黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | Scoparin, 8-Glykosyl-5.7.4'-trihydroxy-3'-methoxy-flavon | 100438-24-2 | C22H22O11 |
|
| —— | cis-3-Amino-4',7-dimethoxy-flavanon | 93818-34-9 | C17H17NO4 |
|
| —— | 6-Iod-3',4'-methylendioxy-flavanon | 109722-39-6 | C16H11IO4 |
|
| —— | 7-O-(N,N-Diethylaminothiocarbonylmethyl)3'-O-cyclopentyldiosmetin | 205524-10-3 | C27H31NO6S |
|
| —— | 7-n-Butoxy-flavonolacetat | 59880-43-2 | C21H20O5 |
|
| —— | (2R,3S,4S)-2-[3,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)-3,4-dihydro-2H-chromene-3,4-diol | 137624-11-4 | C43H38O7 |
|
| —— | (+/-)-4',7-dibenzyloxy<2,3,3-2H3>flavanone | 95307-75-8 | C29H24O4 |
|
| —— | 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one | 4657-07-2 | C25H28O11 |
|
| —— | 8-Bromo-7-butoxy-2-(4-methoxy-phenyl)-6-nitro-chroman-4-one | 135879-09-3 | C20H20BrNO6 |
|
| —— | 8-amino-3-(benzyloxy)-2-[4-(benzyloxy)-3-fluorophenyl]-6-methyl-4H-chromen-4-one | 372102-38-0 | C30H24FNO4 |
|
| —— | 2-[2-[2,4-Bis(2-phenoxyethoxy)phenyl]-4-oxochromen-3-yl]oxypropanedioic acid | 1099682-37-7 | C34H28O11 |
|
| —— | 7-ethoxy-3-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 1364733-22-1 | C17H14O5 |
|
| —— | [(2R,3S,4S,5R,6R)-6-[[(2R,3R,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromenylium-3-yl]oxy-3,4-dihydroxy-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]methoxy]-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-(2-methoxyphenyl)prop-2-enoate | 217661-68-2 | C42H47O22 |
|
| —— | Isoliquiritigenin metabolite MG4 | 1084629-09-3 | C21H20O10 |
|
| —— | 4,9-dimethoxy-7-(4-methoxy-phenyl)-6,7-dihydro-furo[3,2-<i>g</i>]chromen-5-one | 62061-97-6 | C20H18O6 |
|
| —— | 3'',5''-diethoxyphenyl 4',5,7-trimethoxyflavone-3'-ylacetate | 77670-47-4 | C30H30O9 |
|
| —— | 6-(2-oxopropyl)chromeno[4,3-b]chromen-7(6H)-one | 1609940-21-7 | C19H14O4 |
|
| —— | (+/-)-5,7-dihydroxy-3'-bromo-8-(3,3-dimethylallyl)-flavanone | 1075171-27-5 | C20H19BrO4 |
|
| —— | 3-(But-2-ynyloxy)-2-(2-methoxyphenyl)-4H-chromen-4-one | 1429665-30-4 | C20H16O4 |
|
| —— | 1-<α-(3,4-dimethoxybenzoyl)(3,4-dimethoxy-6N-morpholinomethylbenzylidene)>-3-(3,4-dimethoxyphenyl)-6,7-dimethoxyisochromene | 125416-98-0 | C42H45NO11 |
|
| —— | 3,8-dibromo-7-butoxy-2-(2,4-dichlorophenyl)-6-nitrochromen-4-one | 139589-38-1 | C19H13Br2Cl2NO5 |
|
| —— | 7-<β-D-2,3,4,6-Tetraacetyl-glucopyranosyl>-diosmetin | 121330-72-1 | C30H30O15 |
|
| —— | [(7R,8R)-5-hydroxy-10-[(2R)-2-hydroxy-3-methylbut-3-enyl]-2,2-dimethyl-6-oxo-8-phenyl-7,8-dihydropyrano[3,2-g]chromen-7-yl] (2S)-2-methoxy-2-phenylacetate | 1323905-38-9 | C34H34O8 |
|
| —— | 3-(benzyloxy)-2-[4-(benzyloxy)-3-fluorophenyl]-6-methyl-8-nitro-4H-chromen-4-one | 372102-37-9 | C30H22FNO6 |
|
| —— | 6-Brom-7-hydroxy-flavonol | 100914-53-2 | C15H9BrO4 |
|
| —— | 7-Hydroxy-8-methoxy-6-allyl-flavon | 94305-80-3 | C19H16O4 |
|
| —— | Deca-O-acetyl-leucocyanidin | 7060-65-3 | C50H46O23 |
|
| —— | 4-[2-(3,3-diphenyl-3H-benzo[f]chromen-5-yl)ethenyl]-N,N-4-[2-(3,3-diphenyl-3H-benzo[f]chromen-5-yl)ethenyl]-N,N-diethylaniline | 1381878-67-6 | C37H33NO |
|
| —— | 2'',3'',4'',6''-tetra-O-acetyl-4',5,7-tri-O-methylisovitexin | 6991-11-3 | C32H34O14 |
|
| —— | 3,8-dibromo-6-chloro-2-phenyl-chroman-4-one | 264282-96-4 | C15H9Br2ClO2 |
|
| —— | 2-[2,4-Bis(2-phenoxyethoxy)phenyl]-3-ethoxychromen-4-one | 1099682-35-5 | C33H30O7 |
|
| —— | 7-(3-Iodo-propoxy)-2-phenyl-chromen-4-one | 213891-09-9 | C18H15IO3 |
|
| —— | 6-chloro-8-methyl-2-(4-nitrophenyl)-4H-chromen-4-one | 1343513-33-6 | C16H10ClNO4 |
|
| —— | 4-[2-(3-chloro-4-hydroxyphenyl)-3-hydroxy-6-methyl-4-oxo-4H-chromen-8-yl]-1-methylpyridinium bromide | 372103-35-0 | Br*C22H17ClNO4 |
|
| —— | 7-Methoxy-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-2-phenyl-chroman-4-one | 24467-46-7 | C24H20O4 |
|
| —— | 4-(6-methoxy-4-oxo-4H-chromen-2-yl)benzonitrile | 39679-63-5 | C17H11NO3 |
|
| —— | N-[[4'-N,N-diethylamino-3-hydroxy-6-flavonyl]methyl]-N-methyl-N-(3-sulfopropyl)-1-dodecanaminium | 937025-73-5 | C36H54N2O6S |
|
| —— | 3,8-dibromo-6-chloro-2-(2-methoxyphenyl)chromen-4-one | 134640-70-3 | C16H9Br2ClO3 |
|
| —— | 2-hydroxy-6-phenyl-6,12-methano-12H-dibenzo[d,g][1,3]dioxocin | 1429326-76-0 | C21H16O3 |
|
| —— | 5-hydroxy-3,3',4',5'-tetramethoxyflavone | 356543-13-0 | C19H18O7 |
|
| —— | 4-(1-bromonaphthalen-2-yloxy)-6-methoxy-2H-chromene | 115997-83-6 | C20H15BrO3 |
|
| —— | 6-Chloro-2-phenyl-chroman-4-ol | 97723-88-1 | C15H13ClO2 |
|
| —— | (2R,3S)-8-bromo-3,6-dihydroxy-5,7,3',4'-tetra-O-benzylflavan | 848047-69-8 | C43H37BrO7 |
|
| —— | 11-methyl-2-phenyl-2,3,6,7,8,9-hexahydro-4H-benzofuro[3,2-g]chromen-4-one | 1233321-98-6 | C22H20O3 |
|
| —— | 5,3'-Diacetoxy-3,7,8,4'-tetramethoxy-flavon | 4670-43-3 | C23H22O10 |
|
| —— | 5-Hydroxy-7-acetoxy-3'.4'-dioxymethylen-flavon | 109695-17-2 | C18H12O7 |
|
| —— | (2'R,3'R)-acetic acid 3-{[2'-(4''-benzyloxyphenyl)-5'-bromo-2',3'-dihydrobenzofuran-3'-carbonyl]-[4'-(tert-butyldiphenylsilanyloxy)butyl]amino}propyl ester | 566202-93-5 | C47H52BrNO6Si |
|
| —— | Bis-<5.7.3'.4'-tetramethoxy-flavenyliden-(4)> | 106168-94-9 | C38H36O10 |
|
| —— | (+/-)-2,3-trans-5',4-dimethoxyflavan-3-ol | 86788-70-7 | C17H18O4 |
|
| —— | 5-Chlorospiro<benzofuran-2(3H),1'-<2>cyclohexene>-3-phenyl-3-ol | 141883-78-5 | C19H17ClO2 |
|
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