黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | larycitrin-7,5'-diglucoside | 89345-44-8 | C28H32O18 |
| —— | 1233321-99-7 | C22H20O4 | |
| —— | 8-acetyl-3,6-dimethyl-2-phenylchromen-4-one | 94305-53-0 | C19H16O3 |
| —— | 8-(2-bromo-propyl)-7-hydroxy-3-methoxy-2-phenyl-chromen-4-one | 101894-57-9 | C19H17BrO4 |
| —— | 7-[4-(1-amino-cyclobutyl)-phenyl]-2-ethyl-8-phenyl-2H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one hydrochloride | 1279086-40-6 | C28H25N3O2*ClH |
| —— | 6,7-Dihydroxy-2,4-diphenylbenzopyranol | 26073-81-4 | C21H14O3 |
| —— | 5-Hydroxy-6-methoxy-2-(3,4-dimethoxy-phenyl)-chromen-4-on | 93876-58-5 | C18H16O6 |
| —— | 3-iodo-6-methoxy-7-methyl-2-phenyl-chromen-4-one | 1279087-60-3 | C17H13IO3 |
| —— | (+/-)-7,8,4'-Trimethoxy-3-p-toluolsulfonyloxy-2,3-trans-flavan | 103535-75-7 | C25H26O7S |
| —— | (1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea | 373631-94-8 | C23H19ClF2N2O3 |
| —— | (E)-5-hydroxy-2-(4-hydroxy-2-((4-methoxybenzyl)oxy)phenyl)-7-methoxy-6-(3-methylbut-1-en-1-yl)-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | 1443276-30-9 | C34H36O7 |
| —— | 3-(1,3-benzodioxole-5-yl)-3-phenyl-3H-naphtho-[2,1-b]pyran | 164064-03-3 | C26H18O3 |
| —— | 7-hydroxy-6-n-pentyloxy flavanone | 203190-99-2 | C20H22O4 |
| —— | 2'-Methoxy-6-carbomethxy-flavon | 63070-95-1 | C18H14O5 |
| —— | tephroleocarpin A | 138590-93-9 | C21H22O5 |
| —— | 3-chloro-2-(4-chlorophenyl)-3,4-dihydro-4-hydroxy-8-methoxy-3-nitro-2H-1-benzopyran | 127143-48-0 | C16H13Cl2NO5 |
| —— | 4-chloro-2-(p-chlorophenyl)-2H-chromene-3-carbaldehyde | 1259418-55-7 | C16H10Cl2O2 |
| —— | [(1S,4R,5S,12S,13R)-16,18-diacetyloxy-4,12-bis(4-acetyloxyphenyl)-13-hydroxy-8,14-dioxo-3,11,21-trioxapentacyclo[11.8.0.01,10.02,7.015,20]henicosa-2(7),9,15(20),16,18-pentaen-5-yl] acetate | 142674-68-8 | C40H32O16 |
| —— | 4'-acetoxy-6-C-(tri-O-acetyl-α-L-arabinopyranosyl)-8-C-(tri-O-acetyl-β-D-xylopyranosyl)-5,7-dihydroxyflavan | 1253227-87-0 | C39H44O19 |
| —— | 3,5,7-Trimethoxy-3',4'-diphenylmethylendioxy-flavon | 97434-01-0 | C31H24O7 |
| —— | 5-Amino-2-[4-(2-dimethylamino)ethylamino]phenyl-4H-benzopyran-4-one | 130599-47-2 | C19H21N3O2 |
| —— | 5,7-dimethoxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-2-[3-(trifluoromethoxy)-phenyl]-4H-benzopyran-4-one | 358739-73-8 | C24H24F3NO6 |
| —— | 7-iodo-2-methyl-8-phenyl-2H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one | 1279088-95-7 | C17H11IN2O2 |
| —— | 7-iodo-1-methyl-8-phenyl-1H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one | 1279088-94-6 | C17H11IN2O2 |
| —— | ethyl 4-[6-(adamantan-1-yl)-7-(2-methoxyethoxymethoxy)-4-oxo-4-chromen-2-yl]benzoate | 1448617-95-5 | C32H36O7 |
| —— | 1089147-04-5 | C57H55N5O10 | |
| —— | 6-chloro-2-phenyl-pyrano[3,2-h]quinolin-4-one | 21357-30-2 | C18H10ClNO2 |
| —— | 5,7-dihydroxy-3',4'-dimethoxy-6-n-propyloxy flavone | 203190-89-0 | C20H20O7 |
| —— | (1R,4S,6S)-4-(5,7-bis(benzyloxy)-2-(4-benzyloxyphenyl)-4-oxo-4H-chromen-3-yl)-6-methylcyclohex-2-enyl acetate | 1232680-41-9 | C45H40O8 |
| —— | 6-chloro-4'-dimethylaminoflavone | 908251-99-0 | C17H14ClNO2 |
| —— | 6-(5-methylamino-1,3,4-thiadiazol-2-ylthiomethyl)-4-morpholino-2-[3-(2-propenyloxycarbonylamino)benzylamino]pyridine | 196497-95-7 | C24H29N7O3S2 |
| —— | 1590454-62-8 | C25H24O12 | |
| —— | 1421324-72-2 | C15H7Br2NO4 | |
| —— | 2'-Hydroxy-6-carboxy-flavon | 63071-00-1 | C16H10O5 |
| —— | 6,7-dimethoxy-2-{4-[(ethylmethylamino)-methyl]-phenyl}-chroman-4-one | 916060-89-4 | C21H25NO4 |
| —— | 3',4'-bis(benzyloxy)-3,5-dihydroxy-7,8-dimethoxyflavone | 116512-12-0 | C31H26O8 |
| —— | Toluene-4-sulfonic acid 2-(3,4-bis-benzyloxy-phenyl)-5-hydroxy-7,8-dimethoxy-4-oxo-4H-chromen-3-yl ester | 116512-13-1 | C38H32O10S |
| —— | {1-[4-(7-bromo-6-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl} carbamic acid tert-butyl ester | 1279088-10-6 | C31H30BrNO5 |
| —— | 6-Bromo-3-(2-phenoxyethoxy)-2-(4-phenylphenyl)chromen-4-one | 1099682-27-5 | C29H21BrO4 |
| —— | (5S)-5-[4-(2-morpholin-4-yl-ethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | 1157856-46-6 | C29H29NO6 |
| —— | 5-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate | 1610737-90-0 | C43H34O8S |
| —— | (5R)-5-[4-(2-morpholin-4-yl-ethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | 1157856-45-5 | C29H29NO6 |
| —— | 1172118-67-0 | C22H23N3O3 | |
| —— | 7-benzyloxy-2-(3,4-dimethoxy-phenyl)-5-hydroxy-chromen-4-one | 742077-30-1 | C24H20O6 |
| —— | 2,3-dimethoxy-2-(4-methoxy-phenyl)-2H-chromene | 34811-87-5 | C18H18O4 |
| —— | 2-(2,4-bis(benzyloxy)phenyl)-5,7-dihydroxy-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one | 1610962-12-3 | C34H30O6 |
| —— | 2-(4-Hydroxy-3-methoxy-phenyl)-chroman-4-ol | 859440-51-0 | C16H16O4 |
| —— | 7-<(3-Hydroxy-but-2-yl)-carbamoylmethoxy>-4-oxo-2-phenyl-4H-chromen | 101121-80-6 | C21H21NO5 |
| —— | (+/-)-4',7-dimethoxymethoxy-8-allyl-3'-methoxy-flavanone | 1134396-41-0 | C23H26O7 |
| —— | 2-(2,4-dibenzoyloxyphenyl)-5,7-dihydroxy-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one | 1610962-22-5 | C34H26O8 |
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