黄酮类化合物
黄酮类化合物
定义与结构特征
黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注，主要包括：
- 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
- 抗炎效应：有助于减轻炎症反应，缓解症状。
- 心血管保护：可能通过多种机制改善心脑血管健康。
- 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | 2-[4-(Cyclopentylamino)-3-hydroxyphenyl]-3-hydroxybenzo[h]chromen-4-one | 1373232-43-9 | C24H21NO4 |
|
| —— | (1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide | 373632-11-2 | C23H18F3NO4 |
|
| —— | 7-((2-bromobenzyl)oxy)-4-oxo-2-phenyl-4H-chromene-3,5-diyl diacetate | 1254040-72-6 | C26H19BrO7 |
|
| —— | 2-(2-isopropoxy-phenyl)-4-oxo-4<i>H</i>-chromene-6-carboxylic acid 2-morpholin-4-yl-ethyl ester | 57009-69-5 | C25H27NO6 |
|
| —— | 2-{2-[7-Methoxy-2-phenyl-chroman-(4E)-ylidene]-ethyl}-2-methyl-cyclopentane-1,3-diol | 58701-53-4 | C24H28O4 |
|
| —— | 4'-p-Brom-acetylflavon | 60324-53-0 | C17H11BrO3 |
|
| —— | Acetic acid (2R,3R,4S)-4-acetoxy-7-methoxy-2-(2,4,6-trimethoxy-phenyl)-chroman-3-yl ester | 58484-57-4 | C23H26O9 |
|
| —— | 3,3',4',7-Tetrakis(benzyloxy)-5-hydroxy-8-methoxyflavon | 62506-99-4 | C44H36O8 |
|
| —— | 4'-acetoxy-6,7,3'-trimethoxyflavone | 118793-54-7 | C20H18O7 |
|
| —— | 5,7-Diacetoxy-3,6-dimethoxy-flavon | 74175-73-8 | C21H18O8 |
|
| —— | 3-Benzenesulfonyl-6-methoxy-3-phenyl-chroman-4-one | 140870-49-1 | C22H18O5S |
|
| —— | (1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide | 373630-76-3 | C23H20FNO4 |
|
| —— | 3',4'-dibenzyloxy-3-tetraacetylglucosylflavone | 331651-16-2 | C43H40O14 |
|
| —— | 7-((4-cyanobenzyl)oxy)-4-oxo-2-phenyl-4H-chromene-3,5-diyl diacetate | 1254040-82-8 | C27H19NO7 |
|
| —— | 2,8-dimethyl-4,4-diphenyl-4,4a-dihydro-2<i>H</i>-chromeno[3,2-<i>c</i>]pyridine-3,10-dione | 70611-86-8 | C26H21NO3 |
|
| —— | 6-(phenylamino)-2-phenyl-4H-chromen-4-one | 1644565-49-0 | C21H15NO2 |
|
| —— | 3,8-dimethyl-7-phenyl-chromeno[6,5-<i>d</i>]isoxazol-9-one | 49586-13-2 | C18H13NO3 |
|
| —— | (2R,3S,4R)-3-acetoxy-6-<(2R,3S,4S)-3-acetoxy-3',4',7-trimethoxyflavan-4-yl>-4-<(2R,3S)-3-acetoxy-3',4',7-trimethoxyflavan-6-yl>-3',4',7-trimethoxyflavan | 85950-33-0 | C60H62O18 |
|
| —— | 2-(2-hydroxy-phenyl)-2,3-dihydro-benzo[<i>h</i>]chromen-4-one | 110937-45-6 | C19H14O3 |
|
| —— | 3-hydroxyflavylium chloride | 72117-69-2 | C15H11O2*Cl |
|
| —— | 8-bromo-5-methoxy-2-(4-methoxy-phenyl)-chroman-4-one | 51032-13-4 | C17H15BrO4 |
|
| —— | 6-methyl-d1-6-phenyldibenzo[d,f][1,3]dioxepine | 1042724-37-7 | C20H16O2 |
|
| —— | (2S,3S)-4'-hydroxy-3-α-L-rhamnopyranosyloxyflavanone | 905564-55-8 | C21H22O8 |
|
| —— | Acetic acid (2R,3R)-3,7-diacetoxy-2-(4-acetoxy-phenyl)-6-((E)-3,7-dimethyl-octa-2,6-dienyl)-4-oxo-chroman-5-yl ester | 96917-36-1 | C33H36O10 |
|
| —— | N-(3-{1-methoxy-8-[(methylsulfonyl)amino]-6H-benzo[c]chromen-6-yl}phenyl)-N-methyl-1-propanesulfonamide | 373622-67-4 | C25H28N2O6S2 |
|
| —— | (E)-7-(3-hydroxy-3-methylbut-1-enyl)flavone | 1393811-70-5 | C20H18O3 |
|
| —— | 1403356-91-1 | C18H16Cl2O4 |
|
|
| —— | (1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide | 373632-50-9 | C25H23F2NO6 |
|
| —— | 5-Hydroxy-2'-C-prenyl-7,3',4',5'-tetramethoxyflavanon | 62287-45-0 | C24H28O7 |
|
| —— | 6-Hydroxy-5-jod-flavon | 4311-02-8 | C15H9IO3 |
|
| —— | Tetrahydroartobilochromen | 64379-38-0 | C25H28O7 |
|
| —— | 2-(3-((E)-4-methylstyryl)phenyl)-6-chloro-2,3-dihydrochromen-4-one | 1251022-70-4 | C24H19ClO2 |
|
| —— | 2-benzo[1,3]dioxol-5-yl-6,8-dibromo-chroman-4-one | 130986-75-3 | C16H10Br2O4 |
|
| —— | 7-((3-methoxybenzyl)oxy)-4-oxo-2-phenyl-4H-chromene-3,5-diyl diacetate | 1254040-80-6 | C27H22O8 |
|
| —— | 7-chloro-2-phenyl-2<i>H</i>-chromene | 67859-08-9 | C15H11ClO |
|
| —— | 6-(2-(2-hydroxyethoxy)ethoxy)-4'-dimethylaminoflavone | 1147337-36-7 | C21H23NO5 |
|
| —— | (1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide | 373632-41-8 | C24H23F2NO5S |
|
| —— | 2-(4-benzyloxy-phenyl)-5-methoxy-chromen-4-one | 742079-31-8 | C23H18O4 |
|
| —— | 7-O-[2-(N-Ethylimino)propyl]-3'-O-cyclopentyldiosmetin N-oxide | 1099011-23-0 | C26H29NO7 |
|
| —— | 2,2-dimethyl-propionic acid 8-(2,2-dimethyl-propionyloxy)-5-methyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,11-dihydro-chromeno[4,3-c]chromen-2-yl ester | 554431-08-2 | C39H45NO7 |
|
| —— | 3',4'-bis(benzyloxy)-5-(hexyloxy)-3,7,8-trimethoxyflavone | 134109-95-8 | C38H40O8 |
|
| —— | (1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide | 373631-35-7 | C21H18BrNO4S |
|
| —— | 4'-benzyloxy-3',5,6,7,8-pentamethoxyflavanone | 938041-78-2 | C27H28O8 |
|
| —— | tri-O-methyl-3-O-acetyl-(-)-fisetinidol-(4β,6)-tetra-O-methyl-3-O-acetyl-(-)-robinetinidol | 117479-75-1 | C41H44O13 |
|
| —— | 2-<p-(N,N-dimethyl) aminophenyl>-naphtho-<2,1-b>-2,3-dihydropyran-4-one | 156641-31-5 | C21H19NO2 |
|
| —— | 3-hydroxy-7-iodo-2-(4-phenylmethoxyphenyl)chromen-4-one | 132020-72-5 | C22H15IO4 |
|
| —— | 2-(3-((E)-4-methoxystyryl)phenyl)-5-methoxy-2,3-dihydrochromen-4-one | 1251022-74-8 | C25H22O4 |
|
| —— | 7-benzyloxy-3-hydroxy-5,6-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one | 59171-33-4 | C25H22O7 |
|
| —— | 5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | 1157856-47-7 | C29H29NO5 |
|
| —— | tetra-O-methyl-6,6''-bischrysin | 104416-57-1 | C34H26O8 |
|
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