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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-[(E)-(2-{[1-(4-ammonio-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazol-4-yl]carbonyl}hydrazinylidene)methyl]phenolate —— C16H15N11O3S
    4-[(E)-(2-{[1-(4-ammonio-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazol-4-yl]carbonyl}hydrazinylidene)methyl]phenolate
    —— N-[2-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-2-methylpropyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide —— C15H26N4OS2
    N-[2-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-2-methylpropyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide
    —— 2-[[5-cyclohexyl-4-[(E)-(3-fluorophenyl)methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C17H19FN4O2S
    2-[[5-cyclohexyl-4-[(E)-(3-fluorophenyl)methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— 3-(difluoromethyl)-N-[(E)-(3-methylphenyl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine —— C12H12F2N4S
    3-(difluoromethyl)-N-[(E)-(3-methylphenyl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine
    —— 2-(2-methyl-1,3-dithiolan-2-yl)-N'-[(E)-phenylmethylidene]acetohydrazide —— C13H16N2OS2
    2-(2-methyl-1,3-dithiolan-2-yl)-N'-[(E)-phenylmethylidene]acetohydrazide
    —— 3-(difluoromethyl)-N-[(E)-(4-fluorophenyl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine —— C11H9F3N4S
    3-(difluoromethyl)-N-[(E)-(4-fluorophenyl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine
    —— (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-di(propan-2-yl)propanamide —— C14H21BrN2OS
    (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-di(propan-2-yl)propanamide
    —— 5,6-dimethyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]thieno[2,3-d]pyrimidin-4-amine —— C19H17N7O2S2
    5,6-dimethyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]thieno[2,3-d]pyrimidin-4-amine
    —— (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-di(propan-2-yl)propanamide —— C14H21BrN2OS
    (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-di(propan-2-yl)propanamide
    —— 3-(difluoromethyl)-5-(methylsulfanyl)-N-[(E)-pyridin-3-ylmethylidene]-4H-1,2,4-triazol-4-amine —— C10H9F2N5S
    3-(difluoromethyl)-5-(methylsulfanyl)-N-[(E)-pyridin-3-ylmethylidene]-4H-1,2,4-triazol-4-amine
    —— N-[(E)-(4,5-dibromothiophen-2-yl)methylidene]-3-(difluoromethyl)-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine —— C9H6Br2F2N4S2
    N-[(E)-(4,5-dibromothiophen-2-yl)methylidene]-3-(difluoromethyl)-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine
    —— (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-ethyl-N-(2-methylprop-2-enyl)propanamide —— C14H19BrN2OS
    (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-ethyl-N-(2-methylprop-2-enyl)propanamide
    —— N-(2-methoxyphenyl)-4-[(2E)-2-[[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylidene]hydrazinyl]-3-nitrobenzenesulfonamide —— C24H21N7O7S2
    N-(2-methoxyphenyl)-4-[(2E)-2-[[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylidene]hydrazinyl]-3-nitrobenzenesulfonamide
    —— 3-[(E)-{[3-(difluoromethyl)-5-(methylsulfanyl)-4H-1,2,4-triazol-4-yl]imino}methyl]phenol —— C11H10F2N4OS
    3-[(E)-{[3-(difluoromethyl)-5-(methylsulfanyl)-4H-1,2,4-triazol-4-yl]imino}methyl]phenol
    —— 3-(difluoromethyl)-N-[(E)-(1-ethyl-3-methyl-1H-pyrazol-4-yl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine —— C11H14F2N6S
    3-(difluoromethyl)-N-[(E)-(1-ethyl-3-methyl-1H-pyrazol-4-yl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine
    —— (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-methyl-N-[(2-methylphenyl)methyl]propanamide —— C17H19BrN2OS
    (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-methyl-N-[(2-methylphenyl)methyl]propanamide
    —— 3-[(2,4-dimethylphenyl)sulfamoyl]-N-[(E)-[2-methyl-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]pyrazolo[1,5-a]quinazolin-3-yl]methylideneamino]benzamide —— C30H27N9O3S2
    3-[(2,4-dimethylphenyl)sulfamoyl]-N-[(E)-[2-methyl-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]pyrazolo[1,5-a]quinazolin-3-yl]methylideneamino]benzamide
    —— (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-methyl-N-[(2-methylphenyl)methyl]propanamide —— C17H19BrN2OS
    (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-methyl-N-[(2-methylphenyl)methyl]propanamide
    —— N'-[(E)-(1,5-dimethyl-1H-pyrazol-4-yl)methylidene]-2-({4-ethyl-5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-4H-1,2,4-triazol-3-yl}sulfanyl)acetohydrazide —— C17H20F3N9OS
    N'-[(E)-(1,5-dimethyl-1H-pyrazol-4-yl)methylidene]-2-({4-ethyl-5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-4H-1,2,4-triazol-3-yl}sulfanyl)acetohydrazide
    —— (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-diethylpropanamide —— C12H17BrN2OS
    (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-diethylpropanamide
    —— (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-butylpropanamide —— C12H17BrN2OS
    (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-butylpropanamide
    —— (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-pentylpropanamide —— C13H19BrN2OS
    (2S)-2-(5-bromopyridin-2-yl)sulfanyl-N-pentylpropanamide
    —— (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-diethylpropanamide —— C12H17BrN2OS
    (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N,N-diethylpropanamide
    —— (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-ethyl-N-(2-methylprop-2-enyl)propanamide —— C14H19BrN2OS
    (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-ethyl-N-(2-methylprop-2-enyl)propanamide
    —— (2R)-1-(azepan-1-yl)-2-(5-bromopyridin-2-yl)sulfanylpropan-1-one —— C14H19BrN2OS
    (2R)-1-(azepan-1-yl)-2-(5-bromopyridin-2-yl)sulfanylpropan-1-one
    —— (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-pentylpropanamide —— C13H19BrN2OS
    (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-pentylpropanamide
    —— 3-(difluoromethyl)-N-[(E)-(2-methylphenyl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine —— C12H12F2N4S
    3-(difluoromethyl)-N-[(E)-(2-methylphenyl)methylidene]-5-(methylsulfanyl)-4H-1,2,4-triazol-4-amine
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-chlorophenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C16H14ClN11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-chlorophenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— (2S)-1-(azepan-1-yl)-2-(5-bromopyridin-2-yl)sulfanylpropan-1-one —— C14H19BrN2OS
    (2S)-1-(azepan-1-yl)-2-(5-bromopyridin-2-yl)sulfanylpropan-1-one
    —— (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-butylpropanamide —— C12H17BrN2OS
    (2R)-2-(5-bromopyridin-2-yl)sulfanyl-N-butylpropanamide
    —— (2R)-3-(2-cyclopentylpyrimidin-4-yl)sulfanylpropane-1,2-diol —— C12H18N2O2S
    (2R)-3-(2-cyclopentylpyrimidin-4-yl)sulfanylpropane-1,2-diol
    —— (2S)-3-(2-cyclopentylpyrimidin-4-yl)sulfanylpropane-1,2-diol —— C12H18N2O2S
    (2S)-3-(2-cyclopentylpyrimidin-4-yl)sulfanylpropane-1,2-diol
    —— N-[(E)-[4-(dimethylamino)phenyl]methylideneamino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide —— C17H21N5O2S
    N-[(E)-[4-(dimethylamino)phenyl]methylideneamino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide
    —— N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]pyridine-2-carbohydrazide —— C17H11BrClN3O2S
    N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]pyridine-2-carbohydrazide
    —— (4-chlorophenyl)sulfanylmethyl (NE,1E)-N-[(3-nitro-4-phenylsulfanylphenyl)methylidene]methanehydrazonate —— C21H16ClN3O3S2
    (4-chlorophenyl)sulfanylmethyl (NE,1E)-N-[(3-nitro-4-phenylsulfanylphenyl)methylidene]methanehydrazonate
    —— N-[(E)-benzylideneamino]-2-(6-methylpyrimidin-4-yl)sulfanylacetamide —— C14H14N4OS
    N-[(E)-benzylideneamino]-2-(6-methylpyrimidin-4-yl)sulfanylacetamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methylphenyl)sulfanyl]methyl}-N'-[(1E)-1-phenylethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C21H20N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methylphenyl)sulfanyl]methyl}-N'-[(1E)-1-phenylethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(E)-(4-chlorophenyl)methylideneamino]-2-[2-[2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-oxoethyl]sulfanyl-6-methylpyrimidin-4-yl]oxyacetamide —— C23H20Cl2N6O3S
    N-[(E)-(4-chlorophenyl)methylideneamino]-2-[2-[2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-oxoethyl]sulfanyl-6-methylpyrimidin-4-yl]oxyacetamide
    —— N-[(E)-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylideneamino]pentanamide —— C17H17N3O2S2
    N-[(E)-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylideneamino]pentanamide
    —— 1-[(3S)-3-(1-methylpyrrol-2-yl)morpholin-4-yl]-2-pyridin-4-ylsulfanylethanone —— C16H19N3O2S
    1-[(3S)-3-(1-methylpyrrol-2-yl)morpholin-4-yl]-2-pyridin-4-ylsulfanylethanone
    —— 1-[(3R)-3-(1-methylpyrrol-2-yl)morpholin-4-yl]-2-pyridin-4-ylsulfanylethanone —— C16H19N3O2S
    1-[(3R)-3-(1-methylpyrrol-2-yl)morpholin-4-yl]-2-pyridin-4-ylsulfanylethanone
    —— 2-{[5-{[(4-methylphenyl)amino]methyl}-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E)-pyridin-4-ylmethylidene]acetohydrazide —— C21H23N7OS
    2-{[5-{[(4-methylphenyl)amino]methyl}-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E)-pyridin-4-ylmethylidene]acetohydrazide
    —— 4-fluoro-N-[(E)-[3-nitro-4-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]phenyl]methylideneamino]benzamide —— C21H12FN5O5S2
    4-fluoro-N-[(E)-[3-nitro-4-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]phenyl]methylideneamino]benzamide
    —— N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]pyridine-4-carboxamide —— C17H14N6O3S
    N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]pyridine-4-carboxamide
    —— N-[(E)-[2-methyl-5-(1-methyltetrazol-5-yl)sulfanylpyrazolo[1,5-a]quinazolin-3-yl]methylideneamino]-4-nitroaniline —— C20H16N10O2S
    N-[(E)-[2-methyl-5-(1-methyltetrazol-5-yl)sulfanylpyrazolo[1,5-a]quinazolin-3-yl]methylideneamino]-4-nitroaniline
    —— N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide —— C20H20N4O2S3
    N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide
    —— 2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(4-chlorobenzylidene)propanohydrazide —— C22H23ClN6OS
    2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(4-chlorobenzylidene)propanohydrazide
    —— 2-[(4E,8E,12E)-12-hydroxyiminocyclododeca-4,8-dien-1-yl]sulfanylphenol —— C18H23NO2S
    2-[(4E,8E,12E)-12-hydroxyiminocyclododeca-4,8-dien-1-yl]sulfanylphenol
    —— 1-[(2R,4S)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea —— C18H26N2O2S
    1-[(2R,4S)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea
    —— N'-[(E)-[5-(Thiophen-2-ylsulfanyl)thiophen-2-YL]methylidene]pyridine-4-carbohydrazide —— C15H11N3OS3
    N'-[(E)-[5-(Thiophen-2-ylsulfanyl)thiophen-2-YL]methylidene]pyridine-4-carbohydrazide