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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)ethyl]acetamide —— C16H16N4O3S3
    2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)ethyl]acetamide
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H18ClN3O2S
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(4-Methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-thiophen-2-ylethanone —— C15H12N2O2S2
    2-[[5-(4-Methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-thiophen-2-ylethanone
    —— N-(2-cyanoethyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C14H14N4O2S
    N-(2-cyanoethyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-(2-methoxyethyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C14H17N3O3S
    N-(2-methoxyethyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— methyl 2,4-dimethyl-5-[(2R)-2-[2-(2-methylphenyl)sulfanylacetyl]oxypropanoyl]-1H-pyrrole-3-carboxylate —— C20H23NO5S
    methyl 2,4-dimethyl-5-[(2R)-2-[2-(2-methylphenyl)sulfanylacetyl]oxypropanoyl]-1H-pyrrole-3-carboxylate
    —— [2-[(1-Cyanocyclohexyl)amino]-2-oxoethyl] 2-(2-methylphenyl)sulfanylacetate —— C18H22N2O3S
    [2-[(1-Cyanocyclohexyl)amino]-2-oxoethyl] 2-(2-methylphenyl)sulfanylacetate
    —— (5-Phenyl-1,3,4-oxadiazol-2-yl)methyl 2-(2-methylphenyl)sulfanylacetate —— C18H16N2O3S
    (5-Phenyl-1,3,4-oxadiazol-2-yl)methyl 2-(2-methylphenyl)sulfanylacetate
    —— [5-(4-Bromophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium —— C15H17BrN5OS+
    [5-(4-Bromophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium
    —— (2S)-N-(1-cyanocyclohexyl)-2-(4-fluorophenyl)sulfanylpropanamide —— C16H19FN2OS
    (2S)-N-(1-cyanocyclohexyl)-2-(4-fluorophenyl)sulfanylpropanamide
    —— (2R)-N-(1-cyanocyclohexyl)-2-(4-fluorophenyl)sulfanylpropanamide —— C16H19FN2OS
    (2R)-N-(1-cyanocyclohexyl)-2-(4-fluorophenyl)sulfanylpropanamide
    —— [2-[4-(3,4-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 3,5-dimethyl-1,2-oxazole-4-carboxylate —— C22H22N2O4S
    [2-[4-(3,4-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 3,5-dimethyl-1,2-oxazole-4-carboxylate
    —— N,N-dimethyl-4-[(2S,5S)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline —— C21H25N4O2S+
    N,N-dimethyl-4-[(2S,5S)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline
    —— 4-[(2S,5R)-5-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline —— C19H24N5O2S+
    4-[(2S,5R)-5-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline
    —— 4-[(2S,5S)-5-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline —— C19H24N5O2S+
    4-[(2S,5S)-5-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline
    —— 4-[(2S,5R)-5-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]-N,N-dimethylaniline —— C22H26N4O2S
    4-[(2S,5R)-5-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]-N,N-dimethylaniline
    —— N,N-dimethyl-4-[(2R,5R)-5-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline —— C20H26N5O2S+
    N,N-dimethyl-4-[(2R,5R)-5-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline
    —— N,N-dimethyl-4-[(2R,5S)-5-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline —— C21H25N4O2S+
    N,N-dimethyl-4-[(2R,5S)-5-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline
    —— N,N-dimethyl-4-[(2R,5S)-5-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline —— C20H26N5O2S+
    N,N-dimethyl-4-[(2R,5S)-5-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline
    —— ethyl 2-[2-[[(2S,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-1,3-thiazol-4-yl]acetate —— C19H25N3O3S2
    ethyl 2-[2-[[(2S,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-1,3-thiazol-4-yl]acetate
    —— 4-[(2R,5S)-5-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline —— C20H22FN4O2S+
    4-[(2R,5S)-5-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]-N,N-dimethylaniline
    —— 4-[(2R,5S)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]-N,N-dimethylaniline —— C18H20N4O3S
    4-[(2R,5S)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]-N,N-dimethylaniline
    —— N,N-dimethyl-4-[(2R,5R)-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline —— C18H21N5OS2
    N,N-dimethyl-4-[(2R,5R)-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline
    —— N,N-dimethyl-4-[(2S,5S)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline —— C20H22N4O2S
    N,N-dimethyl-4-[(2S,5S)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline
    —— N,N-dimethyl-4-[(2R,5S)-5-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline —— C21H24N4O2S
    N,N-dimethyl-4-[(2R,5S)-5-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline
    —— N,N-dimethyl-4-[(2S,5S)-5-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline —— C21H24N4O2S
    N,N-dimethyl-4-[(2S,5S)-5-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3-oxazolidin-2-yl]aniline
    —— 5-[[(2S,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H19N5OS2
    5-[[(2S,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 5-[[(2S,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H19N5OS2
    5-[[(2S,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— (2R)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclohexyl-N-methylpropanamide —— C18H22ClN3O2S
    (2R)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclohexyl-N-methylpropanamide
    —— 5-Benzylsulfanyl-3-(4-fluorophenyl)-1,3,4-thiadiazole-2-thione —— C15H11FN2S3
    5-Benzylsulfanyl-3-(4-fluorophenyl)-1,3,4-thiadiazole-2-thione
    —— (2S)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C17H19FN4OS3
    (2S)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2R)-2-methylcyclohexyl]propanamide —— C18H22FN3OS3
    (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2R)-2-methylcyclohexyl]propanamide
    —— (2R)-1-(4-ethylpiperazin-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one —— C17H21FN4OS3
    (2R)-1-(4-ethylpiperazin-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one
    —— (2S)-1-(4-ethylpiperazin-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one —— C17H21FN4OS3
    (2S)-1-(4-ethylpiperazin-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one
    —— 2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)acetamide —— C15H12FN3O2S3
    2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)acetamide
    —— (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]propanamide —— C18H22FN3OS3
    (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]propanamide
    —— (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one —— C17H22FN4OS3+
    (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one
    —— (2R)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C17H19FN4OS3
    (2R)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-[[6-(2-aminophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]-N-(1-cyanocyclopentyl)acetamide —— C17H18N6O2S
    2-[[6-(2-aminophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]-N-(1-cyanocyclopentyl)acetamide
    —— ethyl N-[2-[[6-(2-aminophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]acetyl]carbamate —— C14H15N5O4S
    ethyl N-[2-[[6-(2-aminophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]acetyl]carbamate
    —— N-(4,5-dihydro-1,3-thiazol-2-yl)-2-(2-fluorophenyl)sulfanylacetamide —— C11H11FN2OS2
    N-(4,5-dihydro-1,3-thiazol-2-yl)-2-(2-fluorophenyl)sulfanylacetamide
    —— 2-(3-Chlorophenyl)-5-[(3-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazole —— C15H10Cl2N2OS
    2-(3-Chlorophenyl)-5-[(3-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methylacetamide —— C15H16ClN3O4S2
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methylacetamide
    —— N-[2-(4-chlorophenyl)ethyl]-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H15Cl2N3O2S
    N-[2-(4-chlorophenyl)ethyl]-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(1R,5S)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone —— C20H24ClN3O2S
    2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(1R,5S)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone
    —— 2-(3-Chlorophenyl)-5-[(2,5-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazole —— C17H15ClN2OS
    2-(3-Chlorophenyl)-5-[(2,5-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-(3-Chlorophenyl)-5-[(4-methylsulfanylphenyl)methylsulfanyl]-1,3,4-oxadiazole —— C16H13ClN2OS2
    2-(3-Chlorophenyl)-5-[(4-methylsulfanylphenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[(2-Bromophenyl)methylsulfanyl]-5-(3-chlorophenyl)-1,3,4-oxadiazole —— C15H10BrClN2OS
    2-[(2-Bromophenyl)methylsulfanyl]-5-(3-chlorophenyl)-1,3,4-oxadiazole
    —— 2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylbutyl]acetamide —— C15H20N4OS
    2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylbutyl]acetamide
    —— 2-[2-(2,5-dimethylthiophen-3-yl)-2-oxoethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C15H18N2O2S2
    2-[2-(2,5-dimethylthiophen-3-yl)-2-oxoethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one