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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (3S)-3-hydroxy-6-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]-1,3-dihydroindol-2-one —— C12H10N2O2S2
    (3S)-3-hydroxy-6-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]-1,3-dihydroindol-2-one
    —— [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C14H16N4O3S
    [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— (3S)-6-(4-bromophenyl)sulfanyl-3-hydroxy-1,3-dihydroindol-2-one —— C14H10BrNO2S
    (3S)-6-(4-bromophenyl)sulfanyl-3-hydroxy-1,3-dihydroindol-2-one
    —— (3R)-3-hydroxy-6-(1,3,4-thiadiazol-2-ylsulfanyl)-1,3-dihydroindol-2-one —— C10H7N3O2S2
    (3R)-3-hydroxy-6-(1,3,4-thiadiazol-2-ylsulfanyl)-1,3-dihydroindol-2-one
    —— (2R)-1-[1,3-dimethyl-5-(2-methylsulfonylethylsulfanyl)pyrazol-4-yl]butan-2-amine —— C12H23N3O2S2
    (2R)-1-[1,3-dimethyl-5-(2-methylsulfonylethylsulfanyl)pyrazol-4-yl]butan-2-amine
    —— (2S)-1-[1,3-dimethyl-5-(2-methylsulfonylethylsulfanyl)pyrazol-4-yl]butan-2-amine —— C12H23N3O2S2
    (2S)-1-[1,3-dimethyl-5-(2-methylsulfonylethylsulfanyl)pyrazol-4-yl]butan-2-amine
    —— (2S)-1-(2-chloro-6-thiophen-2-ylsulfanylphenyl)butan-2-amine —— C14H16ClNS2
    (2S)-1-(2-chloro-6-thiophen-2-ylsulfanylphenyl)butan-2-amine
    —— (2S)-1-(4-phenylsulfanylphenyl)butan-2-amine —— C16H19NS
    (2S)-1-(4-phenylsulfanylphenyl)butan-2-amine
    —— (2R)-1-(2-chloro-6-thiophen-2-ylsulfanylphenyl)propan-2-amine —— C13H14ClNS2
    (2R)-1-(2-chloro-6-thiophen-2-ylsulfanylphenyl)propan-2-amine
    —— (2R)-1-(1,3-dimethyl-5-thiophen-2-ylsulfanylpyrazol-4-yl)butan-2-amine —— C13H19N3S2
    (2R)-1-(1,3-dimethyl-5-thiophen-2-ylsulfanylpyrazol-4-yl)butan-2-amine
    —— (2S)-1-(6-thiophen-2-ylsulfanylimidazo[2,1-b][1,3]thiazol-5-yl)butan-2-amine —— C13H15N3S3
    (2S)-1-(6-thiophen-2-ylsulfanylimidazo[2,1-b][1,3]thiazol-5-yl)butan-2-amine
    —— (2S)-1-(2-chloro-6-thiophen-2-ylsulfanylphenyl)propan-2-amine —— C13H14ClNS2
    (2S)-1-(2-chloro-6-thiophen-2-ylsulfanylphenyl)propan-2-amine
    —— (2R)-1-(6-tert-butylsulfanylimidazo[2,1-b][1,3]thiazol-5-yl)propan-2-amine —— C12H19N3S2
    (2R)-1-(6-tert-butylsulfanylimidazo[2,1-b][1,3]thiazol-5-yl)propan-2-amine
    —— [(1S,2R)-1-[5-[(4-bromophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium —— C14H19BrN3OS+
    [(1S,2R)-1-[5-[(4-bromophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium
    —— (2R)-1-(2-thiophen-2-ylsulfanylphenyl)butan-2-amine —— C14H17NS2
    (2R)-1-(2-thiophen-2-ylsulfanylphenyl)butan-2-amine
    —— (2R)-2-[2-(4-methylphenyl)sulfanylethyl]piperidine —— C14H21NS
    (2R)-2-[2-(4-methylphenyl)sulfanylethyl]piperidine
    —— N'-[2-(2-methylphenyl)sulfanylacetyl]-2-(2-oxopyridin-1-yl)acetohydrazide —— C16H17N3O3S
    N'-[2-(2-methylphenyl)sulfanylacetyl]-2-(2-oxopyridin-1-yl)acetohydrazide
    —— N'-[2-(4-bromophenyl)sulfanylacetyl]-2-(2-oxopyridin-1-yl)acetohydrazide —— C15H14BrN3O3S
    N'-[2-(4-bromophenyl)sulfanylacetyl]-2-(2-oxopyridin-1-yl)acetohydrazide
    —— (2R)-N'-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]acetyl]-2-phenylsulfanylpropanehydrazide —— C20H18FN3O2S2
    (2R)-N'-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]acetyl]-2-phenylsulfanylpropanehydrazide
    —— (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C16H21NOS
    (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— 2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(furan-2-yl)ethyl]acetamide —— C16H14FN3O2S3
    2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(furan-2-yl)ethyl]acetamide
    —— 3-(4-Fluorophenyl)-5-[[5-(furan-2-yl)-1,2-oxazol-3-yl]methylsulfanyl]-1,3,4-thiadiazole-2-thione —— C16H10FN3O2S3
    3-(4-Fluorophenyl)-5-[[5-(furan-2-yl)-1,2-oxazol-3-yl]methylsulfanyl]-1,3,4-thiadiazole-2-thione
    —— (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C16H21NOS
    (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— methyl N-[(Z)-[2-(1,3-benzothiazol-2-ylsulfanyl)-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]carbamate —— C18H13N5O3S2
    methyl N-[(Z)-[2-(1,3-benzothiazol-2-ylsulfanyl)-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]carbamate
    —— (1R,6S)-8-methylsulfanyl-7-azabicyclo[4.2.2]deca-2,4,7,9-tetraene —— C10H11NS
    (1R,6S)-8-methylsulfanyl-7-azabicyclo[4.2.2]deca-2,4,7,9-tetraene
    —— (1S,6S)-8-methylsulfanyl-7-azabicyclo[4.2.2]deca-2,4,7,9-tetraene —— C10H11NS
    (1S,6S)-8-methylsulfanyl-7-azabicyclo[4.2.2]deca-2,4,7,9-tetraene
    —— [2-[(2-Methylphenyl)methylamino]-2-oxoethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C21H25NO3S
    [2-[(2-Methylphenyl)methylamino]-2-oxoethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— [2-oxo-2-(2-phenylsulfanylanilino)ethyl] 2-[(1S)-cyclopent-2-en-1-yl]acetate —— C21H21NO3S
    [2-oxo-2-(2-phenylsulfanylanilino)ethyl] 2-[(1S)-cyclopent-2-en-1-yl]acetate
    —— N-(3-chlorophenyl)-5-[(5-methyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C13H11ClN4OS2
    N-(3-chlorophenyl)-5-[(5-methyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— (5-phenyl-1,3,4-oxadiazol-2-yl)methyl (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate —— C21H24N2O3S2
    (5-phenyl-1,3,4-oxadiazol-2-yl)methyl (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate
    —— 1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C16H22N2O2S
    1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— 1-(2,5-Dimethylthiophen-3-yl)-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C16H14FN3OS3
    1-(2,5-Dimethylthiophen-3-yl)-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— [2-(ethoxycarbonylamino)-2-oxoethyl] (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate —— C17H25NO5S2
    [2-(ethoxycarbonylamino)-2-oxoethyl] (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate
    —— (2S)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide —— C17H20F2N2OS
    (2S)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide
    —— 1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— (2R)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide —— C17H20F2N2OS
    (2R)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide
    —— (2R)-2-(2,5-difluorophenyl)sulfanyl-N-(thiophen-2-ylmethyl)propanamide —— C14H13F2NOS2
    (2R)-2-(2,5-difluorophenyl)sulfanyl-N-(thiophen-2-ylmethyl)propanamide
    —— 1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— 1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C16H22N2O2S
    1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— (2S)-2-(2,5-difluorophenyl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]propanamide —— C14H14F2N2O3S2
    (2S)-2-(2,5-difluorophenyl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]propanamide
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— 1-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]-3-[(1-phenylsulfanylcyclopropyl)methyl]urea —— C17H22N2O2S
    1-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]-3-[(1-phenylsulfanylcyclopropyl)methyl]urea
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— [2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] (E)-3-(5-methylthiophen-2-yl)prop-2-enoate —— C19H21NO3S2
    [2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] (E)-3-(5-methylthiophen-2-yl)prop-2-enoate
    —— (2R)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C18H15N3OS3
    (2R)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— (2R)-4-[(5-butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C14H16N4OS4
    (2R)-4-[(5-butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— (2S)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C18H15N3OS3
    (2S)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— (2R)-N-(1-adamantyl)-2-(3,4-difluorophenyl)sulfanylpropanamide —— C19H23F2NOS
    (2R)-N-(1-adamantyl)-2-(3,4-difluorophenyl)sulfanylpropanamide
    —— N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(3,4-difluorophenyl)sulfanylacetamide —— C14H16F2N2OS
    N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(3,4-difluorophenyl)sulfanylacetamide
    —— (1R,3S)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid —— C11H19NO5S
    (1R,3S)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid