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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(E)-1-phenylethylideneamino]-2-phenylsulfanylacetamide —— C16H16N2OS
    N-[(E)-1-phenylethylideneamino]-2-phenylsulfanylacetamide
    —— N-[(E)-(2-bromophenyl)methylideneamino]-2-(4-chlorophenyl)sulfanylacetamide —— C15H12BrClN2OS
    N-[(E)-(2-bromophenyl)methylideneamino]-2-(4-chlorophenyl)sulfanylacetamide
    —— N-[(E)-[(Z)-2-bromo-3-phenylprop-2-enylidene]amino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide —— C17H17BrN4O2S
    N-[(E)-[(Z)-2-bromo-3-phenylprop-2-enylidene]amino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-(5-methylfuran-2-yl)methylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C18H15ClN8O3S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-(5-methylfuran-2-yl)methylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— ethyl (2E)-2-[(5Z)-3-[2-(diethylamino)-2-oxoethyl]-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]acetate —— C21H26N2O4S2
    ethyl (2E)-2-[(5Z)-3-[2-(diethylamino)-2-oxoethyl]-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]acetate
    —— ethyl (2E)-2-[(5E)-3-[2-(diethylamino)-2-oxoethyl]-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]acetate —— C21H26N2O4S2
    ethyl (2E)-2-[(5E)-3-[2-(diethylamino)-2-oxoethyl]-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]acetate
    —— (2S)-2-ethyl-N-[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propyl]hexanamide —— C18H34N4OS
    (2S)-2-ethyl-N-[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propyl]hexanamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(4-fluorophenyl)ethylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C21H19FN8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(4-fluorophenyl)ethylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— (2R)-2-ethyl-N-[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propyl]hexanamide —— C18H34N4OS
    (2R)-2-ethyl-N-[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propyl]hexanamide
    —— N-[4-(4,6-dimethylpyrimidin-2-yl)sulfanylphenyl]-2-[(2S)-3-oxo-4H-1,4-benzothiazin-2-yl]acetamide —— C22H20N4O2S2
    N-[4-(4,6-dimethylpyrimidin-2-yl)sulfanylphenyl]-2-[(2S)-3-oxo-4H-1,4-benzothiazin-2-yl]acetamide
    —— 2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-[(1E)-1-(3-bromophenyl)ethylidene]acetohydrazide —— C19H17BrN4OS3
    2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-[(1E)-1-(3-bromophenyl)ethylidene]acetohydrazide
    —— N-[4-(4,6-dimethylpyrimidin-2-yl)sulfanylphenyl]-2-[(2R)-3-oxo-4H-1,4-benzothiazin-2-yl]acetamide —— C22H20N4O2S2
    N-[4-(4,6-dimethylpyrimidin-2-yl)sulfanylphenyl]-2-[(2R)-3-oxo-4H-1,4-benzothiazin-2-yl]acetamide
    —— 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-[(E)-dimethylaminomethylideneamino]acetamide —— C11H12ClF3N4OS
    2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-[(E)-dimethylaminomethylideneamino]acetamide
    —— 5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(2,4-dichlorobenzyl)oxime —— C19H13Cl3F3N3OS
    5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(2,4-dichlorobenzyl)oxime
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(3-bromophenyl)methylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide —— C19H15BrN8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(3-bromophenyl)methylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide
    —— (1E)-1-({5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-2-(4-nitrophenyl)hydrazine —— C17H12ClN3O3S
    (1E)-1-({5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-2-(4-nitrophenyl)hydrazine
    —— 2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-[(E)-1-(2-hydroxyphenyl)ethylidene]acetohydrazide —— C19H18N4O2S3
    2-{[5-(benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N'-[(E)-1-(2-hydroxyphenyl)ethylidene]acetohydrazide
    —— 2-{[4-allyl-5-(4-toluidinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(2-fluorobenzylidene)propanohydrazide —— C23H25FN6OS
    2-{[4-allyl-5-(4-toluidinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(2-fluorobenzylidene)propanohydrazide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(2R)-3-ethyl-2-morpholin-4-ylpentyl]acetamide —— C19H29ClN2O2S
    2-(2-chlorophenyl)sulfanyl-N-[(2R)-3-ethyl-2-morpholin-4-ylpentyl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(2S)-3-ethyl-2-morpholin-4-ylpentyl]acetamide —— C19H29ClN2O2S
    2-(2-chlorophenyl)sulfanyl-N-[(2S)-3-ethyl-2-morpholin-4-ylpentyl]acetamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(4-fluorophenyl)ethylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide —— C20H17FN8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(4-fluorophenyl)ethylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(2S)-3-ethyl-2-morpholin-4-ylpentyl]-3-phenylsulfanylpropanamide —— C20H32N2O2S
    N-[(2S)-3-ethyl-2-morpholin-4-ylpentyl]-3-phenylsulfanylpropanamide
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2R)-3-ethyl-2-morpholin-4-ylpentyl]acetamide —— C26H35N5O3S
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2R)-3-ethyl-2-morpholin-4-ylpentyl]acetamide
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-3-ethyl-2-morpholin-4-ylpentyl]acetamide —— C26H35N5O3S
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-3-ethyl-2-morpholin-4-ylpentyl]acetamide
    —— 6-[[4-[(1R)-1-[(1S,2R,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile —— C21H21N5OS
    6-[[4-[(1R)-1-[(1S,2R,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile
    —— 6-[[4-[(1S)-1-[(1S,2R,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile —— C21H21N5OS
    6-[[4-[(1S)-1-[(1S,2R,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile
    —— (2S)-N-benzyl-2-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide —— C22H27N5O2S
    (2S)-N-benzyl-2-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide
    —— 6-[[4-[(1S)-1-[(1S,2S,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile —— C21H21N5OS
    6-[[4-[(1S)-1-[(1S,2S,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile
    —— 6-[[4-[(1R)-1-[(1S,2S,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile —— C21H21N5OS
    6-[[4-[(1R)-1-[(1S,2S,4S)-2-bicyclo[2.2.1]heptanyl]ethyl]-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile
    —— (2R)-N-benzyl-2-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide —— C22H27N5O2S
    (2R)-N-benzyl-2-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide
    —— 2-[(1S)-1-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole —— C19H20N6O2S2
    2-[(1S)-1-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(1E)-1-phenylethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C17H17N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(1E)-1-phenylethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(E)-(3-bromophenyl)methylideneamino]-2-[2-[2-[(2E)-2-[(3-bromophenyl)methylidene]hydrazinyl]-2-oxoethyl]sulfanyl-6-methylpyrimidin-4-yl]oxyacetamide —— C23H20Br2N6O3S
    N-[(E)-(3-bromophenyl)methylideneamino]-2-[2-[2-[(2E)-2-[(3-bromophenyl)methylidene]hydrazinyl]-2-oxoethyl]sulfanyl-6-methylpyrimidin-4-yl]oxyacetamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(2,5-dimethylthiophen-3-yl)ethylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide —— C20H20N8O2S2
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(2,5-dimethylthiophen-3-yl)ethylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-[(1R)-1-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole —— C19H20N6O2S2
    2-[(1R)-1-[[4-(furan-2-ylmethyl)-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole
    —— 1-[4-(isopropylsulfanyl)phenyl]ethanone O-[3-(dimethylamino)propyl]oxime —— C16H26N2OS
    1-[4-(isopropylsulfanyl)phenyl]ethanone O-[3-(dimethylamino)propyl]oxime
    —— [(1R)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate —— C18H16BrN3O3S
    [(1R)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(2,5-dimethylthiophen-3-yl)ethylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C17H19N11O2S2
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(2,5-dimethylthiophen-3-yl)ethylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-1-[(2R)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one —— C17H18ClNOS2
    (2R)-2-(2-chlorophenyl)sulfanyl-1-[(2R)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one
    —— (2S)-2-(2-chlorophenyl)sulfanyl-1-[(2S)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one —— C17H18ClNOS2
    (2S)-2-(2-chlorophenyl)sulfanyl-1-[(2S)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one
    —— [(1S)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate —— C18H16BrN3O3S
    [(1S)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4-bromo-2-methylphenyl)sulfanylacetate
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-[(1-morpholin-4-ylcyclohexyl)methyl]propanamide —— C20H29ClN2O2S
    (2R)-2-(2-chlorophenyl)sulfanyl-N-[(1-morpholin-4-ylcyclohexyl)methyl]propanamide
    —— (2E)-2-{3-nitro-4-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]benzylidene}hydrazinecarbothioamide —— C16H12N6O3S2
    (2E)-2-{3-nitro-4-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]benzylidene}hydrazinecarbothioamide
    —— 6-[(4-chlorophenyl)sulfanyl]nicotinaldehyde O-methyloxime —— C13H11ClN2OS
    6-[(4-chlorophenyl)sulfanyl]nicotinaldehyde O-methyloxime
    —— (2S)-2-(2-chlorophenyl)sulfanyl-1-[(2R)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one —— C17H18ClNOS2
    (2S)-2-(2-chlorophenyl)sulfanyl-1-[(2R)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one
    —— N-{[5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene}-N-[(4-methylbenzoyl)oxy]amine —— C20H15ClF3N3O2S
    N-{[5-[(4-chlorophenyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene}-N-[(4-methylbenzoyl)oxy]amine
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-[(1-morpholin-4-ylcyclohexyl)methyl]propanamide —— C20H29ClN2O2S
    (2S)-2-(2-chlorophenyl)sulfanyl-N-[(1-morpholin-4-ylcyclohexyl)methyl]propanamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-1-[(2S)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one —— C17H18ClNOS2
    (2R)-2-(2-chlorophenyl)sulfanyl-1-[(2S)-2-thiophen-2-ylpyrrolidin-1-yl]propan-1-one
    —— (2S)-2-(4-amino-5-cyanopyrimidin-2-yl)sulfanyl-N-[(1S,2S)-2-methylcyclohexyl]propanamide —— C15H21N5OS
    (2S)-2-(4-amino-5-cyanopyrimidin-2-yl)sulfanyl-N-[(1S,2S)-2-methylcyclohexyl]propanamide
    —— N-[(E)-1-(3-bromophenyl)ethylideneamino]-2-(4-chlorophenyl)sulfanylpropanamide —— C17H16BrClN2OS
    N-[(E)-1-(3-bromophenyl)ethylideneamino]-2-(4-chlorophenyl)sulfanylpropanamide