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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(4-chlorophenyl)methyl]-2-(2,4-difluorophenyl)sulfanylacetamide —— C15H12ClF2NOS
    N-[(4-chlorophenyl)methyl]-2-(2,4-difluorophenyl)sulfanylacetamide
    —— (1R,2S)-1-(5-chlorothiophen-2-yl)-1-pyrimidin-4-ylsulfanylpropan-2-amine —— C11H12ClN3S2
    (1R,2S)-1-(5-chlorothiophen-2-yl)-1-pyrimidin-4-ylsulfanylpropan-2-amine
    —— 2-[[5-ethyl-4-[(3R)-6-oxopiperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C11H16N4O3S
    2-[[5-ethyl-4-[(3R)-6-oxopiperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— 2-[[5-[[(3R)-6-oxopiperidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetic acid —— C9H12N4O3S2
    2-[[5-[[(3R)-6-oxopiperidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetic acid
    —— (1R,2S)-1-(3-methylphenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine —— C15H19N3S
    (1R,2S)-1-(3-methylphenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine
    —— (1S,2S)-1-(3-bromophenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine —— C14H16BrN3S
    (1S,2S)-1-(3-bromophenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine
    —— (1S)-1-(3-aminophenyl)-2-pyrimidin-4-ylsulfanylethanol —— C12H13N3OS
    (1S)-1-(3-aminophenyl)-2-pyrimidin-4-ylsulfanylethanol
    —— 2-[[5-[[(3S)-6-oxopiperidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetic acid —— C9H12N4O3S2
    2-[[5-[[(3S)-6-oxopiperidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetic acid
    —— 5-fluoro-N'-hydroxy-2-phenylsulfanylbenzenecarboximidamide —— C13H11FN2OS
    5-fluoro-N'-hydroxy-2-phenylsulfanylbenzenecarboximidamide
    —— 2-[4-oxo-1-[(3S)-6-oxopiperidin-3-yl]pyrimidin-2-yl]sulfanylacetic acid —— C11H13N3O4S
    2-[4-oxo-1-[(3S)-6-oxopiperidin-3-yl]pyrimidin-2-yl]sulfanylacetic acid
    —— 2-[4-oxo-1-[(3R)-6-oxopiperidin-3-yl]pyrimidin-2-yl]sulfanylacetic acid —— C11H13N3O4S
    2-[4-oxo-1-[(3R)-6-oxopiperidin-3-yl]pyrimidin-2-yl]sulfanylacetic acid
    —— N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-(2-fluorophenyl)sulfanylacetamide —— C18H20FNOS
    N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-(2-fluorophenyl)sulfanylacetamide
    —— (Z)-[(3E)-3-hydrazinylidene-1-[(S)-methylsulfinyl]-4-[(R)-methylsulfinyl]butan-2-ylidene]hydrazine —— C6H14N4O2S2
    (Z)-[(3E)-3-hydrazinylidene-1-[(S)-methylsulfinyl]-4-[(R)-methylsulfinyl]butan-2-ylidene]hydrazine
    —— 2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-5-fluoro-N'-hydroxybenzenecarboximidamide —— C11H12FN5OS
    2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-5-fluoro-N'-hydroxybenzenecarboximidamide
    —— (Z)-[(3Z)-3-hydrazinylidene-1-[(R)-methylsulfinyl]-4-[(S)-methylsulfinyl]butan-2-ylidene]hydrazine —— C6H14N4O2S2
    (Z)-[(3Z)-3-hydrazinylidene-1-[(R)-methylsulfinyl]-4-[(S)-methylsulfinyl]butan-2-ylidene]hydrazine
    —— 3-(3,4-difluorophenyl)sulfanyl-N-[(1S)-1-phenylethyl]propanamide —— C17H17F2NOS
    3-(3,4-difluorophenyl)sulfanyl-N-[(1S)-1-phenylethyl]propanamide
    —— (E)-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-(5-methylthiophen-2-yl)prop-2-enoate —— C16H10ClN2O3S2-
    (E)-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-(5-methylthiophen-2-yl)prop-2-enoate
    —— 2-[[6-(3,4-difluorophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1R,2S,3R)-2,3-dimethylcyclohexyl]acetamide —— C19H22F2N4O2S
    2-[[6-(3,4-difluorophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1R,2S,3R)-2,3-dimethylcyclohexyl]acetamide
    —— (2S)-2-(4-bromophenyl)-2-pyrimidin-4-ylsulfanylethanamine —— C12H12BrN3S
    (2S)-2-(4-bromophenyl)-2-pyrimidin-4-ylsulfanylethanamine
    —— (1S)-1-(4-aminophenyl)-2-pyrimidin-4-ylsulfanylethanol —— C12H13N3OS
    (1S)-1-(4-aminophenyl)-2-pyrimidin-4-ylsulfanylethanol
    —— (1R)-1-(4-aminophenyl)-2-pyrimidin-4-ylsulfanylethanol —— C12H13N3OS
    (1R)-1-(4-aminophenyl)-2-pyrimidin-4-ylsulfanylethanol
    —— (2S)-2-(2-methylphenyl)-2-pyrimidin-4-ylsulfanylethanamine —— C13H15N3S
    (2S)-2-(2-methylphenyl)-2-pyrimidin-4-ylsulfanylethanamine
    —— 2-[[6-(3,4-difluorophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1S,2S,3R)-2,3-dimethylcyclohexyl]acetamide —— C19H22F2N4O2S
    2-[[6-(3,4-difluorophenyl)-5-oxo-4H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1S,2S,3R)-2,3-dimethylcyclohexyl]acetamide
    —— 2-[[6-(3,4-difluorophenyl)-5-oxo-2H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]acetamide —— C19H22F2N4O2S
    2-[[6-(3,4-difluorophenyl)-5-oxo-2H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]acetamide
    —— (2R)-2-(4-bromophenyl)-2-pyrimidin-4-ylsulfanylethanamine —— C12H12BrN3S
    (2R)-2-(4-bromophenyl)-2-pyrimidin-4-ylsulfanylethanamine
    —— 5-fluoro-N'-hydroxy-2-(4-methylpyrimidin-2-yl)sulfanylbenzenecarboximidamide —— C12H11FN4OS
    5-fluoro-N'-hydroxy-2-(4-methylpyrimidin-2-yl)sulfanylbenzenecarboximidamide
    —— 2-[[6-(3,4-difluorophenyl)-5-oxo-2H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]acetamide —— C19H22F2N4O2S
    2-[[6-(3,4-difluorophenyl)-5-oxo-2H-1,2,4-triazin-3-yl]sulfanyl]-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]acetamide
    —— 5-fluoro-N'-hydroxy-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]benzenecarboximidamide —— C10H10FN5O2S
    5-fluoro-N'-hydroxy-2-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)sulfanyl]benzenecarboximidamide
    —— 5-fluoro-N'-hydroxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]benzenecarboximidamide —— C10H10FN5OS
    5-fluoro-N'-hydroxy-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]benzenecarboximidamide
    —— 5-fluoro-N'-hydroxy-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]benzenecarboximidamide —— C10H10FN5OS
    5-fluoro-N'-hydroxy-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]benzenecarboximidamide
    —— methyl (2E,5S)-7-methyl-2-[[5-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]furan-2-yl]methylidene]-3-oxo-5-(4-propan-2-ylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C26H24N4O5S2
    methyl (2E,5S)-7-methyl-2-[[5-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]furan-2-yl]methylidene]-3-oxo-5-(4-propan-2-ylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— methyl (2E,5R)-7-methyl-2-[[5-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]furan-2-yl]methylidene]-3-oxo-5-(4-propan-2-ylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C26H24N4O5S2
    methyl (2E,5R)-7-methyl-2-[[5-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]furan-2-yl]methylidene]-3-oxo-5-(4-propan-2-ylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— 1-[4-(3,4-Difluorophenyl)sulfanyl-3-nitrophenyl]sulfonylpiperidine —— C17H16F2N2O4S2
    1-[4-(3,4-Difluorophenyl)sulfanyl-3-nitrophenyl]sulfonylpiperidine
    —— 2-[[10-(morpholin-4-ium-4-ylmethyl)-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl]sulfanyl]-1H-pyrimidin-6-one —— C18H20N5O2S2+
    2-[[10-(morpholin-4-ium-4-ylmethyl)-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl]sulfanyl]-1H-pyrimidin-6-one
    —— 2-[5,6-dimethyl-2-[(4-methylpiperidin-1-ium-1-yl)methyl]thieno[2,3-d]pyrimidin-4-yl]sulfanyl-1H-pyrimidin-6-one —— C19H24N5OS2+
    2-[5,6-dimethyl-2-[(4-methylpiperidin-1-ium-1-yl)methyl]thieno[2,3-d]pyrimidin-4-yl]sulfanyl-1H-pyrimidin-6-one
    —— 2-[5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-1H-pyrimidin-6-one —— C16H9FN4OS2
    2-[5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-1H-pyrimidin-6-one
    —— 2-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1H-pyrimidin-6-one —— C16H10N4OS2
    2-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1H-pyrimidin-6-one
    —— 2-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1H-pyrimidin-6-one —— C13H10N4OS2
    2-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-1H-pyrimidin-6-one
    —— 3-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1H-1,2,4-triazol-5-amine —— C12H12N6OS
    3-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1H-1,2,4-triazol-5-amine
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(2-methylbutan-2-yl)cyclohexyl]acetamide —— C15H27N5OS
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(2-methylbutan-2-yl)cyclohexyl]acetamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[2-(2-methylphenyl)ethyl]acetamide —— C13H17N5OS
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[2-(2-methylphenyl)ethyl]acetamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-cyclopropyl-N-[(2-fluorophenyl)methyl]acetamide —— C14H16FN5OS
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-cyclopropyl-N-[(2-fluorophenyl)methyl]acetamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide —— C14H20N6OS
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-benzyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide —— C18H20N6OS2
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-benzyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide
    —— ethyl (2S)-2-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)sulfanyl]dodecanoate —— C17H29N3O4S
    ethyl (2S)-2-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)sulfanyl]dodecanoate
    —— 5-[(1S)-2-amino-1-(3-chlorophenyl)ethyl]sulfanyl-N,N-dimethyl-1,3,4-thiadiazol-2-amine —— C12H15ClN4S2
    5-[(1S)-2-amino-1-(3-chlorophenyl)ethyl]sulfanyl-N,N-dimethyl-1,3,4-thiadiazol-2-amine
    —— 5-[(1R)-2-amino-1-(3-chlorophenyl)ethyl]sulfanyl-N,N-dimethyl-1,3,4-thiadiazol-2-amine —— C12H15ClN4S2
    5-[(1R)-2-amino-1-(3-chlorophenyl)ethyl]sulfanyl-N,N-dimethyl-1,3,4-thiadiazol-2-amine
    —— 4-chloro-6-[(1S,3R)-3-methylcyclohexyl]sulfanyl-5-propan-2-ylpyrimidine —— C14H21ClN2S
    4-chloro-6-[(1S,3R)-3-methylcyclohexyl]sulfanyl-5-propan-2-ylpyrimidine
    —— ethyl (2S)-2-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)sulfanyl]decanoate —— C15H25N3O4S
    ethyl (2S)-2-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)sulfanyl]decanoate
    —— ethyl (2R)-2-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)sulfanyl]dodecanoate —— C17H29N3O4S
    ethyl (2R)-2-[(3,5-dioxo-2H-1,2,4-triazin-6-yl)sulfanyl]dodecanoate