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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C11H16N2O3S3
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-tert-butyl-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C10H16N2OS2
    N-tert-butyl-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— (2R)-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)propan-1-one —— C16H17N3O2S2
    (2R)-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)propan-1-one
    —— 2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C15H15N3O3S2
    2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— (2R)-N-(1-adamantyl)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide —— C15H21N3OS2
    (2R)-N-(1-adamantyl)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide
    —— 2-[[4-[(2R)-butan-2-yl]-5-(3-morpholin-4-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylsulfanylphenyl)acetamide —— C30H33N5O4S3
    2-[[4-[(2R)-butan-2-yl]-5-(3-morpholin-4-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylsulfanylphenyl)acetamide
    —— 1-[2,5-dimethyl-1-[(1S)-1-phenylethyl]pyrrol-3-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanone —— C18H19N3OS2
    1-[2,5-dimethyl-1-[(1S)-1-phenylethyl]pyrrol-3-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanone
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide —— C8H11N3O3S3
    N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide
    —— 2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C17H17N3O3S
    2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— (2S)-N-cyclopentyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C15H19N3O3S
    (2S)-N-cyclopentyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-N-[(E)-[3-bromo-4-(dimethylamino)phenyl]methylideneamino]-2-phenylsulfanylpropanamide —— C18H20BrN3OS
    (2R)-N-[(E)-[3-bromo-4-(dimethylamino)phenyl]methylideneamino]-2-phenylsulfanylpropanamide
    —— 1-[2-[[5-(2-Methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrrolidin-2-one —— C13H13N3O4S
    1-[2-[[5-(2-Methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrrolidin-2-one
    —— 2-[[4-[(2S)-butan-2-yl]-5-(3-morpholin-4-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylsulfanylphenyl)acetamide —— C30H33N5O4S3
    2-[[4-[(2S)-butan-2-yl]-5-(3-morpholin-4-ylsulfonylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylsulfanylphenyl)acetamide
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H15FN4O2S
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C20H19N3O4S
    1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— (2S)-N-[(E)-[3-bromo-4-(dimethylamino)phenyl]methylideneamino]-2-phenylsulfanylpropanamide —— C18H20BrN3OS
    (2S)-N-[(E)-[3-bromo-4-(dimethylamino)phenyl]methylideneamino]-2-phenylsulfanylpropanamide
    —— N-[3-[(2-chlorophenyl)methyl]-1,3-thiazol-2-ylidene]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C15H13ClN4OS3
    N-[3-[(2-chlorophenyl)methyl]-1,3-thiazol-2-ylidene]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 1-[2,5-Dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C14H14N4OS3
    1-[2,5-Dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— (2S)-2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pentanedinitrile —— C19H23N5S2
    (2S)-2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pentanedinitrile
    —— 2-[[2-(2-Chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(2-fluorophenyl)-1,3,4-oxadiazole —— C18H11ClFN3OS2
    2-[[2-(2-Chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(2-fluorophenyl)-1,3,4-oxadiazole
    —— 1-[2,5-dimethyl-1-[(1S)-1-phenylethyl]pyrrol-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C19H21N3OS2
    1-[2,5-dimethyl-1-[(1S)-1-phenylethyl]pyrrol-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— N-[(1S)-1-(4-ethylphenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C15H19N3OS2
    N-[(1S)-1-(4-ethylphenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-(1-cyanocyclohexyl)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C17H17FN4O2S
    N-(1-cyanocyclohexyl)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-benzyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H19N3O3S3
    N-benzyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2S)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one —— C14H13FN2O2S
    (2S)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one
    —— 2-(2-Fluorophenyl)-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole —— C19H14FN3OS2
    2-(2-Fluorophenyl)-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole
    —— (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C17H19FN4O2S
    (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C16H14FN3O3S
    (2S)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
    —— 1-[2,5-dimethyl-1-[(1R)-1-phenylethyl]pyrrol-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C19H21N3OS2
    1-[2,5-dimethyl-1-[(1R)-1-phenylethyl]pyrrol-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— 2-(2-Fluorophenyl)-5-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole —— C16H10FN3O2S2
    2-(2-Fluorophenyl)-5-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— (2R)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C16H14FN3O3S
    (2R)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H18FN3O4S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— Ethyl 2-[4-methyl-5-[[2-(4-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-3-yl]acetate —— C18H21N5O2S2
    Ethyl 2-[4-methyl-5-[[2-(4-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-3-yl]acetate
    —— ethyl N-[2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]carbamate —— C13H12FN3O4S
    ethyl N-[2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]carbamate
    —— 2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide —— C12H9F4N3O2S
    2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide
    —— 2-[[4-Benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(5-ethylthiophen-2-yl)ethanone —— C21H19N3O2S2
    2-[[4-Benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(5-ethylthiophen-2-yl)ethanone
    —— [(2R)-1-(dimethylamino)-1-oxopropan-2-yl] 2-(4-chlorophenyl)sulfanylpyridine-3-carboxylate —— C17H17ClN2O3S
    [(2R)-1-(dimethylamino)-1-oxopropan-2-yl] 2-(4-chlorophenyl)sulfanylpyridine-3-carboxylate
    —— 2-(4-fluorophenyl)-5-[(1R)-1-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]ethyl]-1,3,4-oxadiazole —— C14H12FN3OS2
    2-(4-fluorophenyl)-5-[(1R)-1-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]ethyl]-1,3,4-oxadiazole
    —— (2S)-4-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C18H17N5OS3
    (2S)-4-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— [2-[cyclopentyl-[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-phenylsulfanylacetate —— C19H25NO5S2
    [2-[cyclopentyl-[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-phenylsulfanylacetate
    —— 2-(4-methylphenyl)-5-[(1R)-1-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]ethyl]-1,3,4-oxadiazole —— C15H15N3OS2
    2-(4-methylphenyl)-5-[(1R)-1-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]ethyl]-1,3,4-oxadiazole
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-[(5E)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]acetamide —— C27H22FN5O4S2
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-[(5E)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]acetamide
    —— [(1S)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl] 2-phenylsulfanylacetate —— C18H15FN2O3S
    [(1S)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl] 2-phenylsulfanylacetate
    —— (2S)-N-[(E)-[(2R)-2-(2-cyanoethyl)cyclohexylidene]amino]-2-phenylsulfanylpropanamide —— C18H23N3OS
    (2S)-N-[(E)-[(2R)-2-(2-cyanoethyl)cyclohexylidene]amino]-2-phenylsulfanylpropanamide
    —— (2R)-2-(4-chlorophenyl)sulfanyl-N-[(E)-(2,3,4-trimethylphenyl)methylideneamino]propanamide —— C19H21ClN2OS
    (2R)-2-(4-chlorophenyl)sulfanyl-N-[(E)-(2,3,4-trimethylphenyl)methylideneamino]propanamide
    —— (2R)-N-[(2-chlorophenyl)methyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C15H19ClN4OS
    (2R)-N-[(2-chlorophenyl)methyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methylpropanamide —— C13H20N4O3S2
    (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methylpropanamide
    —— (2R)-N-ethyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide —— C7H11N3OS2
    (2R)-N-ethyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide
    —— (2S)-N-cycloheptyl-2-[[5-(2-methoxyethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C15H26N4O2S2
    (2S)-N-cycloheptyl-2-[[5-(2-methoxyethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide —— C14H22N4O3S2
    (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide