黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | 2-[3,4-bis(phenylmethoxy)phenyl]-3-decyl-5-hydroxy-6,7-dimethoxychromen-4-one | 134082-36-3 | C41H46O7 |
|
| —— | 6-ethynylflavone | 1446428-62-1 | C17H10O2 |
|
| —— | 3-Acetoxy-6-acetyl-5-hydroxy-2,3-trans-flavan | 95056-02-3 | C19H18O5 |
|
| —— | [2-(4-Methoxy-phenyl)-4-oxo-4H-chromen-8-yl]-acetic acid 2-diethylamino-ethyl ester; hydrochloride | 87627-12-1 | C24H27NO5*ClH |
|
| —— | 2-(4-methoxyphenyl)-7-(2-tetrahydro-1H-1-pyrrolylethoxy)-4-chromanone | 850152-79-3 | C22H25NO4 |
|
| —— | (2rH)-3c,4c-Dibenzoyloxy-7,3',4'-trimethoxy-flavan | 96582-13-7 | C32H28O8 |
|
| —— | 7-Benzyloxy-6-hydroxy-3-methoxyflavone | 87232-86-8 | C23H18O5 |
|
| —— | (1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide | 373631-08-4 | C24H25NO5S |
|
| —— | 1,19-bis[4-((5-benzyloxy-7-methoxymethoxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13,16,19-heptaoxanonadecane | 916330-74-0 | C60H62O17 |
|
| —— | 4α-acetoxy-5,7,3',4'-trimethoxyflavan | 88363-06-8 | C21H24O7 |
|
| —— | 6,4'-Diacetoxy-7,3'-dimethoxyflavone | 82298-16-6 | C21H18O8 |
|
| —— | (2S,3S,4R,5R,6S)-5-(benzyloxy)-6-((5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3,4-diyl bis(propylcarbamate) | 1374854-18-8 | C57H58N2O12 |
|
| —— | 2,5,7-trimethyl-2-phenyl-chroman-4-one | 101789-48-4 | C18H18O2 |
|
| —— | Acetic acid (2R,3R,4S)-4-acetoxy-2-(2-hydroxy-4,6-dimethoxy-phenyl)-7-methoxy-chroman-3-yl ester | 58484-50-7 | C22H24O9 |
|
| —— | (1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide | 373630-89-8 | C23H22FNO4S |
|
| —— | (1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline | 373632-57-6 | C32H29F2NO4 |
|
| —— | [(2S,3R)-3-hydroxy-5-methylsulfonyloxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-7-yl] methanesulfonate | 1131849-80-3 | C17H18O11S2 |
|
| —— | 3,3-bis-(4-methoxyphenyl)-6-morpholino-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran | 1360882-71-8 | C40H36FNO4 |
|
| —— | Acetic acid 2-phenyl-2a,7a-dihydro-7-oxa-cyclobuta[a]inden-1-yl ester | 65933-79-1 | C18H14O3 |
|
| —— | 5-acetoxy-7,5',7'-trimethoxy-2,2'-bis-(4-methoxy-phenyl)-2,3,2',3'-tetrahydro-[6,8']bichromenyl-4,4'-dione | 58965-09-6 | C37H34O11 |
|
| —— | 3,3'-Dimethyl-4'-benzyl-quercetagetin | 59171-20-9 | C24H20O8 |
|
| —— | 4'-Chloro-2-phenylchromon-3-carboxanilid | 52281-11-5 | C22H14ClNO3 |
|
| —— | 3,3-bis(4-methoxyphenyl)-10-bromo-5,7-fluoro-13-methyl-13-butyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran | 1311274-83-5 | C39H33BrF2O3 |
|
| —— | 2-(4-Chlorophenyl)-4-oxo-4H-1-benzopyran-8-acetonitrile | 101002-45-3 | C17H10ClNO2 |
|
| —— | 6-chloro-3-nitro-2-phenylchroman | 113968-82-4 | C15H12ClNO3 |
|
| —— | 2-(2,3-bis-benzyloxy-4-methoxy-phenyl)-3,5,7-trimethoxy-chromen-4-one | 56128-65-5 | C33H30O8 |
|
| —— | 3,4'-Diacetoxy-7-benzyloxy-5,6,8-trimethoxy-flavon | 57393-72-3 | C29H26O10 |
|
| —— | (1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide | 373631-25-5 | C28H25NO6S |
|
| —— | 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-7-(isopentyloxy)-4H-chromen-4-one | 1201808-16-3 | C33H28O6 |
|
| —— | 5-methyl-4-oxo-2-phenylchromane-7,8-diyl dibenzoate | 670224-92-7 | C30H22O6 |
|
| —— | 1198053-58-5 | C21H15ClO4 |
|
|
| —— | 2-(4-Benzyloxy-phenyl)-3,5-dihydroxy-7-((2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-chromen-4-one | 58947-51-6 | C28H26O10 |
|
| —— | Acetic acid (2R,3R,8R)-3,5,7a-triacetoxy-8-((S)-1,2-diacetoxy-ethyl)-10-oxo-2-(3,4,5-triacetoxy-phenyl)-3,4,7a,8-tetrahydro-2H-furo[3',4':4,5]furo[2,3-h]chromen-10a-yl ester | 126716-01-6 | C39H38O22 |
|
| —— | (1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide | 373630-55-8 | C24H20ClNO3 |
|
| —— | 3-chloro-N-(3-{1-methoxy-8-[(methylsulfonyl)amino]-6H-benzo[c]chromen-6-yl}phenyl)-N-methyl-1-propanesulfonamide | 373622-65-2 | C25H27ClN2O6S2 |
|
| —— | pinostrobin oxime | 612836-69-8 | C16H15NO4 |
|
| —— | 3-nitro-2-(2-(trifluoromethyl)phenyl)-2H-chromene | 1175542-10-5 | C16H10F3NO3 |
|
| —— | 1427470-12-9 | C51H50O4S |
|
|
| —— | 6,8-dibromo-2-(2-methoxyphenyl)chromen-4-one | 134640-66-7 | C16H10Br2O3 |
|
| —— | 4-(p-Dimethylaminophenyl)-flavan | 58530-43-1 | C23H23NO |
|
| —— | Acetic acid 1-methyl-2-phenyl-7aH-7-oxa-cyclobuta[a]inden-2a-yl ester | 65933-83-7 | C19H16O3 |
|
| —— | 2-o-Chlorphenyl-8-methoxy-3-nitro-Δ<sup>3</sup>-chromen | 57544-11-3 | C16H12ClNO4 |
|
| —— | 7,8-Dimethoxy-5-methyl-2-phenyl-chroman-4-one | 670224-90-5 | C18H18O4 |
|
| —— | (2R)-2r-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-3c-(toluene-4-sulfonyloxy)-chroman | 120640-48-4 | C26H28O8S |
|
| —— | 6-bromo-2-(4-methoxyphenyl)chroman-4-one | 75595-30-1 | C16H13BrO3 |
|
| —— | (1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide | 373630-90-1 | C26H19F2NO4S |
|
| —— | 5,7-Dihydroxy-6-methoxy-4'-amino-flavon | 16297-04-4 | C16H13NO5 |
|
| —— | 2'-Hydroxy-4'.6'.7'-trimethoxyflavan | 17470-77-8 | C18H20O5 |
|
| —— | (E)-N-tert-butyl-3-(6,7-dimethoxy-4-oxo-2-phenyl-4H-chromen-3-yl)acrylamide | 1412410-94-6 | C24H25NO5 |
|
| —— | 3,3'-Diacetoxy-4',7-dimethoxy-flavon | 2552-73-0 | C21H18O8 |
|
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