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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-5-pyridin-3-yl-1,3,4-oxadiazole —— C17H13N5OS2
    2-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-5-pyridin-3-yl-1,3,4-oxadiazole
    —— 2-(2-Fluorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C14H8FN3O3S
    2-(2-Fluorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(furan-2-yl)-1,3,4-oxadiazole —— C18H9FN4O2S2
    2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(furan-2-yl)-1,3,4-oxadiazole
    —— 2-(Furan-2-yl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C18H10N4O2S2
    2-(Furan-2-yl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-(2-Methylfuran-3-yl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C13H9N3O4S
    2-(2-Methylfuran-3-yl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-(4-Methoxyphenyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-oxadiazole —— C19H16N4O2S2
    2-(4-Methoxyphenyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-oxadiazole
    —— 2-[[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C16H10N4O4S
    2-[[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 2-[[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C13H6N4O4S
    2-[[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 2-Phenyl-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole —— C18H14N4OS2
    2-Phenyl-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole
    —— N-benzyl-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-amine —— C19H17N5S3
    N-benzyl-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-(4-Chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole —— C14H7ClN4OS2
    2-(4-Chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole
    —— 5-Nitro-2-[(12-oxo-11-prop-2-enyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-10-yl)sulfanyl]benzonitrile —— C19H14N4O3S2
    5-Nitro-2-[(12-oxo-11-prop-2-enyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-10-yl)sulfanyl]benzonitrile
    —— 5-Nitro-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]benzonitrile —— C15H8N4O3S
    5-Nitro-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]benzonitrile
    —— 4-Methyl-2-[4-(4-methylpiperidin-1-yl)sulfonyl-2-nitrophenyl]sulfanylpyrimidine —— C17H20N4O4S2
    4-Methyl-2-[4-(4-methylpiperidin-1-yl)sulfonyl-2-nitrophenyl]sulfanylpyrimidine
    —— 4-[[(7R)-7-methyl-4-pyrimidin-2-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholin-4-ium —— C20H24N5OS2+
    4-[[(7R)-7-methyl-4-pyrimidin-2-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholin-4-ium
    —— 2-(3,4-Dimethoxyphenyl)-5-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C18H16N4O3S2
    2-(3,4-Dimethoxyphenyl)-5-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-(1,3-Benzodioxol-5-yl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole —— C19H14N4O3S2
    2-(1,3-Benzodioxol-5-yl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole
    —— 2-(4-Chlorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C14H8ClN3O3S
    2-(4-Chlorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-[4-[(3R)-3-methylpiperidin-1-yl]sulfonyl-2-nitrophenyl]sulfanylpyrimidine —— C16H18N4O4S2
    2-[4-[(3R)-3-methylpiperidin-1-yl]sulfonyl-2-nitrophenyl]sulfanylpyrimidine
    —— 2-Methyl-5-phenyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C17H12N4S2
    2-Methyl-5-phenyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 2-(2-Nitro-4-pyrrolidin-1-ylsulfonylphenyl)sulfanylpyrimidine —— C14H14N4O4S2
    2-(2-Nitro-4-pyrrolidin-1-ylsulfonylphenyl)sulfanylpyrimidine
    —— 4-(4-Methylpyrimidin-2-yl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C15H14N4S2
    4-(4-Methylpyrimidin-2-yl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— 5,6-Dimethyl-2-[(4-methylpiperidin-1-ium-1-yl)methyl]-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C19H24N5S2+
    5,6-Dimethyl-2-[(4-methylpiperidin-1-ium-1-yl)methyl]-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 5,6-Dimethyl-2-(phenylsulfanylmethyl)-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C19H16N4S3
    5,6-Dimethyl-2-(phenylsulfanylmethyl)-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 2-(4-Chloro-2-nitrophenyl)sulfanyl-4-methylpyrimidine —— C11H8ClN3O2S
    2-(4-Chloro-2-nitrophenyl)sulfanyl-4-methylpyrimidine
    —— 4-[[12-(4-Methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-10-yl]methyl]morpholine —— C19H21N5OS2
    4-[[12-(4-Methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-10-yl]methyl]morpholine
    —— 1-(3-Nitro-4-pyrimidin-2-ylsulfanylphenyl)sulfonylazepane —— C16H18N4O4S2
    1-(3-Nitro-4-pyrimidin-2-ylsulfanylphenyl)sulfonylazepane
    —— 5-(4-Chlorophenyl)-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine —— C17H11ClN4S2
    5-(4-Chlorophenyl)-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine
    —— 5-(4-Fluorophenyl)-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine —— C17H11FN4S2
    5-(4-Fluorophenyl)-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine
    —— 5-(4-Methylphenyl)-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine —— C18H14N4S2
    5-(4-Methylphenyl)-4-(4-methylpyrimidin-2-yl)sulfanylthieno[2,3-d]pyrimidine
    —— 4-[[12-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-10-yl]methyl]morpholin-4-ium —— C20H24N5OS2+
    4-[[12-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-10-yl]methyl]morpholin-4-ium
    —— (3Z)-3-(1-aminoethylidene)-1-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]pentane-2,4-dione —— C14H16N4O3S
    (3Z)-3-(1-aminoethylidene)-1-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]pentane-2,4-dione
    —— 4-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-2,5,6-trimethylthieno[2,3-d]pyrimidine —— C15H16N4S2
    4-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-2,5,6-trimethylthieno[2,3-d]pyrimidine
    —— 4-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine —— C18H13FN4S2
    4-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine
    —— (7S)-4-(4,6-dimethylpyrimidin-2-yl)sulfanyl-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C17H18N4S2
    (7S)-4-(4,6-dimethylpyrimidin-2-yl)sulfanyl-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— (3Z)-3-(1-aminoethylidene)-1-pyrimidin-2-ylsulfanylpentane-2,4-dione —— C11H13N3O2S
    (3Z)-3-(1-aminoethylidene)-1-pyrimidin-2-ylsulfanylpentane-2,4-dione
    —— 2-(4-Chloro-2-nitrophenyl)sulfanyl-4,6-dimethylpyrimidine —— C12H10ClN3O2S
    2-(4-Chloro-2-nitrophenyl)sulfanyl-4,6-dimethylpyrimidine
    —— (2R)-2-phenylsulfanyl-N,N-bis(thiophen-2-ylmethyl)propanamide —— C19H19NOS3
    (2R)-2-phenylsulfanyl-N,N-bis(thiophen-2-ylmethyl)propanamide
    —— (E)-4-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-benzyl-2-cyano-3-hydroxybut-2-enamide —— C20H17N5O2S2
    (E)-4-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-benzyl-2-cyano-3-hydroxybut-2-enamide
    —— (2S)-2-phenylsulfanyl-N,N-bis(thiophen-2-ylmethyl)propanamide —— C19H19NOS3
    (2S)-2-phenylsulfanyl-N,N-bis(thiophen-2-ylmethyl)propanamide
    —— (2R)-2-(1-benzyltetrazol-5-yl)sulfanyl-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]propanamide —— C19H27N5OS
    (2R)-2-(1-benzyltetrazol-5-yl)sulfanyl-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]propanamide
    —— (Z)-3-amino-2-[2-[[4-(3-chloro-4-methylphenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile —— C15H13ClN4OS3
    (Z)-3-amino-2-[2-[[4-(3-chloro-4-methylphenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile
    —— 2-(2-methylphenyl)sulfanyl-N-[(1S)-1-phenylethyl]acetamide —— C17H19NOS
    2-(2-methylphenyl)sulfanyl-N-[(1S)-1-phenylethyl]acetamide
    —— (2R)-2-(1-benzyltetrazol-5-yl)sulfanyl-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]propanamide —— C19H27N5OS
    (2R)-2-(1-benzyltetrazol-5-yl)sulfanyl-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]propanamide
    —— (2S)-2-(1-benzyltetrazol-5-yl)sulfanyl-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]propanamide —— C19H27N5OS
    (2S)-2-(1-benzyltetrazol-5-yl)sulfanyl-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]propanamide
    —— (Z)-3-amino-2-[2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile —— C16H17N5OS2
    (Z)-3-amino-2-[2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile
    —— 3-(3-Methoxypropyl)-1-methyl-1-[(2-phenylsulfanylacetyl)amino]thiourea —— C14H21N3O2S2
    3-(3-Methoxypropyl)-1-methyl-1-[(2-phenylsulfanylacetyl)amino]thiourea
    —— 4-benzyl-3-[(3S,5R)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H15N3O3S
    4-benzyl-3-[(3S,5R)-5-methyl-2-oxooxolan-3-yl]sulfanyl-1H-1,2,4-triazol-5-one
    —— (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one —— C18H26N5OS2+
    (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamide —— C19H19ClN4OS2
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamide