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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-[(2S,4S)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea —— C18H26N2O2S
    1-[(2S,4S)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea
    —— 1-[(2R,4R)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea —— C18H26N2O2S
    1-[(2R,4R)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea
    —— 1-[(2S,4R)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea —— C18H26N2O2S
    1-[(2S,4R)-2-cyclopropyloxan-4-yl]-3-[(3-methyl-4-methylsulfanylphenyl)methyl]urea
    —— 2-[(4-Chlorophenyl)sulfanyl]-N'-[(E)-1-methyl-2-(3-nitro-1H-1,2,4-triazol-1-YL)ethylidene]-5-nitrobenzohydrazide —— C18H14ClN7O5S
    2-[(4-Chlorophenyl)sulfanyl]-N'-[(E)-1-methyl-2-(3-nitro-1H-1,2,4-triazol-1-YL)ethylidene]-5-nitrobenzohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(E)-pyridin-3-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C15H14N12O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(E)-pyridin-3-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-hydroxy-N-[(E)-[2-(4-methylphenyl)sulfanyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]benzamide —— C23H18N4O3S
    2-hydroxy-N-[(E)-[2-(4-methylphenyl)sulfanyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]benzamide
    —— 2-[(2E)-2-({4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)hydrazinyl]-5-nitropyridine —— C16H10BrClN4O3S
    2-[(2E)-2-({4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)hydrazinyl]-5-nitropyridine
    —— (NE)-N-[(4E,8E)-12-pyridin-2-ylsulfanylcyclododeca-4,8-dien-1-ylidene]hydroxylamine —— C17H22N2OS
    (NE)-N-[(4E,8E)-12-pyridin-2-ylsulfanylcyclododeca-4,8-dien-1-ylidene]hydroxylamine
    —— 3-[(E)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]quinazolin-4-one —— C22H16N4O3S
    3-[(E)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]quinazolin-4-one
    —— 2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[4-(dimethylamino)benzylidene]propanohydrazide —— C24H29N7OS
    2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[4-(dimethylamino)benzylidene]propanohydrazide
    —— N-[(E)-(3-bromophenyl)methylideneamino]-2-(2-ethylsulfanyl-6-methylpyrimidin-4-yl)oxyacetamide —— C16H17BrN4O2S
    N-[(E)-(3-bromophenyl)methylideneamino]-2-(2-ethylsulfanyl-6-methylpyrimidin-4-yl)oxyacetamide
    —— [(E)-1-(4-methyl-2-methylsulfanylpyrimidin-5-yl)ethylideneamino]thiourea —— C9H13N5S2
    [(E)-1-(4-methyl-2-methylsulfanylpyrimidin-5-yl)ethylideneamino]thiourea
    —— 3-nitro-N-[(E)-(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylideneamino]benzenesulfonamide —— C17H12N6O6S2
    3-nitro-N-[(E)-(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylideneamino]benzenesulfonamide
    —— (2R)-2-[4-[2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]piperazin-1-yl]-2-phenylacetonitrile —— C23H23N5O2S
    (2R)-2-[4-[2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]piperazin-1-yl]-2-phenylacetonitrile
    —— 2-[(4-Benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)ethanone —— C24H24N4OS2
    2-[(4-Benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)ethanone
    —— (2S)-2-[4-[2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]piperazin-1-yl]-2-phenylacetonitrile —— C23H23N5O2S
    (2S)-2-[4-[2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]piperazin-1-yl]-2-phenylacetonitrile
    —— [4-cyclopropyl-5-[[(1S,3S)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol —— C14H23N3OS
    [4-cyclopropyl-5-[[(1S,3S)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol
    —— [4-cyclopropyl-5-[[(1R,3S)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol —— C14H23N3OS
    [4-cyclopropyl-5-[[(1R,3S)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol
    —— [4-cyclopropyl-5-[[(1R,3R)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol —— C14H23N3OS
    [4-cyclopropyl-5-[[(1R,3R)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol
    —— [4-cyclopropyl-5-[[(1S,3R)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol —— C14H23N3OS
    [4-cyclopropyl-5-[[(1S,3R)-3-methylcyclohexyl]methylsulfanyl]-1,2,4-triazol-3-yl]methanol
    —— 4,7,7-trimethyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxamide —— C18H22N2O3S
    4,7,7-trimethyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxamide
    —— N-[(E)-(4-methylsulfanylphenyl)methylideneamino]hexanamide —— C14H20N2OS
    N-[(E)-(4-methylsulfanylphenyl)methylideneamino]hexanamide
    —— 2-(5-chloropyrimidin-2-yl)sulfanyl-N-[(E)-(2-fluorophenyl)methylideneamino]acetamide —— C13H10ClFN4OS
    2-(5-chloropyrimidin-2-yl)sulfanyl-N-[(E)-(2-fluorophenyl)methylideneamino]acetamide
    —— 4-chlorobenzenecarbaldehyde O-{[5-[(4-bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}oxime —— C19H14BrClF3N3OS
    4-chlorobenzenecarbaldehyde O-{[5-[(4-bromophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}oxime
    —— 2-[[5-[(3-chloroanilino)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-1-(4-methylphenyl)ethylideneamino]propanamide —— C22H25ClN6OS
    2-[[5-[(3-chloroanilino)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-1-(4-methylphenyl)ethylideneamino]propanamide
    —— 5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(3,4-dichlorobenzyl)oxime —— C19H13Cl3F3N3OS
    5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(3,4-dichlorobenzyl)oxime
    —— N-[(E)-(4-methylsulfanylphenyl)methylideneamino]dodecanamide —— C20H32N2OS
    N-[(E)-(4-methylsulfanylphenyl)methylideneamino]dodecanamide
    —— 1-[(E)-[2-(4-methylphenyl)sulfanyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]-3-phenylthiourea —— C23H19N5OS2
    1-[(E)-[2-(4-methylphenyl)sulfanyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]-3-phenylthiourea
    —— 2-{[4-allyl-5-(4-toluidinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(4-chlorobenzylidene)propanohydrazide —— C23H25ClN6OS
    2-{[4-allyl-5-(4-toluidinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(4-chlorobenzylidene)propanohydrazide
    —— 2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-[(1E)-1-(pyridin-4-yl)ethylidene]acetohydrazide —— C18H17N5OS3
    2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-[(1E)-1-(pyridin-4-yl)ethylidene]acetohydrazide
    —— 3-(tert-butylsulfanyl)-6-methyl-4-{[(E)-(4-methylphenyl)methylidene]amino}-1,2,4-triazin-5(4H)-one —— C16H20N4OS
    3-(tert-butylsulfanyl)-6-methyl-4-{[(E)-(4-methylphenyl)methylidene]amino}-1,2,4-triazin-5(4H)-one
    —— 2-naphthalen-1-yl-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]acetamide —— C22H17N3O2S
    2-naphthalen-1-yl-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]acetamide
    —— N'-[(E)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methylethylidene]-2-[(4-chlorophenyl)thio]-5-nitrobenzohydrazide —— C22H17ClN6O3S
    N'-[(E)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methylethylidene]-2-[(4-chlorophenyl)thio]-5-nitrobenzohydrazide
    —— N'-[(1E)-1-(3-hydroxyphenyl)ethylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide —— C20H20N4O2S3
    N'-[(1E)-1-(3-hydroxyphenyl)ethylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide
    —— 2-[(1R)-1-(3-butyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-pyridin-4-yl-1,3,4-oxadiazole —— C15H17N5O2S
    2-[(1R)-1-(3-butyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-pyridin-4-yl-1,3,4-oxadiazole
    —— 3-butyl-5-[(1S)-1-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C14H23N5O2S
    3-butyl-5-[(1S)-1-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 2-[(1S)-1-(3-butyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-pyridin-4-yl-1,3,4-oxadiazole —— C15H17N5O2S
    2-[(1S)-1-(3-butyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-pyridin-4-yl-1,3,4-oxadiazole
    —— 3-butyl-5-[(1R)-1-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C14H23N5O2S
    3-butyl-5-[(1R)-1-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— N-(4-methylphenyl)-4-[[4-(oxolan-2-ylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazol-2-amine —— C22H23N5OS3
    N-(4-methylphenyl)-4-[[4-(oxolan-2-ylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazol-2-amine
    —— N-[(E)-3,3-dimethylbutan-2-ylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide —— C14H22N4OS
    N-[(E)-3,3-dimethylbutan-2-ylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide
    —— (1R)-2-(4-chlorophenyl)sulfanyl-1-(2,4-difluorophenyl)ethanol —— C14H11ClF2OS
    (1R)-2-(4-chlorophenyl)sulfanyl-1-(2,4-difluorophenyl)ethanol
    —— (1S)-2-(4-chlorophenyl)sulfanyl-1-(2,4-difluorophenyl)ethanol —— C14H11ClF2OS
    (1S)-2-(4-chlorophenyl)sulfanyl-1-(2,4-difluorophenyl)ethanol
    —— N'-{(E)-[4-oxo-2-(phenylsulfanyl)-4H-pyrido[1,2-a]pyrimidin-3-yl]methylidene}benzohydrazide —— C22H16N4O2S
    N'-{(E)-[4-oxo-2-(phenylsulfanyl)-4H-pyrido[1,2-a]pyrimidin-3-yl]methylidene}benzohydrazide
    —— 4-nitro-N'-{(E)-[4-oxo-2-(2-pyridinylthio)-4H-pyrido[1,2-a]pyrimidin-3-yl]methylidene}benzohydrazide —— C21H14N6O4S
    4-nitro-N'-{(E)-[4-oxo-2-(2-pyridinylthio)-4H-pyrido[1,2-a]pyrimidin-3-yl]methylidene}benzohydrazide
    —— [(4-{[(E)-(4-bromophenyl)methylidene]amino}-5-propyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetic acid —— C14H15BrN4O2S
    [(4-{[(E)-(4-bromophenyl)methylidene]amino}-5-propyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetic acid
    —— 1-[(E)-(4-oxo-2-pyridin-2-ylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylideneamino]-3-phenylthiourea —— C21H16N6OS2
    1-[(E)-(4-oxo-2-pyridin-2-ylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylideneamino]-3-phenylthiourea
    —— 3-[(4-Chlorophenyl)sulfanyl]-N'-[(E)-1-methyl-2-(5-nitro-2H-tetraazol-2-YL)ethylidene]-5-nitrobenzohydrazide —— C17H13ClN8O5S
    3-[(4-Chlorophenyl)sulfanyl]-N'-[(E)-1-methyl-2-(5-nitro-2H-tetraazol-2-YL)ethylidene]-5-nitrobenzohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-furan-3-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C17H13ClN8O3S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-furan-3-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 4-Oxo-2-(phenylthio)-4H-pyrido(1,2-A)pyrimidine-3-carbaldehyde phenylhydrazone —— C21H16N4OS
    4-Oxo-2-(phenylthio)-4H-pyrido(1,2-A)pyrimidine-3-carbaldehyde phenylhydrazone
    —— N-[(E)-(2-chlorophenyl)methylideneamino]-2-[2-[2-[(2E)-2-[(2-chlorophenyl)methylidene]hydrazinyl]-2-oxoethyl]sulfanyl-6-methylpyrimidin-4-yl]oxyacetamide —— C23H20Cl2N6O3S
    N-[(E)-(2-chlorophenyl)methylideneamino]-2-[2-[2-[(2E)-2-[(2-chlorophenyl)methylidene]hydrazinyl]-2-oxoethyl]sulfanyl-6-methylpyrimidin-4-yl]oxyacetamide