黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | 7.8.3'.4'-Tetramethoxy-flav-3-en | 20052-34-0 | C19H20O5 |
| —— | 3-(2-bromophenyl)-1-phenyl-3H-benzo[f]chromene | 1257875-45-8 | C25H17BrO |
| —— | 6-bromo-7-(2-hydroxy-ethoxy)-2-phenyl-chromen-4-one | 857823-80-4 | C17H13BrO4 |
| —— | 2-(3,4-Bis-benzyloxy-phenyl)-3,5-dihydroxy-7-methoxy-6-methoxymethoxy-chromen-4-one | 154048-33-6 | C32H28O9 |
| —— | [2-(4-chlorophenyl)-2'-oxo-2,3-dihydro-3'H-spiro[chromene-4,5'-[1,3]oxazolidin]-3'-yl]acetic acid | 1313611-59-4 | C19H16ClNO5 |
| —— | (2R,5''S)-5,7,4'-trihydroxy-6-(2-oxopyrrolidin-5-yl)flavanone | 1029363-26-5 | C19H17NO6 |
| —— | 6-acetoxy-3,7-dimethoxy-5-(tosyloxy)flavone | 154047-94-6 | C26H22O9S |
| —— | Nechesperidin-chalcon | 57476-42-3 | C28H34O15 |
| —— | 2-(2-(4-chlorophenyl)chroman-4-ylidene)hydrazine-1-carboxamide | 534569-36-3 | C16H14ClN3O2 |
| —— | (2R,5''R)-5,7,4'-trihydroxy-8-(2-oxopyrrolidin-5-yl)flavanone | 1029363-36-7 | C19H17NO6 |
| —— | 2',6'-dihydroxy-3',4',5,6,7-pentamethoxyflavone | 111786-46-0 | C20H20O9 |
| —— | 2-benzo[1,3]dioxol-5-yl-5-hydroxy-6-nitro-chroman-4-one | 132727-13-0 | C16H11NO7 |
| —— | 5,7-dihydroxy-2-(4-methoxy-phenyl)-6,8-bis-(3-methyl-but-2-enyl)-chromen-4-one | 68634-21-9 | C26H28O5 |
| —— | 3-[(3R,4S,5S,6R)-6-((3aR,4R,6S,7S,7aR)-2,2-Diheptyl-7-hydroxy-6-methyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yloxymethyl)-3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy]-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-one | 70189-41-2 | C42H58O16 |
| —— | 2'-Acetoxy-5-hydroxy-3,4',5',7-tetramethoxy-flavon | 72962-92-6 | C21H20O9 |
| —— | 1620563-56-5 | C21H20O3 | |
| —— | (2S,3R)-trans-4',6-dimethoxyflavan-3-ol | 1196870-26-4 | C17H18O4 |
| —— | 2,3-cis-flav-3-ene epoxide | 13329-08-3 | C15H12O2 |
| —— | 2-(3,4-dimethoxy-phenyl)-6-hydroxy-3,7-dimethoxy-chromen-4-one | 858801-48-6 | C19H18O7 |
| —— | 8-[3-(3-methyl-2-butenyl)-4-hydroxyphenyl]-2,2-dimethyl-3,4,7,8-tetrahydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one | 415921-46-9 | C25H28O4 |
| —— | (2R,3R)-5,7-bis(benzyloxy)-2-(3,4,5-tris(benzyl-oxy)phenyl)chroman-3-yl 4-hydroxybenzoate | 1338810-05-1 | C57H48O9 |
| —— | 5-hydroxy-2'-chloro-4'-aminoflavone | 1388722-94-8 | C15H10ClNO3 |
| —— | [(2R,3R,4S)-2-(3,4-Dimethoxy-phenyl)-3-hydroxy-5,7-dimethoxy-chroman-4-yl]-acetic acid methyl ester | 126655-12-7 | C22H26O8 |
| —— | Methyl 4,10-dioxo-3-methyl-2-phenyl-4H,10H-benzo<1,2-b:3,4-b'>dipyran-8-carboxylate | 95095-14-0 | C21H14O6 |
| —— | 69711-92-8 | C27H28O11 | |
| —— | 7-O-(N-Benzyloxyaminocarbonylmethyl)-3'-O-cyclopentyldiosmetin | 205524-27-2 | C30H29NO8 |
| —— | dorsilurin I | 1094298-41-5 | C30H34O7 |
| —— | Acetic acid (2R,3R,4R,2'S,3'S)-3,5,7,3',5'-pentaacetoxy-2,2'-bis-(3,4-diacetoxy-phenyl)-3,4,3',4'-tetrahydro-2H,2'H-[4,8']bichromenyl-7'-yl ester | 88079-91-8 | C50H46O22 |
| —— | Acetic acid 2-(3,4-bis-benzyloxy-phenyl)-3-hydroxy-7-methoxy-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester | 154048-09-6 | C39H32O11S |
| —— | 7,8,4'-Trimethoxy-dihydro-flavonol | 1194711-76-6 | C18H18O6 |
| —— | 3-Aethyl-7-methoxy-8-dimethylaminomethyl-flavon | 102449-54-7 | C21H23NO3 |
| —— | 7-Hydroxy-3-(4-hydroxyphenyl)-2-[4-(3-piperidin-1-ylpropoxy)-phenyl]-4-(trifluoromethyl)-2H-1-benzopyran | 361390-67-2 | C30H30F3NO4 |
| —— | Dimethyl flavonyl-7-oxymaleate | 95094-99-8 | C21H16O7 |
| —— | (R)-2-(2-fluorophenyl)chromane | 1132755-79-3 | C15H13FO |
| —— | 7-benzyloxy-2-(3-benzyloxy-4-methoxyphenyl)-5-(phenylamino)-4H-chromen-4-one | 1094471-38-1 | C36H29NO5 |
| —— | 3-(4-methoxyphenyl)-3-(4-morpholinophenyl)-5,7-difluoro-10,11,12-trimethoxy-13,13-dimethyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran | 1381922-56-0 | C42H39F2NO6 |
| —— | 3,10-dimethyl-2-phenyl-pyrano[2,3-f]chromene-4,8-dione | 39818-58-1 | C20H14O4 |
| —— | sodium 5-hydroxy-7-methoxyflavone-6-sulfonate | 1149053-99-5 | C16H11O7S*Na |
| —— | 1428646-28-9 | C22H18O5 | |
| —— | 7-{2-[1-(4-benzylpiperazin-1-yl)-2-oxopropylidene]hydrazinyl}-2-phenyl-4H-chromen-4-one | 1394154-25-6 | C29H28N4O3 |
| —— | (2R,3S,4R)-2,3-trans-3,4-trans-3-acetoxy-6-<(2R,3S,4S)-2,3-trans-3,4-cis-3-acetoxy-3',4',7-trimethoxyflavan-4-yl>-4-<(2R,3S,4R)-2,3-trans-3,4-trans-3,4-diacetoxy-3',4',7-trimethoxyflavan-6-yl>-3',4',7-trimethoxyflavan | 81542-96-3 | C62H64O20 |
| —— | 4'-acetoxy-6,8-di-C-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-5,7-dihydroxyflavan | 1253227-81-4 | C39H44O19 |
| —— | (2R,3R)-cis-3',4'-dimethoxyflavan-3-ol | 1196870-23-1 | C17H18O4 |
| —— | 3,4,6-triacetoxy-1,8-bis-(3,5,7-triacetoxy-chroman-2-yl)-benzocyclohepten-5-one | 7408-45-9 | C47H42O21 |
| —— | N-(tert-butoxycarbonyl)-3-(2-[4-(dimethylamino)phenyl]-3-hydroxy-4-oxo-4H-chromen-6-yl)-L-alanine | 1508268-94-7 | C25H28N2O7 |
| —— | 2-benzo[1,3]dioxol-5-yl-3-hydroxy-7-methoxymethoxy-chromen-4-one | 109697-19-0 | C18H14O7 |
| —— | 73683-51-9 | C20H20O7 | |
| —— | (2R,3R)-5,7-diacetoxy-2-(3,4,5-triacetoxyphenyl)-chroman-3-yl 4-(hydroxy)benzoate | 1338810-01-7 | C32H28O14 |
| —— | 6,8-Difluoro-2-(3-fluoro-4-methylaminophenyl)-5-(5-hexenylamino)-4H-1-benzopyran-4-one | 152169-26-1 | C22H21F3N2O2 |
| —— | 5-Amino-6,8-difluoro-2-(3-fluoro-4-methylaminophenyl)-4H-1-benzopyran-4-one | 152835-89-7 | C16H11F3N2O2 |
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