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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-propyl-3-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C13H15N5O2S2
    4-propyl-3-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C10H9N5OS3
    5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H18N4O3S3
    N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 3-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-amine —— C10H10N6OS2
    3-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-amine
    —— 5-[(2-Phenylethyl)thio]-1,3,4-thiadiazol-2-amine —— C10H11N3S2
    5-[(2-Phenylethyl)thio]-1,3,4-thiadiazol-2-amine
    —— 2-(4-methylphenyl)sulfanyl-N-[(2R)-4-phenylbutan-2-yl]pyridine-3-carboxamide —— C23H24N2OS
    2-(4-methylphenyl)sulfanyl-N-[(2R)-4-phenylbutan-2-yl]pyridine-3-carboxamide
    —— N-[(1S)-1-(4-fluorophenyl)ethyl]-2-(4-methylphenyl)sulfanylpyridine-3-carboxamide —— C21H19FN2OS
    N-[(1S)-1-(4-fluorophenyl)ethyl]-2-(4-methylphenyl)sulfanylpyridine-3-carboxamide
    —— (5-Allylsulfanyl-[1,3,4]thiadiazol-2-yl)-p-tolyl-amine —— C12H13N3S2
    (5-Allylsulfanyl-[1,3,4]thiadiazol-2-yl)-p-tolyl-amine
    —— 1-[[5-[[2-(2-Methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one —— C18H19N5O2S2
    1-[[5-[[2-(2-Methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazol-2-yl]methyl]pyrrolidin-2-one
    —— N-(2-cyanoethyl)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C14H14FN5OS2
    N-(2-cyanoethyl)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— (2S)-2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]propanamide —— C21H24N4O3S
    (2S)-2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]propanamide
    —— N-(2-cyanoethyl)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C13H12FN5OS2
    N-(2-cyanoethyl)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(4-Cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]ethyl-dimethylazanium —— C18H28N4OS+2
    2-[(4-Cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]ethyl-dimethylazanium
    —— 1-(Morpholin-4-yl)-3-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C20H28N4OS
    1-(Morpholin-4-yl)-3-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 1-(Piperidin-1-yl)-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C22H32N4S
    1-(Piperidin-1-yl)-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— N-benzyl-2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetamide —— C23H27N4O2S+
    N-benzyl-2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetamide
    —— 3-(2-Morpholin-4-yl-2-oxoethyl)sulfanyl-1-piperidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile —— C21H29N4O2S+
    3-(2-Morpholin-4-yl-2-oxoethyl)sulfanyl-1-piperidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile
    —— 1-Morpholin-4-yl-3-(2-piperidin-1-ium-1-ylethylsulfanyl)-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile —— C21H32N4OS+2
    1-Morpholin-4-yl-3-(2-piperidin-1-ium-1-ylethylsulfanyl)-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile
    —— Ethyl 4-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]butanoate —— C20H28N3O3S+
    Ethyl 4-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]butanoate
    —— Ethyl 4-{[4-cyano-1-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}butanoate —— C20H27N3O3S
    Ethyl 4-{[4-cyano-1-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}butanoate
    —— 2-{[4-Cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetamide —— C18H24N4OS
    2-{[4-Cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetamide
    —— 5-[(Cyclopropylmethyl)sulfanyl]-1,3,4-thiadiazol-2-amine —— C6H9N3S2
    5-[(Cyclopropylmethyl)sulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[4-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanylmethyl]phenyl]acetate —— C11H10N3O2S2-
    2-[4-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanylmethyl]phenyl]acetate
    —— 5-[(3,5-Difluorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C9H7F2N3S2
    5-[(3,5-Difluorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 1-(4-Methyl-1,4-diazepan-4-ium-1-yl)-2-phenylsulfanylethanone —— C14H21N2OS+
    1-(4-Methyl-1,4-diazepan-4-ium-1-yl)-2-phenylsulfanylethanone
    —— 2-[(5-methyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C16H20N4OS
    2-[(5-methyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— 1-Morpholin-4-yl-3-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile —— C20H27N4O3S+
    1-Morpholin-4-yl-3-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile
    —— 3-(Butylsulfanyl)-6-methyl[1,2,4]triazino[5,6-d][3,1]benzoxazepine —— C15H16N4OS
    3-(Butylsulfanyl)-6-methyl[1,2,4]triazino[5,6-d][3,1]benzoxazepine
    —— 1-(Morpholin-4-yl)-3-{[2-(morpholin-4-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C20H28N4O2S
    1-(Morpholin-4-yl)-3-{[2-(morpholin-4-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— [(1S,2S)-2-methyl-1-(5-propan-2-ylsulfanyl-1,3,4-oxadiazol-2-yl)butyl]azanium —— C10H20N3OS+
    [(1S,2S)-2-methyl-1-(5-propan-2-ylsulfanyl-1,3,4-oxadiazol-2-yl)butyl]azanium
    —— 2-(2-fluorophenyl)sulfanyl-N-[(Z)-pyridin-3-ylmethylideneamino]acetamide —— C14H12FN3OS
    2-(2-fluorophenyl)sulfanyl-N-[(Z)-pyridin-3-ylmethylideneamino]acetamide
    —— N-[(Z)-(2-chlorophenyl)methylideneamino]-2-(2-fluorophenyl)sulfanylacetamide —— C15H12ClFN2OS
    N-[(Z)-(2-chlorophenyl)methylideneamino]-2-(2-fluorophenyl)sulfanylacetamide
    —— N-[(4-tert-butylcyclohexylidene)amino]-2-(2-fluorophenyl)sulfanylacetamide —— C18H25FN2OS
    N-[(4-tert-butylcyclohexylidene)amino]-2-(2-fluorophenyl)sulfanylacetamide
    —— N-(1H-imidazol-2-ylmethyl)-N-[(1R)-1-phenylethyl]-2-pyridin-4-ylsulfanylacetamide —— C19H20N4OS
    N-(1H-imidazol-2-ylmethyl)-N-[(1R)-1-phenylethyl]-2-pyridin-4-ylsulfanylacetamide
    —— 2-(2-fluorophenyl)sulfanyl-N-[(Z)-(2,4,6-trimethylphenyl)methylideneamino]acetamide —— C18H19FN2OS
    2-(2-fluorophenyl)sulfanyl-N-[(Z)-(2,4,6-trimethylphenyl)methylideneamino]acetamide
    —— 2-(2-fluorophenyl)sulfanyl-N-[(Z)-pyridin-2-ylmethylideneamino]acetamide —— C14H12FN3OS
    2-(2-fluorophenyl)sulfanyl-N-[(Z)-pyridin-2-ylmethylideneamino]acetamide
    —— N-[(Z)-[(Z)-2-bromo-3-phenylprop-2-enylidene]amino]-2-(2-fluorophenyl)sulfanylacetamide —— C17H14BrFN2OS
    N-[(Z)-[(Z)-2-bromo-3-phenylprop-2-enylidene]amino]-2-(2-fluorophenyl)sulfanylacetamide
    —— N-(cyclooctylideneamino)-2-(2-fluorophenyl)sulfanylacetamide —— C16H21FN2OS
    N-(cyclooctylideneamino)-2-(2-fluorophenyl)sulfanylacetamide
    —— 2-(2-fluorophenyl)sulfanyl-N-[(Z)-(3-methylthiophen-2-yl)methylideneamino]acetamide —— C14H13FN2OS2
    2-(2-fluorophenyl)sulfanyl-N-[(Z)-(3-methylthiophen-2-yl)methylideneamino]acetamide
    —— N-[(5-methyl-1H-imidazol-4-yl)methyl]-N-[(1S)-1-phenylethyl]-2-pyridin-4-ylsulfanylacetamide —— C20H22N4OS
    N-[(5-methyl-1H-imidazol-4-yl)methyl]-N-[(1S)-1-phenylethyl]-2-pyridin-4-ylsulfanylacetamide
    —— ethyl (1S,2R)-2-[[cyclohexyl-(2-pyridin-4-ylsulfanylacetyl)amino]methyl]cyclopropane-1-carboxylate —— C20H28N2O3S
    ethyl (1S,2R)-2-[[cyclohexyl-(2-pyridin-4-ylsulfanylacetyl)amino]methyl]cyclopropane-1-carboxylate
    —— N-(cyclohexylmethyl)-N-(furan-2-ylmethyl)-2-pyridin-4-ylsulfanylacetamide —— C19H24N2O2S
    N-(cyclohexylmethyl)-N-(furan-2-ylmethyl)-2-pyridin-4-ylsulfanylacetamide
    —— 2-[(Z)-(4-methylsulfanylphenyl)methylideneamino]guanidine —— C9H12N4S
    2-[(Z)-(4-methylsulfanylphenyl)methylideneamino]guanidine
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide —— C23H20N4O2S
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(4-oxo-1,2,3-benzotriazin-3-yl)acetamide
    —— N,N-dimethyl-3-[3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]aniline —— C18H17N5S2
    N,N-dimethyl-3-[3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]aniline
    —— 3-[(2-Hydroxyethyl)sulfanyl]-1-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C16H21N3O2S
    3-[(2-Hydroxyethyl)sulfanyl]-1-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 2-[4-chloro-6-[cyclohexyl(methyl)amino]pyrimidin-2-yl]sulfanyl-N-(2-pyrrolidin-1-ylethyl)acetamide —— C19H30ClN5OS
    2-[4-chloro-6-[cyclohexyl(methyl)amino]pyrimidin-2-yl]sulfanyl-N-(2-pyrrolidin-1-ylethyl)acetamide
    —— propan-2-yl N'-acetylcarbamimidothioate —— C6H12N2OS
    propan-2-yl N'-acetylcarbamimidothioate
    —— (6R)-6-(2,3-dimethylanilino)-2-(ethylamino)-4-ethylimino-7H-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-ol —— C17H24N6OS
    (6R)-6-(2,3-dimethylanilino)-2-(ethylamino)-4-ethylimino-7H-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-ol
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(3R)-3-phenyl-3,4-dihydropyrazol-2-yl]ethanone —— C19H15ClN4O2S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(3R)-3-phenyl-3,4-dihydropyrazol-2-yl]ethanone