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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-[3-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one —— C21H29N3O3S
    5-[3-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]ethanone —— C22H24ClN3O3S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]ethanone
    —— 5-[3-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one —— C21H29N3O3S
    5-[3-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one
    —— 2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 6,7-Dichloro-2-isopropyl-3-(5-cyclopropylmethylsulfanyl-1,3,4-thiadiazol-2-ylsulfanyl)quinoxaline —— C17H16Cl2N4S3
    6,7-Dichloro-2-isopropyl-3-(5-cyclopropylmethylsulfanyl-1,3,4-thiadiazol-2-ylsulfanyl)quinoxaline
    —— 5-(2-Anilinopyrimidin-4-yl)-4-(4-chlorophenyl)-2-methylsulfanylthiophene-3-carbonitrile —— C22H15ClN4S2
    5-(2-Anilinopyrimidin-4-yl)-4-(4-chlorophenyl)-2-methylsulfanylthiophene-3-carbonitrile
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3S)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide —— C24H31N3O2S
    2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3S)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide
    —— 2-(3-bromopyridin-2-yl)sulfanyl-N-[(1S)-3-methyl-1-phenylbutyl]acetamide —— C18H21BrN2OS
    2-(3-bromopyridin-2-yl)sulfanyl-N-[(1S)-3-methyl-1-phenylbutyl]acetamide
    —— N-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2-[(2S)-4-propan-2-ylmorpholin-2-yl]acetamide —— C15H24N4O2S
    N-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2-[(2S)-4-propan-2-ylmorpholin-2-yl]acetamide
    —— 2-(3-bromopyridin-2-yl)sulfanyl-N-[(1R)-3-methyl-1-phenylbutyl]acetamide —— C18H21BrN2OS
    2-(3-bromopyridin-2-yl)sulfanyl-N-[(1R)-3-methyl-1-phenylbutyl]acetamide
    —— 2-[(1R)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole —— C16H14BrN3OS
    2-[(1R)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3R)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide —— C24H31N3O2S
    2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3R)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide
    —— 2-[(1S)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole —— C16H14BrN3OS
    2-[(1S)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
    —— 2-[(6-methylpyridin-3-yl)methyl]-5-(8-phenyloctylsulfanyl)-1H-pyrimidin-6-one —— C25H31N3OS
    2-[(6-methylpyridin-3-yl)methyl]-5-(8-phenyloctylsulfanyl)-1H-pyrimidin-6-one
    —— 3-[5-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenyl]sulfanyl-2-(methylamino)phenyl]propanoic acid —— C22H26FNO4S
    3-[5-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenyl]sulfanyl-2-(methylamino)phenyl]propanoic acid
    —— N-[4-[4-[(2,2-dimethylcyclopropanecarbonyl)amino]phenyl]sulfanylphenyl]-2,2-dimethylcyclopropane-1-carboxamide —— C24H28N2O2S
    N-[4-[4-[(2,2-dimethylcyclopropanecarbonyl)amino]phenyl]sulfanylphenyl]-2,2-dimethylcyclopropane-1-carboxamide
    —— (6S)-8-chloro-6-(4-methylpiperazin-1-yl)-5,6-dihydropyrrolo[2,1-b][1,3]benzothiazepine;dihydrochloride —— C17H22Cl3N3S
    (6S)-8-chloro-6-(4-methylpiperazin-1-yl)-5,6-dihydropyrrolo[2,1-b][1,3]benzothiazepine;dihydrochloride
    —— 5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C15H13F2N5OS2
    5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— 5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C15H13F2N5OS2
    5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— 5-(4'-Cyanobenzyl)-1-[2-(3"methylphenylthio)pyrid-5-ylmethyl)imidazole —— C24H20N4S
    5-(4'-Cyanobenzyl)-1-[2-(3"methylphenylthio)pyrid-5-ylmethyl)imidazole
    —— 7-[[2-Hydroxy-1-(hydroxymethyl)ethyl]amino]-5-[[(2-methyl-4-thiazolyl)methyl] thio]thiazolo[4,5-d]pyrimidin-2(3H)-one —— C13H15N5O3S3
    7-[[2-Hydroxy-1-(hydroxymethyl)ethyl]amino]-5-[[(2-methyl-4-thiazolyl)methyl] thio]thiazolo[4,5-d]pyrimidin-2(3H)-one
    —— 5-[(2,3-difluorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H14F2N4O2S2
    5-[(2,3-difluorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— N-[[(5S)-3-[5-(5-aminopyridin-2-yl)sulfanylpyridin-3-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]ethanethioamide —— C16H17N5O2S2
    N-[[(5S)-3-[5-(5-aminopyridin-2-yl)sulfanylpyridin-3-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]ethanethioamide
    —— 5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine —— C16H13ClFN3S2
    5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— (R)-(+)-N-hydroxy-6-[4-(2-(4-methylthiophenyl)ethynyl)phenyl]-6-hydroxyhexanamide —— C21H23NO3S
    (R)-(+)-N-hydroxy-6-[4-(2-(4-methylthiophenyl)ethynyl)phenyl]-6-hydroxyhexanamide
    —— 2-(3-Methoxyphenyl)sulfanyl-3-(3-pyridin-4-ylpropoxy)pyridine —— C20H20N2O2S
    2-(3-Methoxyphenyl)sulfanyl-3-(3-pyridin-4-ylpropoxy)pyridine
    —— 6-Acetyl-4-[2-(dimethylamino)ethylsulfanyl]-2-(4-fluorophenyl)-5-methylpyridazin-3-one —— C17H20FN3O2S
    6-Acetyl-4-[2-(dimethylamino)ethylsulfanyl]-2-(4-fluorophenyl)-5-methylpyridazin-3-one
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-2-[(2S)-morpholin-2-yl]acetamide —— C14H19ClN2O2S
    N-[2-(4-chlorophenyl)sulfanylethyl]-2-[(2S)-morpholin-2-yl]acetamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-2-[(2R)-morpholin-2-yl]acetamide —— C14H19ClN2O2S
    N-[2-(4-chlorophenyl)sulfanylethyl]-2-[(2R)-morpholin-2-yl]acetamide
    —— 3-(4-chloro-anilino)-5-(2-methyl-thiazol-4-ylmethylthio)-1,2,4-triazole 334539-41-2 C13H12ClN5S2
    3-(4-chloro-anilino)-5-(2-methyl-thiazol-4-ylmethylthio)-1,2,4-triazole
    —— (2S)-N-methyl-N-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-1-pyrazin-2-ylpropan-2-amine —— C16H20N6OS
    (2S)-N-methyl-N-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-1-pyrazin-2-ylpropan-2-amine
    —— 6-[2-[2-(4-Hydroxyphenyl)sulfanylethoxy]ethylsulfanyl]pyridin-3-ol —— C15H17NO3S2
    6-[2-[2-(4-Hydroxyphenyl)sulfanylethoxy]ethylsulfanyl]pyridin-3-ol
    —— 3-(4-chloro-anilino)-5-(2-fluoro-benzylthio)-1,2,4-triazole 334539-36-5 C15H12ClFN4S
    3-(4-chloro-anilino)-5-(2-fluoro-benzylthio)-1,2,4-triazole
    —— 8-[(4-chlorophenyl)methyl]-5-methyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]thiazepin-9-one —— C15H16ClN3OS
    8-[(4-chlorophenyl)methyl]-5-methyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]thiazepin-9-one
    —— (3S)-3-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C18H24N4OS2
    (3S)-3-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-methylpyrrolidin-2-one
    —— 5-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-[(1R)-1-ethoxyethyl]-1,2,4-oxadiazole —— C16H19N5O2S2
    5-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-[(1R)-1-ethoxyethyl]-1,2,4-oxadiazole
    —— (3R)-3-[[5-[4-(difluoromethylsulfanyl)anilino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C14H14F2N4OS3
    (3R)-3-[[5-[4-(difluoromethylsulfanyl)anilino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one
    —— 5-[[3-[(1S)-1-ethoxyethyl]-1,2,4-oxadiazol-5-yl]methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione —— C15H16N4O2S3
    5-[[3-[(1S)-1-ethoxyethyl]-1,2,4-oxadiazol-5-yl]methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione
    —— (3R)-3-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C18H24N4OS2
    (3R)-3-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-methylpyrrolidin-2-one
    —— 5-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-[(1S)-1-ethoxyethyl]-1,2,4-oxadiazole —— C16H19N5O2S2
    5-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-[(1S)-1-ethoxyethyl]-1,2,4-oxadiazole
    —— (3S)-3-[[5-[4-(difluoromethylsulfanyl)anilino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C14H14F2N4OS3
    (3S)-3-[[5-[4-(difluoromethylsulfanyl)anilino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one
    —— 5-[[3-[(1R)-1-ethoxyethyl]-1,2,4-oxadiazol-5-yl]methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione —— C15H16N4O2S3
    5-[[3-[(1R)-1-ethoxyethyl]-1,2,4-oxadiazol-5-yl]methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione
    —— 3-(4-methyl-anilino)-5-(5-methyl-isoxazol-3-ylmethylthio)-1,2,4-triazole 334538-93-1 C14H15N5OS
    3-(4-methyl-anilino)-5-(5-methyl-isoxazol-3-ylmethylthio)-1,2,4-triazole
    —— 7-Ethylsulfanyl-2-(4-methylphenyl)pyrimido[4,5-d][1,3]oxazin-4-one —— C15H13N3O2S
    7-Ethylsulfanyl-2-(4-methylphenyl)pyrimido[4,5-d][1,3]oxazin-4-one
    —— (Z)-tert-butyl-[[5-(4-ethylphenyl)sulfanylfuran-2-yl]methylidene]-hydroxyazanium —— C17H22NO2S+
    (Z)-tert-butyl-[[5-(4-ethylphenyl)sulfanylfuran-2-yl]methylidene]-hydroxyazanium
    —— 3-(3-methylthiophen-2-yl)sulfanyl-N-phenyl-1H-1,2,4-triazol-5-amine —— C13H12N4S2
    3-(3-methylthiophen-2-yl)sulfanyl-N-phenyl-1H-1,2,4-triazol-5-amine
    —— 4-[2-(4-fluorophenylsulfanyl)-phenyl]-1,2,3,6-tetrahydropyridine —— C17H16FNS
    4-[2-(4-fluorophenylsulfanyl)-phenyl]-1,2,3,6-tetrahydropyridine