黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | 7-Methoxyflavanon-oxim | 37884-21-2 | C16H15NO3 |
| —— | 3-hydroxy-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromenylium; chloride | 37715-28-9 | C18H17O5*Cl |
| —— | 2-Methoxy-4-(3-nitro-2H-chromen-2-yl)-phenol | 86628-45-7 | C16H13NO5 |
| —— | 5,8-Diacetoxy-3,3',4',7-tetrakis(benzyloxy)flavon | 62506-98-3 | C47H38O10 |
| —— | bonanniol B | 96917-37-2 | C26H30O6 |
| —— | Kidamycin-11,3''-diacetat | 58809-15-7 | C43H52N2O11 |
| —— | 3''-(E)-p-coumaroylquercitrin | 1242284-53-2 | C30H26O13 |
| —— | 616201-22-0 | C69H66O31 | |
| —— | 3-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-8-(1,1-dioxidoisothiazolidin-2-yl)-6-methyl-4H-chromen-4-one | 934374-21-7 | C40H35NO7S |
| —— | 6,8-dibromo-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 1609456-14-5 | C15H8Br2O4 |
| —— | 8,8-dimethyl-2-phenyl-2,3,9,10-tetrahydro-8<i>H</i>-pyrano[2,3-<i>f</i>]chromen-4-one | 51619-61-5 | C20H20O3 |
| —— | 3,3-Dichloro-6-ethoxy-2-phenyl-chroman-4-one | 75595-37-8 | C17H14Cl2O3 |
| —— | 10-Acetyl-11-phenyl-12-oxa-benzo[e]acephenanthrylen-9-one | 69826-21-7 | C27H16O3 |
| —— | 6-acetoxy-4-(5-oxo-2-phenyl-4,5-dihydro-3<i>H</i>-naphtho[1,8-<i>bc</i>]furan-4-ylmethyl)-benzo[<i>d</i>]isoxazole-7-carboxylic acid methyl ester | 32855-66-6 | C29H21NO7 |
| —— | 6-chloro-2-(4'-methylphenyl)-3-{(thiophen-2-yl)methoxy}-4-oxo-4H-1-benzo-pyran | 1262841-06-4 | C21H15ClO3S |
| —— | 3,3-bis(4-methoxyphenyl)-10-bromo-6-trifluoromethoxy-13,13-dimethyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran | 1311274-79-9 | C37H28BrF3O4 |
| —— | Apigenidin-trimethylaether | 47224-76-0 | C18H17O4 |
| —— | 3-(4-Methoxybenzylidene)-7-methoxyflavanone | 24467-43-4 | C24H20O4 |
| —— | 1447801-11-7 | C46H40AuN | |
| —— | 7,8,4'-Trimethoxy-flavan | 16984-98-8 | C18H20O4 |
| —— | 8-{5-[4-(2-Methoxyphenyl)-1-piperazinyl]pentyl}-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran methanesulfonate | 188017-51-8 | CH4O3S*C32H36N2O3 |
| —— | 2,5,7-Trihydroxy-3-benzyloxyflavanon | 70651-41-1 | C22H18O6 |
| —— | (2S,3R)-3-Chloro-6-methoxy-2-phenyl-chroman-4-one | 75595-96-9 | C16H13ClO3 |
| —— | 6-bromo-4-[(trimethylsilyl)oxy]-2-(4-methoxyphenyl)-3,4-dihydro-2H-chromene-4-carbonitrile | 1313611-71-0 | C20H22BrNO3Si |
| —— | (R)-5-(5,7-bis(benzyloxy)-3-oxochroman-2-yl)benzene-1,2,3-triyl tris(2,2-dimethylpropanoate) | 1449477-38-6 | C44H48O10 |
| —— | 7-(p-Methoxyphenacyl)-4'-methoxy-5-methylflavon | 56150-43-7 | C26H22O5 |
| —— | (S)-2-(3-Hydroxy-4,5-dimethoxy-phenyl)-5,7-dimethoxy-chroman-4-one | 78335-38-3 | C19H20O7 |
| —— | 7-O-(N,N-Dimethylaminocarbonylmethyl)-3'-O-isopropyldiosmetin | 205524-24-9 | C23H25NO7 |
| —— | 2-Dimethylamino-N-(3-methyl-4-oxo-2-phenyl-4H-chromen-6-yl)-acetamide | 56822-65-2 | C20H20N2O3 |
| —— | 58544-97-1 | C17H16O3 | |
| —— | 7,4'-Diacetoxy-6,3'-dimethoxyflavone | 82298-05-3 | C21H18O8 |
| —— | 2-[2-(4-Methoxyphenyl)-4-oxochromen-8-yl]acetonitrile | 87627-09-6 | C18H13NO3 |
| —— | 8-methyl-2-(3-fluorophenyl)-4H-benzopyran-4-one | 131402-09-0 | C16H11FO2 |
| —— | (2R,3S,8R,9R,10S)-10-(3,4-Dihydroxy-phenyl)-8-(2,4-dihydroxy-phenyl)-6-[(2R,3S,4S)-2-(3,4-dihydroxy-phenyl)-3,7-dihydroxy-chroman-4-yl]-2-(3-hydroxy-4-methoxy-phenyl)-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromene-3,5,9-triol | 176896-92-7 | C46H40O16 |
| —— | Acetic acid 4-methyl-2-oxo-8-phenyl-6-((E)-3-phenyl-allyl)-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-5-yl ester | 70093-42-4 | C30H26O5 |
| —— | (E)-3-(3-hydroxy-3-methylbut-1-enyl)-4’-methylflavone | 1393811-56-7 | C21H20O3 |
| —— | 7-bromomethyl-2-phenyl-chromen-4-one | 50400-65-2 | C16H11BrO2 |
| —— | 7S-2-(2-Fluoro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one | 1242983-27-2 | C23H24FNO5 |
| —— | (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-((2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate | 1096656-81-3 | C31H32O14 |
| —— | (1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide | 373631-71-1 | C24H21F2NO3 |
| —— | 7,8-methylenedioxy-4',5,6-trimethoxyflavone | 90545-66-7 | C19H16O7 |
| —— | 4,5α-epoxy-3-methoxy-17-methyl-6,7,8,14-tetrahydro-7β-(2-trifluoromethylbenzyl)-morphinan | 1039688-01-1 | C26H24F3NO2 |
| —— | 3,3-bis-(4-methoxyphenyl)-6-piperidino-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran | 1360882-75-2 | C41H38FNO3 |
| —— | 8-(3''-Formyl-6''-methoxyphenyl)-5,7,4'-trimethoxyflavon | 69818-21-9 | C26H22O7 |
| —— | 2-[2-(6-chloro-pyridin-3-yl)-chroman-6-yloxy]-thiazole-5-carboxylic acid methyl ester | 1426900-35-7 | C19H15ClN2O4S |
| —— | 8-[3-(4-Phenyl-1-piperidinyl)propylcarbamoyl]-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran methanesulfonate | 152735-68-7 | CH4O3S*C31H32N2O3 |
| —— | (2R,3R)-2-(9-hydroxy-2,2,4,4-tetraisopropylbenzo[f][1,3,5,2,4]trioxadisilepin-7-yl)chromane-3,5,7-triol | 1304014-18-3 | C27H40O8Si2 |
| —— | 7,7''-Dimethoxy-6,6''-biflavonyl | 37042-22-1 | C32H22O6 |
| —— | Toluene-4-sulfonic acid 2-(4-methylsulfanylmethoxy-phenyl)-6-oxo-5-[1-(toluene-4-sulfonyl)-1,4-dihydro-pyridin-4-yl]-3,6-dihydro-2H-pyran-4-yl ester | 80741-48-6 | C32H31NO8S3 |
| —— | 2-(dihydrobenzofuran-5-yl)-3-hydroxy-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one hydrochloride | 1187087-54-2 | C19H16N2O4 |
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