黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | 5-Hydroxy-3,4'-dimethoxy-flavon | 7736-79-0 | C17H14O5 |
|
| —— | 7-Hydroxy-8-allyl-3-methyl-3',4'-dimethoxyflavon | 63455-93-6 | C21H20O5 |
|
| —— | 1-[(4-chloro-2-(p-tolyl)-2H-chromen-3-yl)-methylene]-2-phenylhydrazine | 1372550-17-8 | C23H19ClN2O |
|
| —— | 7-bromo-3-iodo-6-methoxy-2-phenyl-chromen-4-one | 1279088-09-3 | C16H10BrIO3 |
|
| —— | 3-(2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolin-5-yl)phenol 4-Methylbenzenesulfonate (Ester) | 239067-62-0 | C33H31NO5S |
|
| —— | 5-fluoro-3-iodo-2-phenyl-chromen-4-one | 1279087-51-2 | C15H8FIO2 |
|
| —— | 1453812-77-5 | C15H9ClO3 |
|
|
| —— | 5-amino-3,3-diphenylnaphtho[2,1-b]pyrane | 859850-00-3 | C25H19NO |
|
| —— | 2-(3-methoxy-phenyl)-3-(tetra-<i>O</i>-acetyl-β-D-glucopyranosyloxy)-chromen-4-one | 119621-52-2 | C30H30O13 |
|
| —— | 2-(4-cyclohexylphenyl)-2-(4-methoxyphenyl)-13,14-dihydronaphtho[1,2-h]-benzo[f]-chromene | 1194840-19-1 | C40H36O2 |
|
| —— | 2,2'-bis-(4-methoxy-phenyl)-7,7'-dimethyl-5,5'-ethane-1,2-diyl-bis-chroman-4-one | 61923-76-0 | C36H34O6 |
|
| —— | 3-(tert-butyldimethylsilyloxy)-5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 1160162-37-7 | C21H24O5Si |
|
| —— | Acetic acid 7-acetoxy-2-(3,4-diacetoxy-phenyl)-6,8-dimethyl-4-oxo-4H-chromen-5-yl ester | 93290-64-3 | C25H22O10 |
|
| —— | Flavanyl-(3)-methylether | 38492-99-8 | C16H16O2 |
|
| —— | 2-(2,4-dibenzoyloxyphenyl)-5-hydroxy-7-((3-methyl-2-buten-1-yl)oxy)-3-(3-methyl-2-buten-1-yl)-4H-chromen-4-one | 1610962-23-6 | C39H34O8 |
|
| —— | methyl 1-(4-(4-oxo-2-phenyl-4H-chromen-6-yl)benzyl)azetidine-3-carboxylate | 1220973-20-5 | C27H23NO4 |
|
| —— | 1-(2-hydroxy-ethyl)-7-iodo-8-phenyl-1H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one | 1279089-50-7 | C18H13IN2O3 |
|
| —— | 7-acetoxy-8-(1',1'-dimethylallyl)-3-methylflavone | 77609-92-8 | C23H22O4 |
|
| —— | symposide peracetate | 126595-97-9 | C35H38O17 |
|
| —— | 7-[2-(2-oxo-1-thiomorpholinopropylidene)hydrazinyl]-2-phenyl-4H-chromen-4-one | 1394154-35-8 | C22H21N3O3S |
|
| —— | 3,7,3'-triacetoxy catechin | 1071725-94-4 | C21H20O9 |
|
| —— | rac-2-(3,4-dichlorophenyl)-2H-benzo[h]chromene-3-carboxylic acid | 1204755-19-0 | C20H12Cl2O3 |
|
| —— | rac-2-(3,5-dichlorophenyl)-2H-chromene-3-carboxylic acid | 1204754-61-9 | C16H10Cl2O3 |
|
| —— | 7-(Benzoyloxy)-5,8-dihydroxy-2-phenyl-4H-1-benzopyran-4-one | 114482-87-0 | C22H14O6 |
|
| —— | tert-butyl (R)-3-[(S)-6-chloro-2-phenyl-2H-chromen-3-yl]-3-hydroxypropanoate | 1101850-50-3 | C22H23ClO4 |
|
| —— | 4-(dihydrospiro[chroman-4,2'-[1,3]dioxolan]-2-yl)phenyl pivalate | 1554400-57-5 | C22H24O5 |
|
| —— | 3,3',4',5-Tetraacetoxy-7-pentyloxy-flavon | 96215-32-6 | C28H28O11 |
|
| —— | (Z)-6-fluoro-3-((naphthalen-1-ylmethylamino)methylene)-2-phenylchroman-4-one | 1430097-91-8 | C27H20FNO2 |
|
| —— | 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-4-oxo-4H-chromen-7-yl butyrate | 1201808-19-6 | C32H24O7 |
|
| —— | 7,4'-Dibenzyloxy-6,3'-dimethoxyflavone | 82298-04-2 | C31H26O6 |
|
| —— | 6,8-Dideuterio-2-(2-deuterio-3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | 1428642-39-0 | C15H10O7 |
|
| —— | 2,3-dihydroquercetin 7-O-(neopentylenephosphate) | 1360574-44-2 | C20H21O10P |
|
| —— | 5-Amino-2-(4-methylamino)phenyl-8-methoxy-4H-benzopyran-4-one | 130599-80-3 | C17H16N2O3 |
|
| —— | 3',6'-Dihydroxy-4'-methoxy-flavon | 1621-68-7 | C16H12O5 |
|
| —— | 2-(1-naphthyl)-3-nitrochroman | 113968-79-9 | C19H15NO3 |
|
| —— | (2R,3S,4S)-2,3-trans-3,4-cis-3-acetoxy-3',4',5,7-tetramethoxy-4-(2,4-dimethoxyphenyl)flavan | 78284-54-5 | C29H32O9 |
|
| —— | 6,8-Dichloro-3-methyl-3-morpholin-4-ylmethyl-2-phenyl-chroman-4-one | 90486-56-9 | C21H21Cl2NO3 |
|
| —— | Methyl 3-[4-(5,15-dihydroxy-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaen-19-yl)phenoxy]propanoate | 1056053-49-6 | C27H24O7 |
|
| —— | 4-chloro-7-iodo-8-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-chromeno[7,8-d]imidazol-6-one | 1279088-62-8 | C22H22ClIN2O3Si |
|
| —— | 5R-[4-(2-piperidin-1-yl-ethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol | 1157856-50-2 | C30H31NO4 |
|
| —— | 1,13-bis[4'-(7-fluoro-4H-chromen-4-on-2-yl)-phenyl]-1,4,7,10,13-pentaoxatridecane | 958457-94-8 | C38H32F2O9 |
|
| —— | 6-chloro-8-((3-(dimethylamino)propyl)amino)-2-(3-methoxy-2-nitrophenyl)-4H-chromen-4-one | 1621457-94-0 | C21H22ClN3O5 |
|
| —— | 8-Nitro-6-methyl-4'-methoxy-flavon | 93325-63-4 | C17H13NO5 |
|
| —— | tert-butyl-[[(19R)-5-[tert-butyl(dimethyl)silyl]oxy-19-[4-(2-iodoethoxy)phenyl]-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaen-15-yl]oxy]-dimethylsilane | 1157856-75-1 | C37H49IO5Si2 |
|
| —— | 3',5-dihydroxy-4'-methoxy-7-(carbethoxymethoxy)flavanone | 62917-61-7 | C20H20O8 |
|
| —— | 8-Benzyloxy-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one | 89456-28-0 | C25H22O6 |
|
| —— | 7-iodo-2-isopropyl-8-phenyl-2H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one | 1279089-47-2 | C19H15IN2O2 |
|
| —— | 1201808-15-2 | C32H26O6 |
|
|
| —— | 5-methoxy-4-methylflav-3-ene | 1233713-62-6 | C17H16O2 |
|
| —— | 5R-(+)-[4-(2-piperidin-1-yl-ethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | 554431-74-2 | C30H31NO5 |
|
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