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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-methylthio-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-2-ethylbromobenzene 391199-95-4 C13H16BrNOS
    4-methylthio-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-2-ethylbromobenzene
    —— (5R,6R)-6-(3-isohexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane 162299-98-1 C15H25N3S2
    (5R,6R)-6-(3-isohexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 4-Isopropyl-5-isopropylthio-2-methyl-1-[(4-pyridyl)methyl]-1H-pyrrole-3-methanol —— C18H26N2OS
    4-Isopropyl-5-isopropylthio-2-methyl-1-[(4-pyridyl)methyl]-1H-pyrrole-3-methanol
    —— (E)-N-methoxy-1-[4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridin-2-yl]methanimine —— C16H14N2OS2
    (E)-N-methoxy-1-[4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridin-2-yl]methanimine
    —— Methyl 2-[4-(4-chloro-3,5-dimethylpyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate —— C12H13ClN4O2S
    Methyl 2-[4-(4-chloro-3,5-dimethylpyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate
    —— 5-(3-Hexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C15H25N3S2
    5-(3-Hexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C16H14ClN3O2S2
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide —— C16H14ClN3O2S2
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide
    —— (1R)-2,2-dichloro-N'-[2-(4-chlorophenyl)sulfanylacetyl]cyclopropane-1-carbohydrazide —— C12H11Cl3N2O2S
    (1R)-2,2-dichloro-N'-[2-(4-chlorophenyl)sulfanylacetyl]cyclopropane-1-carbohydrazide
    —— exo-8-methyl-6-(3-butylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C14H23N3S2
    exo-8-methyl-6-(3-butylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 2-([1,2,4]Oxadiazol-3-ylmethylsulfanyl)-5-thiophen-2-ylmethyl-pyrimidin-4-ylamine 476302-13-3 C12H11N5OS2
    2-([1,2,4]Oxadiazol-3-ylmethylsulfanyl)-5-thiophen-2-ylmethyl-pyrimidin-4-ylamine
    —— 3-(cyclohexylmethylsulfanyl)-5-[(3-methylphenyl)methyl]-1H-1,2,4-triazole —— C17H23N3S
    3-(cyclohexylmethylsulfanyl)-5-[(3-methylphenyl)methyl]-1H-1,2,4-triazole
    —— (1S)-2,2-dichloro-N'-[2-(4-chlorophenyl)sulfanylacetyl]cyclopropane-1-carbohydrazide —— C12H11Cl3N2O2S
    (1S)-2,2-dichloro-N'-[2-(4-chlorophenyl)sulfanylacetyl]cyclopropane-1-carbohydrazide
    —— 2-cyclopropylmethylsulfanyl-5-thiophen-2-ylmethyl-pyrimidin-4-ylamine 476302-12-2 C13H15N3S2
    2-cyclopropylmethylsulfanyl-5-thiophen-2-ylmethyl-pyrimidin-4-ylamine
    —— 7-methyl-4-[(4-methylphenyl)thio]thieno[3,2-d]pyrimidine —— C14H12N2S2
    7-methyl-4-[(4-methylphenyl)thio]thieno[3,2-d]pyrimidine
    —— Ethyl 2-[4-(3-methylpyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate —— C12H14N4O2S
    Ethyl 2-[4-(3-methylpyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate
    —— 4-[4-(1H-1,2,4-triazol-5-ylsulfanylmethyl)phenyl]thiadiazole —— C11H9N5S2
    4-[4-(1H-1,2,4-triazol-5-ylsulfanylmethyl)phenyl]thiadiazole
    —— N-[2-[(5E)-2,4-dioxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethyl]-2-(1-methyltetrazol-5-yl)sulfanylacetamide —— C15H15N7O3S2
    N-[2-[(5E)-2,4-dioxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethyl]-2-(1-methyltetrazol-5-yl)sulfanylacetamide
    —— 2-allylsulfanyl-5-thiophen-2-ylmethyl-pyrimidin-4-ylamine 476302-11-1 C12H13N3S2
    2-allylsulfanyl-5-thiophen-2-ylmethyl-pyrimidin-4-ylamine
    —— N-[2-[(5E)-2,4-dioxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C17H17N5O3S4
    N-[2-[(5E)-2,4-dioxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 1-Cyclohex-3-enylmethyl-3-(2-hydroxy-ethyl)-thiourea —— C10H18N2OS
    1-Cyclohex-3-enylmethyl-3-(2-hydroxy-ethyl)-thiourea
    —— 1-[(3S,3aR,7Z)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C20H19N5O3S2
    1-[(3S,3aR,7Z)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— 1-[(3S,3aS,7Z)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C20H19N5O3S2
    1-[(3S,3aS,7Z)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— 2-(2,3-Dihydro-1-benzothiophen-2-ylmethyl)guanidine —— C10H13N3S
    2-(2,3-Dihydro-1-benzothiophen-2-ylmethyl)guanidine
    —— 3-aminopropyl[1-hydroxy-1-(2-methylthiocyclopropyl)methyl]phosphinic acid —— C8H18NO3PS
    3-aminopropyl[1-hydroxy-1-(2-methylthiocyclopropyl)methyl]phosphinic acid
    —— 3-(1-Azabicyclo[2.2.1]heptan-3-yl)-4-ethylsulfanyl-1,2,5-thiadiazole —— C10H15N3S2
    3-(1-Azabicyclo[2.2.1]heptan-3-yl)-4-ethylsulfanyl-1,2,5-thiadiazole
    —— 3-Isobutylthio-1,2,4-triazole —— C6H11N3S
    3-Isobutylthio-1,2,4-triazole
    —— 5,6-Dihydroxy-1-benzothiophen-3-one —— C8H6O3S
    5,6-Dihydroxy-1-benzothiophen-3-one
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-pyridin-4-ylethyl]acetamide —— C22H21N5O2S
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-pyridin-4-ylethyl]acetamide
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-pyridin-4-ylethyl]acetamide —— C22H21N5O2S
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-pyridin-4-ylethyl]acetamide
    —— N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H15Cl2N3O2S
    N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[2-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C22H17FN4O4S2
    N-[2-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-(4-ethylphenyl)ethyl]acetamide —— C20H20ClN3O2S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-(4-ethylphenyl)ethyl]acetamide
    —— N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H15Cl2N3O2S
    N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (4S)-N-ethyl-2,2-dimethyl-N-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]oxan-4-amine —— C17H26N4O2S
    (4S)-N-ethyl-2,2-dimethyl-N-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]oxan-4-amine
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide —— C20H20ClN3O2S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide
    —— (4R)-N-ethyl-2,2-dimethyl-N-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]oxan-4-amine —— C17H26N4O2S
    (4R)-N-ethyl-2,2-dimethyl-N-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]oxan-4-amine
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H18ClN3O3S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H18ClN3O3S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H18ClN3O3S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— [(Z)-[5,5-dimethyl-2-(6-oxo-1,3-benzothiazol-2-ylidene)-1,3-thiazolidin-4-ylidene]-(4-methylphenyl)sulfanylmethyl] dihydrogen phosphate —— C20H19N2O5PS3
    [(Z)-[5,5-dimethyl-2-(6-oxo-1,3-benzothiazol-2-ylidene)-1,3-thiazolidin-4-ylidene]-(4-methylphenyl)sulfanylmethyl] dihydrogen phosphate
    —— (2S)-2-(4-fluorophenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide —— C11H11F4NOS
    (2S)-2-(4-fluorophenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H15Cl2N3O2S
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 3-pyridin-3-ylpropyl (2S)-2-phenylsulfanylpropanoate —— C17H19NO2S
    3-pyridin-3-ylpropyl (2S)-2-phenylsulfanylpropanoate
    —— (2R)-2-(4-fluorophenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide —— C11H11F4NOS
    (2R)-2-(4-fluorophenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-2-(4-fluorophenyl)sulfanyl-N-methylacetamide —— C13H16FNO3S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-2-(4-fluorophenyl)sulfanyl-N-methylacetamide
    —— (1S)-2,2-dichloro-N-[3-(4-fluorophenyl)sulfanylpropyl]cyclopropane-1-carboxamide —— C13H14Cl2FNOS
    (1S)-2,2-dichloro-N-[3-(4-fluorophenyl)sulfanylpropyl]cyclopropane-1-carboxamide
    —— (1R)-2,2-dichloro-N-[3-(4-fluorophenyl)sulfanylpropyl]cyclopropane-1-carboxamide —— C13H14Cl2FNOS
    (1R)-2,2-dichloro-N-[3-(4-fluorophenyl)sulfanylpropyl]cyclopropane-1-carboxamide
    —— Bis-(6,7-dichloro-2-isopropylquinoxalin-3-yl)sulfide —— C22H18Cl4N4S
    Bis-(6,7-dichloro-2-isopropylquinoxalin-3-yl)sulfide
    —— 2-(Ethylthio)benzyl-3-(2,2-difluoro-2-(2-pyridyl-N-oxide)ethylamino)-6-chloropyrazin-2-one-1-acetamide —— C22H22ClF2N5O3S
    2-(Ethylthio)benzyl-3-(2,2-difluoro-2-(2-pyridyl-N-oxide)ethylamino)-6-chloropyrazin-2-one-1-acetamide