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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-2-(4-amino-5-cyanopyrimidin-2-yl)sulfanyl-N-[(1R,2S)-2-methylcyclohexyl]propanamide —— C15H21N5OS
    (2S)-2-(4-amino-5-cyanopyrimidin-2-yl)sulfanyl-N-[(1R,2S)-2-methylcyclohexyl]propanamide
    —— (E)-2-hydroxy-N'-((4-oxo-2-(phenylthio)-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)benzohydrazide —— C22H16N4O3S
    (E)-2-hydroxy-N'-((4-oxo-2-(phenylthio)-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)benzohydrazide
    —— 2,2'-(1,3,4-thiadiazole-2,5-diyldisulfanediyl)bis{N'-[(1E)-1-phenylethylidene]acetohydrazide} —— C22H22N6O2S3
    2,2'-(1,3,4-thiadiazole-2,5-diyldisulfanediyl)bis{N'-[(1E)-1-phenylethylidene]acetohydrazide}
    —— N'-[(E)-pyridin-3-ylmethylidene]-2-(pyrimidin-2-ylsulfanyl)acetohydrazide —— C12H11N5OS
    N'-[(E)-pyridin-3-ylmethylidene]-2-(pyrimidin-2-ylsulfanyl)acetohydrazide
    —— N-[(E)-(4-methylsulfanylphenyl)methylideneamino]cyclohexanecarboxamide —— C15H20N2OS
    N-[(E)-(4-methylsulfanylphenyl)methylideneamino]cyclohexanecarboxamide
    —— N-[(E)-[5-(dimethylamino)furan-2-yl]methylideneamino]-2-[[5-[1-[(2E)-2-[[5-(dimethylamino)furan-2-yl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C22H28N8O4S3
    N-[(E)-[5-(dimethylamino)furan-2-yl]methylideneamino]-2-[[5-[1-[(2E)-2-[[5-(dimethylamino)furan-2-yl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E,2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C19H19N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E,2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(E)-[2,5-bis(methylsulfanyl)-4-[(E)-(octanoylhydrazinylidene)methyl]thiophen-3-yl]methylideneamino]octanamide —— C24H40N4O2S3
    N-[(E)-[2,5-bis(methylsulfanyl)-4-[(E)-(octanoylhydrazinylidene)methyl]thiophen-3-yl]methylideneamino]octanamide
    —— 3-[(E)-[2-(difluoromethoxy)phenyl]methylideneamino]-6-(2-nitrophenyl)sulfanyl-5-phenylthieno[2,3-d]pyrimidin-4-one —— C26H16F2N4O4S2
    3-[(E)-[2-(difluoromethoxy)phenyl]methylideneamino]-6-(2-nitrophenyl)sulfanyl-5-phenylthieno[2,3-d]pyrimidin-4-one
    —— 2-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1-phenylcyclopropyl)methyl]acetamide —— C25H35N5O2S
    2-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1-phenylcyclopropyl)methyl]acetamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(2,5-difluorophenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C16H13F2N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(2,5-difluorophenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-pentyl-3-phenylacrylaldehyde N-[6-chloro-2-(methylsulfanyl)-4-pyrimidinyl]hydrazone —— C19H23ClN4S
    2-pentyl-3-phenylacrylaldehyde N-[6-chloro-2-(methylsulfanyl)-4-pyrimidinyl]hydrazone
    —— 2-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1-phenylcyclopropyl)methyl]acetamide —— C25H35N5O2S
    2-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1-phenylcyclopropyl)methyl]acetamide
    —— 1-cyclohexyl-3-[(E)-(4-methylsulfanylphenyl)methylideneamino]thiourea —— C15H21N3S2
    1-cyclohexyl-3-[(E)-(4-methylsulfanylphenyl)methylideneamino]thiourea
    —— methyl 2-{[4-[(methoxyimino)methyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate —— C15H14F3N3O3S
    methyl 2-{[4-[(methoxyimino)methyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}benzenecarboxylate
    —— N-[(E)-(6-methylpyridin-2-yl)methylideneamino]-2-pyridin-2-ylsulfanylacetamide —— C14H14N4OS
    N-[(E)-(6-methylpyridin-2-yl)methylideneamino]-2-pyridin-2-ylsulfanylacetamide
    —— 3-[4-(furan-2-ylmethyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C18H18N6O3S2
    3-[4-(furan-2-ylmethyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— 2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(pyridin-4-yl)ethylidene]acetohydrazide —— C19H19N5OS3
    2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(pyridin-4-yl)ethylidene]acetohydrazide
    —— 3-[5-[(2R)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-1-oxopropan-2-yl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide —— C21H25N5O4S
    3-[5-[(2R)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-1-oxopropan-2-yl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[(2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-1-oxopropan-2-yl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide —— C21H25N5O4S
    3-[5-[(2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-1-oxopropan-2-yl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]propanamide
    —— [(2R)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C18H22N2O4S
    [(2R)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— N'-[(1E)-phenylmethylene]-2-(phenylthio)propanohydrazide —— C16H16N2OS
    N'-[(1E)-phenylmethylene]-2-(phenylthio)propanohydrazide
    —— (2R)-2-[[4-(3-amino-3-oxopropyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylpropyl)propanamide —— C16H23N5O2S2
    (2R)-2-[[4-(3-amino-3-oxopropyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylpropyl)propanamide
    —— 3-[4-(furan-2-ylmethyl)-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C18H18N6O3S2
    3-[4-(furan-2-ylmethyl)-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— [(2S)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C18H22N2O4S
    [(2S)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— [(2R)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C18H22N2O4S
    [(2R)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— [(2S)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C18H22N2O4S
    [(2S)-1-(4-acetylpiperazin-1-yl)-1-oxopropan-2-yl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— N-[(E)-benzylideneamino]-2-(4,6-dimethoxypyrimidin-2-yl)sulfanylacetamide —— C15H16N4O3S
    N-[(E)-benzylideneamino]-2-(4,6-dimethoxypyrimidin-2-yl)sulfanylacetamide
    —— N-(1-cyanocycloheptyl)-2-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C23H36N6O2S
    N-(1-cyanocycloheptyl)-2-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 3-bromo-N'-[(E)-{5-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide —— C21H16BrN3O3S2
    3-bromo-N'-[(E)-{5-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide
    —— 4-([(3Z)-5-(4-Chloroanilino)-4-(4-chlorophenyl)-4,5-dihydro-3H-1,2,4-triazol-3-ylidene]amino)-6-methyl-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one —— C19H16Cl2N8OS
    4-([(3Z)-5-(4-Chloroanilino)-4-(4-chlorophenyl)-4,5-dihydro-3H-1,2,4-triazol-3-ylidene]amino)-6-methyl-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one
    —— N'-[(E)-{5-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl}methylidene]pyridine-4-carbohydrazide —— C25H18N6O2S
    N'-[(E)-{5-[(4,5-diphenyl-4H-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl}methylidene]pyridine-4-carbohydrazide
    —— 3-(benzylsulfanyl)-5-[(2E)-2-(4-bromobenzylidene)hydrazinyl]-1,2-thiazole-4-carbonitrile —— C18H13BrN4S2
    3-(benzylsulfanyl)-5-[(2E)-2-(4-bromobenzylidene)hydrazinyl]-1,2-thiazole-4-carbonitrile
    —— 4-fluoro-N'-[(E)-{5-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide —— C26H17FN4O3S
    4-fluoro-N'-[(E)-{5-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide
    —— N'-[(E)-[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene]-3-hydroxybenzohydrazide —— C21H14N4O4S2
    N'-[(E)-[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene]-3-hydroxybenzohydrazide
    —— (2R)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C14H24N4O2S
    (2R)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2S)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C14H24N4O2S
    (2S)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 3-nitro-N'-[(E)-{5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide —— C19H11N5O6S2
    3-nitro-N'-[(E)-{5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide
    —— N',N''-{sulfanediylbis[furan-5,2-diyl(E)methylylidene]}bis[2-(2-bromo-4-methoxyphenoxy)acetohydrazide] —— C28H24Br2N4O8S
    N',N''-{sulfanediylbis[furan-5,2-diyl(E)methylylidene]}bis[2-(2-bromo-4-methoxyphenoxy)acetohydrazide]
    —— (2R)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C14H24N4O2S
    (2R)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (R)-[1-[2-(4-chlorophenyl)sulfanylethyl]piperidin-4-yl]-phenylmethanol —— C20H24ClNOS
    (R)-[1-[2-(4-chlorophenyl)sulfanylethyl]piperidin-4-yl]-phenylmethanol
    —— (S)-[1-[2-(4-chlorophenyl)sulfanylethyl]piperidin-4-yl]-phenylmethanol —— C20H24ClNOS
    (S)-[1-[2-(4-chlorophenyl)sulfanylethyl]piperidin-4-yl]-phenylmethanol
    —— (2S)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C14H24N4O2S
    (2S)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 2-[(3-butyl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C18H22N4O2S
    2-[(3-butyl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-(Phenylsulfanyl)-N'-[(E)-(pyridin-4-YL)methylidene]propanehydrazide —— C15H15N3OS
    2-(Phenylsulfanyl)-N'-[(E)-(pyridin-4-YL)methylidene]propanehydrazide
    —— 2-[(3-butyl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C18H22N4O2S
    2-[(3-butyl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 3-(3,4-dimethylphenyl)sulfanyl-N-[(1S,2S)-2-(trifluoromethyl)cyclohexyl]propanamide —— C18H24F3NOS
    3-(3,4-dimethylphenyl)sulfanyl-N-[(1S,2S)-2-(trifluoromethyl)cyclohexyl]propanamide
    —— 3-(3,4-dimethylphenyl)sulfanyl-N-[(1R,2S)-2-(trifluoromethyl)cyclohexyl]propanamide —— C18H24F3NOS
    3-(3,4-dimethylphenyl)sulfanyl-N-[(1R,2S)-2-(trifluoromethyl)cyclohexyl]propanamide
    —— (2S)-N-[(1S,2S)-2-methylcyclohexyl]-2-methylsulfonylpropanamide —— C11H21NO3S
    (2S)-N-[(1S,2S)-2-methylcyclohexyl]-2-methylsulfonylpropanamide
    —— 3-(3,4-dimethylphenyl)sulfanyl-N-[(1S,2R)-2-(trifluoromethyl)cyclohexyl]propanamide —— C18H24F3NOS
    3-(3,4-dimethylphenyl)sulfanyl-N-[(1S,2R)-2-(trifluoromethyl)cyclohexyl]propanamide