxazole
    —— N-benzyl-N-cyclopropyl-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C23H25N3O2S
    N-benzyl-N-cyclopropyl-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-ethylsulfanyl-5-[[(3S)-3-(4-methylpiperazin-1-yl)pyrrolidin-1-yl]methyl]pyrimidine —— C16H27N5S
    2-ethylsulfanyl-5-[[(3S)-3-(4-methylpiperazin-1-yl)pyrrolidin-1-yl]methyl]pyrimidine
    —— 5-[(3-methylphenyl)methyl]-3-(thiophen-2-ylmethylsulfanyl)-1H-1,2,4-triazole —— C15H15N3S2
    5-[(3-methylphenyl)methyl]-3-(thiophen-2-ylmethylsulfanyl)-1H-1,2,4-triazole
    —— (+)-Exo-6-(3-(2-hydroxypropylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C12H19N3OS2
    (+)-Exo-6-(3-(2-hydroxypropylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— Ethyl 6-(4,6-dimethylpyrimidin-2-yl)sulfanylhexanoate —— C14H22N2O2S
    Ethyl 6-(4,6-dimethylpyrimidin-2-yl)sulfanylhexanoate
    —— 2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1S,2R)-2-methylcyclohexyl]oxyethyl]acetamide —— C16H27N5O2S
    2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1S,2R)-2-methylcyclohexyl]oxyethyl]acetamide
    —— 2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1R,2R)-2-methylcyclohexyl]oxyethyl]acetamide —— C16H27N5O2S
    2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1R,2R)-2-methylcyclohexyl]oxyethyl]acetamide
    —— 6-Ethyl-5-fluoro-2-[1-(methylamino)pentan-3-ylsulfanyl]pyridine-3-carbonitrile —— C14H20FN3S
    6-Ethyl-5-fluoro-2-[1-(methylamino)pentan-3-ylsulfanyl]pyridine-3-carbonitrile
    —— 2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-2,2-dimethyl-1-thiophen-2-ylpropyl]acetamide —— C16H23N5OS2
    2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-2,2-dimethyl-1-thiophen-2-ylpropyl]acetamide
    —— (2S)-2-(5-methylpyridin-2-yl)sulfanylpentan-3-one —— C11H15NOS
    (2S)-2-(5-methylpyridin-2-yl)sulfanylpentan-3-one
    —— 2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1R,2S)-2-methylcyclohexyl]oxyethyl]acetamide —— C16H27N5O2S
    2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1R,2S)-2-methylcyclohexyl]oxyethyl]acetamide
    —— 1-[2-(2-Hydroxybutylsulfonyl)ethylsulfanyl]butan-2-ol —— C10H22O4S2
    1-[2-(2-Hydroxybutylsulfonyl)ethylsulfanyl]butan-2-ol
    —— 2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-2,2-dimethyl-1-thiophen-2-ylpropyl]acetamide —— C16H23N5OS2
    2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-2,2-dimethyl-1-thiophen-2-ylpropyl]acetamide
    —— Chloro-ethylsulfanylcarbonyloxy-acetic acid ethyl ester —— C7H11ClO4S
    Chloro-ethylsulfanylcarbonyloxy-acetic acid ethyl ester
    —— 2-[(1S)-2-amino-1-phenylethyl]sulfanyl-6-methylpyridine-3-carbonitrile —— C15H15N3S
    2-[(1S)-2-amino-1-phenylethyl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— (2R)-2-(5-methylpyridin-2-yl)sulfanylpentan-3-one —— C11H15NOS
    (2R)-2-(5-methylpyridin-2-yl)sulfanylpentan-3-one
    —— 2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1S,2S)-2-methylcyclohexyl]oxyethyl]acetamide —— C16H27N5O2S
    2-[(5-amino-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(1S,2S)-2-methylcyclohexyl]oxyethyl]acetamide