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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(S)-cyclopropyl(phenyl)methyl]-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H24N4O3S
    N-[(S)-cyclopropyl(phenyl)methyl]-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(S)-cyclopropyl(phenyl)methyl]-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H24N4O3S
    N-[(S)-cyclopropyl(phenyl)methyl]-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(R)-cyclopropyl(phenyl)methyl]-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H24N4O3S
    N-[(R)-cyclopropyl(phenyl)methyl]-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2R)-2-(trifluoromethyl)cyclohexyl]acetamide —— C14H21F3N4OS
    2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2R)-2-(trifluoromethyl)cyclohexyl]acetamide
    —— 2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2R)-2-(trifluoromethyl)cyclohexyl]acetamide —— C14H21F3N4OS
    2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2R)-2-(trifluoromethyl)cyclohexyl]acetamide
    —— 2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2S)-2-(trifluoromethyl)cyclohexyl]acetamide —— C14H21F3N4OS
    2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2S)-2-(trifluoromethyl)cyclohexyl]acetamide
    —— [(2S)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] 3-(4-fluorophenyl)sulfanylpropanoate —— C18H23FN2O4S
    [(2S)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] 3-(4-fluorophenyl)sulfanylpropanoate
    —— 2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2S)-2-(trifluoromethyl)cyclohexyl]acetamide —— C14H21F3N4OS
    2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2S)-2-(trifluoromethyl)cyclohexyl]acetamide
    —— (2S)-N-(3-methylbutyl)-2-(3-methyl-2,4-dioxo-7-propan-2-yl-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanamide —— C21H33N5O3S
    (2S)-N-(3-methylbutyl)-2-(3-methyl-2,4-dioxo-7-propan-2-yl-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanamide
    —— ethyl 2-[[5-[(2E)-2-[(3-bromophenyl)methylidene]hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetate —— C13H14BrN5O2S
    ethyl 2-[[5-[(2E)-2-[(3-bromophenyl)methylidene]hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— [(2R)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] 3-(4-fluorophenyl)sulfanylpropanoate —— C18H23FN2O4S
    [(2R)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] 3-(4-fluorophenyl)sulfanylpropanoate
    —— (1S)-5-amino-1,3-dimethyl-1-oxo-1λ6-thia-2-azacyclohexa-1,3,5-triene-4-carbonitrile —— C7H9N3OS
    (1S)-5-amino-1,3-dimethyl-1-oxo-1λ6-thia-2-azacyclohexa-1,3,5-triene-4-carbonitrile
    —— N'-[(Z)-(3-oxo-1-benzothiophen-2-ylidene)methyl]-2-[(Z)-1-phenylethylideneamino]oxyacetohydrazide —— C19H17N3O3S
    N'-[(Z)-(3-oxo-1-benzothiophen-2-ylidene)methyl]-2-[(Z)-1-phenylethylideneamino]oxyacetohydrazide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(2S)-4-methyl-2-morpholin-4-ylpentyl]acetamide —— C20H32N2O2S
    2-(2,5-dimethylphenyl)sulfanyl-N-[(2S)-4-methyl-2-morpholin-4-ylpentyl]acetamide
    —— (2R)-N-(2-phenylethyl)-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H16F3N3OS
    (2R)-N-(2-phenylethyl)-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— (2S)-N-(2-phenylethyl)-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H16F3N3OS
    (2S)-N-(2-phenylethyl)-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— (2R)-N-[(4-methylphenyl)methyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H16F3N3OS
    (2R)-N-[(4-methylphenyl)methyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— (2S)-N-[(4-methylphenyl)methyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H16F3N3OS
    (2S)-N-[(4-methylphenyl)methyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(2R)-4-methyl-2-morpholin-4-ylpentyl]acetamide —— C20H32N2O2S
    2-(2,5-dimethylphenyl)sulfanyl-N-[(2R)-4-methyl-2-morpholin-4-ylpentyl]acetamide
    —— N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(2-methylphenyl)sulfanylacetamide —— C18H25NO3S2
    N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(2-methylphenyl)sulfanylacetamide
    —— N-[(1S)-1-phenylbutyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylacetamide —— C17H18F3N3OS
    N-[(1S)-1-phenylbutyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylacetamide
    —— N-[(E)-(4-bromophenyl)methylideneamino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide —— C15H15BrN4O2S
    N-[(E)-(4-bromophenyl)methylideneamino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide
    —— 2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(2-furylmethylene)acetohydrazide —— C19H20N6O2S
    2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(2-furylmethylene)acetohydrazide
    —— N-[(1R)-1-phenylbutyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylacetamide —— C17H18F3N3OS
    N-[(1R)-1-phenylbutyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylacetamide
    —— N-[(E)-(3-chlorophenyl)methylideneamino]-2-(4-chlorophenyl)sulfanylacetamide —— C15H12Cl2N2OS
    N-[(E)-(3-chlorophenyl)methylideneamino]-2-(4-chlorophenyl)sulfanylacetamide
    —— N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(2-methylphenyl)sulfanylacetamide —— C18H25NO3S2
    N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(2-methylphenyl)sulfanylacetamide
    —— 2-benzylsulfanyl-N-[(E)-butylideneamino]pyrimidin-4-amine —— C15H18N4S
    2-benzylsulfanyl-N-[(E)-butylideneamino]pyrimidin-4-amine
    —— N-[(2S)-2-(5-methylfuran-2-yl)-2-morpholin-4-ylethyl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide —— C19H22F3N3O3S
    N-[(2S)-2-(5-methylfuran-2-yl)-2-morpholin-4-ylethyl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-3-methyl-2-morpholin-4-ylbutyl]acetamide —— C24H31N5O3S
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-3-methyl-2-morpholin-4-ylbutyl]acetamide
    —— 6-[(4-Methoxyphenyl)sulfanyl]imidazo[2,1-b][1,3]thiazole-5-carbaldehyde oxime —— C13H11N3O2S2
    6-[(4-Methoxyphenyl)sulfanyl]imidazo[2,1-b][1,3]thiazole-5-carbaldehyde oxime
    —— 3-[(E)-hydroxyiminomethyl]-2-phenylsulfanylpyrido[1,2-a]pyrimidin-4-one —— C15H11N3O2S
    3-[(E)-hydroxyiminomethyl]-2-phenylsulfanylpyrido[1,2-a]pyrimidin-4-one
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2R)-3-methyl-2-morpholin-4-ylbutyl]acetamide —— C24H31N5O3S
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2R)-3-methyl-2-morpholin-4-ylbutyl]acetamide
    —— methyl 2-{[4-[(hydroxyimino)methyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate —— C14H12F3N3O3S
    methyl 2-{[4-[(hydroxyimino)methyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate
    —— 5-[(4-chlorobenzyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime —— C13H11ClF3N3OS
    5-[(4-chlorobenzyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime
    —— N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]-2-cyanoacetohydrazide —— C14H9BrClN3O2S
    N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]-2-cyanoacetohydrazide
    —— 3-[5-[2-[2-(4-chlorophenyl)ethylamino]-2-oxoethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide —— C20H26ClN5O3S
    3-[5-[2-[2-(4-chlorophenyl)ethylamino]-2-oxoethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[2-[2-(4-chlorophenyl)ethylamino]-2-oxoethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide —— C20H26ClN5O3S
    3-[5-[2-[2-(4-chlorophenyl)ethylamino]-2-oxoethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide
    —— (3R)-4-hydroxy-2-imino-3H-thiophene-3-carbonitrile —— C5H4N2OS
    (3R)-4-hydroxy-2-imino-3H-thiophene-3-carbonitrile
    —— 3-[5-[2-[[(1R,2R,3R)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide —— C20H29N5O3S
    3-[5-[2-[[(1R,2R,3R)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide
    —— (3S)-4-hydroxy-2-imino-3H-thiophene-3-carbonitrile —— C5H4N2OS
    (3S)-4-hydroxy-2-imino-3H-thiophene-3-carbonitrile
    —— 3-[3-[(2R)-1-(1-adamantyl)-1-oxopropan-2-yl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide —— C22H28N4O2S2
    3-[3-[(2R)-1-(1-adamantyl)-1-oxopropan-2-yl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide
    —— 3-[5-[2-[[(1S)-1-(4-ethylphenyl)ethyl]amino]-2-oxoethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide —— C22H31N5O3S
    3-[5-[2-[[(1S)-1-(4-ethylphenyl)ethyl]amino]-2-oxoethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide
    —— 3-[3-[(2S)-1-(1-adamantyl)-1-oxopropan-2-yl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide —— C22H28N4O2S2
    3-[3-[(2S)-1-(1-adamantyl)-1-oxopropan-2-yl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide
    —— 3-[3-[(2S)-1-(azepan-1-yl)-1-oxopropan-2-yl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide —— C18H25N5O2S2
    3-[3-[(2S)-1-(azepan-1-yl)-1-oxopropan-2-yl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide
    —— 3-[3-[2-[[(2R)-1-methoxypropan-2-yl]amino]-2-oxoethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide —— C15H21N5O3S2
    3-[3-[2-[[(2R)-1-methoxypropan-2-yl]amino]-2-oxoethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide
    —— (E)-1-{4-bromo-5-[(4-methylphenyl)sulfanyl]furan-2-yl}-N-hydroxymethanimine —— C12H10BrNO2S
    (E)-1-{4-bromo-5-[(4-methylphenyl)sulfanyl]furan-2-yl}-N-hydroxymethanimine
    —— 3-[3-[2-[[(2S)-1-methoxypropan-2-yl]amino]-2-oxoethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide —— C15H21N5O3S2
    3-[3-[2-[[(2S)-1-methoxypropan-2-yl]amino]-2-oxoethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide
    —— 3-[5-[2-[[(1S,2R,3S)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide —— C20H29N5O3S
    3-[5-[2-[[(1S,2R,3S)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide —— C21H25N5O2S2
    3-[5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[2-[[(1S,2R,3R)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide —— C20H29N5O3S
    3-[5-[2-[[(1S,2R,3R)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide