黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | 3-hydroxy-5-acetoxy-7-methoxyflavone | 1265223-41-3 | C18H14O6 |
|
| —— | 3-(methoxymethyl)oxy-4'-(bromomethyl)flavone | 263153-73-7 | C18H15BrO4 |
|
| —— | Catechin 3-glucuronide | 94495-57-5 | C21H22O12 |
|
| —— | 6-hydroxy-5-formylflavone | 87232-92-6 | C16H10O4 |
|
| —— | 11-Phenyl-12-oxa-benzo[e]acephenanthrylen-9-one | 69864-32-0 | C25H14O2 |
|
| —— | 3,3'-dihydroxy-2,2'-(2,5,2',5'-tetramethoxy-biphenyl-4,4'-diyl)-bis-chromen-4-one | 63359-11-5 | C34H26O10 |
|
| —— | 5-Acetoxy-3,3',4',7-tetrakis(benzyloxy)-8-methoxyflavon | 62507-00-0 | C46H38O9 |
|
| —— | (4-Oxo-2-p-tolyl-4H-chromen-8-yl)-acetic acid 2-diethylamino-ethyl ester; hydrochloride | 87627-06-3 | C24H27NO4*ClH |
|
| —— | 3,6-Dimethoxy-7-benzyloxyflavone | 87232-87-9 | C24H20O5 |
|
| —— | 2-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-[(1-iminopropyl-3-methoxy)amino]-4H-1-benzopyran-4-one hydrochloride | 1187087-58-6 | C20H18N2O6 |
|
| —— | 2-(2-hydroxyphenyl)-3-phenyl-2H-1-benzopyran | 130406-87-0 | C21H16O2 |
|
| —— | 7,8-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-4H-chromen-4-one | 1377187-73-9 | C36H28O5 |
|
| —— | 3-(carbethoxycyanomethyl)-4'-methylflavone | 80907-32-0 | C21H17NO4 |
|
| —— | 2-<2-(benzyloxy)phenyl>-3-phenyl-2H-1-benzopyran | 130406-88-1 | C28H22O2 |
|
| —— | (1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide | 373631-15-3 | C26H25NO5 |
|
| —— | 1198053-60-9 | C17H11ClO4 |
|
|
| —— | 1203579-94-5 | C25H30O4S |
|
|
| —— | (2R,3S)-6-chloro-3-nitro-2-phenyl-3,4-dihydro-2H-chromene | 106824-22-0 | C15H12ClNO3 |
|
| —— | 6,8-dibromo-3-hydroxy-2-(3-methoxy-4-(methoxymethoxy)phenyl)-4H-chromen-4-one | 1609456-20-3 | C18H14Br2O6 |
|
| —— | N-[2-[3,4-bis(phenylmethoxy)phenyl]-3-hydroxy-6-methyl-4-oxochromen-8-yl]acetamide | 941269-56-3 | C32H27NO6 |
|
| —— | 8-acetylamino-6-methoxy-2-phenyl-chromen-4-one | 109806-21-5 | C18H15NO4 |
|
| —— | 2-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-[(1-iminoethyl-2-cyclopropylmethyl)amino]-4H-1-benzopyran-4-one | 1187087-57-5 | C21H18N2O5 |
|
| —— | (-)-balsacone F | 1572949-07-5 | C25H24O6 |
|
| —— | 1333313-19-1 | C18H17ClO5 |
|
|
| —— | 5,7,5',7'-tetramethoxy-2,2'-(5,6,5',6'-tetramethoxy-biphenyl-3,3'-diyl)-bis-chromen-4-one | 52222-82-9 | C38H34O12 |
|
| —— | 3',5'-bis(4-methylbenzyloxy)-7-[3-(2-chloro-benzylamino)-2-hydroxypropoxy]flavone | 1374792-23-0 | C41H38ClNO6 |
|
| —— | 6,4'-Dihydroxy-7,3'-dimethoxyflavone | 82298-11-1 | C17H14O6 |
|
| —— | 3',5,7-Trimethyl-6-benzyl-quercetagetin | 59171-32-3 | C25H22O8 |
|
| —— | (2R,3S,4S)-2-(2-Benzyloxy-4-methoxy-phenyl)-5,7-dimethoxy-chroman-3,4-diol | 56761-20-7 | C25H26O7 |
|
| —— | Dimethylsophoronol | 62499-02-9 | C23H24O7 |
|
| —— | 4-[(2,4-Dinitro-phenyl)-hydrazono]-2-phenyl-chroman-3-ol | 18500-74-8 | C21H16N4O6 |
|
| —— | 5,8-dihydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one | 859050-46-7 | C20H20O9 |
|
| —— | bonanniol A | 96917-35-0 | C25H28O6 |
|
| —— | [2,3-bis(2,2-dimethylpropanoyloxy)-5-[(2R,3R)-3-hydroxy-5,7-bis(phenylmethoxy)-3,4-dihydro-2H-chromen-2-yl]phenyl] 2,2-dimethylpropanoate | 1449477-36-4 | C44H50O10 |
|
| —— | Flavanon | 36745-34-3 | C17H16O5 |
|
| —— | 6-methoxykaemferol-3-O-β-D-glucosyl (1'''->2'')-β-D-glucopyranosyl-(6''''-(E)-caffeoyl)-7-O-β-D-glucopyranoside | 1005416-14-7 | C43H48O25 |
|
| —— | 6-methyl-2,4-diphenyl-2,3-dihydrofuro[3,2-c]pyridine | 1401693-73-9 | C20H17NO |
|
| —— | 1,1',1'',1''',1'''',1'''''-(12,32,52,72,92,112-hexahydroxy-1,3,5,7,9,11(1,3)-hexabenzenacyclododecaphane-15,35,55,75,95,115-hexayl)hexakis(butan-1-one) | 1268626-67-0 | C15H10O7*C85H140N2O69 |
|
| —— | 8-Methoxy-2-naphthalen-2-yl-3-nitro-2H-chromene | 106230-54-0 | C20H15NO4 |
|
| —— | (E)-N-tert-butyl-3-(7-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-3-yl)acrylamide | 1412410-89-9 | C24H25NO5 |
|
| —— | permethyl-6-C-β-D-glucopyranosylapigenin | 38953-87-6 | C28H34O10 |
|
| —— | 7-Morpholinomethylflavon | 50400-66-3 | C20H19NO3 |
|
| —— | 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride | 1443992-73-1 | C31H35NO5S*ClH |
|
| —— | 5,7,5',7'-tetraacetoxy-2,2'-bis-(4-acetoxy-phenyl)-[6,6']bichromenyl-4,4'-dione | 57403-17-5 | C42H30O16 |
|
| —— | (13S,14R,17S)-3-Methoxy-13-methyl-7-phenyl-7,11,12,13,14,15,16,17-octahydro-6-oxa-cyclopenta[a]phenanthren-17-ol | 58932-10-8 | C24H26O3 |
|
| —— | 3-{4-[2,8-bis-(tert-butyldimethylsilanyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl]phenoxy}propionic acid | 1056053-47-4 | C38H50O7Si2 |
|
| —— | 6-<(5-cyanopentyl)oxy>flavone | 140439-53-8 | C21H19NO3 |
|
| —— | (1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide | 373631-17-5 | C24H20F3NO5 |
|
| —— | 6,8-dibromo-2-(4-fluorophenyl)-4H-chromen-4-one | 1198475-10-3 | C15H7Br2FO2 |
|
| —— | 6,8-dibromo-3-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one | 1417634-86-6 | C16H10Br2O5 |
|
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