黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | (1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide | 373630-56-9 | C23H20ClNO4 |
|
| —— | 6-(4-methoxyphenyl)-6-methyldibenzo[d,f][1,3]dioxepine | 1332877-67-4 | C21H18O3 |
|
| —— | 1-[2-Hydroxy-4,6-bis-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-3-(4-methoxy-phenyl)-propan-1-one | 25218-12-6 | C28H36O15 |
|
| —— | 6-Chloro-2-phenyl-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione | 82320-13-6 | C17H13ClN2O3 |
|
| —— | 5-benzoyloxy-7,4'-dihydroxy-6-methoxyflavone | 117951-83-4 | C23H16O7 |
|
| —— | N-flavan-4β-ylbenzylamine | 88214-63-5 | C22H21NO |
|
| —— | 5,5'-dihydroxy-7,7'-dimethoxy-2,2'-bis-(4-methoxy-phenyl)-2,3,2',3'-tetrahydro-[6,8']bichromenyl-4,4'-dione | 58965-07-4 | C34H30O10 |
|
| —— | 5,8-Dihydroxy-6,7,3',4',5'-pentamethoxy-flavon | 29215-56-3 | C20H20O9 |
|
| —— | 2-(2,3-bis-benzyloxy-4-methoxy-phenyl)-5,7-dihydroxy-3-methoxy-chromen-4-one | 56128-27-9 | C31H26O8 |
|
| —— | 7-Allyloxy-2-(4-methoxy-phenyl)-chromen-4-one | 73937-49-2 | C19H16O4 |
|
| —— | 3-Acetoxy-4',7-dibenzyloxy-5,6,8-trimethoxy-flavon | 57393-73-4 | C34H30O9 |
|
| —— | (1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide | 373631-92-6 | C23H18ClF2NO4 |
|
| —— | 1-(2,4-bis-β-D-glucopyranosyloxy-6-hydroxy-phenyl)-3-(4-methoxy-phenyl)-propan-1-one | 25218-12-6 | C28H36O15 |
|
| —— | 6-(2-(2-hydroxyethoxy)ethoxy)-4'-nitroflavone | 1147337-07-2 | C19H17NO7 |
|
| —— | trans-4-acetamidoflavan | 6517-13-1 | C17H17NO2 |
|
| —— | 5-Methoxyflavanon-2,4-dinitrophenylhydrazon | 95025-13-1 | C22H18N4O6 |
|
| —— | 8-allyl-7-hydroxy-5-methoxy-4-oxo-2-phenyl-4H-chromene-6-carbaldehyde | 1616883-52-3 | C20H16O5 |
|
| —— | 5,7,4',3'',4'',6''-hexa-O-methyl-6-C-β-D-glucopyranosylapigenin | 60767-78-4 | C27H32O10 |
|
| —— | (2S,4S)-2-(3-chlorophenyl)chroman-4-ol | 67765-46-2 | C15H13ClO2 |
|
| —— | 6,6,10,10-tetramethyl-2-phenyl-7,8,11,12-tetrahydro-6<i>H</i>,10<i>H</i>-dipyrano[2,3-<i>f</i>;2',3'-<i>h</i>]chromen-4-one | 50678-95-0 | C25H26O4 |
|
| —— | 5-[4-(2-morpholin-4-yl-ethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | 1157856-44-4 | C29H29NO6 |
|
| —— | N-[1-methoxy-6-(3'-methoxy[1,1'-biphenyl]-3-yl)-6H-benzo[c]chromen-8-yl]methanesulfonamide | 373622-59-4 | C28H25NO5S |
|
| —— | 2-methoxy-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5H-6-oxa-chrysen-8-ol | 862081-61-6 | C31H31NO4 |
|
| —— | Acetic acid (2S,3S,4S,5R,6R)-2-[5,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-6-yl]-4,5-dimethoxy-6-methoxymethyl-tetrahydro-pyran-3-yl ester | 60767-79-5 | C29H34O11 |
|
| —— | 3,7-bis(benzyloxy)-2-{4-(benzyloxy)-3-{[2,3,4,6-tetra-O-(3-carboxy-1-oxopropyl)-β-D-glucopyranosy]oxy}phenyl}-5-hydroxy-4H-1-benzopyran-4-one | 357194-18-4 | C58H54O24 |
|
| —— | 6-bromo-5,7-dimethyl-2,2-diphenyl-2H-1-benzopyran | 949111-79-9 | C23H19BrO |
|
| —— | 8-[(Z)-2-(2,5,8,11,14-pentaoxabicyclo[13.4.0]nonadeca-1(15),16,18-trien-17-yl)ethenyl]-3,3-diphenylbenzo[f]chromene | 1346947-10-1 | C41H38O6 |
|
| —— | (2S,3R)-4,4-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrochromen-3-ol | 139006-31-8 | C18H20O5 |
|
| —— | 2,4-Bis-(4-dimethylamino-phenyl)-chroman-2-ol | 55850-50-5 | C25H28N2O2 |
|
| —— | Monomethylsophoronol | 62499-01-8 | C22H22O7 |
|
| —— | 3-[4-(2,8-dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)phenoxy]propionic acid | 1056053-48-5 | C26H22O7 |
|
| —— | 6,8,4'-trichloroflavanone | 1403817-37-7 | C15H9Cl3O2 |
|
| —— | (1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide | 373632-47-4 | C26H25F2NO5 |
|
| —— | (R)-5-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-7-(methoxymethoxy)chroman-3-one | 1365537-65-0 | C38H34O7 |
|
| —— | (1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea | 373631-19-7 | C25H26N2O4S |
|
| —— | 6-bromo-2-(4-methoxyphenyl)-2-methyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one | 1313611-48-1 | C19H18BrNO4 |
|
| —— | 2-benzo[1,3]dioxol-5-yl-6,8-dichloro-chroman-4-one | 130986-86-6 | C16H10Cl2O4 |
|
| —— | 2-[3,4-bis(phenylmethoxy)phenyl]-3-decyl-5,6,7-trimethoxychromen-4-one | 134082-20-5 | C42H48O7 |
|
| —— | (1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline | 373632-58-7 | C35H29F2NO4 |
|
| —— | (1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide | 373630-67-2 | C23H22ClNO4S |
|
| —— | Acetic acid (2R,3S,4S,5R,6S)-6-[2-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-4-oxo-4H-chromen-3-yloxy]-3,4,5-trihydroxy-tetrahydro-pyran-2-ylmethyl ester | 54542-52-8 | C27H30O13 |
|
| —— | 3-Ethoxy-5,8-dihydroxy-7,4'-dimethoxyflavon | 58264-81-6 | C19H18O7 |
|
| —— | 3-hydroxy-10-methyl-2-phenylpyrano[2,3-a]carbazol-4(11H)-one | 1140919-28-3 | C22H15NO3 |
|
| —— | 2,3-dihydro-2-phenyl-4-oxopyrano[2,3-a]carbazole | 875535-12-9 | C21H15NO2 |
|
| —— | 1-chloro-1a,6b-dihydro-1-phenyl-1H-cyclopropa<b>benzofuran | 124127-39-5 | C15H11ClO |
|
| —— | 2-benzo[1,3]dioxol-5-yl-6,8-dibromo-chromen-4-one | 132569-25-6 | C16H8Br2O4 |
|
| —— | (7aS,13aS)-2,4,9,11-Tetrahydroxy-6-(4-hydroxy-3-methoxy-phenyl)-5-methyl-7a,13a-dihydro-7,13-dioxa-benzo[3,4]cyclohepta[1,2-b]naphthalen-8-one | 61276-40-2 | C25H20O9 |
|
| —— | 8-(3-Acetyl-2-hydroxy-4,6-dimethoxy-phenyl)-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one | 37879-26-8 | C28H26O9 |
|
| —— | Dolabriproanthocyanidin-dodecamethylether-triacetat | 61671-07-6 | C63H68O21 |
|
| —— | (1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline | 373631-23-3 | C32H31NO4 |
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