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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-ethylphenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C18H19N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-ethylphenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(E)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylideneamino]-2-naphthalen-1-yloxyacetamide —— C26H18N4O4S2
    N-[(E)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylideneamino]-2-naphthalen-1-yloxyacetamide
    —— (2R)-N-cyclopentyl-3-methyl-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]butanamide —— C17H22N4O2S
    (2R)-N-cyclopentyl-3-methyl-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]butanamide
    —— (1S)-1-[4-(4-fluorophenyl)-5-(4-methoxypyrimidin-2-yl)sulfanyl-1,2,4-triazol-3-yl]-N,N-dimethylethanamine —— C17H19FN6OS
    (1S)-1-[4-(4-fluorophenyl)-5-(4-methoxypyrimidin-2-yl)sulfanyl-1,2,4-triazol-3-yl]-N,N-dimethylethanamine
    —— N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide —— C19H17BrN4O2S3
    N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide
    —— N'-{(E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide —— C22H22N4O2S3
    N'-{(E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide
    —— (1R)-1-[4-(4-fluorophenyl)-5-(4-methoxypyrimidin-2-yl)sulfanyl-1,2,4-triazol-3-yl]-N,N-dimethylethanamine —— C17H19FN6OS
    (1R)-1-[4-(4-fluorophenyl)-5-(4-methoxypyrimidin-2-yl)sulfanyl-1,2,4-triazol-3-yl]-N,N-dimethylethanamine
    —— 2-(2-benzylsulfanyl-6-methylpyrimidin-4-yl)oxy-N-[(E)-(3-bromophenyl)methylideneamino]acetamide —— C21H19BrN4O2S
    2-(2-benzylsulfanyl-6-methylpyrimidin-4-yl)oxy-N-[(E)-(3-bromophenyl)methylideneamino]acetamide
    —— 3-benzyl-5-[[5-[(Z)-2-(5-methylfuran-2-yl)ethenyl]-1H-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazole —— C19H17N5O2S
    3-benzyl-5-[[5-[(Z)-2-(5-methylfuran-2-yl)ethenyl]-1H-1,2,4-triazol-3-yl]sulfanylmethyl]-1,2,4-oxadiazole
    —— N'-[(1E)-{4-[(4-chlorophenyl)sulfanyl]-3-nitrophenyl}methylidene]-2-(phenylamino)acetohydrazide —— C21H17ClN4O3S
    N'-[(1E)-{4-[(4-chlorophenyl)sulfanyl]-3-nitrophenyl}methylidene]-2-(phenylamino)acetohydrazide
    —— 3-[(2E)-5-(2-cyanoethylsulfanyl)-2-pyrrol-2-ylidene-1,3,4-oxadiazol-3-yl]propanenitrile —— C12H11N5OS
    3-[(2E)-5-(2-cyanoethylsulfanyl)-2-pyrrol-2-ylidene-1,3,4-oxadiazol-3-yl]propanenitrile
    —— N-[[(1R,2R)-2-methylcyclohexyl]methyl]-3-[(S)-methylsulfinyl]propan-1-amine —— C12H25NOS
    N-[[(1R,2R)-2-methylcyclohexyl]methyl]-3-[(S)-methylsulfinyl]propan-1-amine
    —— 2-benzyl-4-[[5-[(Z)-2-thiophen-2-ylethenyl]-1H-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole —— C19H16N4S3
    2-benzyl-4-[[5-[(Z)-2-thiophen-2-ylethenyl]-1H-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole
    —— N-[[(1R,2S)-2-methylcyclohexyl]methyl]-3-[(S)-methylsulfinyl]propan-1-amine —— C12H25NOS
    N-[[(1R,2S)-2-methylcyclohexyl]methyl]-3-[(S)-methylsulfinyl]propan-1-amine
    —— N-[[(1S,2S)-2-methylcyclohexyl]methyl]-3-[(S)-methylsulfinyl]propan-1-amine —— C12H25NOS
    N-[[(1S,2S)-2-methylcyclohexyl]methyl]-3-[(S)-methylsulfinyl]propan-1-amine
    —— N'-[(E)-(2-bromophenyl)methylidene]-2-(pyrimidin-2-ylsulfanyl)acetohydrazide —— C13H11BrN4OS
    N'-[(E)-(2-bromophenyl)methylidene]-2-(pyrimidin-2-ylsulfanyl)acetohydrazide
    —— N'-[(E)-(2-bromophenyl)methylidene]-3-[(4-chlorophenyl)sulfanyl]propanehydrazide —— C16H14BrClN2OS
    N'-[(E)-(2-bromophenyl)methylidene]-3-[(4-chlorophenyl)sulfanyl]propanehydrazide
    —— [(E)-(4-oxo-2-pyridin-2-ylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylideneamino]urea —— C15H12N6O2S
    [(E)-(4-oxo-2-pyridin-2-ylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylideneamino]urea
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(E)-thiophen-3-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C14H13N11O2S2
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(E)-thiophen-3-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 3,5,6-trichloro-4-[(2E)-2-[[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylidene]hydrazinyl]pyridine-2-carboxylic acid —— C17H11Cl3N6O4S
    3,5,6-trichloro-4-[(2E)-2-[[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylidene]hydrazinyl]pyridine-2-carboxylic acid
    —— 2-cyclohexyl-5-[(1R)-1-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]ethyl]sulfanyl-1,3,4-oxadiazole —— C14H20N4O3S
    2-cyclohexyl-5-[(1R)-1-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]ethyl]sulfanyl-1,3,4-oxadiazole
    —— (2S)-N-methyl-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanyl-3-phenylpropanamide —— C17H21N3O2S
    (2S)-N-methyl-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanyl-3-phenylpropanamide
    —— 5-[(1R)-1-(1H-imidazol-2-ylsulfanyl)ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole —— C9H12N4O2S
    5-[(1R)-1-(1H-imidazol-2-ylsulfanyl)ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole
    —— (2S)-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-3-phenylpropanamide —— C14H18N4OS
    (2S)-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-3-phenylpropanamide
    —— 4,6-dimethyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]pyrimidin-2-amine —— C14H16N4S
    4,6-dimethyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]pyrimidin-2-amine
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E,2E)-3-(furan-2-yl)-2-methylprop-2-en-1-ylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C21H20N8O3S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E,2E)-3-(furan-2-yl)-2-methylprop-2-en-1-ylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— (2R)-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-3-phenylpropanamide —— C14H18N4OS
    (2R)-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-3-phenylpropanamide
    —— (2R)-2-[(5-tert-butyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-methyl-3-phenylpropanamide —— C16H21N3O2S
    (2R)-2-[(5-tert-butyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-methyl-3-phenylpropanamide
    —— (2R)-2-(1-ethylimidazol-2-yl)sulfanyl-N-methyl-3-phenylpropanamide —— C15H19N3OS
    (2R)-2-(1-ethylimidazol-2-yl)sulfanyl-N-methyl-3-phenylpropanamide
    —— (2E,2'E)-1,1'-ethane-1,2-diylbis{1-methyl-2-[4-(methylsulfanyl)benzylidene]hydrazine} —— C20H26N4S2
    (2E,2'E)-1,1'-ethane-1,2-diylbis{1-methyl-2-[4-(methylsulfanyl)benzylidene]hydrazine}
    —— (2R)-N-methyl-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanyl-3-phenylpropanamide —— C17H21N3O2S
    (2R)-N-methyl-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanyl-3-phenylpropanamide
    —— 2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-{(E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide —— C21H20N4O2S3
    2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-{(E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
    —— 5-[(1S)-1-(1H-imidazol-2-ylsulfanyl)ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole —— C9H12N4O2S
    5-[(1S)-1-(1H-imidazol-2-ylsulfanyl)ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole
    —— methyl (2S)-2-(2-chloro-6-fluorophenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetate —— C11H9ClFN3O2S
    methyl (2S)-2-(2-chloro-6-fluorophenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetate
    —— (2S)-2-[(5-tert-butyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-methyl-3-phenylpropanamide —— C16H21N3O2S
    (2S)-2-[(5-tert-butyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-methyl-3-phenylpropanamide
    —— 5-[(1R)-1-[(3-ethyl-1,2,4-thiadiazol-5-yl)sulfanyl]ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole —— C10H14N4O2S2
    5-[(1R)-1-[(3-ethyl-1,2,4-thiadiazol-5-yl)sulfanyl]ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole
    —— (2R)-2-(5-cyano-2,6-dimethylpyrimidin-4-yl)sulfanyl-N-methyl-3-phenylpropanamide —— C17H18N4OS
    (2R)-2-(5-cyano-2,6-dimethylpyrimidin-4-yl)sulfanyl-N-methyl-3-phenylpropanamide
    —— 3-(methoxymethyl)-5-[(1R)-1-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole —— C12H13N5O2S2
    3-(methoxymethyl)-5-[(1R)-1-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 2-[(1R)-1-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]ethyl]sulfanylphenol —— C12H14N2O3S
    2-[(1R)-1-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]ethyl]sulfanylphenol
    —— (2R)-N-methyl-3-phenyl-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C15H20N4OS
    (2R)-N-methyl-3-phenyl-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— methyl (2R)-2-(2-chloro-6-fluorophenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetate —— C11H9ClFN3O2S
    methyl (2R)-2-(2-chloro-6-fluorophenyl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetate
    —— 5-[(1S)-1-[(3-ethyl-1,2,4-thiadiazol-5-yl)sulfanyl]ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole —— C10H14N4O2S2
    5-[(1S)-1-[(3-ethyl-1,2,4-thiadiazol-5-yl)sulfanyl]ethyl]-3-(methoxymethyl)-1,2,4-oxadiazole
    —— (2S)-2-(5-cyano-2,6-dimethylpyrimidin-4-yl)sulfanyl-N-methyl-3-phenylpropanamide —— C17H18N4OS
    (2S)-2-(5-cyano-2,6-dimethylpyrimidin-4-yl)sulfanyl-N-methyl-3-phenylpropanamide
    —— (2S)-2-(1-tert-butyltetrazol-5-yl)sulfanyl-N-methyl-3-phenylpropanamide —— C15H21N5OS
    (2S)-2-(1-tert-butyltetrazol-5-yl)sulfanyl-N-methyl-3-phenylpropanamide
    —— (2R)-2-(1-tert-butyltetrazol-5-yl)sulfanyl-N-methyl-3-phenylpropanamide —— C15H21N5OS
    (2R)-2-(1-tert-butyltetrazol-5-yl)sulfanyl-N-methyl-3-phenylpropanamide
    —— (2S)-2-(1-ethylimidazol-2-yl)sulfanyl-N-methyl-3-phenylpropanamide —— C15H19N3OS
    (2S)-2-(1-ethylimidazol-2-yl)sulfanyl-N-methyl-3-phenylpropanamide
    —— 3-(methoxymethyl)-5-[(1S)-1-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole —— C12H13N5O2S2
    3-(methoxymethyl)-5-[(1S)-1-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(2,5-dimethylthiophen-3-yl)ethylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C21H22N8O2S2
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(2,5-dimethylthiophen-3-yl)ethylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(4-chlorophenyl)ethylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C17H16ClN11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(4-chlorophenyl)ethylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— 4-[(2E)-2-[[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylidene]hydrazinyl]-3-nitrobenzenesulfonamide —— C16H14N8O6S2
    4-[(2E)-2-[[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylidene]hydrazinyl]-3-nitrobenzenesulfonamide