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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(E)-1-(4-fluorophenyl)ethylideneamino]-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine —— C13H14FN5S
    N-[(E)-1-(4-fluorophenyl)ethylideneamino]-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine
    —— 2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(1H-pyrrol-2-yl)ethanone —— C14H10FN3OS3
    2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(1H-pyrrol-2-yl)ethanone
    —— N-[(E)-1-(4-bromophenyl)ethylideneamino]-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine —— C13H14BrN5S
    N-[(E)-1-(4-bromophenyl)ethylideneamino]-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine
    —— 3-[(4-chlorophenyl)methylsulfanyl]-N-[(E)-1-phenylethylideneamino]-1H-1,2,4-triazol-5-amine —— C17H16ClN5S
    3-[(4-chlorophenyl)methylsulfanyl]-N-[(E)-1-phenylethylideneamino]-1H-1,2,4-triazol-5-amine
    —— N-benzyl-2-[[5-[(2E)-2-(1-phenylethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H20N6OS
    N-benzyl-2-[[5-[(2E)-2-(1-phenylethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 1-(2-adamantyl)-2-[[5-[(2E)-2-(1-thiophen-2-ylethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C20H25N5OS2
    1-(2-adamantyl)-2-[[5-[(2E)-2-(1-thiophen-2-ylethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 3-[(2-chlorophenyl)methylsulfanyl]-N-[(E)-1-pyridin-4-ylethylideneamino]-1H-1,2,4-triazol-5-amine —— C16H15ClN6S
    3-[(2-chlorophenyl)methylsulfanyl]-N-[(E)-1-pyridin-4-ylethylideneamino]-1H-1,2,4-triazol-5-amine
    —— N-[2-(4-fluorophenyl)ethyl]-2-[[5-[(2E)-2-(1-pyridin-2-ylethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H20FN7OS
    N-[2-(4-fluorophenyl)ethyl]-2-[[5-[(2E)-2-(1-pyridin-2-ylethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-(1-adamantylmethyl)-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C24H31N3O2S
    N-(1-adamantylmethyl)-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylacetamide —— C16H18ClN3O4S2
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylacetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylacetamide —— C16H18ClN3O4S2
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylacetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone —— C20H22ClN3O3S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— 2‐(2‐bromobenzylthio)−5‐(4‐chlorophenyl)−1,3,4‐oxadiazole —— C15H10BrClN2OS
    2‐(2‐bromobenzylthio)−5‐(4‐chlorophenyl)−1,3,4‐oxadiazole
    —— 1-[2-[[5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrrolidin-2-one —— C14H12ClN3O3S
    1-[2-[[5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrrolidin-2-one
    —— [2-(Cyclopentylamino)-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate —— C15H18BrNO3S
    [2-(Cyclopentylamino)-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate
    —— [2-Oxo-2-(propan-2-ylamino)ethyl] 2-(4-bromophenyl)sulfanylacetate —— C13H16BrNO3S
    [2-Oxo-2-(propan-2-ylamino)ethyl] 2-(4-bromophenyl)sulfanylacetate
    —— [2-[[(1S,2R)-2-methylcyclohexyl]amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate —— C17H22BrNO3S
    [2-[[(1S,2R)-2-methylcyclohexyl]amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate
    —— [2-[(1-Cyanocyclopentyl)amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate —— C16H17BrN2O3S
    [2-[(1-Cyanocyclopentyl)amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate
    —— [2-(Cyclohexylmethylamino)-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate —— C17H22BrNO3S
    [2-(Cyclohexylmethylamino)-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C16H19N3O4S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C16H19N3O4S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-(2-cyanoethyl)-2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C18H23N5OS2
    N-(2-cyanoethyl)-2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-N-(4-methylphenyl)-1,3-thiazol-2-amine —— C19H19N5OS2
    4-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-N-(4-methylphenyl)-1,3-thiazol-2-amine
    —— methyl 2-[[5-[(2Z)-2-benzylidenehydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetate —— C12H13N5O2S
    methyl 2-[[5-[(2Z)-2-benzylidenehydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 7-[(4-Chlorophenyl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C14H11ClN2OS2
    7-[(4-Chlorophenyl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2S)-4-phenylbutan-2-yl]propanamide —— C19H22ClNOS
    (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2S)-4-phenylbutan-2-yl]propanamide
    —— N-(1-adamantylmethyl)-2-(4-chlorophenyl)sulfanylacetamide —— C19H24ClNOS
    N-(1-adamantylmethyl)-2-(4-chlorophenyl)sulfanylacetamide
    —— [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 2-thiophen-2-ylacetate —— C22H21NO3S2
    [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 2-thiophen-2-ylacetate
    —— 4-[(4-chlorophenyl)sulfanylmethyl]-N-(4-methylphenyl)-1,3-thiazol-2-amine —— C17H15ClN2S2
    4-[(4-chlorophenyl)sulfanylmethyl]-N-(4-methylphenyl)-1,3-thiazol-2-amine
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-1-methoxypropan-2-yl]acetamide —— C16H22N4O2S2
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-1-methoxypropan-2-yl]acetamide
    —— [2-[2-(4-Chlorophenyl)sulfanylanilino]-2-oxoethyl] 4-aminobenzoate —— C21H17ClN2O3S
    [2-[2-(4-Chlorophenyl)sulfanylanilino]-2-oxoethyl] 4-aminobenzoate
    —— (2R)-N-[2-(cyclohexen-1-yl)ethyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C21H28N4OS2
    (2R)-N-[2-(cyclohexen-1-yl)ethyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 4-aminobenzoate —— C23H22N2O3S
    [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 4-aminobenzoate
    —— 2-[5-[2-[(4-Methyl-1,3-thiazol-2-yl)sulfanyl]acetyl]thiophen-2-yl]-1-morpholin-4-ylethanone —— C16H18N2O3S3
    2-[5-[2-[(4-Methyl-1,3-thiazol-2-yl)sulfanyl]acetyl]thiophen-2-yl]-1-morpholin-4-ylethanone
    —— 2-[[5-[2-[(1-Cyanocyclohexyl)amino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C13H17N5O2S3
    2-[[5-[2-[(1-Cyanocyclohexyl)amino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide —— C15H17FN4O2S3
    (2R)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide
    —— 2-[[5-[(5-Phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C13H11N5O2S3
    2-[[5-[(5-Phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-ethanimidoyl-3-oxo-4-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]butanenitrile —— C13H19N5OS
    (2R)-2-ethanimidoyl-3-oxo-4-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]butanenitrile
    —— 2-[[5-[2-[Di(propan-2-yl)amino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C12H20N4O2S3
    2-[[5-[2-[Di(propan-2-yl)amino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2S)-2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclopropylpropanamide —— C14H24N6O2S2
    (2S)-2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclopropylpropanamide
    —— 2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R,2R)-2-methylcyclohexyl]acetamide —— C17H30N6O2S2
    2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R,2R)-2-methylcyclohexyl]acetamide
    —— N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C14H16N4O4S2
    N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C17H22N4O2S
    (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— [2-[Di(propan-2-yl)amino]-2-oxoethyl] 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate —— C18H22ClN3O4S
    [2-[Di(propan-2-yl)amino]-2-oxoethyl] 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
    —— 1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C17H15F3N4O2S
    1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— (2-Morpholin-4-yl-2-oxoethyl) 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate —— C16H16ClN3O5S
    (2-Morpholin-4-yl-2-oxoethyl) 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
    —— 2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide —— C17H30N6O2S2
    2-[[4-amino-5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide
    —— (2S)-N-[2-(cyclohexen-1-yl)ethyl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H22N4O2S
    (2S)-N-[2-(cyclohexen-1-yl)ethyl]-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— N-[(1S,2R)-2-methylcyclohexyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide —— C16H26N4OS
    N-[(1S,2R)-2-methylcyclohexyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide
    —— N-[(2R)-3-methylbutan-2-yl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide —— C14H24N4OS
    N-[(2R)-3-methylbutan-2-yl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide