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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-(4-Fluorophenyl)-4-methyl-3-(pyrimidin-2-ylsulfanylmethyl)-1,2-oxazole —— C15H12FN3OS
    5-(4-Fluorophenyl)-4-methyl-3-(pyrimidin-2-ylsulfanylmethyl)-1,2-oxazole
    —— 3-(2-Pyrimidin-2-ylsulfanylacetyl)-1,3-oxazolidin-2-one —— C9H9N3O3S
    3-(2-Pyrimidin-2-ylsulfanylacetyl)-1,3-oxazolidin-2-one
    —— N-[2-(3-chlorophenyl)ethyl]-2-[(4,5-dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C18H21ClN4OS
    N-[2-(3-chlorophenyl)ethyl]-2-[(4,5-dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(1R,2S,3R)-2,3-dimethylcyclohexyl]-4-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)butanamide —— C19H27N3O2S
    N-[(1R,2S,3R)-2,3-dimethylcyclohexyl]-4-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)butanamide
    —— N-[(1S,2S,3R)-2,3-dimethylcyclohexyl]-4-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)butanamide —— C19H27N3O2S
    N-[(1S,2S,3R)-2,3-dimethylcyclohexyl]-4-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)butanamide
    —— N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-4-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)butanamide —— C19H27N3O2S
    N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-4-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)butanamide
    —— 3-[4-Ethyl-5-[2-[2-(2-methylphenyl)ethylamino]-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C18H25N5O2S
    3-[4-Ethyl-5-[2-[2-(2-methylphenyl)ethylamino]-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[2-(Azocan-1-yl)-2-oxoethyl]sulfanyl-4-(2-methylpropyl)-1,2,4-triazol-3-yl]propanamide —— C18H31N5O2S
    3-[5-[2-(Azocan-1-yl)-2-oxoethyl]sulfanyl-4-(2-methylpropyl)-1,2,4-triazol-3-yl]propanamide
    —— 2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-[(3-methylthiophen-2-yl)methyl]acetamide —— C19H22N4OS3
    2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-[(3-methylthiophen-2-yl)methyl]acetamide
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2S)-heptan-2-yl]acetamide —— C18H26N4OS2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2S)-heptan-2-yl]acetamide
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(furan-2-yl)ethyl]acetamide —— C17H18N4O2S2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(furan-2-yl)ethyl]acetamide
    —— 3-[5-[2-[(2-Fluorophenyl)methylamino]-2-oxoethyl]sulfanyl-4-(2-methylpropyl)-1,2,4-triazol-3-yl]propanamide —— C18H24FN5O2S
    3-[5-[2-[(2-Fluorophenyl)methylamino]-2-oxoethyl]sulfanyl-4-(2-methylpropyl)-1,2,4-triazol-3-yl]propanamide
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4,4-trimethylpentan-2-yl)acetamide —— C19H28N4OS2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4,4-trimethylpentan-2-yl)acetamide
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2-fluorophenyl)methyl]-N-methylacetamide —— C18H15ClFN3O2S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2-fluorophenyl)methyl]-N-methylacetamide
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-ethyl-N-[(3-fluorophenyl)methyl]acetamide —— C20H21FN4OS2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-ethyl-N-[(3-fluorophenyl)methyl]acetamide
    —— 2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-6-methylheptan-2-yl]acetamide —— C20H30N4OS2
    2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-6-methylheptan-2-yl]acetamide
    —— 2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(2-methylphenyl)ethyl]acetamide —— C21H24N4OS2
    2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(2-methylphenyl)ethyl]acetamide
    —— N-benzyl-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)acetamide —— C20H20ClN3O3S
    N-benzyl-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)acetamide
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-6-methylheptan-2-yl]acetamide —— C19H28N4OS2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-6-methylheptan-2-yl]acetamide
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-(furan-2-yl)ethyl]acetamide —— C16H14ClN3O3S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-(furan-2-yl)ethyl]acetamide
    —— 2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-propan-2-yloxypropyl)acetamide —— C17H24N4O2S2
    2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-propan-2-yloxypropyl)acetamide
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethanone —— C21H18ClN3O2S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethanone
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-ethylhexyl]acetamide —— C18H24ClN3O2S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-ethylhexyl]acetamide
    —— 3-[4-(2-methylpropyl)-5-[2-oxo-2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C22H29N5O2S
    3-[4-(2-methylpropyl)-5-[2-oxo-2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-6-methylheptan-2-yl]acetamide —— C18H24ClN3O2S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-6-methylheptan-2-yl]acetamide
    —— (2S)-N,N-dimethyl-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C16H21N3O2S2
    (2S)-N,N-dimethyl-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— N-[(R)-phenyl(thiophen-2-yl)methyl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C19H15N3O2S3
    N-[(R)-phenyl(thiophen-2-yl)methyl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1S)-1-(furan-2-yl)ethyl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C14H13N3O3S2
    N-[(1S)-1-(furan-2-yl)ethyl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(2S)-5-methylhexan-2-yl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C15H21N3O2S2
    N-[(2S)-5-methylhexan-2-yl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-dimethylpropanamide —— C12H13N5OS
    (2R)-2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-dimethylpropanamide
    —— [5-[4-[(1S)-1-hydroxyethyl]phenyl]furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium —— C17H22N5O2S+
    [5-[4-[(1S)-1-hydroxyethyl]phenyl]furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium
    —— (2R)-2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide —— C13H24N6O2S2
    (2R)-2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide
    —— N-[4-[4-chloro-6-[(5-methyl-4H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide —— C18H17ClN6OS
    N-[4-[4-chloro-6-[(5-methyl-4H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide
    —— N'-acetyl-2-(3,4-dimethylphenyl)sulfanylacetohydrazide —— C12H16N2O2S
    N'-acetyl-2-(3,4-dimethylphenyl)sulfanylacetohydrazide
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-(3,4-dimethylphenyl)sulfanylacetamide —— C16H20N2OS
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-(3,4-dimethylphenyl)sulfanylacetamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide —— C10H12N4O2S2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide
    —— 5-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-1,3,4-thiadiazol-2-amine —— C12H9ClN4S3
    5-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-1,3,4-thiadiazol-2-amine
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]ethanone —— C18H17N5O2S2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(4-chlorophenyl)methyl]-N-methylacetamide —— C12H13ClN4OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(4-chlorophenyl)methyl]-N-methylacetamide
    —— (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]cyclohexan-1-one —— C8H11N3OS2
    (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]cyclohexan-1-one
    —— (2R)-2-(3,4-dimethylphenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide —— C19H22FNOS
    (2R)-2-(3,4-dimethylphenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— 2-(2,4-difluorophenyl)sulfanyl-N-[(R)-phenyl(thiophen-2-yl)methyl]acetamide —— C19H15F2NOS2
    2-(2,4-difluorophenyl)sulfanyl-N-[(R)-phenyl(thiophen-2-yl)methyl]acetamide
    —— (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]propan-1-one —— C16H18N4O2S2
    (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]propan-1-one
    —— (2R)-N-(1-adamantyl)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C15H22N4OS2
    (2R)-N-(1-adamantyl)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— N-butyl-N-ethyl-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H21FN4OS2
    N-butyl-N-ethyl-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide —— C12H20N4OS2
    (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide
    —— N-[(1S)-1-cyclopropylethyl]-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C15H17FN4OS2
    N-[(1S)-1-cyclopropylethyl]-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 1-[2-(4-Chlorophenyl)sulfanylethyl]-5-nitro-2-oxopyridine-3-carbonitrile —— C14H10ClN3O3S
    1-[2-(4-Chlorophenyl)sulfanylethyl]-5-nitro-2-oxopyridine-3-carbonitrile
    —— N-(1-adamantyl)-N-(2-cyanoethyl)-2-[[5-(cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C20H27N5OS2
    N-(1-adamantyl)-N-(2-cyanoethyl)-2-[[5-(cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1S)-1-(1-adamantyl)ethyl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H24N4OS2
    N-[(1S)-1-(1-adamantyl)ethyl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide