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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-Butylsulfanyl-2,2,5,5-tetramethyl-1-prop-2-enylimidazole —— C14H26N2S
    4-Butylsulfanyl-2,2,5,5-tetramethyl-1-prop-2-enylimidazole
    —— 1-(2-Hydroxy-ethyl)-3-(cis-2-methyl-cyclopentyl)-thiourea —— C9H18N2OS
    1-(2-Hydroxy-ethyl)-3-(cis-2-methyl-cyclopentyl)-thiourea
    —— 1-(Cyclohex-2-enyl)-3-(2-hydroxy-ethyl)-thiourea —— C9H16N2OS
    1-(Cyclohex-2-enyl)-3-(2-hydroxy-ethyl)-thiourea
    —— phenyl (2E,5R)-2-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C31H21ClN2O4S2
    phenyl (2E,5R)-2-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— 2-[3-Amino-1-(1,2-oxazol-5-yl)propyl]sulfanyl-6-methylpyridine-3-carbonitrile —— C13H14N4OS
    2-[3-Amino-1-(1,2-oxazol-5-yl)propyl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— 2-[(2R)-2-hydroxy-3-octylsulfonylpropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile —— C19H30N2O3S2
    2-[(2R)-2-hydroxy-3-octylsulfonylpropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
    —— N-methyl-3-[3-(2-methylphenyl)sulfanylphenyl]propan-1-amine;N-methyl-3-(3-thiophen-2-ylsulfanylphenyl)propan-1-amine;N-methyl-3-[3-[4-(trifluoromethyl)phenyl]sulfanylphenyl]propan-1-amine —— C48H56F3N3S4
    N-methyl-3-[3-(2-methylphenyl)sulfanylphenyl]propan-1-amine;N-methyl-3-(3-thiophen-2-ylsulfanylphenyl)propan-1-amine;N-methyl-3-[3-[4-(trifluoromethyl)phenyl]sulfanylphenyl]propan-1-amine
    —— N-methyl-3-[[4-(trifluoromethyl)phenyl]thio]benzenepropanamine —— C17H18F3NS
    N-methyl-3-[[4-(trifluoromethyl)phenyl]thio]benzenepropanamine
    —— (16S)-3,8-bis(heptylsulfanyl)-16-methyl-19-thia-2,4,5,7,9,10-hexazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),3,5,8,13(18)-pentaene —— C27H42N6S3
    (16S)-3,8-bis(heptylsulfanyl)-16-methyl-19-thia-2,4,5,7,9,10-hexazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),3,5,8,13(18)-pentaene
    —— 3-chloro-N-[3-chloro-4-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]phenyl]-5-(trifluoromethyl)benzenesulfonamide —— C20H10Cl3F3N2O2S3
    3-chloro-N-[3-chloro-4-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]phenyl]-5-(trifluoromethyl)benzenesulfonamide
    —— 1-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]-4-[3-[[4-methyl-5-(4-methyl-1H-pyrazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1,4-diazepane —— C24H34F3N9S
    1-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]-4-[3-[[4-methyl-5-(4-methyl-1H-pyrazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1,4-diazepane
    —— 3-chloro-N-[3-chloro-4-[(6-methyl-1,3-benzothiazol-2-yl)sulfanyl]phenyl]-5-(trifluoromethyl)benzenesulfonamide —— C21H13Cl2F3N2O2S3
    3-chloro-N-[3-chloro-4-[(6-methyl-1,3-benzothiazol-2-yl)sulfanyl]phenyl]-5-(trifluoromethyl)benzenesulfonamide
    —— 1-[5-[[5-(2-Amino-4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-2-methylpyrimidin-4-yl]-2,3-diethylguanidine —— C19H23ClN8OS
    1-[5-[[5-(2-Amino-4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-2-methylpyrimidin-4-yl]-2,3-diethylguanidine
    —— 1-[(R)-ethenylsulfinyl]octane —— C10H20OS
    1-[(R)-ethenylsulfinyl]octane
    —— 1-(4-isopropylphenylamino)-4-[5-(4-pyridyl)-1H-1,2,4-triazolyl-3-ylthio]phthalazine 325781-33-7 C24H21N7S
    1-(4-isopropylphenylamino)-4-[5-(4-pyridyl)-1H-1,2,4-triazolyl-3-ylthio]phthalazine
    —— 1-Bromo-3,5-bis(1,1,2,2,2-pentafluoroethylsulfanyl)benzene —— C10H3BrF10S2
    1-Bromo-3,5-bis(1,1,2,2,2-pentafluoroethylsulfanyl)benzene
    —— 1-[(S)-ethenylsulfinyl]octane —— C10H20OS
    1-[(S)-ethenylsulfinyl]octane
    —— 1,4-bis(1,1,2,2,2-pentafluoroethylsulfanyl)benzene —— C10H4F10S2
    1,4-bis(1,1,2,2,2-pentafluoroethylsulfanyl)benzene
    —— ethyl (4S)-6-amino-4-(4-chlorophenyl)-5-cyano-2-[(3-cyano-6-thiophen-2-ylpyridin-2-yl)sulfanylmethyl]-4H-pyran-3-carboxylate —— C26H19ClN4O3S2
    ethyl (4S)-6-amino-4-(4-chlorophenyl)-5-cyano-2-[(3-cyano-6-thiophen-2-ylpyridin-2-yl)sulfanylmethyl]-4H-pyran-3-carboxylate
    —— 1,2,4,5-tetrafluoro-3,6-bis(1,1,2,2,2-pentafluoroethylsulfanyl)benzene —— C10F14S2
    1,2,4,5-tetrafluoro-3,6-bis(1,1,2,2,2-pentafluoroethylsulfanyl)benzene
    —— 5-[(3-bromophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H15BrN4O2S2
    5-[(3-bromophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— ethyl (4R)-6-amino-4-(4-chlorophenyl)-5-cyano-2-[(3-cyano-6-thiophen-2-ylpyridin-2-yl)sulfanylmethyl]-4H-pyran-3-carboxylate —— C26H19ClN4O3S2
    ethyl (4R)-6-amino-4-(4-chlorophenyl)-5-cyano-2-[(3-cyano-6-thiophen-2-ylpyridin-2-yl)sulfanylmethyl]-4H-pyran-3-carboxylate
    —— (+/-)-5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(methoxymethyl)ethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one —— C16H16F2N4O3S2
    (+/-)-5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(methoxymethyl)ethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one
    —— 1,2-Diethyl-3-[5-[[5-(5-methylfuran-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]pyrimidin-4-yl]guanidine —— C17H21N7O2S
    1,2-Diethyl-3-[5-[[5-(5-methylfuran-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]pyrimidin-4-yl]guanidine
    —— 6-[(4-chlorophenyl)thio]-2,3-dihydro-2-(4-methoxyphenyl)-5-methyl-3-oxo-4-pyridazinecarbonitrile —— C19H14ClN3O2S
    6-[(4-chlorophenyl)thio]-2,3-dihydro-2-(4-methoxyphenyl)-5-methyl-3-oxo-4-pyridazinecarbonitrile
    —— 2-[4-[4-(3-Hydroxyphenyl)-1,3-thiazol-2-yl]-5-methylsulfanylthiophen-2-yl]-2-oxoethanimidamide —— C16H13N3O2S3
    2-[4-[4-(3-Hydroxyphenyl)-1,3-thiazol-2-yl]-5-methylsulfanylthiophen-2-yl]-2-oxoethanimidamide
    —— 5-[3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)propylsulfanyl]-1,3,4-thiadiazol-2-amine —— C16H20N4S2
    5-[3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)propylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 1-[4-(4-Chlorophenyl)sulfanylthiophen-3-yl]-3-[3-(dimethylamino)propyl]urea —— C16H20ClN3OS2
    1-[4-(4-Chlorophenyl)sulfanylthiophen-3-yl]-3-[3-(dimethylamino)propyl]urea
    —— 4-[[(2R,4R)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol;hydrochloride —— C17H20ClNO2S2
    4-[[(2R,4R)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol;hydrochloride
    —— 1-[(5S)-3,5-bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-2-[[5-[[3,5-bis(difluoromethyl)pyrazol-1-yl]methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C17H17F8N7O2S
    1-[(5S)-3,5-bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-2-[[5-[[3,5-bis(difluoromethyl)pyrazol-1-yl]methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— (Z,E)-N-[3-(furan-2-yl)-5-(furan-2-ylsulfanyl)-1,2,4-triazol-4-yl]-3-phenylprop-2-en-1-imine —— C19H14N4O2S
    (Z,E)-N-[3-(furan-2-yl)-5-(furan-2-ylsulfanyl)-1,2,4-triazol-4-yl]-3-phenylprop-2-en-1-imine
    —— 7-[[5-[(3S)-1-methylsulfonylpiperidin-3-yl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C23H26N6O3S3
    7-[[5-[(3S)-1-methylsulfonylpiperidin-3-yl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 6-Amino-9-benzyl-8-hydroxy-2-(p-tolylthio)purine —— C19H17N5OS
    6-Amino-9-benzyl-8-hydroxy-2-(p-tolylthio)purine
    —— 1-[(5R)-3,5-bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-2-[[5-[[3,5-bis(difluoromethyl)pyrazol-1-yl]methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C17H17F8N7O2S
    1-[(5R)-3,5-bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-2-[[5-[[3,5-bis(difluoromethyl)pyrazol-1-yl]methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 7-[[5-[(3R)-1-methylsulfonylpiperidin-3-yl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C23H26N6O3S3
    7-[[5-[(3R)-1-methylsulfonylpiperidin-3-yl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— Bismuth;diethylcarbamodithioic acid —— C5H11BiNS2+3
    Bismuth;diethylcarbamodithioic acid
    —— 5-benzylsulfanyl-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H16N4O2S2
    5-benzylsulfanyl-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— 1-(Cyclopropylmethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-propylpyrimidine-2,4-dione —— C19H24N2O2S
    1-(Cyclopropylmethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-propylpyrimidine-2,4-dione
    —— 3-[(4-chlorophenyl)methylsulfanyl]-N-(4-methylphenyl)-1H-1,2,4-triazol-5-amine —— C16H15ClN4S
    3-[(4-chlorophenyl)methylsulfanyl]-N-(4-methylphenyl)-1H-1,2,4-triazol-5-amine
    —— 4-[(1-Methylimidazol-2-yl)sulfanylmethyl]-2-(pyridin-4-ylsulfanylmethyl)pyridine —— C16H16N4S2
    4-[(1-Methylimidazol-2-yl)sulfanylmethyl]-2-(pyridin-4-ylsulfanylmethyl)pyridine
    —— 6-[(3,8,8-trimethyl-6,7-dihydro-5H-naphthalen-2-yl)sulfanyl]pyridine-3-carboxylic acid —— C19H21NO2S
    6-[(3,8,8-trimethyl-6,7-dihydro-5H-naphthalen-2-yl)sulfanyl]pyridine-3-carboxylic acid
    —— 3-anilino-5-(3,4-difluoro-benzylthio)-1,2,4-triazole 334538-77-1 C15H12F2N4S
    3-anilino-5-(3,4-difluoro-benzylthio)-1,2,4-triazole
    —— 2-ethenylsulfonyl-N-[[(2-ethenylsulfonylacetyl)amino]methyl]acetamide —— C9H14N2O6S2
    2-ethenylsulfonyl-N-[[(2-ethenylsulfonylacetyl)amino]methyl]acetamide
    —— N-(4-methylphenyl)-3-(1-phenylethylsulfanyl)-1H-1,2,4-triazol-5-amine —— C17H18N4S
    N-(4-methylphenyl)-3-(1-phenylethylsulfanyl)-1H-1,2,4-triazol-5-amine
    —— 5-Methyl-8-thiophen-2-ylsulfanyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine —— C11H7F3N4S2
    5-Methyl-8-thiophen-2-ylsulfanyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
    —— 3-(4-methyl-anilino)-5-(2-methyl-thiazol-4-ylmethylthio)-1,2,4-triazole 334538-97-5 C14H15N5S2
    3-(4-methyl-anilino)-5-(2-methyl-thiazol-4-ylmethylthio)-1,2,4-triazole
    —— (Z)-tert-butyl-hydroxy-[[5-(2-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium —— C16H20NO3S+
    (Z)-tert-butyl-hydroxy-[[5-(2-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium
    —— 4-[2-(2-Pyridin-4-ylsulfanylethoxy)ethylsulfanyl]phenol —— C15H17NO2S2
    4-[2-(2-Pyridin-4-ylsulfanylethoxy)ethylsulfanyl]phenol
    —— 3-Chloro-4-(3,4-dichloro-phenylsulfanyl)-phenylamine 32631-30-4 C12H8Cl3NS
    3-Chloro-4-(3,4-dichloro-phenylsulfanyl)-phenylamine
    —— 3-(4-methyl-anilino)-5-(cyclohexylmethylthio)-1,2,4-triazole 334538-89-5 C16H22N4S
    3-(4-methyl-anilino)-5-(cyclohexylmethylthio)-1,2,4-triazole