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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [2-[4-(2,5-dimethylphenyl)sulfanylanilino]-2-oxoethyl] (2R)-oxolane-2-carboxylate —— C21H23NO4S
    [2-[4-(2,5-dimethylphenyl)sulfanylanilino]-2-oxoethyl] (2R)-oxolane-2-carboxylate
    —— (2R)-1-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-morpholin-4-ylpropan-2-ol —— C17H24N4O2S2
    (2R)-1-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-morpholin-4-ylpropan-2-ol
    —— 3-[[5-(3-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C12H14N4OS2
    3-[[5-(3-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (3R,4R)-4-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1,1-dioxothiolan-3-ol —— C14H17N3O3S3
    (3R,4R)-4-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1,1-dioxothiolan-3-ol
    —— (2S)-1-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-morpholin-4-ium-4-ylpropan-2-ol —— C17H25N4O2S2+
    (2S)-1-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-morpholin-4-ium-4-ylpropan-2-ol
    —— (2R)-1-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-(thiophen-2-ylmethoxy)propan-2-ol —— C18H21N3O2S3
    (2R)-1-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-(thiophen-2-ylmethoxy)propan-2-ol
    —— N-(3,4-dimethylphenyl)-5-(2-pyridin-4-ylethylsulfanyl)-1,3,4-thiadiazol-2-amine —— C17H18N4S2
    N-(3,4-dimethylphenyl)-5-(2-pyridin-4-ylethylsulfanyl)-1,3,4-thiadiazol-2-amine
    —— methyl 2-[2-[2-[2-(2-methylphenyl)ethylamino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C18H21N3O4S
    methyl 2-[2-[2-[2-(2-methylphenyl)ethylamino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[[(1R)-1-(4-ethylphenyl)ethyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C19H23N3O4S
    methyl 2-[2-[2-[[(1R)-1-(4-ethylphenyl)ethyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[3-(N-methylanilino)propylamino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C19H24N4O4S
    methyl 2-[2-[2-[3-(N-methylanilino)propylamino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2R)-1-(methoxycarbonylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C12H15N3O6S
    methyl 2-[2-[(2R)-1-(methoxycarbonylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2S)-1-(tert-butylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C14H21N3O4S
    methyl 2-[2-[(2S)-1-(tert-butylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[methyl(thiophen-3-ylmethyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C15H17N3O4S2
    methyl 2-[2-[2-[methyl(thiophen-3-ylmethyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[2-cyanoethyl(furan-2-ylmethyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C17H18N4O5S
    methyl 2-[2-[2-[2-cyanoethyl(furan-2-ylmethyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— ethyl 4-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]butanoate —— C13H18N2O5S
    ethyl 4-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]butanoate
    —— methyl 2-[2-[2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C15H21N3O5S
    methyl 2-[2-[2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2R)-1-(1-adamantylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C20H27N3O4S
    methyl 2-[2-[(2R)-1-(1-adamantylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-(2-methoxy-2-oxoethyl)sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C10H12N2O5S
    methyl 2-[2-(2-methoxy-2-oxoethyl)sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[cyclopropyl-[(2-fluorophenyl)methyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C19H20FN3O4S
    methyl 2-[2-[2-[cyclopropyl-[(2-fluorophenyl)methyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— 1-Benzyl-3-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]thiourea —— C19H27N5S2
    1-Benzyl-3-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]thiourea
    —— 1-[2-(4-Chlorophenyl)sulfanylethyl]-3-(3-pyrrolidin-1-ium-1-ylpropyl)thiourea —— C16H25ClN3S2+
    1-[2-(4-Chlorophenyl)sulfanylethyl]-3-(3-pyrrolidin-1-ium-1-ylpropyl)thiourea
    —— 1-[1-[2-(4-Fluorophenyl)sulfanylethyl]-3,5-dimethylpyrazol-4-yl]sulfonylpiperidine —— C18H24FN3O2S2
    1-[1-[2-(4-Fluorophenyl)sulfanylethyl]-3,5-dimethylpyrazol-4-yl]sulfonylpiperidine
    —— ethyl (2R)-4-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C20H21N3O4S2
    ethyl (2R)-4-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2R)-4-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C19H20N4O3S3
    ethyl (2R)-4-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2R)-2-(4-methyl-1,3-thiazol-2-yl)-4-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-3-oxobutanoate —— C17H18N4O3S3
    ethyl (2R)-2-(4-methyl-1,3-thiazol-2-yl)-4-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-3-oxobutanoate
    —— ethyl (2S)-4-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C20H21N3O4S2
    ethyl (2S)-4-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2S)-4-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C18H16ClN3O4S2
    ethyl (2S)-4-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2R)-4-[6-(3,5-dimethylpyrazol-1-yl)pyridazin-3-yl]sulfanyl-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C19H21N5O3S2
    ethyl (2R)-4-[6-(3,5-dimethylpyrazol-1-yl)pyridazin-3-yl]sulfanyl-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— 2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)-N-methyl-N-[(4-methylsulfanylphenyl)methyl]acetamide —— C20H23NO3S2
    2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)-N-methyl-N-[(4-methylsulfanylphenyl)methyl]acetamide
    —— N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H21N5O2S2
    N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— ethyl (2S)-4-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C18H16ClN3O4S2
    ethyl (2S)-4-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2R)-4-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C18H16ClN3O4S2
    ethyl (2R)-4-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2S)-4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C18H20N4O4S2
    ethyl (2S)-4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2R)-2-(4-methyl-1,3-thiazol-2-yl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-oxobutanoate —— C13H16N4O3S2
    ethyl (2R)-2-(4-methyl-1,3-thiazol-2-yl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-oxobutanoate
    —— ethyl (2S)-4-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C19H20N4O3S3
    ethyl (2S)-4-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2R)-4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C18H20N4O4S2
    ethyl (2R)-4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— ethyl (2S)-2-(4-methyl-1,3-thiazol-2-yl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-oxobutanoate —— C13H16N4O3S2
    ethyl (2S)-2-(4-methyl-1,3-thiazol-2-yl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-oxobutanoate
    —— (Z)-2-cyano-N-(4-fluorophenyl)-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]prop-2-enamide —— C21H15FN2OS2
    (Z)-2-cyano-N-(4-fluorophenyl)-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]prop-2-enamide
    —— (Z)-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]-2-(4-oxo-1H-quinazolin-2-yl)prop-2-enenitrile —— C22H15N3OS2
    (Z)-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]-2-(4-oxo-1H-quinazolin-2-yl)prop-2-enenitrile
    —— (Z)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]prop-2-enenitrile —— C23H15ClN2S3
    (Z)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]prop-2-enenitrile
    —— (Z)-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile —— C23H16N2S3
    (Z)-3-[5-(4-methylphenyl)sulfanylthiophen-2-yl]-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile
    —— ethyl (2S)-4-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C18H20N4O4S2
    ethyl (2S)-4-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— 4-benzyl-3-[[(1S)-2,2-dichlorocyclopropyl]methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole —— C17H15Cl2N3S2
    4-benzyl-3-[[(1S)-2,2-dichlorocyclopropyl]methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole
    —— N-[2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]acetamide —— C12H16N4OS2
    N-[2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]acetamide
    —— 4-benzyl-3-[[(1S)-2,2-dichlorocyclopropyl]methylsulfanyl]-5-(furan-2-yl)-1,2,4-triazole —— C17H15Cl2N3OS
    4-benzyl-3-[[(1S)-2,2-dichlorocyclopropyl]methylsulfanyl]-5-(furan-2-yl)-1,2,4-triazole
    —— ethyl (2R)-4-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate —— C18H20N4O4S2
    ethyl (2R)-4-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanoate
    —— [2-oxo-2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl] (2S)-2-phenylsulfanylpropanoate —— C22H23NO3S
    [2-oxo-2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)ethyl] (2S)-2-phenylsulfanylpropanoate
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-(2-fluorophenyl)sulfanylacetamide —— C14H15FN2OS
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-(2-fluorophenyl)sulfanylacetamide
    —— [2-[(2-Methylphenyl)methylamino]-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate —— C20H23NO3S
    [2-[(2-Methylphenyl)methylamino]-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate
    —— [2-oxo-2-[[(S)-phenyl(thiophen-2-yl)methyl]amino]ethyl] 2-(2-fluorophenyl)sulfanylacetate —— C21H18FNO3S2
    [2-oxo-2-[[(S)-phenyl(thiophen-2-yl)methyl]amino]ethyl] 2-(2-fluorophenyl)sulfanylacetate