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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-(3,4-dimethylphenyl)sulfanylpropanamide —— C17H24N2OS
    (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-(3,4-dimethylphenyl)sulfanylpropanamide
    —— [2-[[4-(Dimethylamino)phenyl]methyl-methylamino]-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate —— C22H28N2O3S
    [2-[[4-(Dimethylamino)phenyl]methyl-methylamino]-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate
    —— [2-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate —— C21H22O5S
    [2-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate
    —— [2-[[4-(Dimethylamino)phenyl]methyl-methylamino]-2-oxoethyl] 2-(2-fluorophenyl)sulfanylacetate —— C20H23FN2O3S
    [2-[[4-(Dimethylamino)phenyl]methyl-methylamino]-2-oxoethyl] 2-(2-fluorophenyl)sulfanylacetate
    —— 3-benzylsulfanyl-4-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione —— C17H16N4S3
    3-benzylsulfanyl-4-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione
    —— (5R)-N-[2-(4-chlorophenyl)sulfanylethyl]-5-methyl-4,5-dihydro-1,3-thiazol-2-amine —— C12H15ClN2S2
    (5R)-N-[2-(4-chlorophenyl)sulfanylethyl]-5-methyl-4,5-dihydro-1,3-thiazol-2-amine
    —— 2-[(3-tert-butyl-4-oxo-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-7-yl)sulfanyl]-N,N-bis(2-methylpropyl)acetamide —— C18H29N5O2S2
    2-[(3-tert-butyl-4-oxo-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-7-yl)sulfanyl]-N,N-bis(2-methylpropyl)acetamide
    —— (1'S,2S,4S,5'R,6'S)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H16N4O2S
    (1'S,2S,4S,5'R,6'S)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (1'S,2S,4S,5'S,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H16N4O2S
    (1'S,2S,4S,5'S,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (2S,3S,4R,5S)-1,1-bis(ethylsulfanyl)hexane-2,3,4,5-tetrol —— C10H22O4S2
    (2S,3S,4R,5S)-1,1-bis(ethylsulfanyl)hexane-2,3,4,5-tetrol
    —— N'-(2-phenylsulfanylacetyl)-1H-pyrrole-2-carbohydrazide —— C13H13N3O2S
    N'-(2-phenylsulfanylacetyl)-1H-pyrrole-2-carbohydrazide
    —— N'-[2-(3,4-dimethylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide —— C15H17N3O2S
    N'-[2-(3,4-dimethylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide
    —— 2-(4-methylphenyl)-5-[(1S)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole —— C15H14N4OS
    2-(4-methylphenyl)-5-[(1S)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole
    —— 2-(4-methylphenyl)-5-[(1S)-1-(1-oxidopyridin-1-ium-2-yl)sulfanylethyl]-1,3,4-oxadiazole —— C16H15N3O2S
    2-(4-methylphenyl)-5-[(1S)-1-(1-oxidopyridin-1-ium-2-yl)sulfanylethyl]-1,3,4-oxadiazole
    —— N-[[1-[(3S)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-phenylsulfanylacetamide —— C19H25N3O3S2
    N-[[1-[(3S)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-phenylsulfanylacetamide
    —— 5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(3,4-dimethylphenyl)-1,3,4-thiadiazol-2-amine —— C19H19N5O2S2
    5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(3,4-dimethylphenyl)-1,3,4-thiadiazol-2-amine
    —— Ethyl 4-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate —— C15H19N3O2S2
    Ethyl 4-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate
    —— Ethyl 4-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate —— C16H21N3O2S2
    Ethyl 4-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate
    —— 4-[(Z)-[4-(azepan-1-yl)phenyl]methylideneamino]-3-benzylsulfanyl-1H-1,2,4-triazole-5-thione —— C22H25N5S2
    4-[(Z)-[4-(azepan-1-yl)phenyl]methylideneamino]-3-benzylsulfanyl-1H-1,2,4-triazole-5-thione
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-(3,6-dioxo-1H-pyridazin-2-yl)acetamide —— C20H19N3O3S
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-(3,6-dioxo-1H-pyridazin-2-yl)acetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(2-fluorophenyl)methyl]acetamide —— C16H15BrFNOS
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(2-fluorophenyl)methyl]acetamide
    —— N-(3-methylphenyl)-5-[[(2S)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H17N3OS2
    N-(3-methylphenyl)-5-[[(2S)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-ethylpropanamide —— C13H16N4OS2
    (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-ethylpropanamide
    —— 2-[[5-(2,3-Dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol —— C12H15N3OS2
    2-[[5-(2,3-Dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol
    —— N-(3-methylphenyl)-5-[[(2R)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H17N3OS2
    N-(3-methylphenyl)-5-[[(2R)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— [2-[(4-fluorophenyl)methylamino]-2-oxoethyl] 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetate —— C18H16FN3O4S
    [2-[(4-fluorophenyl)methylamino]-2-oxoethyl] 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetate
    —— [2-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-oxoethyl] 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetate —— C20H23N3O4S
    [2-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-oxoethyl] 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetate
    —— [2-[2-(4-fluorophenyl)ethylamino]-2-oxoethyl] 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetate —— C19H18FN3O4S
    [2-[2-(4-fluorophenyl)ethylamino]-2-oxoethyl] 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetate
    —— (2R)-N-ethyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C14H18N4OS2
    (2R)-N-ethyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-Ethanimidoyl-4-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxobutanenitrile —— C14H12FN5OS2
    2-Ethanimidoyl-4-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxobutanenitrile
    —— N-(2-methylphenyl)-5-[[(2R)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H17N3OS2
    N-(2-methylphenyl)-5-[[(2R)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(2,4-dimethylphenyl)-5-[[(2R)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H19N3OS2
    N-(2,4-dimethylphenyl)-5-[[(2R)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-[(1S)-3-methyl-1-phenylbutyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C17H21N3O2S
    N-[(1S)-3-methyl-1-phenylbutyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— (2S)-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C15H20N4OS2
    (2S)-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide
    —— (2S)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C15H20N4OS2
    (2S)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide
    —— (2R)-N,N-dimethyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C14H18N4OS2
    (2R)-N,N-dimethyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]propanenitrile —— C14H16N4OS2
    (2S)-2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]propanenitrile
    —— 1-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-3-pentylthiourea —— C14H21N3S2
    1-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-3-pentylthiourea
    —— ethyl (2S)-2-phenyl-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetate —— C17H21N3O2S
    ethyl (2S)-2-phenyl-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetate
    —— 2-methyl-4-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole —— C16H18N4OS3
    2-methyl-4-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole
    —— (4R)-N-[2-(4-chlorophenyl)sulfanylethyl]-4-ethyl-1,3-thiazolidin-2-imine —— C13H17ClN2S2
    (4R)-N-[2-(4-chlorophenyl)sulfanylethyl]-4-ethyl-1,3-thiazolidin-2-imine
    —— 2-[[4-amino-5-[(2S)-2-phenylpropyl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C13H16N4O2S
    2-[[4-amino-5-[(2S)-2-phenylpropyl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— (2S)-2-ethanimidoyl-3-oxo-4-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanenitrile —— C11H15N5OS2
    (2S)-2-ethanimidoyl-3-oxo-4-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanenitrile
    —— (2S)-4-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C17H15N5OS3
    (2S)-4-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— 2-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C17H17FN4O2S
    2-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one
    —— [2-[(1-Cyanocyclohexyl)amino]-2-oxoethyl] 2-phenylsulfanylacetate —— C17H20N2O3S
    [2-[(1-Cyanocyclohexyl)amino]-2-oxoethyl] 2-phenylsulfanylacetate
    —— N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C18H27N3O4S2
    N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— [(2R)-1-[[(1S,2S)-2-methylcyclohexyl]amino]-1-oxopropan-2-yl] 2-phenylsulfanylacetate —— C18H25NO3S
    [(2R)-1-[[(1S,2S)-2-methylcyclohexyl]amino]-1-oxopropan-2-yl] 2-phenylsulfanylacetate
    —— [(2R)-1-(1-adamantylamino)-1-oxopropan-2-yl] 2-phenylsulfanylacetate —— C21H27NO3S
    [(2R)-1-(1-adamantylamino)-1-oxopropan-2-yl] 2-phenylsulfanylacetate
    —— [(2R)-1-[(1-cyanocyclohexyl)amino]-1-oxopropan-2-yl] 2-phenylsulfanylacetate —— C18H22N2O3S
    [(2R)-1-[(1-cyanocyclohexyl)amino]-1-oxopropan-2-yl] 2-phenylsulfanylacetate